Cited by 171Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism

Open access

Pearson, B. L., Pobbe, R. L. H., Defensor, E. B., Oasay, L., Bolivar, V. J., Blanchard, D. C., Blanchard, R. J.·2011·Genes, Brain and Behavior

DOI 10.1111/j.1601-183x.2010.00659.xPMC PMC3037433

Open this paper in CoChat — free account

Abstract

The BTBR T+tf/J inbred mouse strain displays a variety of persistent phenotypic alterations similar to those exhibited in autism spectrum disorders (ASDs). The unique genetic background of the BTBR strain is thought to underlie its lack of reciprocal social interactions, elevated repetitive self-directed grooming, and restricted exploratory behaviors. In order to clarify the existence, range, and mechanisms of abnormal repetitive behaviors within BTBR mice, we performed detailed analyses of the microstructure of self-grooming patterns and noted increased overall grooming, higher percentages of interruptions in grooming bouts and a concomitant decrease in the proportion of incorrect sequence transitions compared to C57BL/6J inbred mice. Analyses of active phase home-cage behavior also revealed an increase in stereotypic bar-biting behavior in the BTBR strain relative to B6 mice. Finally, in a novel object investigation task, the BTBR mice exhibited greater baseline preference for specific unfamiliar objects as well as more patterned sequences of sequential investigations of those items. These results suggest that the repetitive, stereotyped behavior patterns of BTBR mice are relatively pervasive and reflect both motor and cognitive mechanisms. Furthermore, other pre-clinical mouse models of ASDs may benefit from these more detailed analyses of stereotypic behavior.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1601-183x.2010.00659.x

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,168
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
Stereotypies: a critical review
Mason, G. J. (1991) · Animal Behaviour · doi:10.1016/s0003-3472(05)80640-2 · Cited by 1,302
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812
Self-citation
Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776
Ethology and neurobiology of grooming behavior
Spruijt, B. M., van Hooff, J. A. R. A. M., & Gispen, W. H. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.3.825 · Cited by 738
Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety
Thomas, A., Burant, A., Bui, N., Graham, D., Yuva-Paylor, L. A., & Paylor, R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1466-y · Cited by 698
Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism
Scattoni, M. L., Gandhy, S. U., Ricceri, L., & Crawley, J. N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003067 · Cited by 550
Genetic Heterogeneity Between the Three Components of the Autism Spectrum: A Twin Study
RONALD, A., HAPPÉ, F., BOLTON, P., BUTCHER, L. M., PRICE, T. S., WHEELWRIGHT, S., BARON-COHEN, S., & PLOMIN, R. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000215325.13058.9d · Cited by 508
Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism
Pierce, K., & Courchesne, E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01008-8 · Cited by 464

Show all 47 references

Sorted by citations

Neurobiology of rodent self-grooming and its value for translational neuroscience
Kalueff, A. V., Stewart, A. M., Song, C., Berridge, K. C., Graybiel, A. M., & Fentress, J. C. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.8 · Cited by 852
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
Schmeisser, M. J., Ey, E., Wegener, S., Bockmann, J., Stempel, A. V., Kuebler, A., Janssen, A.-L., Udvardi, P. T., Shiban, E., Spilker, C., et al. (2012) · Nature · doi:10.1038/nature11015 · Cited by 638
Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation
Gogolla, N., Takesian, A. E., Feng, G., Fagiolini, M., & Hensch, T. K. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.033 · Cited by 310
Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism
Silverman, J. L., Smith, D. G., Rizzo, S. J. S., Karras, M. N., Turner, S. M., Tolu, S. S., Bryce, D. K., Smith, D. L., Fonseca, K., Ring, R. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003501 · Cited by 251
