Cited by 463Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMemory and Neural MechanismsNeural and Behavioral Psychology Studies

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Neuroimaging Studies of Amygdala Function in Anxiety Disorders

RAUCH, SCOTT L., SHIN, LISA M., WRIGHT, CHRISTOPHER I.·2003·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2003.tb07096.x

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Abstract

A bstract : Neuroimaging research has helped to advance neurobiological models of anxiety disorders. The amygdala is known to play an important role in normal fear conditioning and is implicated in the pathophysiology of anxiety disorders. The amygdala may also be a target for the beneficial effects of cognitive‐behavioral and medication treatments for anxiety disorders. In the current paper, we review neuroimaging research pertaining to the role of the amygdala in anxiety disorders and their treatment. Moreover, we discuss the development of new neuroimaging paradigms for measuring aspects of amygdala function, as well as the function of related brain regions. We conclude that such tools hold great promise for facilitating progress in relevant basic neuroscience as well as clinical research domains.

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Looking at pictures: Affective, facial, visceral, and behavioral reactions
LANG, P. J., GREENWALD, M. K., BRADLEY, M. M., & HAMM, A. O. (1993) · Psychophysiology · doi:10.1111/j.1469-8986.1993.tb03352.x · Cited by 3,190
Masked Presentations of Emotional Facial Expressions Modulate Amygdala Activity without Explicit Knowledge
Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205
Self-citation
A differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013
Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711
Self-citation
Conscious and unconscious emotional learning in the human amygdala
Morris, J. S., Öhman, A., & Dolan, R. J. (1998) · Nature · doi:10.1038/30976 · Cited by 1,665
MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610
Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study
LaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., & Phelps, E. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80475-4 · Cited by 1,402
Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder
Baxter, L. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820090009002 · Cited by 1,293
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., Capelli, S., McCarthy, G., Innis, R. B., & Charney, D. S. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00162-x · Cited by 1,283
Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study
Sheline, Y. I., Barch, D. M., Donnelly, J. M., Ollinger, J. M., Snyder, A. Z., & Mintun, M. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01263-x · Cited by 1,191

Show all 110 references

Research works printed but not linked: 7

Rauch S.L. & L.R. Baxter. 1998. Neuroimaging of OCD and related disorders.InObsessive‐Compulsive Disorders: Theory and Management. M.A. Jenike L. Baer & W.E. Minichiello Eds. :289–317. Mosby. Boston MA.
Rauch S.L.et al.1998. Neurobiological models of obsessive‐compulsive disorders.InObsessive‐Compulsive Disorders: Theory and Management. M.A. Jenike L. Baer & W.E. Minichiello Eds. :222–253. Mosby. Boston MA.
Nathan P.E. & J.M. Gorman Eds. 2002. Treatments That Work. Oxford University Press. New York NY.
Aggleton J.P. Ed. 1992. The Amygdala: Neurobiological Aspects of Emotion Memory and Mental Dysfunction. Wiley‐Liss. New York NY.
DeBellis M.D., 1999, Developmental traumatology, Part II: Brain development. Biol. Psychiatry, 45, 1271
Amaral D.G.et al.1992. Anatomical organization of the primate amygdaloid complex. In The Amygdala: Neurobiological Aspects of Emotion Memory and Mental Dysfunction. J.P. Aggleton Ed. :1–66. Wiley‐Liss. New York NY.
Rauch S.L.et al.2001. Probing striato‐thalamic function in OCD and TS using neuroimaging methods. In Tourette Syndrome. Vol. 85. D.J. Cohen C. Goetz & J. Jankovic Eds. :207–224. Lippincott Williams & Wilkins. Philadelphia PA.

