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Neuroimaging Studies of Amygdala Function in Anxiety Disorders
Abstract
A bstract : Neuroimaging research has helped to advance neurobiological models of anxiety disorders. The amygdala is known to play an important role in normal fear conditioning and is implicated in the pathophysiology of anxiety disorders. The amygdala may also be a target for the beneficial effects of cognitive‐behavioral and medication treatments for anxiety disorders. In the current paper, we review neuroimaging research pertaining to the role of the amygdala in anxiety disorders and their treatment. Moreover, we discuss the development of new neuroimaging paradigms for measuring aspects of amygdala function, as well as the function of related brain regions. We conclude that such tools hold great promise for facilitating progress in relevant basic neuroscience as well as clinical research domains.
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“There is evidence for dysregulation of amygdala activity in anxious and depressed children (Thomas et al. 2001a) and adults (Leppanen 2006; Rauch et al. 2003; Thomas et al. 2001a).”
From The Adolescent Brain (2008) · cites this paper as Rauch et al. 2003
In the citing paper
“This module is comprised of the amygdala, hippocampus, and insula, which consistently respond to aversive stimuli (Hardin et al., 2009b; Rauch et al., 2003).”
From A systematic review of fMRI reward paradigms used in studies of adolescents vs. adults: The impact of task design and implications for understanding neurodevelopment (2013) · cites this paper as Rauch et al., 2003
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Metadata
- Authors
- RAUCH, S. L., SHIN, L. M., & WRIGHT, C. I.
- Affiliations
- Harvard University (US)
- Tufts University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- RAUCH, SCOTT L.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2003-04
- Volume
- 985
- Issue
- 1
- Pages
- 389-410
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2008245053
- Cited by
- 463
- References
- 110
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 12 · 2023: 21 · 2022: 9 · 2021: 23 · 2020: 15 · 2019: 17 · 2018: 18 · 2017: 14 · 2016: 9 · 2015: 16 · 2014: 19 · 2013: 30 · 2012: 27
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, anxiety disorders, fear conditioning, cognitive behavioral therapy, pharmacotherapy, treatment response
- MeSH terms
- Amygdala, Anxiety Disorders, Brain Mapping, Humans, Magnetic Resonance Imaging, Obsessive-Compulsive Disorder, Phobic Disorders, Tomography, Emission-Computed, Panic Disorder
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