Enhancement of Inhibitory Neurotransmission by GABA A Receptors Having α 2,3 -Subunits Ameliorates Behavioral Deficits in a Mouse Model of Autism
Han, S., Tai, C., Jones, C. J., Scheuer, T., & Catterall, W. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.016 · Cited by 231
GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism
Silverman, J. L., Pride, M. C., Hayes, J. E., Puhger, K. R., Butler-Struben, H. M., Baker, S., & Crawley, J. N. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.66 · Cited by 215
Prenatal infection leads to ASD-like behavior and altered synaptic pruning in the mouse offspring
de Cossío, L. F., Guzman, A. S., van der Veldt, S., & Luheshi, G. N. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.028 · Cited by 227
Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors
Amodeo, D. A., Jones, J. H., Sweeney, J. A., & Ragozzino, M. E. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.032 · Cited by 200
mGluR5-Antagonist Mediated Reversal of Elevated Stereotyped, Repetitive Behaviors in the VPA Model of Autism
Mehta, M. V., Gandal, M. J., & Siegel, S. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026077 · Cited by 188
Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder
Coretti, L., Cristiano, C., Florio, E., Scala, G., Lama, A., Keller, S., Cuomo, M., Russo, R., Pero, R., Paciello, O., et al. (2017) · Scientific Reports · doi:10.1038/srep45356 · Cited by 175
Modeling Autistic Features in Animals
Patterson, P. H. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212b80f · Cited by 172
Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression
Chung, W., Choi, S. Y., Lee, E., Park, H., Kang, J., Park, H., Choi, Y., Lee, D., Park, S.-G., Kim, R., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3927 · Cited by 166
The BTBR T+tf/J mouse model for autism spectrum disorders–in search of biomarkers
Meyza, K. Z., Defensor, E. B., Jensen, A. L., Corley, M. J., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.021 · Cited by 147
Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism
Silverman, J. L., Yang, M., Turner, S. M., Katz, A. M., Bell, D. B., Koenig, J. I., & Crawley, J. N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.059 · Cited by 146
Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors
Pobbe, R. L. H., Pearson, B. L., Defensor, E. B., Bolivar, V. J., Young, W. S., Lee, H., Blanchard, D. C., & Blanchard, R. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.010 · Cited by 143
Self-citation
A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice
Defensor, E. B., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.033 · Cited by 136
Self-citation
Neuroanatomical analysis of the BTBR mouse model of autism using magnetic resonance imaging and diffusion tensor imaging
Ellegood, J., Babineau, B. A., Henkelman, R. M., Lerch, J. P., & Crawley, J. N. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.12.029 · Cited by 135
Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism
Ellegood, J., & Crawley, J. N. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0360-z · Cited by 137
The BTBR Mouse Model of Autism Spectrum Disorders Has Learning and Attentional Impairments and Alterations in Acetylcholine and Kynurenic Acid in Prefrontal Cortex
McTighe, S. M., Webb, S. J. N., Lin, Q., Hughes, Z. A., & Smith, D. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062189 · Cited by 139
Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: current status and future perspectives
Kas, M. J., Glennon, J. C., Buitelaar, J., Ey, E., Biemans, B., Crawley, J., Ring, R. H., Lajonchere, C., Esclassan, F., Talpos, J., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3268-5 · Cited by 132
Long-term exposure to intranasal oxytocin in a mouse autism model
Bales, K. L., Solomon, M., Jacob, S., Crawley, J. N., Silverman, J. L., Larke, R. H., Sahagún, E., Puhger, K. R., Pride, M. C., & Mendoza, S. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.117 · Cited by 131
Environmental enrichment as a therapy for autism: A clinical trial replication and extension.
