Cited by 607Diet, Metabolism, and DiseaseRegulation of Appetite and ObesityBiochemical Analysis and Sensing Techniques

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Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.

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Havel, Peter J.·2005·Nutrition Reviews

DOI 10.1111/j.1753-4887.2005.tb00132.x

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Abstract

Fructose intake and the prevalence of obesity have both increased over the past two to three decades. Compared with glucose, the hepatic metabolism of fructose favors lipogenesis, which may contribute to hyperlipidemia and obesity. Fructose does not increase insulin and leptin or suppress ghrelin, which suggests an endocrine mechanism by which it induces a positive energy balance. This review examines the available data on the effects of dietary fructose on energy homeostasis and lipid/carbohydrate metabolism. Recent publications, studies in human subjects, and areas in which additional research is needed are emphasized.

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See all 607

Authors: Havel, P. J.
Affiliations: University of California, Davis (US)
Corresponding author: Havel, Peter J.
ORCID: Havel, Peter J.
Venue: Nutrition Reviews
Publisher: Oxford University Press (OUP)
Published: 2005-05
Volume: 63
Issue: 5
Pages: 133-157
ISSN: 0029-6643 (ISSN-L)
1753-4887
DOI: 10.1111/j.1753-4887.2005.tb00132.x
OpenAlex: W2162627097
Cited by: 607
References: 230
Citations by year: 2026: 5 · 2025: 11 · 2024: 13 · 2023: 13 · 2022: 14 · 2021: 21 · 2020: 20 · 2019: 28 · 2018: 32 · 2017: 23 · 2016: 46 · 2015: 54 · 2014: 42 · 2013: 48 · 2012: 37
FWCI: 15.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Nutrition Reviews (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: American Diabetes Association
U.S. Department of Agriculture
Dairy Management
National Institutes of Health (5r01hl075675-05, 58108, HL‐075675)
National Heart, Lung, and Blood Institute (HL 075675, R01 HL-091333, R01HL107256)
National Institute of Diabetes and Digestive and Kidney Diseases (R03DK058108, DK-58108)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: dietary fructose, energy homeostasis, lipid metabolism, carbohydrate metabolism, obesity, hepatic lipogenesis, hyperlipidemia, insulin, leptin, ghrelin, energy balance
MeSH terms: Beverages, Diabetes Mellitus, Type 2, Energy Metabolism, Fructose, Glucose, Humans, Hyperlipidemias, Insulin, Insulin Resistance, Obesity, Leptin, Peptide Hormones, Ghrelin

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Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.

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