Cited by 607Diet, Metabolism, and DiseaseRegulation of Appetite and ObesityBiochemical Analysis and Sensing Techniques

The DOI matches its Crossref record; 226 of the 230 references it cites were found in a registry or an index.

Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.

Open access

Havel, Peter J.·2005·Nutrition Reviews

DOI 10.1111/j.1753-4887.2005.tb00132.x

Open this paper in CoChat — free account Open PDF

Abstract

Fructose intake and the prevalence of obesity have both increased over the past two to three decades. Compared with glucose, the hepatic metabolism of fructose favors lipogenesis, which may contribute to hyperlipidemia and obesity. Fructose does not increase insulin and leptin or suppress ghrelin, which suggests an endocrine mechanism by which it induces a positive energy balance. This review examines the available data on the effects of dietary fructose on energy homeostasis and lipid/carbohydrate metabolism. Recent publications, studies in human subjects, and areas in which additional research is needed are emphasized.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1753-4887.2005.tb00132.x

Cites

226 of 226 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids
Trumbo, P., Schlicker, S., Yates, A. A., & Poos, M. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90346-9 · Cited by 5,993
Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002.
Hedley, A. A., Ogden, C., Johnson, C. L., Carroll, M., Curtin, L. R., & Flegal, K. (2004) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.291.23.2847 · Cited by 4,670
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
Ghrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Marina, K., Dellinger, E. P., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,271

Show all 230 references

Research works printed but not linked: 8

Havel, 2003, Pituitary and Periphery: Communication In and Out, 89
Bowman, 1999, Diets of individuals based on energy intakes from added sugars, Fam Econ Nutr Rev, 12, 31
Schwarz, 1993, De novo lipogenesis during fasting and oral fructose ingestion in lean and obese hyperinsuline-mic subjects, Diabetes, 42, A39
Havel, 2003, Short-term and long-term consumption of high fructose, but not high glucose, diets increases postprandial triglyc-erides and apo-lipoprotein-B in women, J Invest Med, 51, S163
Schwarz, 1993, Effect of oral fructose on lipolysis, fat oxidation, fractional and absolute de novo lipogenesis (DNL) using mass isotopomer distribution analysis (MIDA), FASEB J, 7, A867
Schwarz, 1994, Effect of fructose ingestion on glucose production (GP) and de novo lipogenesis (DNL) in normal and hyperinsulinemic obese humans, Diabetes, 43, A52
Moore, 2000, Fructose decreases the glucose and insulin responses to an oral glucose tolerance test (OGTT) in individuals with type 2 diabetes (DM2), Diabetes, 49, A84
Havel, 2002, Consuming high fructose meals reduces 24 hour circulating insulin and leptin concentrations and does not suppress circulating ghrelin in women, J Invest Med, 50, 26A