Woo, C. C., Donnelly, J. H., Steinberg-Epstein, R., & Leon, M. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000068 · Cited by 132
Object recognition memory in zebrafish
May, Z., Morrill, A., Holcombe, A., Johnston, T., Gallup, J., Fouad, K., Schalomon, M., & Hamilton, T. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.09.016 · Cited by 127
Genetic and non-genetic animal models for autism spectrum disorders (ASD)
Ergaz, Z., Weinstein‐Fudim, L., & Ornoy, A. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.04.024 · Cited by 121
AMPAKINE enhancement of social interaction in the BTBR mouse model of autism
Silverman, J. L., Oliver, C. F., Karras, M. N., Gastrell, P. T., & Crawley, J. N. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.013 · Cited by 116
Neurobiology of rodent self-grooming and its value for translational neuroscience
Kalueff, A. V., Stewart, A., Song, C., Berridge, K. C., Fentress, J. C., & Graybiel, A. M. (2017) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 114
The role of immune mechanisms in Tourette syndrome
Martino, D., Zis, P., & Buttiglione, M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.027 · Cited by 109
Behavioral Phenotyping of an Improved Mouse Model of Phelan–McDermid Syndrome with a Complete Deletion of the Shank3 Gene
Drapeau, E., Riad, M., Kajiwara, Y., & Buxbaum, J. D. (2018) · eNeuro · doi:10.1523/eneuro.0046-18.2018 · Cited by 111
Variation in restricted and repetitive behaviors and interests relates to inhibitory control and shifting in children with autism spectrum disorder
Faja, S., & Darling, L. N. (2018) · Autism · doi:10.1177/1362361318804192 · Cited by 117
Validation and implementation of a novel high-throughput behavioral phenotyping instrument for mice
Brodkin, J. D., Frank, D. M., Grippo, R. M., Hausfater, M., Gulinello, M. E., Achterholt, N., & Gutzen, C. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.12.010 · Cited by 102
Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice
Segal‐Gavish, H., Karvat, G., Barak, N., Barzilay, R., Ganz, J., Edry, L., Aharony, I., Offen, D., & Kimchi, T. (2015) · Autism Research · doi:10.1002/aur.1530 · Cited by 96
Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities
Mohn, J. L., Alexander, J., Pirone, A., Palka, C., Lee, S.-Y., Mebane, L. M., Haydon, P. G., & Jacob, M. H. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.61 · Cited by 83
Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models
Homberg, J. R., Kyzar, E. J., Nguyen, M., Norton, W., Pittman, J. T., Poudel, M. K., Gaikwad, S., Nakamura, S., Koshiba, M., Yamanouchi, H., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.013 · Cited by 86
Risperidone and the 5‐ HT2A Receptor Antagonist M 100907 Improve Probabilistic Reversal Learning in BTBR T + tf / J Mice
Amodeo, D. A., Jones, J. H., Sweeney, J. A., & Ragozzino, M. E. (2014) · Autism Research · doi:10.1002/aur.1395 · Cited by 79
A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice
Burrows, E. L., Laskaris, L., Koyama, L., Churilov, L. P., Bornstein, J. C., Hill‐Yardin, E. L., & Hannan, A. J. (2015) · Molecular Autism · doi:10.1186/s13229-015-0055-7 · Cited by 82
Inflammatory profiles in the BTBR mouse: how relevant are they to autism spectrum disorders?
Careaga, M., Schwartzer, J., & Ashwood, P. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.006 · Cited by 77
Early-life seizures result in deficits in social behavior and learning
Lugo, J. N., Swann, J. W., & Anderson, A. E. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.03.014 · Cited by 78
Dietary Zinc Supplementation Prevents Autism Related Behaviors and Striatal Synaptic Dysfunction in Shank3 Exon 13–16 Mutant Mice
Fourie, C., Vyas, Y., Lee, K., Jung, Y., Garner, C. C., & Montgomery, J. M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00374 · Cited by 78
Enhancing the value of psychiatric mouse models; differential expression of developmental behavioral and cognitive profiles in four inbred strains of mice
Molenhuis, R. T., de Visser, L., Bruining, H., & Kas, M. J. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.01.013 · Cited by 71
Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish
Dougnon, G., & Matsui, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147550 · Cited by 76
High-fat diet exacerbates cognitive rigidity and social deficiency in the BTBR mouse model of autism
Zilkha, N., Kuperman, Y., & Kimchi, T. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.070 · Cited by 72
Effects of Environmental Enrichment on Repetitive Behaviors in the BTBR T+tf/J Mouse Model of Autism
Reynolds, S., Urruela, M., & Devine, D. P. (2013) · Autism Research · doi:10.1002/aur.1298 · Cited by 65
Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder
Daimon, C. M., Jasien, J., Wood, W. H., Zhang, Y., Becker, K. G., Silverman, J. L., Crawley, J. N., Martin, B., & Maudsley, S. R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00324 · Cited by 67
Environmental Enrichment Therapy for Autism: Outcomes with Increased Access
Aronoff, E., Hillyer, R., & Leon, M. (2016) · Neural Plasticity · doi:10.1155/2016/2734915 · Cited by 68
Water T-maze: A useful assay for determination of repetitive behaviors in mice
Guariglia, S. R., & Chadman, K. K. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.08.019 · Cited by 62
The role of behavior in translational models for psychopathology: functionality and dysfunctional behaviors
Blanchard, D. C., Summers, C. H., & Blanchard, R. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.008 · Cited by 60
Quantitative trait loci for interhemispheric commissure development and social behaviors in the BTBR T+ tf/J mouse model of autism
Jones-Davis, D. M., Yang, M., Rider, E., Osbun, N. C., da Gente, G. J., Li, J., Katz, A. M., Weber, M. D., Sen, S., Crawley, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061829 · Cited by 61
The translational study of apathy—an ecological approach
Cathomas, F., Hartmann-Riemer, M. N., Seifritz, E., Pryce, C. R., & Kaiser, S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00241 · Cited by 61
Prenatal Exposure to a Common Organophosphate Insecticide Delays Motor Development in a Mouse Model of Idiopathic Autism
Felice, A. D., Scattoni, M. L., Ricceri, L., & Calamandrei, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121663 · Cited by 61
Absence of social conditioned place preference in BTBR T+tf/J mice: Relevance for social motivation testing in rodent models of autism
Pearson, B. L., Bettis, J. K., Meyza, K. Z., Yamamoto, L. Y., Blanchard, D. C., & Blanchard, R. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.040 · Cited by 57
Self-citation
Immune-mediated animal models of Tourette syndrome
Hornig, M., & Lipkin, W. I. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.007 · Cited by 56
Resveratrol Improves Neuroimmune Dysregulation Through the Inhibition of Neuronal Toll-Like Receptors and COX-2 Signaling in BTBR T+ Itpr3tf/J Mice
Ahmad, S. F., Ansari, M. A., Nadeem, A., Alzahrani, M. Z., Bakheet, S. A., & Attia, S. M. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8483-0 · Cited by 56
BTBR T+tf/J mice: Autism-relevant behaviors and reduced fractone-associated heparan sulfate
Blanchard, D. C., Defensor, E. B., Meyza, K. Z., Pobbe, R. L. H., Pearson, B. L., Bolivar, V. J., & Blanchard, R. J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.008 · Cited by 56
Self-citation
Recent advances in the understanding of microglial development and homeostasis
Low, D., & Ginhoux, F. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.004 · Cited by 57
Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review
Alamoudi, M. U. A., Hosie, S., Shindler, A. E., Wood, J. L., Franks, A. E., & Hill‐Yardin, E. L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.905841 · Cited by 59
Further characterization of repetitive behavior in C58 mice: Developmental trajectory and effects of environmental enrichment
Muehlmann, A. M., Edington, G., Mihalik, A., Buchwald, Z., Koppuzha, D., Korah, M. M., & Lewis, M. H. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.041 · Cited by 52