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Cardoner, N., Harrison, B. J., Pujol, J., Soriano‐Mas, C., Hernández‐Ribas, R., López‐Solà, M., Real, E., Deus, J., Ortiz, H., Alonso, P., et al. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.559268 · Cited by 67
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Test‐retest reliability of amygdala response to emotional faces
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Herrington, J. D., Miller, J. S., Pandey, J., & Schultz, R. T. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw015 · Cited by 70
Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit
Dehdar, K., Mahdidoust, S., Salimi, M., Gholami-Mahtaj, L., Nazari, M., Mohammadi, S., Dehghan, S., Jamaati, H., Khosrowabadi, R., Nasiraei‐Moghaddam, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55539-3 · Cited by 64
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Alpers, G. W., Gerdes, A. B. M., Lagarie, B., Tabbert, K., Vaitl, D., & Stark, R. M. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0106-8 · Cited by 65
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Bair, M. J., Poleshuck, E. L., Wu, J., Krebs, E. E., Damush, T. M., Tu, W., & Kroenke, K. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3182652ee9 · Cited by 71
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Dumas, T., Dubal, S., Attal, Y., Marie Chupin, A., Jouvent, R., Morel‐Kohlmeyer, S., & George, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074145 · Cited by 111
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MacDonald, K. S., Berlow, R., & Thomas, M. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.07.040 · Cited by 65
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Different neural responses to stranger and personally familiar faces in shy and bold adults.
Beaton, E. A., Schmidt, L. A., Schulkin, J. A., Antony, M. M., Swinson, R. P., & Hall, G. B. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.3.704 · Cited by 60
Increased whole-body auditory startle reflex and autonomic reactivity in children with anxiety disorders
Bakker, M. J., Tijssen, M. A. J., van der Meer, J. N., Koelman, J. H. T. M., & Boer, F. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0941 · Cited by 59
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Ravinder, S., Burghardt, N. S., Brodsky, R., Bauer, E. P., & Chattarji, S. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.137 · Cited by 63
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Boyle, L. M. (2013) · Europe PMC (PubMed Central) · Cited by 57
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Diamond, D. M., & Zoladz, P. R. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23684 · Cited by 61
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Hashimoto, H., Monserratt, L., Nguyen, P., Feil, D., Harwood, D., Mandelkern, M., & Sultzer, D. (2006) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.2006.18.4.521 · Cited by 47
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South, M., Dana, J., White, S. E., & Crowley, M. J. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1021-z · Cited by 66
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Tzanoulinou, S., García-Mompó, C., Castillo-Gómez, E., Veenit, V., Nacher, J., & Sandi, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094666 · Cited by 56
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van Wingen, G. A., Rijpkema, M., Franke, B., van Eijndhoven, P., Tendolkar, I., Verkes, R. J., Buitelaar, J. K., & Fernández, G. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.058 · Cited by 58
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Kosson, D. S., Budhani, S., Nakic, M., Chen, G., Saad, Z. S., Vythilingam, M., Pine, D. S., & Blair, J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.060 · Cited by 58
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Venard, C., Boujedaini, N., Mensah‐Nyagan, A. G., & Patte‐Mensah, C. (2009) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nep083 · Cited by 55
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Sachdev, P. S., Chen, X., Joscelyne, A., Wen, W. X., & Brodaty, H. (2007) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3180581fe6 · Cited by 49
Assessments of Cognitive Deficits in Mutant Mice
Levin, E. D., & Buccafusco, J. J. (2006) · CRC Press eBooks · doi:10.1201/9781420004335-17 · Cited by 48
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Impact of stress on brain morphology: insights into structural biomarkers of stress-related disorders.
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Authors: RAUCH, S. L., SHIN, L. M., & WRIGHT, C. I.
Affiliations: Harvard University (US)
Tufts University (US)
Brigham and Women's Hospital (US)
Corresponding author: RAUCH, SCOTT L.
ORCID: RAUCH, SCOTT L.
SHIN, LISA M.
WRIGHT, CHRISTOPHER I.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2003-04
Volume: 985
Issue: 1
Pages: 389-410
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2003.tb07096.x
OpenAlex: W2008245053
Cited by: 463
References: 110
Citations by year: 2026: 7 · 2025: 12 · 2024: 12 · 2023: 21 · 2022: 9 · 2021: 23 · 2020: 15 · 2019: 17 · 2018: 18 · 2017: 14 · 2016: 9 · 2015: 16 · 2014: 19 · 2013: 30 · 2012: 27
FWCI: 4.68
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1029 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: amygdala, anxiety disorders, fear conditioning, cognitive behavioral therapy, pharmacotherapy, treatment response
MeSH terms: Amygdala, Anxiety Disorders, Brain Mapping, Humans, Magnetic Resonance Imaging, Obsessive-Compulsive Disorder, Phobic Disorders, Tomography, Emission-Computed, Panic Disorder

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Neuroimaging Studies of Amygdala Function in Anxiety Disorders

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