Sorted by citations

Uric Acid and Cardiovascular Risk
Feig, D. I., Kang, D., & Johnson, R. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800885 · Cited by 2,467
Intake of sugar-sweetened beverages and weight gain: a systematic review
Malik, V. S., Schulze, M. B., & Hu, F. B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.274 · Cited by 2,100
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
Stanhope, K. L., Schwarz, J. M., Keim, N. L., Griffen, S. C., Bremer, A. A., Graham, J. L., Hatcher, B., Cox, C. L., Dyachenko, A., Zhang, W., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37385 · Cited by 1,765
Self-citation
Sugar-Sweetened Beverages, Obesity, Type 2 Diabetes Mellitus, and Cardiovascular Disease Risk
Malik, V. S., Popkin, B. M., Bray, G. A., Després, J.-P., & Hu, F. B. (2010) · Circulation · doi:10.1161/circulationaha.109.876185 · Cited by 1,641
The SLC2 (GLUT) family of membrane transporters
Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328
Metabolic Effects of Fructose and the Worldwide Increase in Obesity
Tappy, L., & Lê, K.-A. (2010) · Physiological Reviews · doi:10.1152/physrev.00019.2009 · Cited by 1,256
Dietary Sugars Intake and Cardiovascular Health: A Scientific Statement From the American Heart Association
Johnson, R. K., Appel, L. J., Brands, M., Howard, B. V., Lefevre, M., Lustig, R. H., Sacks, F., Steffen, L. M., & Wylie-Rosett, J. (2009) · Circulation · doi:10.1161/circulationaha.109.192627 · Cited by 1,207
Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence
Hu, F. B., & Malik, V. S. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.01.036 · Cited by 909
Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline
Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3213 · Cited by 887
“Foods that contain potent substrates for triglyceride production such as simple sugars, fructose, and alcohol can substantially increase triglyceride levels in susceptible people (80, 81).”
Fructose consumption as a risk factor for non-alcoholic fatty liver disease
Ouyang, X., Cirillo, P., Sautin, Y. Y., McCall, S. J., Bruchette, J. L., Diehl, A. M., Johnson, R. J., & Abdelmalek, M. F. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.02.011 · Cited by 862
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome
Lim, J. S., Mietus-Snyder, M., Valente, A., Schwarz, J.-M., & Lustig, R. H. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.41 · Cited by 771
Sugar consumption, metabolic disease and obesity: The state of the controversy
Stanhope, K. L. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1084990 · Cited by 739
Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress
Lanaspa, M. A., Sánchez‐Lozada, L. G., Choi, Y.-J., Cicerchi, C., Kanbay, M., Roncal-Jiménez, C. A., Ishimoto, T., Li, N., Marek, G. W., Duranay, M., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.399899 · Cited by 728
Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study
Maersk, M., Belza, A., Stødkilde-Jørgensen, H., Ringgaard, S., Chabanova, E., Thomsen, H., Pedersen, S. B., Astrup, A., & Richelsen, B. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.022533 · Cited by 603
Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes?
Johnson, R. J., Perez-Pozo, S. E., Sautin, Y. Y., Manitius, J., Sánchez‐Lozada, L. G., Feig, D. I., Shafiu, M., Segal, M. S., Glassock, R. J., Shimada, M., et al. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0033 · Cited by 509
Regulation of the fructose transporter GLUT5 in health and disease
Douard, V., & Ferraris, R. P. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90245.2008 · Cited by 498
National Estimates of Dietary Fructose Intake Increased from 1977 to 2004 in the United States
Marriott, B. P., Cole, N., & Lee, E. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.098277 · Cited by 473
Slowly Digestible Starch: Concept, Mechanism, and Proposed Extended Glycemic Index
Zhang, G., & Hamaker, B. R. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372466 · Cited by 476
Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey.
Vos, M. B., Kimmons, J. E., Gillespie, C., Welsh, J. A., & Blanck, H. M. (2008) · PubMed Central · Cited by 456
Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease
Zivkovic, A. M., German, J. B., & Sanyal, A. J. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.285 · Cited by 422
Consumption of added sugars is decreasing in the United States
Welsh, J. A., Sharma, A. J., Grellinger, L., & Vos, M. B. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.018366 · Cited by 420