Studying Autism in Rodent Models: Reconciling Endophenotypes with Comorbidities
Argyropoulos, A., Gilby, K. L., & Hill‐Yardin, E. L. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00417 · Cited by 51
Influence of maternal zinc supplementation on the development of autism-associated behavioural and synaptic deficits in offspring Shank3-knockout mice
Vyas, Y., Lee, K., Jung, Y., & Montgomery, J. M. (2020) · Molecular Brain · doi:10.1186/s13041-020-00650-0 · Cited by 51
Implication of the social function of excessive self-grooming behavior in BTBR T+ltpr3tf/J mice as an idiopathic model of autism
Arakawa, H. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113432 · Cited by 49
Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism
Wang, Y., Billon, C., Walker, J. K., & Burris, T. P. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00159 · Cited by 48
Metformin Administration During Early Postnatal Life Rescues Autistic-Like Behaviors in the BTBR T+ Itpr3tf/J Mouse Model of Autism
Wang, L. Y., Cai, Y., & Fan, X. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00290 · Cited by 48
Systematic autistic-like behavioral phenotyping of 4 mouse strains using a novel wheel-running assay
Karvat, G., & Kimchi, T. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.028 · Cited by 46
Non-diagnostic symptoms in a mouse model of autism in relation to neuroanatomy: the BTBR strain reinvestigated
Faraji, J., Karimi, M., Lawrence, C., Mohajerani, M. H., & Metz, G. A. S. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0280-x · Cited by 47
Prenatal and Early‐Life Exposure to High‐Level Diesel Exhaust Particles Leads to Increased Locomotor Activity and Repetitive Behaviors in Mice
Thirtamara Rajamani, K., Doherty‐Lyons, S., Bolden, C., Willis, D., Hoffman, C., Zelikoff, J., Chen, L., & Gu, H. (2013) · Autism Research · doi:10.1002/aur.1287 · Cited by 42
Oxotremorine treatment reduces repetitive behaviors in BTBR T+ tf/J mice
Amodeo, D. A., Yi, J., Sweeney, J. A., & Ragozzino, M. E. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00017 · Cited by 47
Effect of social odor context on the emission of isolation-induced ultrasonic vocalizations in the BTBR T+tf/J mouse model for autism
Wöhr, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00073 · Cited by 43
Validation of operant social motivation paradigms using BTBR T+tf/J and C57 BL /6J inbred mouse strains
Martin, L. A., Sample, H. A., Gregg, M., & Wood, C. A. (2014) · Brain and Behavior · doi:10.1002/brb3.273 · Cited by 46
Differences in the expression of restricted repetitive behaviors in female and male BTBR T + tf/J mice
Amodeo, D. A., Pahua, A. E., Zarate, M., Taylor, J. A., Peterson, S., Posadas, R., Oliver, B. L., & Amodeo, L. R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112028 · Cited by 43
Response to Comment on “Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring”
Eftekhari, S., Shahrokhi, A., Tsintsadze, V., Nardou, R., Brouchoud, C., Conesa, M., Burnashev, N., Ferrari, D. C., & Ben‐Ari, Y. (2014) · Science · doi:10.1126/science.1256009 · Cited by 42
Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism
Silverman, J. L., Babineau, B. A., Oliver, C. F., Karras, M. N., & Crawley, J. N. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.042 · Cited by 46
Prebiotic, Probiotic, and Synbiotic Consumption Alter Behavioral Variables and Intestinal Permeability and Microbiota in BTBR Mice
Nettleton, J. E., Klančič, T., Schick, A., Choo, A. C., Cheng, N., Shearer, J., Borgland, S. L., Rho, J. M., & Reimer, R. A. (2021) · Microorganisms · doi:10.3390/microorganisms9091833 · Cited by 43
Oxytocin receptor and Mecp2308/Y knockout mice exhibit altered expression of autism-related social behaviors
Pobbe, R. L. H., Pearson, B. L., Blanchard, D. C., & Blanchard, R. J. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.02.024 · Cited by 40
Self-citation
The effects of aging on the BTBR mouse model of autism spectrum disorder
Jasien, J., Daimon, C. M., Wang, R., Shapiro, B. K., Martin, B., & Maudsley, S. R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00225 · Cited by 42
