Cited by 305Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

Does the Concept of "Sensitization" Provide a Plausible Mechanism for the Putative Link Between the Environment and Schizophrenia?

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Collip, D., Myin-Germeys, I., Van Os, J.·2007·Schizophrenia Bulletin

Abstract

Previous evidence reviewed in Schizophrenia Bulletin suggests the importance of a range of different environmental factors in the development of psychotic illness. It is unlikely, however, that the diversity of environmental influences associated with schizophrenia can be linked to as many different underlying mechanisms. There is evidence that environmental exposures may induce, in interaction with (epi)genetic factors, psychological or physiological alterations that can be traced to a final common pathway of cognitive biases and/or altered dopamine neurotransmission, broadly referred to as "sensitization," facilitating the onset and persistence of psychotic symptoms. At the population level, the behavioral phenotype for sensitization may be examined by quantifying, in populations exposed to environmental risk factors associated with stress or dopamine-agonist drugs, (1) the increased rate of persistence (indicating lasting sensitization) of normally transient developmental expressions of subclinical psychotic experiences and (2) the subsequent increased rate of transition to clinical psychotic disorder.

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Crossref · 10.1093/schbul/sbm163

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  • Evidence suggests that certain environmental exposures may synergistically lead to subclinical symptoms and subsequent psychiatric disorders by impacting on the HPA axis and mesolimbic dopaminergic neurotransmission.

    “Evidence indeed suggests that certain environmental exposures may synergistically lead to subclinical symptoms and subsequent psychiatric disorders by impacting on the HHPA axis 135 and mesolimbic dopaminergic neurotransmission 136”

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Research works printed but not linked: 3

  1. Myin-Germeys I, van Os J. Stress-reactivity in psychosis: ev- idence for an affective pathway to psychosis. Clin Psychol Rev. 2007;27(4):409-424.
  2. Hall FS, Wilkinson LS, Humby T, Robbins TW. Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse. 1999;32:37-43.
  3. Boileau I, Dagher A, Leyton M, et al. Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emis- sion tomography study in healthy men. Arch Gen Psychiatry. 2006;63:1386-1395.

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Authors
Collip, D., Myin-Germeys, I., & Van Os, J.
Affiliations
Maastricht University (NL)
Venue
Schizophrenia Bulletin
Published
2007-04-09
Volume
34
Issue
2
Pages
220-225
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
OpenAlex
W2103274030
Cited by
305
References
65
Citations by year
2026: 2 · 2025: 6 · 2024: 8 · 2023: 13 · 2022: 20 · 2021: 7 · 2020: 41 · 2019: 11 · 2018: 15 · 2017: 17 · 2016: 17 · 2015: 13 · 2014: 11 · 2013: 22 · 2012: 28
FWCI
2.30
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Bulletin (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
sensitization, schizophrenia
MeSH terms
Dopamine, Environment, Humans, Synaptic Transmission, Phenotype, Schizophrenia, Schizophrenic Psychology, Prefrontal Cortex, Dopamine Agonists

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