Uric acid, hyperuricemia and vascular diseases
Jin, M. J. (2011) · Frontiers in bioscience · doi:10.2741/3950 · Cited by 422
Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways
Page, K. A., Chan, O., Arora, J., Belfort-DeAguiar, R., Dzuira, J., Roehmholdt, B., Cline, G. W., Naik, S., Sinha, R., Constable, R. T., et al. (2013) · JAMA · doi:10.1001/jama.2012.116975 · Cited by 379
High-Fructose, Medium Chain Trans Fat Diet Induces Liver Fibrosis and Elevates Plasma Coenzyme Q9 in a Novel Murine Model of Obesity and Nonalcoholic Steatohepatitis†
Kohli, R., Kirby, M., Xanthakos, S. A., Softic, S., Feldstein, A. E., Saxena, V., Tang, P., Miles, L., Miles, M. V., Balistreri, W. F., et al. (2010) · Hepatology · doi:10.1002/hep.23797 · Cited by 387
Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial
Aeberli, I., Gerber, P. A., Hochuli, M., Kohler, S., Haile, S. R., Gouni-Berthold, I., Berthold, H. K., Spinas, G. A., & Berneis, K. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.013540 · Cited by 372
Fructose and metabolic diseases: New findings, new questions
Tappy, L., Lê, K., Tran, C., & Paquot, N. (2010) · Nutrition · doi:10.1016/j.nut.2010.02.014 · Cited by 375
The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension
Tran, L. T., Yuen, V. G., & McNeill, J. H. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0184-4 · Cited by 374
Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response
Perez-Pozo, S. E., Schold, J. D., Nakagawa, T., Sánchez‐Lozada, L. G., Johnson, R. J., & Lillo, J. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.259 · Cited by 344
Dietary fructose in nonalcoholic fatty liver disease
Vos, M. B., & Lavine, J. E. (2013) · Hepatology · doi:10.1002/hep.26299 · Cited by 319
High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels
Bocarsly, M. E., Powell, E. S., Avena, N. M., & Hoebel, B. G. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.02.012 · Cited by 314
Fructose: Metabolic, Hedonic, and Societal Parallels with Ethanol
Lustig, R. H. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.06.008 · Cited by 317
What is metabolic syndrome, and why are children getting it?
Weiss, R., Bremer, A. A., & Lustig, R. H. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12030 · Cited by 314
Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding
Shapiro, A. M., Mu, W., Roncal, C., Cheng, K., Johnson, R. J., & Scarpace, P. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00195.2008 · Cited by 318
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice
Ishimoto, T., Lanaspa, M. A., Le, M. T., García, G., Diggle, C. P., MacLean, P. S., Jackman, M. R., Asipu, A., Roncal-Jiménez, C. A., Kosugi, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119908109 · Cited by 308
Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses
Teff, K. L., Grudziak, J., Townsend, R. R., Dunn, T. N., Grant, R. W., Adams, S. H., Keim, N. L., Cummings, B. P., Stanhope, K. L., & Havel, P. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2192 · Cited by 301
Self-citation
A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans
Lê, K., Faeh, D., Stettler, R., Ith, M., Kreis, R., Vermathen, P., Boesch, C., Ravussin, É., & Tappy, L. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.6.1374 · Cited by 289
Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Development of Fatty Liver
Lanaspa, M. A., Sánchez‐Lozada, L. G., Cicerchi, C., Li, N., Roncal-Jiménez, C. A., Ishimoto, T., Le, M. T., García, G., Thomas, J. B., Rivard, C. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047948 · Cited by 292
Potential Role of Uric Acid in Metabolic Syndrome, Hypertension, Kidney Injury, and Cardiovascular Diseases: Is It Time for Reappraisal?
Soltani, Z., Rasheed, K., Kapusta, D. R., & Reisin, E. (2013) · Current Hypertension Reports · doi:10.1007/s11906-013-0344-5 · Cited by 271
A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults
Stanhope, K. L., Medici, V., Bremer, A. A., Lee, V., Lam, H. D., Nunez, M. V., Chen, G. X., Keim, N. L., & Havel, P. J. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.100461 · Cited by 270
Self-citation
Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance
Stanhope, K. L., & Havel, P. J. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282f2b24a · Cited by 274
Self-citation
Consumption of Added Sugars and Indicators of Cardiovascular Disease Risk Among US Adolescents
Welsh, J. A., Sharma, A. J., Cunningham, S. A., & Vos, M. B. (2011) · Circulation · doi:10.1161/circulationaha.110.972166 · Cited by 269
Hypertriglyceridemia
Brunzell, J. D. (2007) · New England Journal of Medicine · doi:10.1056/nejmcp070061 · Cited by 268
Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies
Livesey, G., & Taylor, R. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2007.25700 · Cited by 267
Fast Food, Central Nervous System Insulin Resistance, and Obesity
ISGANAITIS, E. M., & Lustig, R. H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000186208.06964.91 · Cited by 262
The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
Gentile, C. L., & Pagliassotti, M. J. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.10.001 · Cited by 254
Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome
Lanaspa, M. A., Ishimoto, T., Li, N., Cicerchi, C., Orlicky, D. J., Ruzycki, P. A., Rivard, C. J., Inaba, S., Roncal-Jiménez, C. A., Bales, E. S., et al. (2013) · Nature Communications · doi:10.1038/ncomms3434 · Cited by 259
Metabolic effects of fructose
Lê, K., & Tappy, L. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000232910.61612.4d · Cited by 247
Fructose and the Metabolic Syndrome: Pathophysiology and Molecular Mechanisms
Rutledge, A. C., & Adeli, K. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00322.x · Cited by 248
Uric Acid - Key Ingredient in the Recipe for Cardiorenal Metabolic Syndrome
Chaudhary, K. R., Malhotra, K., Sowers, J. R., & Aroor, A. R. (2013) · Cardiorenal Medicine · doi:10.1159/000355405 · Cited by 242
Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease
Aragno, M., & Mastrocola, R. (2017) · Nutrients · doi:10.3390/nu9040385 · Cited by 239
Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup
Stanhope, K. L., & Havel, P. J. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.25825d · Cited by 238
Self-citation
Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals
Stanhope, K. L., Griffen, S. C., Bair, B. R., Swarbrick, M. M., Keim, N. L., & Havel, P. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1194 · Cited by 226
Self-citation
Tagatose, a new antidiabetic and obesity control drug
Lu, Y., Levin, G. V., & Donner, T. W. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00799.x · Cited by 226
Role of Fructose-Containing Sugars in the Epidemics of Obesity and Metabolic Syndrome
Stanhope, K. L. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-042010-113026 · Cited by 224
Energy and Fructose From Beverages Sweetened With Sugar or High-Fructose Corn Syrup Pose a Health Risk for Some People
Bray, G. A. (2013) · Advances in Nutrition · doi:10.3945/an.112.002816 · Cited by 233
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation
Li, X., Qian, X., Peng, L.-X., Jiang, Y., Hawke, D. H., Zheng, Y., Xia, Y., Lee, J.-H., Cote, G. J., Wang, H., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3338 · Cited by 215
Liquid calories, sugar, and body weight
Drewnowski, A., & Bellisle, F. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.651 · Cited by 214
Rats Fed Fructose-Enriched Diets Have Characteristics of Nonalcoholic Hepatic Steatosis
Kawasaki, T., Igarashi, K., Koeda, T., Sugimoto, K., Nakagawa, K., Hayashi, S., Yamaji, R., Inui, H., Fukusato, T., & Yamanouchi, T. (2009) · Journal of Nutrition · doi:10.3945/jn.109.105858 · Cited by 206
The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance
Nagai, Y., Yonemitsu, S., Erion, D. M., Iwasaki, T., Stark, R., Weismann, D., Dong, J., Zhang, D., Jurczak, M. J., Löffler, M. G., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.01.011 · Cited by 203
Soft drinks consumption and nonalcoholic fatty liver disease
Nseir, W. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i21.2579 · Cited by 206
Health implications of fructose consumption: A review of recent data
Rizkalla, S. W. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-82 · Cited by 216
Association of fructose consumption and components of metabolic syndrome in human studies: a systematic review and meta-analysis
Kelishadi, R., Mansourian, M., & Heidari-Beni, M. (2014) · Nutrition · doi:10.1016/j.nut.2013.08.014 · Cited by 199
Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice
Mellor, K. M., Bell, J. R., Young, M. J., Ritchie, R. H., & Delbridge, L. M. D. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.03.002 · Cited by 200
The Role of Diet in the Pathogenesis of Cholesterol Gallstones
Ciaula, A. D., Garruti, G., Frühbeck, G., Angelis, M. D., de Bari, O., Wang, D. Q. ‐., Lammert, F., & Portincasa, P. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170530080636 · Cited by 205