Hypothesis‐driven investigations of diverse pharmacological targets in two mouse models of autism
Rhine, M. A., Parrott, J. M., Schultz, M. N., Kazdoba, T. M., & Crawley, J. N. (2019) · Autism Research · doi:10.1002/aur.2066 · Cited by 42
Generation and basic characterization of a gene‐trap knockout mouse model of Scn2a with a substantial reduction of voltage‐gated sodium channel Nav1.2 expression
Eaton, M., Zhang, J., Ma, Z., Park, A. C., Lietzke, E. E., Romero, C. M., Liu, Y., Coleman, E. R., Chen, X., Xiao, T., et al. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12725 · Cited by 41
Potentials and Pitfalls of Cross-Translational Models of Cognitive Impairment
Dahhan, N. Z. A., Felice, F. G. D., & Munoz, D. P. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00048 · Cited by 40
Arsenic exposure via drinking water during pregnancy and lactation induces autism-like behaviors in male offspring mice
Zhang, X., Mei, D., Li, Y., You, M., Da, W., Yao, D., Xu, Y., Zhai, L., & Wang, Y. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.133338 · Cited by 40
Animal models for autism in 2017 and the consequential implications to drug discovery
Chadman, K. K. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1383982 · Cited by 39
Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder
Balaan, C., Corley, M. J., Eulalio, T. Y., Yo, K. L.-A., Pang, A. P. S., Fang, R., Khadka, V. S., Maunakea, A. K., & Ward, M. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.08.005 · Cited by 43
The adenosine A2A receptor agonist, CGS 21680, attenuates a probabilistic reversal learning deficit and elevated grooming behavior in BTBR mice
Amodeo, D. A., Cuevas, L., Dunn, J. T., Sweeney, J. A., & Ragozzino, M. E. (2017) · Autism Research · doi:10.1002/aur.1901 · Cited by 37
Human amniotic epithelial cell transplantation promotes neurogenesis and ameliorates social deficits in BTBR mice
Zhang, R., Cai, Y., Xiao, R., Zhong, H., Li, X., Guo, L., Xu, H., & Fan, X. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1267-0 · Cited by 37
Co-learning facilitates memory in mice: A new avenue in social neuroscience
Lipina, T. V., & Roder, J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.054 · Cited by 34
Fractone-associated N-sulfated heparan sulfate shows reduced quantity in BTBR T+tf/J mice: A strong model of autism
Meyza, K. Z., Blanchard, D. C., Pearson, B. L., Pobbe, R. L. H., & Blanchard, R. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.11.004 · Cited by 35
Self-citation
Dietary interventions that reduce mTOR activity rescue autistic-like behavioral deficits in mice
Wu, J., de Theije, C. G. M., da Silva, S. L., Abbring, S., van der Horst, H. J., Broersen, L. M., Willemsen, L. E. M., Kas, M. J., Garssen, J., & Kraneveld, A. D. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.016 · Cited by 35
New directions in the treatment of autism spectrum disorders from animal model research
Chadman, K. K., Guariglia, S. R., & Yoo, J. H. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.678828 · Cited by 33
Taste dysfunction in BTBR mice due to a mutation ofItpr3, the inositol triphosphate receptor 3 gene
Tordoff, M. G., & Ellis, H. T. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00092.2013 · Cited by 33
Intact and impaired executive abilities in the BTBR mouse model of autism
Rutz, H. L. H., & Rothblat, L. A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.048 · Cited by 32
Serotonin 6 receptor blockade reduces repetitive behavior in the BTBR mouse model of autism spectrum disorder
Amodeo, D. A., Oliver, B. L., Pahua, A. E., Hitchcock, K., Bykowski, A., Tice, D. L., Musleh, A., & Ryan, B. C. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173076 · Cited by 29
Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
Zabegalov, K. N., Khatsko, S. L., Lakstygal, A. M., Demin, K. A., Cleal, M., Fontana, B. D., McBride, S. D., Harvey, B. H., de Abreu, M. S., Parker, M. O., et al. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.03.044 · Cited by 32
Low home cage social behaviors in BTBR T+tf/J mice during juvenile development
Babineau, B. A., Yang, M., Berman, R. F., & Crawley, J. N. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.006 · Cited by 31
Autism-like behavior in the BTBR mouse model of autism is improved by propofol
Cai, Y., Wang, L. Y., Xiao, R., Li, X., He, X., Gao, J., Xu, H., & Fan, X. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.021 · Cited by 31
Normal Taste Acceptance and Preference of PANX1 Knockout Mice
Tordoff, M. G., Aleman, T. R., Ellis, H. T., Ohmoto, M., Matsumoto, I., Shestopalov, V. I., Mitchell, C. H., Foskett, J. K., & Poole, R. L. (2015) · Chemical Senses · doi:10.1093/chemse/bjv025 · Cited by 28
Sulindac attenuates valproic acid-induced oxidative stress levels in primary cultured cortical neurons and ameliorates repetitive/stereotypic-like movement disorders in Wistar rats prenatally exposed to valproic acid
Zhang, Y., Cailing, Y., YUAN, G.-Y., WANG, Z., Cui, W., & Li, R. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1996 · Cited by 31
Novel inter-hemispheric white matter connectivity in the BTBR mouse model of autism
Miller, V. M., Gupta, D., Neu, N., Cotroneo, A., Boulay, C. B., & Seegal, R. F. (2013) · Brain Research · doi:10.1016/j.brainres.2013.04.001 · Cited by 28
In tribute to Bob Blanchard: Divergent behavioral phenotypes of 16p11.2 deletion mice reared in same-genotype versus mixed-genotype cages
Yang, M., Lewis, F., Foley, G., & Crawley, J. N. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.04.023 · Cited by 28
Long-term behavioral effects of neonatal blockade of gastrin-releasing peptide receptors in rats: Similarities to autism spectrum disorders
Merali, Z., Presti-Torres, J., MacKay, J. C., Johnstone, J., Du, L., St-Jean, A., Levesque, D., Kent, P., Schwartsmann, G., Roesler, R., et al. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.008 · Cited by 25
Stereotypies in the Autism Spectrum Disorder: Can We Rely on an Ethological Model?
Keller, R., Costa, T., Imperiale, D., Bianco, A., Rondini, E., Hassiotis, A., & Bertelli, M. O. (2021) · Brain Sciences · doi:10.3390/brainsci11060762 · Cited by 32
The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models
Pietropaolo, S., & Marsicano, G. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.031 · Cited by 23
Modeling Restricted Repetitive Behavior in Animals
Bechard, A. R. (2012) · Autism - Open Access · doi:10.4172/2165-7890.s1-006 · Cited by 24
Mecp2 Truncation in Male Mice Promotes Affiliative Social Behavior
Pearson, B. L., Defensor, E. B., Pobbe, R. L. H., Yamamoto, L. H. L., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9501-2 · Cited by 24
Self-citation

Authors: Pearson, B. L., Pobbe, R. L. H., Defensor, E. B., Oasay, L., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J.
Affiliations: University of Hawaiʻi at Mānoa (US)
New York State Department of Health (US)
Corresponding author: Pearson, B. L.
ORCID: Pearson, B. L.
Bolivar, V. J.
Venue: Genes, Brain and Behavior
Publisher: Wiley
Published: 2010-11-04
Volume: 10
Issue: 2
Pages: 228-235
ISSN: 1601-183X (ISSN-L)
1601-1848
DOI: 10.1111/j.1601-183x.2010.00659.x
PMC: PMC3037433
OpenAlex: W2072319418
Cited by: 171
References: 47
Citations by year: 2026: 4 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 11 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 18 · 2014: 25 · 2013: 14 · 2012: 19
FWCI: 8.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1762 d)
Locations: Genes Brain & Behavior (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH081845, MH081845)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: autism spectrum disorder, mouse models of autism, repetitive behavior, stereotypy, self-grooming, home cage behavior, object preference, C57BL/6J mice, motor stereotypies
MeSH terms: Animals, Autistic Disorder, Cognition, Disease Models, Animal, Exploratory Behavior, Grooming, Male, Mice, Inbred C57BL, Mice, Neurologic Mutants, Motor Activity, Video Recording, Stereotypic Movement Disorder, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks