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Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism
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The BTBR T+tf/J inbred mouse strain displays a variety of persistent phenotypic alterations similar to those exhibited in autism spectrum disorders (ASDs). The unique genetic background of the BTBR strain is thought to underlie its lack of reciprocal social interactions, elevated repetitive self-directed grooming, and restricted exploratory behaviors. In order to clarify the existence, range, and mechanisms of abnormal repetitive behaviors within BTBR mice, we performed detailed analyses of the microstructure of self-grooming patterns and noted increased overall grooming, higher percentages of interruptions in grooming bouts and a concomitant decrease in the proportion of incorrect sequence transitions compared to C57BL/6J inbred mice. Analyses of active phase home-cage behavior also revealed an increase in stereotypic bar-biting behavior in the BTBR strain relative to B6 mice. Finally, in a novel object investigation task, the BTBR mice exhibited greater baseline preference for specific unfamiliar objects as well as more patterned sequences of sequential investigations of those items. These results suggest that the repetitive, stereotyped behavior patterns of BTBR mice are relatively pervasive and reflect both motor and cognitive mechanisms. Furthermore, other pre-clinical mouse models of ASDs may benefit from these more detailed analyses of stereotypic behavior.
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“BTBR T+tf/J (BTBR) is a commercially available inbred strain of mouse that displays behavioral phenotypes relevant to all three diagnostic symptoms of autism (60–62, 64, 66, 68–70, 72, 74–78).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [69]
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Cites
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,168
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
Stereotypies: a critical review
Mason, G. J. (1991) · Animal Behaviour · doi:10.1016/s0003-3472(05)80640-2 · Cited by 1,302
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812
Self-citationMouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776
Ethology and neurobiology of grooming behavior
Spruijt, B. M., van Hooff, J. A. R. A. M., & Gispen, W. H. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.3.825 · Cited by 738
Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety
Thomas, A., Burant, A., Bui, N., Graham, D., Yuva-Paylor, L. A., & Paylor, R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1466-y · Cited by 698
Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism
Scattoni, M. L., Gandhy, S. U., Ricceri, L., & Crawley, J. N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003067 · Cited by 550
Genetic Heterogeneity Between the Three Components of the Autism Spectrum: A Twin Study
RONALD, A., HAPPÉ, F., BOLTON, P., BUTCHER, L. M., PRICE, T. S., WHEELWRIGHT, S., BARON-COHEN, S., & PLOMIN, R. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000215325.13058.9d · Cited by 508
Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism
Pierce, K., & Courchesne, E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01008-8 · Cited by 464
Berridge, K. C., Aldridge, J. W., Houchard, K. R., & Zhuang, X. (2005) · BMC Biology · doi:10.1186/1741-7007-3-4 · Cited by 309
Grooming analysis algorithm for neurobehavioural stress research.
Kalueff, A., & Tuohimaa, P. (2004) · Brain research. Brain research protocols · doi:10.1016/j.brainresprot.2004.04.002 · Cited by 287
Kuczenski, R. T., Segal, D., & Aizenstein, M. L. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-09-02703.1991 · Cited by 285
Animal models of restricted repetitive behavior in autism
Lewis, M. H., TANIMURA, Y., Lee, L., & Bodfish, J. W. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.023 · Cited by 277
Analyzing grooming microstructure in neurobehavioral experiments
Kalueff, A. V., Aldridge, J. W., LaPorte, J. L., Murphy, D. L., & Tuohimaa, P. (2007) · Nature Protocols · doi:10.1038/nprot.2007.367 · Cited by 262
Bolles, R. C. (1960) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0045421 · Cited by 260
Ronald, A., Happé, F., & Plomin, R. (2005) · Developmental Science · doi:10.1111/j.1467-7687.2005.00433.x · Cited by 250
Garner, J. P., & Mason, G. J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00111-0 · Cited by 250
The neurobiology of repetitive behavior: Of mice…
Langen, M., Kas, M. J., Staal, W., van Engeland, H., & Durston, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.004 · Cited by 233
Development of a mouse test for repetitive, restricted behaviors: Relevance to autism
Moy, S. S., Nadler, J. J., Poe, M. D., Nonneman, R. J., Young, N. B., Koller, B. H., Crawley, J. N., Duncan, G. E., & Bodfish, J. W. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.10.029 · Cited by 195
Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism
Wöhr, M., Roullet, F. I., & Crawley, J. N. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00582.x · Cited by 169
Berridge, K. C. (1990) · Behaviour · doi:10.1163/156853990x00428 · Cited by 137
Ryan, B. C., Young, N. B., Crawley, J. N., Bodfish, J. W., & Moy, S. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.031 · Cited by 135
Social deficits in BTBR T + tf/J mice are unchanged by cross‐fostering with C57BL/6J mothers
Yang, M., Zhodzishsky, V., & Crawley, J. N. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.09.008 · Cited by 132
Rituals, stereotypy and compulsive behavior in animals and humans.
Eilam, D., Zor, R., Szechtman, H., & Hermesh, H. (2006) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.08.003 · Cited by 132
Pobbe, R. L. H., Pearson, B. L., Defensor, E. B., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.06.025 · Cited by 124
Self-citationYang, M. (2007) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.001.2007 · Cited by 124
General and social anxiety in the BTBR T+ tf/J mouse strain
Pobbe, R. L. H., Defensor, E. B., Pearson, B. L., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.039 · Cited by 121
Self-citationGrammar of a Movement Sequence in Inbred Mice
Fentress, J. C., & STILWELL, F. P. (1973) · Nature · doi:10.1038/244052a0 · Cited by 118
Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability
Yang, M., Clarke, A. M., & Crawley, J. N. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06714.x · Cited by 117
Causation of the ontogenetic development of stereotypic digging in gerbils
Wiedenmayer, C. P. (1997) · Animal Behaviour · doi:10.1006/anbe.1996.0296 · Cited by 115
Würbel, H., Stauffacher, M., & von Holst, D. (1996) · Ethology · doi:10.1111/j.1439-0310.1996.tb01133.x · Cited by 114
Ricceri, L., Moles, A., & Crawley, J. N. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.024 · Cited by 113
The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning
Denmark, A., Tien, D. H., Wong, K., Chung, A., Cachat, J., Goodspeed, J., Grimes, C., Elegante, M. F., Suciu, C., Elkhayat, S. I., et al. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.041 · Cited by 110
Kalueff, A., & Tuohimaa, P. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.11.010 · Cited by 106
Thornburg, J. E., & Moore, K. E. (1975) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30028-5 · Cited by 90
Why do male ICR(CD-1) mice perform bar-related (stereotypic) behaviour?
Nevison, C. M., Hurst, J. L., & Barnard, C. J. (1999) · Behavioural Processes · doi:10.1016/s0376-6357(99)00053-4 · Cited by 80
Stereotypic animal behavior: fundamentals and applications to welfare
Blokhuis, H. J. (1994) · Livestock Production Science · doi:10.1016/0301-6226(94)90115-5 · Cited by 78
Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype
Benno, R. H., Smirnova, Y., Vera, S., Liggett, A., & Schanz, N. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.041 · Cited by 69
HEREDITARY HAIR LOSS IN THE TUFTED MUTANT OF THE HOUSE MOUSE
Lyon, M. F. (1956) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a106601 · Cited by 56
Berridge, K. C. (1989) · Psychobiology · doi:10.3758/bf03337797 · Cited by 52
Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice
Frye, C. A., & Llaneza, D. C. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.005 · Cited by 52
Rapp, J. T., & Vollmer, T. R. (2005) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2004.11.006 · Cited by 48
Ishiguro, A., Inagaki, M., & Kaga, M. (2007) · International Journal of Neuroscience · doi:10.1080/00207450600936874 · Cited by 21
Comportements répétés et restreints (C2R) dans les troubles autistiques : évaluation clinique
Bourreau, Y., Roux, S., Gomot, M., & Barthélémy, C. (2008) · L Encéphale · doi:10.1016/j.encep.2008.05.004 · Cited by 20
Translational neuroscience in animal research : advancement, challenges, and research ethics
Warnick, J. E., & Kauleff, A. V. (2010) · Cited by 10
Burger (1998) · doi:10.1002/(sici)1098-2779(1998)4:2
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Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
Schmeisser, M. J., Ey, E., Wegener, S., Bockmann, J., Stempel, A. V., Kuebler, A., Janssen, A.-L., Udvardi, P. T., Shiban, E., Spilker, C., et al. (2012) · Nature · doi:10.1038/nature11015 · Cited by 638
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Gogolla, N., Takesian, A. E., Feng, G., Fagiolini, M., & Hensch, T. K. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.033 · Cited by 310
Silverman, J. L., Smith, D. G., Rizzo, S. J. S., Karras, M. N., Turner, S. M., Tolu, S. S., Bryce, D. K., Smith, D. L., Fonseca, K., Ring, R. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003501 · Cited by 251
Han, S., Tai, C., Jones, C. J., Scheuer, T., & Catterall, W. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.016 · Cited by 231
Metadata
- Authors
- Pearson, B. L., Pobbe, R. L. H., Defensor, E. B., Oasay, L., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- New York State Department of Health (US)
- Corresponding author
- Pearson, B. L.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2010-11-04
- Volume
- 10
- Issue
- 2
- Pages
- 228-235
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- PMC
- PMC3037433
- OpenAlex
- W2072319418
- Cited by
- 171
- References
- 47
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 11 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 18 · 2014: 25 · 2013: 14 · 2012: 19
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH081845, MH081845)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, mouse models of autism, repetitive behavior, stereotypy, self-grooming, home cage behavior, object preference, C57BL/6J mice, motor stereotypies
- MeSH terms
- Animals, Autistic Disorder, Cognition, Disease Models, Animal, Exploratory Behavior, Grooming, Male, Mice, Inbred C57BL, Mice, Neurologic Mutants, Motor Activity, Video Recording, Stereotypic Movement Disorder, Mice
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