Sucrose, High-Fructose Corn Syrup, and Fructose, Their Metabolism and Potential Health Effects: What Do We Really Know?
Rippe, J. M., & Angelopoulos, T. J. (2013) · Advances in Nutrition · doi:10.3945/an.112.002824 · Cited by 203
Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys
Blevins, J. E., Graham, J. L., Morton, G. J., Bales, K. L., Schwartz, M. W., Baskin, D. G., & Havel, P. J. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00441.2014 · Cited by 191
Self-citation
Intake of Added Sugar and Sugar-Sweetened Drink and Serum Uric Acid Concentration in US Men and Women
Gao, X., Qi, L., Qiao, N., Choi, H. K., Curhan, G. C., Tucker, K. L., & Ascherio, A. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.091041 · Cited by 187
Toward a unifying hypothesis of metabolic syndrome
Bremer, A. A., Mietus-Snyder, M., & Lustig, R. H. (2012) · PEDIATRICS · doi:10.1542/peds.2011-2912 · Cited by 186
Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake
Roncal-Jiménez, C. A., Lanaspa, M. A., Rivard, C. J., Nakagawa, T., Sánchez‐Lozada, L. G., Jalal, D. I., Andrés-Hernando, A., Tanabe, K., Madero, M., Li, N., et al. (2011) · Metabolism · doi:10.1016/j.metabol.2011.01.008 · Cited by 184
Dietary fructose causes tubulointerstitial injury in the normal rat kidney
Nakayama, T., Kosugi, T., Gersch, M. S., Connor, T., Sánchez‐Lozada, L. G., Lanaspa, M. A., Roncal, C., Perez-Pozo, S. E., Johnson, R. J., & Nakagawa, T. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00433.2009 · Cited by 180
The role of sugars and sweeteners in food, diet and health: Alternatives for the future
Edwards, C. H., Rossi, M., Corpe, C. P., Butterworth, P., & Ellis, P. R. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.07.008 · Cited by 190
Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial
Silbernagel, G., Machann, J., Unmuth, S., Schick, F., Stefan, N., Häring, H. U., & Fritsche, A. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451000574x · Cited by 173
Lactobacillus brevis DM9218 ameliorates fructose-induced hyperuricemia through inosine degradation and manipulation of intestinal dysbiosis
Wang, H., Lü, M., Deng, Y., Liu, Y., Wei, X., Liu, M., Zhou, J., Ma, H., Zheng, P., Yuan, J., et al. (2018) · Nutrition · doi:10.1016/j.nut.2018.11.018 · Cited by 167
Fructose Induces the Inflammatory Molecule ICAM-1 in Endothelial Cells
Glushakova, O. Y., Kosugi, T., Roncal, C., Mu, W., Heinig, M., Cirillo, P., Sánchez‐Lozada, L. G., Johnson, R. J., & Nakagawa, T. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007121304 · Cited by 163
Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease
Spruss, A., & Bergheim, I. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.05.006 · Cited by 162
Pharmacology biochemistry and behavior
A, M. E. B., A, E. S. P., A, N. M. A., & A, B. G. H. (1979) · Brain Research Bulletin · doi:10.1016/s0361-9230(79)80031-3 · Cited by 159
Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans
Cox, C. L., Stanhope, K. L., Schwarz, J. M., Graham, J. L., Hatcher, B., Griffen, S. C., Bremer, A. A., Berglund, L., McGahan, J. P., Keim, N. L., et al. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-68 · Cited by 159
Self-citation
A high fructose diet impairs spatial memory in male rats
Ross, A. P., Bartness, T. J., Mielke, J. G., & Parent, M. B. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.05.007 · Cited by 162
Fructose‐fed Rhesus monkeys: a nonhuman primate model of insulin resistance, metabolic syndrome, and type 2 diabetes
Bremer, A. A., Stanhope, K. L., Graham, J. L., Cummings, B. P., Wang, W., Saville, B. R., & Havel, P. J. (2011) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2011.00298.x · Cited by 148
Self-citation
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
Johnson, R. J., Sautin, Y. Y., Oliver, W. J., Roncal, C., Mu, W., Sánchez‐Lozada, L. G., Rodríguez‐Iturbe, B., Nakagawa, T., & Benner, S. A. (2008) · Journal of Comparative Physiology B · doi:10.1007/s00360-008-0291-7 · Cited by 145
The Role of High-Fructose Corn Syrup in Metabolic Syndrome and Hypertension
Ferder, L., Ferder, M., & Inserra, F. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0097-3 · Cited by 147
Impact of Sugar-Sweetened Beverages on Blood Pressure
Malik, A. H., Akram, Y., Shetty, S. S., Malik, S., & Njike, V. Y. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.01.437 · Cited by 153
Calorie‐sweetened beverages and fructose: what have we learned 10 years later
