Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.

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Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

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The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

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Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

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Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

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Rapamycin passes the torch: a new generation of mTOR inhibitors

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Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer’s disease

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Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

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Regulation of innate immune cell function by mTOR

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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

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Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

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Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling

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PI3K/Akt: getting it right matters

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Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

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The effect of curcumin (turmeric) on Alzheimer’s disease: An overview

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Amyloid beta oligomers induce impairment of neuronal insulin receptors

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A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

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REVIEW: Curcumin and Alzheimer’s disease

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Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin

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Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

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Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

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Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

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Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

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<scp>mTOR</scp> regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

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Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre‐clinical AD, amnestic mild cognitive impairment and late‐stage AD

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Architecture of human mTOR complex 1

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mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy

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Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

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Strategies for the management of adverse events associated with mTOR inhibitors

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mTOR signaling and its roles in normal and abnormal brain development

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Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

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PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

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Reduction of Soluble Aβ and Tau, but Not Soluble Aβ Alone, Ameliorates Cognitive Decline in Transgenic Mice with Plaques and Tangles

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TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model

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Current treatment strategies for inhibiting mTOR in cancer.

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FDA Approval Summary: Temsirolimus as Treatment for Advanced Renal Cell Carcinoma

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Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease

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The role of mTOR signaling in Alzheimer disease

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Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

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Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

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Alzheimer Disease, a Multifactorial Disorder Seeking Multi-therapies

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Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

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mTOR/p70S6k signalling alteration by Aβ exposure as well as in APP‐PS1 transgenic models and in patients with Alzheimer's disease

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Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

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Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

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Autophagic/lysosomal dysfunction in Alzheimer’s disease

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mTOR‐dependent signalling in Alzheimer's disease

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Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

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Updates of mTOR Inhibitors

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Recent advances in drug eluting stents

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The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

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Targeting the mTOR kinase domain: the second generation of mTOR inhibitors

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Regulation of autophagy by amino acids and MTOR-dependent signal transduction

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Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

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Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders.

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Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease

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Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability

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Resveratrol: Cellular actions of a potent natural chemical that confers a diversity of health benefits

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Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

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Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

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Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease

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Mammalian Target of Rapamycin: Hitting the Bull′s‐Eye for Neurological Disorders

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Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

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AMPK: a cellular energy sensor primarily regulated by AMP

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Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer

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Specification of Neuronal Polarity Regulated by Local Translation of CRMP2 and Tau via the mTOR-p70S6K Pathway

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Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

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Communication breaks-Down: From neurodevelopment defects to cognitive disabilities in Down syndrome

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