Bray, G. A., & Popkin, B. M. (2013) · Pediatric Obesity · doi:10.1111/j.2047-6310.2013.00171.x · Cited by 149
Effects of a short-term overfeeding with fructose or glucose in healthy young males
Sock, E. T. N., Lê, K., Ith, M., Kreis, R., Boesch, C., & Tappy, L. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992819 · Cited by 148
Challenging the Fructose Hypothesis: New Perspectives on Fructose Consumption and Metabolism
White, J. S. (2013) · Advances in Nutrition · doi:10.3945/an.112.003137 · Cited by 140
A Critical Examination of the Evidence Relating High Fructose Corn Syrup and Weight Gain
Forshee, R. A., Storey, M. L., Allison, D. B., Glinsmann, W. H., Hein, G. L., Lineback, D. R., Miller, S. A., Nicklas, T. A., Weaver, G. A., & White, J. S. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390600846457 · Cited by 140
Insulin Internalizes GLUT2 in the Enterocytes of Healthy but Not Insulin-Resistant Mice
Tobin, V., Gall, M. L., Fioramonti, X., Stolarczyk, É., Blazquez, A. G., Klein, C., Prigent, M., Serradas, P., Cuif, M., Magnan, C., et al. (2007) · Diabetes · doi:10.2337/db07-0928 · Cited by 135
Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans
Blevins, J. E., & Baskin, D. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.023 · Cited by 135
Intestinal Fructose and Glucose Metabolism in Health and Disease
Merino, B., Fernández-Díaz, C. M., Cózar‐Castellano, I., & Perdomo, G. (2019) · Nutrients · doi:10.3390/nu12010094 · Cited by 147
Relationship Between Insulin Resistance–Associated Metabolic Parameters and Anthropometric Measurements With Sugar-Sweetened Beverage Intake and Physical Activity Levels in US Adolescents: Findings From the 1999-2004 National Health and Nutrition Examination Survey
Bremer, A. A., Auinger, P., & Byrd, R. S. (2009) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.21 · Cited by 132
“Sugar-sweetened beverages may negatively affect he-patic metabolism and energy homeostasis, 24 and the consumption of SSBs has been implicated in many 10,11,24,54 but not all 27,28 studies as a contributing factor to the increased incidence and prevalence of overweight and obesity.”
Background
Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women
Cox, C. L., Stanhope, K. L., Schwarz, J. M., Graham, J. L., Hatcher, B., Griffen, S. C., Bremer, A. A., Berglund, L., McGahan, J. P., Havel, P. J., et al. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.159 · Cited by 132
Self-citation
Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women
Swarbrick, M. M., Stanhope, K. L., Elliott, S. S., Graham, J. L., Krauss, R. M., Christiansen, M. P., Griffen, S. C., Keim, N. L., & Havel, P. J. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508968252 · Cited by 132
Self-citation
Soft drink consumption and obesity: it is all about fructose
Bray, G. A. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283346ca2 · Cited by 134
Fructose-induced inflammation and increased cortisol: A new mechanism for how sugar induces visceral adiposity
DiNicolantonio, J. J., Mehta, V., Onkaramurthy, N. J., & O’Keefe, J. H. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.12.001 · Cited by 135
Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans
Kuhre, R. E., Gribble, F. M., Hartmann, B., Reimann, F. M., Windeløv, J. A., Rehfeld, J. F., & Holst, J. J. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00372.2013 · Cited by 125
Thiazide Diuretics Exacerbate Fructose-Induced Metabolic Syndrome
Reungjui, S., Roncal, C. A., Mu, W., Srinivas, T. R., Sirivongs, D., Johnson, R. J., & Nakagawa, T. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007040416 · Cited by 125
How bad is fructose?1,2
Bray, G. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.895 · Cited by 125
Potential Health Risks From Beverages Containing Fructose Found in Sugar or High-Fructose Corn Syrup
Bray, G. A. (2012) · Diabetes Care · doi:10.2337/dc12-1631 · Cited by 124
Fructose Consumption: Considerations for Future Research on Its Effects on Adipose Distribution, Lipid Metabolism, and Insulin Sensitivity in Humans
Stanhope, K. L., & Havel, P. J. (2009) · Journal of Nutrition · doi:10.3945/jn.109.106641 · Cited by 125
Self-citation
Correlation of Vitamin E, Uric Acid, and Diet Composition With Histologic Features of Pediatric NAFLD
Vos, M. B., Colvin, R., Belt, P. H., Molleston, J. P., Murray, K. F., Rosenthal, P. J., Schwimmer, J. B., Tonascia, J. A., Ünalp, A., & Lavine, J. E. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318229da1a · Cited by 122

Authors: Havel, P. J.
Affiliations: University of California, Davis (US)
Corresponding author: Havel, Peter J.
ORCID: Havel, Peter J.
Venue: Nutrition Reviews
Publisher: Oxford University Press (OUP)
Published: 2005-05
Volume: 63
Issue: 5
Pages: 133-157
ISSN: 0029-6643 (ISSN-L)
1753-4887
DOI: 10.1111/j.1753-4887.2005.tb00132.x
OpenAlex: W2162627097
Cited by: 607
References: 230
Citations by year: 2026: 5 · 2025: 11 · 2024: 13 · 2023: 13 · 2022: 14 · 2021: 21 · 2020: 20 · 2019: 28 · 2018: 32 · 2017: 23 · 2016: 46 · 2015: 54 · 2014: 42 · 2013: 48 · 2012: 37
FWCI: 15.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Nutrition Reviews (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: American Diabetes Association
U.S. Department of Agriculture
Dairy Management
National Institutes of Health (5r01hl075675-05, 58108, HL‐075675)
National Heart, Lung, and Blood Institute (HL 075675, R01 HL-091333, R01HL107256)
National Institute of Diabetes and Digestive and Kidney Diseases (R03DK058108, DK-58108)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: dietary fructose, energy homeostasis, lipid metabolism, carbohydrate metabolism, obesity, hepatic lipogenesis, hyperlipidemia, insulin, leptin, ghrelin, energy balance
MeSH terms: Beverages, Diabetes Mellitus, Type 2, Energy Metabolism, Fructose, Glucose, Humans, Hyperlipidemias, Insulin, Insulin Resistance, Obesity, Leptin, Peptide Hormones, Ghrelin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks