Oxytocin treatment, circuitry and autism: a critical review of the literature placing oxytocin into the autism context
Abstract
Observed impairment in reciprocal social interaction is a diagnostic hallmark of autism spectrum disorders. There is no effective medical treatment for these problems. Psychological treatments remain costly, time intensive, and developmentally sensitive for efficacy. In this review, we explore the potential of oxytocin-based therapies for social impairments in autism. Evidence shows that acute oxytocin administration improves numerous markers critical to the social circuitry underlying social deficits in autism. Oxytocin may optimize these circuits and enhance reward, motivation, and learning to improve therapeutic outcomes. Despite this, the current evidence of therapeutic benefit from extended oxytocin treatment remains very limited. We highlight complexity in crossing from the laboratory to the autism clinical setting in evaluation of this therapeutic. We discuss a clinical trial approach that provides optimal opportunity for therapeutic response by using personalized methods that better target specific circuitry to define who will obtain benefit, at what stage of development, and the optimal delivery approach for circuitry manipulation. For the autism field, the therapeutic challenges will be resolved by a range of treatment strategies, including greater focus on specific interventions, such as oxytocin, that have a strong basis in the fundamental neurobiology of social behavior. More sophisticated and targeted clinical trials utilizing such approaches are now required, placing oxytocin into the autism context.
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Several recent studies document first promising results for cholinergic stimulation and oxytocin application in ASD.
“Several recent studies document first promising results for cholinergic stimulation (150) and oxytocin application (151).”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [151]
Several clinical studies have investigated intranasal oxytocin as a treatment for ASD, but cannot provide a certain conclusion about its therapeutic potential.
“Several clinical studies have also investigated the potential of intranasal oxytocin as a treatment for socio-cognitive, behavioral, and socio-affective symptoms of ASD. So far, these studies cannot provide a certain conclusion about oxytocin’s therapeutic potential43–47.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [45]
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Diagnostic and Statistical Manual of Mental Disorders, 5th ed.
Carter, M. J. (2014) · Therapeutic Recreation Journal · Cited by 15,154 · see citing works
Behavioral treatment and normal educational and intellectual functioning in young autistic children.
Lovaas, O. I. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.55.1.3 · Cited by 3,288 · see citing works
Behavioral treatment and normal educational and intellectual functioning in young autistic children.
Lövaas, O. I. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.55.1.3 · Cited by 3,286 · see citing works
Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., Donaldson, A., & Varley, J. (2010) · Pediatrics · doi:10.1542/peds.2009-0958 · Cited by 2,621 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · cited 1× · see citing works
“Oxytocin effects can be sensitive to social contexts, even to increase defensive tendencies (62,63), and individual differences moderate effects (64,65).”
Gaze fixation and the neural circuitry of face processing in autism
Dalton, K. M., Nacewicz, B. M., Johnstone, T., Schaefer, H. S., Gernsbacher, M. A., Goldsmith, H. H., Alexander, A. L., & Davidson, R. J. (2005) · Nature Neuroscience · doi:10.1038/nn1421 · Cited by 1,543 · see citing works
Costs of Autism Spectrum Disorders in the United Kingdom and the United States
Buescher, A. V. S., Cidav, Z., Knapp, M., & Mandell, D. S. (2014) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2014.210 · Cited by 1,296 · see citing works
A common role of insula in feelings, empathy and uncertainty
Singer, T., Critchley, H. D., & Preuschoff, K. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.05.001 · Cited by 1,270 · see citing works
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258 · see citing works
Autism and Abnormal Development of Brain Connectivity: Figure 1.
Belmonte, M. K., Allen, G., Beckel-Mitchener, A., Boulanger, L. M., Carper, R. A., & Webb, S. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3340-04.2004 · Cited by 1,217 · see citing works
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder
Dawson, G. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000370 · Cited by 1,138 · see citing works
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
Dawson, G., Webb, S. J., & McPartland, J. (2005) · Developmental Neuropsychology · doi:10.1207/s15326942dn2703_6 · Cited by 989 · see citing works
Evidence-Based Comprehensive Treatments for Early Autism
Rogers, S. J., & Vismara, L. A. (2008) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374410701817808 · Cited by 984 · see citing works
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962 · see citing works
Self-citationPromoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941 · see citing works
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 913 · see citing works
Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909579106 · Cited by 812 · see citing works
Dawson, G., Jones, E. J. H., Merkle, K., Venema, K., Lowy, R., Faja, S., Kamara, D., Murias, M., Greenson, J., Winter, J., et al. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.08.018 · Cited by 799 · see citing works
A Systematic Review of Early Intensive Intervention for Autism Spectrum Disorders
Warren, Z., McPheeters, M. L., Sathe, N., Foss-Feig, J. H., Glasser, A., & Veenstra-VanderWeele, J. (2011) · Pediatrics · doi:10.1542/peds.2011-0426 · Cited by 790 · see citing works
Intensive Behavioral Treatment for Children With Autism: Four-Year Outcome and Predictors
Sallows, G. O., & Graupner, T. D. (2005) · American Journal on Mental Retardation · doi:10.1352/0895-8017(2005)110[417:ibtfcw]2.0.co;2 · Cited by 788 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · cited 4× · see citing works
“In neurotypical adults, a large body of research suggests benefits of oxytocin nasal spray for improving social cognition [for review, see (60)], including eye gaze, emotion recognition, affective voice recognition, and interoceptive awareness, along with neural underpinnings of these benefits (61).”
InfluentialOxytocin and social affiliation in humans
Feldman, R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.008 · Cited by 767 · see citing works
Patches of Disorganization in the Neocortex of Children with Autism
Stoner, R., Chow, M. L., Boyle, M. P., Sunkin, S. M., Mouton, P. R., Roy, S., Wynshaw-Boris, A., Colamarino, S. A., Lein, E. S., & Courchesne, E. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1307491 · Cited by 722 · see citing works
Rogers, S. J., Estes, A., Lord, C., Vismara, L., Winter, J., Fitzpatrick, A., Guo, M., & Dawson, G. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.08.003 · Cited by 713 · see citing works
Brain growth across the life span in autism: Age-specific changes in anatomical pathology
Courchesne, E., Campbell, K., & Solso, S. (2011) · Brain Research · doi:10.1016/j.brainres.2010.09.101 · Cited by 711 · see citing works
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · see citing works
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689 · see citing works
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620 · see citing works
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · cited 1× · see citing works
“This field is now delicately poised with claims oxytocin may provide the first targeted treatment for social impairments in autism pitted against assertions that it has little or no therapeutic value (86,87).”
Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring
Tyzio, R., Nardou, R., Ferrari, D. C., Tsintsadze, T., Shahrokhi, A., Eftekhari, S., Khalilov, I., Tsintsadze, V., Brouchoud, C., Chazal, G., et al. (2014) · Science · doi:10.1126/science.1247190 · Cited by 601 · see citing works
Autism as a neural systems disorder: A theory of frontal-posterior underconnectivity
Just, M. A., Keller, T. A., Malave, V. L., Kana, R. K., & Varma, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.007 · Cited by 578 · see citing works
Reichow, B., Barton, E. E., Boyd, B. A., & Hume, K. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009260.pub2 · Cited by 577 · see citing works
Teaching theory of mind: A new approach to social skills training for individuals with autism
Ozonoff, S. J., & Miller, J. N. (1995) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02179376 · Cited by 577 · see citing works
Lecavalier, L. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0147-5 · Cited by 569 · see citing works
Intranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating)
Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., & Levkovitz, Y. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.009 · Cited by 542 · cited 1× · see citing works
“Oxytocin effects can be sensitive to social contexts, even to increase defensive tendencies (62,63), and individual differences moderate effects (64,65).”
Parent-mediated early intervention for young children with autism spectrum disorders (ASD)
Oono, I. P., Honey, E. J., & McConachie, H. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009774.pub2 · Cited by 494 · see citing works
Holt-Lunstad, J., Birmingham, W. A., & Light, K. C. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318187aef7 · Cited by 473 · cited 1× · see citing works
“, tactile and attachment based therapies) (108).”
Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis
Masi, A., Quintana, D. S., Glozier, N., Lloyd, A. R., Hickie, I. B., & Guastella, A. J. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.59 · Cited by 467 · see citing works
Self-citationWhat's in a face? The case of autism
Hobson, R. P., Ouston, J., & Lee, A. L. (1988) · British Journal of Psychology · doi:10.1111/j.2044-8295.1988.tb02745.x · Cited by 452 · see citing works
The biology of mammalian parenting and its effect on offspring social development
Rilling, J. K., & Young, L. J. (2014) · Science · doi:10.1126/science.1252723 · Cited by 452 · see citing works
Oxytocin selectively improves empathic accuracy
Bartz, J. A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N. N., Kolevzon, A., & Ochsner, K. N. (2010) · Psychological Science · doi:10.1177/0956797610383439 · Cited by 442 · see citing works
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook, E. H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.001 · Cited by 425 · see citing works
A Review of the Role of Female Gender in Autism Spectrum Disorders
Kirkovski, M., Enticott, P. G., & Fitzgerald, P. B. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1811-1 · Cited by 397 · see citing works
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.34 · Cited by 383 · cited 1× · see citing works
“revealed that autism was the candidate psychiatric disorder with most potential to benefit (80).”
Oxytocin, vasopressin and sociality
CARTER, C., GRIPPO, A., POURNAJAFINAZARLOO, H., RUSCIO, M., & PORGES, S. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00427-5 · Cited by 380 · see citing works
Graustella, A. J., & MacLeod, C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.002 · Cited by 379 · see citing works
Guastella, A. J., Hickie, I. B., McGuinness, M. M., Otis, M., Woods, E. A., Disinger, H. M., Chan, H.-K., Chen, T. F., & Banati, R. B. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.019 · Cited by 357 · see citing works
Self-citationA Systematic Review of Medical Treatments for Children With Autism Spectrum Disorders
McPheeters, M. L., Warren, Z., Sathe, N., Bruzek, J. L., Krishnaswami, S., Jerome, R. N., & Veenstra-VanderWeele, J. (2011) · Pediatrics · doi:10.1542/peds.2011-0427 · Cited by 356 · see citing works
Abnormal use of facial information in high-functioning autism
Spezio, M. L., Adolphs, R., Hurley, R. S. E., & Piven, J. (2007) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0232-9 · Cited by 352 · see citing works
Anagnostou, E., Soorya, L., Chaplin, W., Bartz, J., Halpern, D., Wasserman, S., Wang, A. T., Pepa, L., Tanel, N., Kushki, A., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-16 · Cited by 350 · see citing works
Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002087 · Cited by 349 · see citing works
The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis
LoParo, D., & Waldman, I. D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.77 · Cited by 343 · see citing works
Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons
Owen, S. F., Tuncdemir, S. N., Bader, P. L., Tirko, N. N., Fishell, G., & Tsien, R. W. (2013) · Nature · doi:10.1038/nature12330 · Cited by 339 · see citing works
Oxytocin enhances brain function in children with autism
Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312857110 · Cited by 336 · see citing works
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Thompson, R., Ditzen, B., Patel, R., & Pagnoni, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.013 · Cited by 303 · see citing works
Guastella, A. J., Gray, K. M., Rinehart, N. J., Alvares, G. A., Tonge, B. J., Hickie, I. B., Keating, C. M., Cacciotti‐Saija, C., & Einfeld, S. L. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12305 · Cited by 299 · see citing works
Self-citationThe implications of brain connectivity in the neuropsychology of autism
Maximo, J. O., Cadena, E. J., & Kana, R. K. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9250-0 · Cited by 259 · see citing works
Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder
Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., & Herpertz, S. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.007 · Cited by 255 · see citing works
Nasal oxytocin for social deficits in childhood autism: A randomized controlled trial
Dadds, M. R., MacDonald, E., Cauchi, A., Williams, K., Levy, F., & Brennan, J. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1899-3 · Cited by 250 · see citing works
Weisman, O., Zagoory-Sharon, O., & Feldman, R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.011 · Cited by 240 · see citing works
the Victorian ASELCC Team, Vivanti, G., Paynter, J. M., Duncan, E., Fothergill, H., Dissanayake, C., & Rogers, S. J. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2168-9 · Cited by 240 · see citing works
Meredith, R. M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.001 · Cited by 237 · see citing works
Heterogeneity within Autism Spectrum Disorders: What have We Learned from Neuroimaging Studies?
Lenroot, R., & Yeung, P. K. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00733 · Cited by 230 · see citing works
The Impact of Parent-Delivered Intervention on Parents of Very Young Children with Autism
Estes, A. M., Vismara, L. A., Mercado, C. I., Fitzpatrick, A. L., Elder, L. M., Greenson, J., Lord, C., MUNSON, J. A., Winter, J., Young, G. S., et al. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1874-z · Cited by 229 · see citing works
Marital behavior, oxytocin, vasopressin, and wound healing
Gouin, J.-P., Carter, C. S., Pournajafi-Nazarloo, H., Glaser, R., Malarkey, W. B., Loving, T. J., Stowell, J., & Kiecolt-Glaser, J. K. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.01.009 · Cited by 227 · see citing works
The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies
Modi, M. E., & Young, L. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.010 · Cited by 218 · see citing works
Parker, K. J., Garner, J. P., Libove, R. A., Hyde, S. A., Hornbeak, K. B., Carson, D. S., Liao, C.-P., Phillips, J. M., Hallmayer, J. F., & Hardan, A. Y. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402236111 · Cited by 215 · cited 1× · see citing works
“In humans, some studies suggest genetic variability in the OXTR gene could increase risk for autism (49-52, 54), but others show associations reflecting broader social-cognitive phenotypes (55-58).”
Anagnostou, E., Jones, N., Huerta, M., Halladay, A. K., Wang, P., Scahill, L., Horrigan, J. P., Kasari, C., Lord, C., Choi, D., et al. (2015) · Autism · doi:10.1177/1362361314542955 · Cited by 210 · see citing works
Skuse, D. H., Lori, A., Cubells, J. F., Lee, I., Conneely, K. N., Puura, K., Lehtimäki, T., Binder, E. B., & Young, L. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302985111 · Cited by 207 · see citing works
Szeto, A., Nation, D. A., Mendez, A. J., Domínguez‐Bendala, J., Brooks, L., Schneiderman, N., & McCabe, P. M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90718.2008 · Cited by 207 · see citing works
Chow, M. L., Pramparo, T., Winn, M. E., Barnes, C. C., Li, H.-R., Weiss, L., Fan, J.-B., Murray, S., April, C., Belinson, H., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002592 · Cited by 202 · see citing works
Liu, X., Kawamura, Y., Shimada, T., Otowa, T., Koishi, S., Sugiyama, T., Nishida, H., Hashimoto, O., Nakagami, R., Tochigi, M., et al. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2009.140 · Cited by 195 · see citing works
Méziane, H., Schaller, F., Bauer, Š., Villard, C., Matarazzo, V. A., Riet, F., Guillon, G., Lafitte, D., Desarménien, M. G., Tauber, M., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.010 · Cited by 194 · see citing works
Use of psychotropic medication in children and adolescents with autism spectrum disorders
Coury, D. L., Anagnostou, E., Manning-Courtney, P., Reynolds, A., Cole, L., McCoy, R., Whitaker, A., & Perrin, J. M. (2012) · PEDIATRICS · doi:10.1542/peds.2012-0900d · Cited by 191 · see citing works
Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism
Aoki, Y., Yahata, N., Watanabe, T., Takano, Y., Kawakubo, Y., Kuwabara, H., Iwashiro, N., Natsubori, T., Inoue, H., Suga, M., et al. (2014) · Brain · doi:10.1093/brain/awu231 · Cited by 187 · see citing works
Social attention: a possible early indicator of efficacy in autism clinical trials
Dawson, G., Bernier, R., & Ring, R. H. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-11 · Cited by 181 · see citing works
Switching brain serotonin with oxytocin
Mottolese, R., Redouté, J., Costes, N., Le Bars, D., & Sirigu, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319810111 · Cited by 179 · see citing works
Wigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179 · see citing works
Psychopathology and Intellectual Disability: The Australian Child to Adult Longitudinal Study
Tonge, B. J., & Einfeld, S. (2003) · International review of research in mental retardation · doi:10.1016/s0074-7750(03)01002-4 · Cited by 178 · see citing works
Scheele, D., Kendrick, K. M., Khouri, C., Kretzer, E., Schläpfer, T. E., Stoffel-Wagner, B., Güntürkün, O., Maier, W., & Hurlemann, R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.78 · Cited by 171 · see citing works
Campbell, D. B., Datta, D., Jones, S. T., Batey Lee, E., Sutcliffe, J. S., Hammock, E. A. D., & Levitt, P. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9071-2 · Cited by 170 · see citing works
Autism as a Disorder of Biological and Behavioral Rhythms: Toward New Therapeutic Perspectives
Tordjman, S., Davlantis, K. S., Georgieff, N., Geoffray, M., Speranza, M., Anderson, G. M., Xavier, J., Botbol, M., Oriol, C., Bellissant, É., et al. (2015) · Frontiers in Pediatrics · doi:10.3389/fped.2015.00001 · Cited by 162 · see citing works
Feng, C., Hackett, P. D., DeMarco, A. C., Chen, X., Stair, S., Haroon, E., Ditzen, B., Pagnoni, G., & Rilling, J. K. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-014-9333-9 · Cited by 157 · see citing works
Anagnostou, E., Soorya, L., Brian, J., Dupuis, A., Mankad, D., Smile, S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.049 · Cited by 155 · see citing works
Tachibana, M., Kagitani-Shimono, K., Mohri, I., Yamamoto, T., Sanefuji, W., Nakamura, A., Oishi, M., Kimura, T., Onaka, T., Ozono, K., et al. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0048 · Cited by 151 · see citing works
Bales, K. L., Plotsky, P. M., Young, L. J., Lim, M. M., Grotte, N., Ferrer, E., & Carter, C. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.009 · Cited by 150 · see citing works
Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149 · see citing works
Self-citationGregory, S., Anthopolos, R., Osgood, C., Grotegut, C. A., & Miranda, M. (2013) · JAMA pediatrics · doi:10.1001/jamapediatrics.2013.2904 · Cited by 142 · see citing works
The motivation for very early intervention for infants at high risk for autism spectrum disorders
Webb, S. J., Jones, E. J. H., Kelly, J. F., & Dawson, G. (2014) · International Journal of Speech-Language Pathology · doi:10.3109/17549507.2013.861018 · Cited by 136 · see citing works
Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism
İşeri, S. Ö., Şener, G., Saǧlam, B., Gedik, N., Ercan, F., & Yeğen, B. Ç. (2004) · Peptides · doi:10.1016/j.peptides.2004.10.005 · Cited by 131 · see citing works
Neuropeptides and the social brain: potential rodent models of autism
Lim, M. M., Bielsky, I. F., & Young, L. J. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.006 · Cited by 129 · see citing works
A systematic review of the use of atypical antipsychotics in autism
Barnard, L., Young, A. H., Pearson, J., Geddes, J. R., & O'Brien, G. (2002) · Journal of Psychopharmacology · doi:10.1177/026988110201600113 · Cited by 124 · see citing works
Association of social and cognitive impairment and biomarkers in autism spectrum disorders
Alabdali, A., Al-Ayadhi, L., & El-Ansary, A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-4 · Cited by 117 · see citing works
Bertoglio, K. C., James, S. J., Deprey, L., Brule, N., & Hendren, R. L. (2010) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2009.0177 · Cited by 109 · see citing works
Sullivan, K. A., Stone, W. L., & Dawson, G. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.07.027 · Cited by 103 · see citing works
Nishimori, K., Takayanagi, Y., YOSHIDA, M., Kasahara, Y., YOUNG, L., & Kawamata, M. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00408-1 · Cited by 98 · see citing works
Neuroimaging in autism—from basic science to translational research
Ecker, C., & Murphy, D. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.276 · Cited by 98 · see citing works
Aoki, Y., Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Takao, H., Kawakubo, Y., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.74 · Cited by 95 · see citing works
Measuring repetitive behaviors as a treatment endpoint in youth with autism spectrum disorder
Scahill, L. D., Aman, M. G., Lecavalier, L., Halladay, A. K., Bishop, S. L., Bodfish, J. W., Grondhuis, S. N., Jones, N. E., Horrigan, J. P., Cook, E. H., et al. (2013) · Autism · doi:10.1177/1362361313510069 · Cited by 94 · see citing works
Neuropeptides and social behavior: animal models relevant to autism
Young, L. J., Pitkow, L. J., & Ferguson, J. N. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001175 · Cited by 91 · see citing works
The Promise and Perils of Oxytocin
Miller, G. (2013) · Science · doi:10.1126/science.339.6117.267 · Cited by 76 · cited 2× · see citing works
“Despite recognition that interventions for autism are optimally provided early in life, debate has been on safety and potential harm of oxytocin administration to young children (86).”
Tonge, B. J., Bull, K., Brereton, A., & Wilson, R. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000043 · Cited by 75 · see citing works
Comprehension of Affect in Context in Children with Pervasive Developmental Disorders
FEIN, D. A., Lucci, D., Braverman, M., & Waterhouse, L. H. (1992) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1992.tb00935.x · Cited by 74 · see citing works
Canitano, R. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s1450 · Cited by 74 · see citing works
Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males
Alvares, G. A., Chen, N. T. M., Balleine, B. W., Hickie, I. B., & Guastella, A. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.018 · Cited by 71 · see citing works
Self-citationOxytocin, social cognition and psychiatry
Young, L. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.186 · Cited by 64 · see citing works
Campbell, D. J., Chang, J. T., & Chawarska, K. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.07.008 · Cited by 64 · see citing works
Quintana, D. S., Kemp, A. H., Alvares, G. A., & Guastella, A. J. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00048 · Cited by 61 · see citing works
Self-citationMurdoch, J. D., Gupta, A. R., Sanders, S., Walker, M. F., Keaney, J. F., Fernandez, T. V., Murtha, M. T., Anyanwu, S. I., Ober, G., Raubeson, M. J., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004852 · Cited by 59 · see citing works
Guastella, A. J., & MacLeod, C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.04.008 · Cited by 53 · see citing works
Self-citationComplementary and alternative medicine for autism spectrum disorders: Rationale, safety and efficacy
Whitehouse, A. (2013) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.12242 · Cited by 48 · see citing works
Lin, I.-F., Kashino, M., Ohta, H., Yamada, T., Tani, M., Watanabe, H., Kanai, C., Ohno, T., Takayama, Y., Iwanami, A., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-20 · Cited by 40 · see citing works
Wong, A. Y. S., Hsia, Y., Chan, E. W., Murphy, D., Simonoff, E. A., Buitelaar, J. K., & Wong, I. C. K. (2014) · Autism Research · doi:10.1002/aur.1391 · Cited by 31 · see citing works
Ochratoxin A as possible factor trigging autism and its male prevalence via epigenetic mechanism
Mezzelani, A., Raggi, M. E., Marabotti, A., & Milanesi, L. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515z.000000000186 · Cited by 27 · see citing works
Sochocky, N., & Milin, R. (2013) · Current Clinical Pharmacology · doi:10.2174/15748847113086660073 · Cited by 24 · see citing works
Rice, C. E., & Disabilities, D. (2012) · Cited by 22 · see citing works
Assessment and Treatment in Autism Spectrum Disorders: A Focus on Genetics and Psychiatry
Butler, M. G., Youngs, E. L., Roberts, J., & Hellings, J. A. (2012) · Autism Research and Treatment · doi:10.1155/2012/242537 · Cited by 22 · see citing works
Atladóttir, H. Ó., Schendel, D., Parner, E. T., & Henriksen, T. B. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2408-7 · Cited by 15 · see citing works
橘, 雅. (2014) · Medical Entomology and Zoology · Cited by 13 · see citing works
Induction or Augmentation of Labor and Autism
Vintzileos, A. M., & Ananth, C. V. (2014) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.4795 · Cited by 5 · see citing works
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Sex differences in autism spectrum disorder: a review
Ferri, S. L., Abel, T., & Brodkin, E. S. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0874-2 · Cited by 392 · see citing works
Yatawara, C. J., Einfeld, S. L., Hickie, I. B., Davenport, T. A., & Guastella, A. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.162 · Cited by 344 · see citing works
Self-citationValstad, M., Alvares, G. A., Egknud, M., Matziorinis, A. M., Andreassen, O. A., Westlye, L. T., & Quintana, D. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.017 · Cited by 277 · see citing works
“Growing clinical interest (5) has focused on neurodevelopmental and psychiatric conditions characterized by social cognition and behavioral impairments, such as autism spectrum disorder (ASD) (6,7) and schizophrenia (8), with the hope to explore the potential of oxytocin as a biomarker of these conditions, better unde…”
Quintana, D. S., Lischke, A., Grace, S., Scheele, D., Ma, Y., & Becker, B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00864-7 · Cited by 263 · see citing works
Autism spectrum disorder in adults: diagnosis, management, and health services development
Murphy, C. M., Wilson, C., Robertson, D., Ecker, C., Daly, E., Hammond, N., Galanopoulos, A., Dud, I., Murphy, D., & McAlonan, G. M. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s65455 · Cited by 268 · see citing works
Lai, M.-C., Anagnostou, E., Wiznitzer, M., Allison, C., & Baron-Cohen, S. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30034-x · Cited by 250 · see citing works
A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors
Li, K., Nakajima, M., Ibañez-Tallon, I., & Heintz, N. (2016) · Cell · doi:10.1016/j.cell.2016.08.067 · Cited by 234 · see citing works
An Allostatic Theory of Oxytocin
Quintana, D. S., & Guastella, A. J. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.03.008 · Cited by 212 · see citing works
Self-citationFreeman, S. M., & Young, L. J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12382 · Cited by 196 · see citing works
“More severe disruptions in eye movements and social visual attention in ASD patients correlate with the intensity of social dysfunction (63,64).”
BackgroundInfluentialOxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat
Harony-Nicolas, H., Kay, M., Hoffmann, J. D., Klein, M. E., Bozdagi-Gunal, O., Riad, M., Daskalakis, N. P., Sonar, S., Castillo, P. E., Hof, P. R., et al. (2017) · eLife · doi:10.7554/elife.18904 · Cited by 168 · see citing works
Molecular Basis of Oxytocin Receptor Signalling in the Brain: What We Know and What We Need to Know
Busnelli, M., & Chini, B. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_6 · Cited by 161 · see citing works
Convergence of Sex Differences and the Neuroimmune System in Autism Spectrum Disorder
McCarthy, M. M., & Wright, C. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.004 · Cited by 158 · see citing works
Genetics of Autism Spectrum Disorder: Current Status and Possible Clinical Applications
Yoo, H. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.257 · Cited by 157 · see citing works
Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice?
Haker, H., Schneebeli, M., & Stephan, K. E. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00107 · Cited by 130 · see citing works
A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments
Qian, T., Wang, H., Wang, P., Geng, L., Mei, L., Osakada, T., Wang, L. A., Tang, Y., Kania, A., Grinevich, V., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-022-01561-2 · Cited by 145 · see citing works
Yu, H., Miao, W., Ji, E., Huang, S., Jin, S., Zhu, X., Liu, M.-Z., Sun, Y.-G., Xu, F., & Yu, X. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.022 · Cited by 144 · see citing works
Epigenetics of Autism Spectrum Disorder
Siu, M. T., & Weksberg, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-53889-1_4 · Cited by 121 · see citing works
Whole-brain wiring diagram of oxytocin system in adult mice
Son, S., Manjila, S. B., Newmaster, K. T., Wu, Y.-T., Vanselow, D. J., Ciarletta, M., Anthony, T. E., Cheng, K. C., & Kim, Y. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.0307-22.2022 · Cited by 125 · see citing works
Intranasal oxytocin in the treatment of autism spectrum disorders: A multilevel meta-analysis
Huang, Y., Huang, X., Ebstein, R. P., & Yu, R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.028 · Cited by 119 · see citing works
Risk factors in autism: Thinking outside the brain
Matelski, L., & van de Water, J. A. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.11.003 · Cited by 127 · see citing works
Overview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121 · see citing works
Self-citationSteinman, M. Q., Duque-Wilckens, N., & Trainor, B. C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.10.008 · Cited by 105 · see citing works
Oxytocin and Autism Spectrum Disorders
Yamasue, H., & Domes, G. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_24 · Cited by 109 · see citing works
Social Decision-Making and the Brain: A Comparative Perspective
Tremblay, S., Sharika, K. M., & Platt, M. L. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.007 · Cited by 105 · see citing works
Quintana, D. S., Westlye, L. T., Alnæs, D., Rustan, Ø. G., Kaufmann, T., Smerud, K. T., Mahmoud, R. A., Djupesland, P. G., & Andreassen, O. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.010 · Cited by 102 · see citing works
Insular function in autism: Update and future directions in neuroimaging and interventions
Nomi, J. S., Molnar-Szakacs, I., & Uddin, L. Q. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.015 · Cited by 95 · see citing works
Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward
Bradley, E., & Woolley, J. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.007 · Cited by 88 · see citing works
Hippocampal deficits in neurodevelopmental disorders
Li, Y., Shen, M., Stockton, M. E., & Zhao, X. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.10.001 · Cited by 84 · see citing works
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons
Ripamonti, S., Ambrozkiewicz, M. C., Guzzi, F., Gravati, M., Biella, G. R., Bormuth, I., Hammer, M., Tuffy, L. P., Sigler, A., Kawabe, H., et al. (2017) · eLife · doi:10.7554/elife.22466 · Cited by 82 · see citing works
Understanding autism spectrum disorders with animal models: applications, insights, and perspectives
Zhu, L., 昆明650500，中国, 云., Zhu, Y., Gu, L., & Cheng, Y. (2021) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2021.251 · Cited by 84 · see citing works
Li, Q., Becker, B., Wernicke, J., Chen, Y., Zhang, Y., Li, R., Le, J., Kou, J., Zhao, W., & Kendrick, K. M. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.11.016 · Cited by 85 · see citing works
Oxytocin receptor expression patterns in the human brain across development
Rokicki, J., Kaufmann, T., de Lange, A. G., van der Meer, D., Bahrami, S., Sartorius, A. M., Haukvik, U. K., Steen, N. E., Schwarz, E., Stein, D. J., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01305-5 · Cited by 74 · see citing works
Passoni, I. P., Leonzino, M., Gigliucci, V., Chini, B., & Busnelli, M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12363 · Cited by 76 · see citing works
Zhang, R., Zhang, H.-F., Han, J., & Han, S. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0120-7 · Cited by 78 · see citing works
Kruppa, J. A., Gossen, A., Oberwelland Weiß, E., Kohls, G., Großheinrich, N., Cholemkery, H., Freitag, C. M., Karges, W., Wölfle, E., Sinzig, J., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0258-7 · Cited by 69 · see citing works
Uhrig, S., Hirth, N., Broccoli, L., von Wilmsdorff, M., Bauer, M., Sommer, C., Zink, M., Steiner, J. H., Frodl, T., Malchow, B., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.04.019 · Cited by 75 · see citing works
Personalized medicine in psychiatry
Wium‐Andersen, I. K., Vinberg, M., Kessing, L. V., & McIntyre, R. S. (2016) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2016.1216163 · Cited by 91 · see citing works
Guastella, A. J., Boulton, K., Whitehouse, A., Song, Y. J. C., Thapa, R., Gregory, S. G., Pokorski, I., Granich, J., DeMayo, M. M., Ambarchi, Z., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01845-8 · Cited by 74 · see citing works
Self-citationAdvances in nonhuman primate models of autism: Integrating neuroscience and behavior
Bauman, M. D., & Schumann, C. M. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.07.021 · Cited by 71 · see citing works
Restoring effects of oxytocin on the attentional preference for faces in autism
Kanat, M., Spenthof, I., Riedel, A., van Elst, L. T., Heinrichs, M., & Domes, G. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.67 · Cited by 70 · see citing works
Sannino, S., Chini, B., & Grinevich, V. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22450 · Cited by 70 · see citing works
DeMayo, M. M., Song, Y. J. C., Hickie, I. B., & Guastella, A. J. (2017) · Pediatric Drugs · doi:10.1007/s40272-017-0248-y · Cited by 71 · see citing works
Self-citationThe endocrinology of human caregiving and its intergenerational transmission
Bos, P. A. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000973 · Cited by 70 · see citing works
Endogenous Oxytocin Levels in Autism—A Meta-Analysis
Moerkerke, M., Peeters, M., de Vries, L. M., Daniëls, N., Steyaert, J. G., Alaerts, K., & Boets, B. (2021) · Brain Sciences · doi:10.3390/brainsci11111545 · Cited by 65 · see citing works
Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases
Yeo, X. Y., Cunliffe, G., Ho, R., Lee, S. S., & Jung, S. (2022) · Biomedicines · doi:10.3390/biomedicines10020343 · Cited by 65 · see citing works
Perets, N., Oron, O., Herman, S., Elliott, E., & Offen, D. (2020) · Molecular Autism · doi:10.1186/s13229-020-00366-x · Cited by 64 · see citing works
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 62 · see citing works
Reward: From Basic Reinforcers to Anticipation of Social Cues
Rademacher, L., Schulte‐Rüther, M., Hanewald, B., & Lammertz, S. E. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_429 · Cited by 64 · see citing works
Apathy in Dementia: Systematic Review of Recent Evidence on Pharmacological Treatments
Harrison, F., Aerts, L., & Brodaty, H. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-016-0737-7 · Cited by 65 · see citing works
Shin, W., Kim, K., Serraz, B., Cho, Y. S., Kim, D., Kang, M., Lee, E., Lee, H., Bae, Y. C., Paoletti, P., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000717 · Cited by 62 · see citing works
Oxytocin Receptors Regulate Social Preference in Zebrafish
Landin, J., Hovey, D., Xu, B., Lagman, D., Zettergren, A., Larhammar, D., Kettunen, P., & Westberg, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-61073-4 · Cited by 63 · see citing works
Sparapani, S., Millet-Boureima, C., Oliver, J., Mu, K., Hadavi, P., Kalostian, T., Ali, N., Avelar, C. M., Bardies, M., Barrow, B., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9010089 · Cited by 63 · see citing works
Antitumor activity of benzaldehyde.
Kochi, M., Takeuchi, S., Mizutani, T., Mochizuki, K., Matsumoto, Y., & Saito, Y. (1980) · PubMed · Cited by 62 · see citing works
Microbiota-gut-brain axis in autism spectrum disorder
Yu, Y., & Zhao, F. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.07.001 · Cited by 63 · see citing works
Higashida, H., Munesue, T., Kosaka, H., Yamasue, H., Yokoyama, S., & Kikuchi, M. (2019) · Diseases · doi:10.3390/diseases7010024 · Cited by 64 · see citing works
Martial arts increase oxytocin production
Rassovsky, Y., Harwood‐Gross, A., Zagoory‐Sharon, O., & Feldman, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-49620-0 · Cited by 55 · see citing works
Daniëls, N., Moerkerke, M., Steyaert, J. G., Bamps, A., Debbaut, E., Prinsen, J., Tang, T., der Donck, S. V., Boets, B., & Alaerts, K. (2023) · Molecular Autism · doi:10.1186/s13229-023-00546-5 · Cited by 57 · see citing works
Oxytocin as a Modulator of Synaptic Plasticity: Implications for Neurodevelopmental Disorders
Rajamani, K. T., Wagner, S., Grinevich, V., & Harony-Nicolas, H. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00017 · Cited by 53 · see citing works
Montag, C., Sindermann, C., Melchers, M., Jung, S., Luo, R., Becker, B., Xie, J., Xu, W., Guastella, A. J., & Kendrick, K. M. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32596 · Cited by 50 · see citing works
Flattery, C. N. R., Ross, A. P., Sahu, S. P., Siegel, E. R., Dooyema, J. M., Cree, M. A., Stopa, E. G., Young, L. J., Rilling, J. K., Albers, H. E., et al. (2018) · American Journal of Primatology · doi:10.1002/ajp.22875 · Cited by 50 · see citing works
El-Ganainy, S. O., Soliman, O., Ghazy, A. A., Allam, M., Elbahnasi, A. I., Mansour, A. M., & Gowayed, M. A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03624-x · Cited by 49 · see citing works
Higashida, H. (2015) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0425-0 · Cited by 49 · see citing works
Avraham, Y., Berry, E. M., Donskoy, M., Ahmad, W. A., Vorobiev, L., Albeck, A., & Mankuta, D. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.041 · Cited by 48 · see citing works
Computer-analyzed facial expression as a surrogate marker for autism spectrum social core symptoms
Owada, K., Kojima, M., Yassin, W., Kuroda, M., Kawakubo, Y., Kuwabara, H., Kano, Y., & Yamasue, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190442 · Cited by 49 · see citing works
Novel treatments for autism spectrum disorder based on genomics and systems biology
Baribeau, D. A., & Anagnostou, E. A. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107939 · Cited by 50 · see citing works
Sen, P., Sherwin, E., Sandhu, K., Bastiaanssen, T. F. S., Moloney, G. M., Golubeva, A. V., Fitzgerald, P., Silva, A. P. V., Chruścicka‐Smaga, B., Olavarría‐Ramírez, L., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.08.007 · Cited by 48 · see citing works
Li, Q., Zhang, B., Cao, H., Liu, W., Guo, F., Shen, F., Ye, B., Liu, H., Li, Y., & Liu, Z. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107836 · Cited by 47 · see citing works
Developmental effects of oxytocin neurons on social affiliation and processing of social information
Nunes, A. R., Gliksberg, M., Varela, S. A. M., Teles, M., Wircer, E., Blechman, J., Petri, G., Levkowitz, G., & Oliveira, R. F. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2939-20.2021 · Cited by 47 · see citing works
Kamp‐Becker, I., Poustka, L., Bachmann, C., Ehrlich, S., Hoffmann, F., Kanske, P., Kirsch, P., Krach, S., Paulus, F. M., Rietschel, M., et al. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1362-7 · Cited by 45 · see citing works
Audunsdottir, K., Sartorius, A. M., Kang, H., Glaser, B. D., Bøen, R., Nærland, T., Alaerts, K., Kildal, E. S.-M., Westlye, L. T., Andreassen, O. A., et al. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107067 · Cited by 41 · see citing works
Oxytocin Modulates the Intrinsic Dynamics Between Attention-Related Large-Scale Networks
Xin, F., Zhou, F., Zhou, X., Ma, X., Geng, Y., Zhao, W., Yao, S., Dong, D., Biswal, B. B., Kendrick, K. M., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy295 · Cited by 39 · see citing works
Structural basis for the activation and ligand recognition of the human oxytocin receptor
Waltenspühl, Y., Ehrenmann, J., Vacca, S., Thom, C., Medalia, O., & Plückthun, A. (2022) · Nature Communications · doi:10.1038/s41467-022-31325-0 · Cited by 42 · see citing works
Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects
Naja, W., & Aoun, M. P. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0819-1 · Cited by 40 · see citing works
Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates
Galbusera, A., Felice, A. D., Girardi, S., Bassetto, G., Maschietto, M., Nishimori, K., Chini, B., Papaleo, F., Vassanelli, S., & Gozzi, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.283 · Cited by 38 · see citing works
Rubinstein, M., Patowary, A., Stanaway, I. B., McCord, E., Nesbitt, R., Archer, M., Scheuer, T., Nickerson, D. A., Raskind, W. H., Wijsman, E. M., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.222 · Cited by 39 · see citing works
Understanding the Oxytocin System and Its Relevance to Psychiatry
Shamay‐Tsoory, S., & Young, L. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.014 · Cited by 39 · see citing works
Bertelli, M. O., Azeem, M. W., Underwood, L., Scattoni, M. L., Persico, A. M., Ricciardello, A., Sappok, T., Bergmann, T. J., Keller, R., Bianco, A., et al. (2022) · Springer eBooks · doi:10.1007/978-3-319-95720-3_16 · Cited by 41 · see citing works
Oxytocin and Sensory Network Plasticity
Pekarek, B. T., Hunt, P. J., & Arenkiel, B. R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00030 · Cited by 37 · see citing works
DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders
Siu, M. T., Goodman, S. J., Yellan, I., Butcher, D. T., Jangjoo, M., Grafodatskaya, D., Rajendram, R., Lou, Y., Zhang, R., Zhao, C., et al. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04792-x · Cited by 36 · see citing works
Oxytocin and Animal Models for Autism Spectrum Disorder
Wagner, S., & Harony‐Nicolas, H. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_15 · Cited by 36 · see citing works
Oxytocin increases eye-gaze towards novel social and non-social stimuli
Eckstein, M., Bamert, V., Stephens, S. B. Z., Wallen, K., Young, L. J., Ehlert, U., & Ditzen, B. (2018) · Social Neuroscience · doi:10.1080/17470919.2018.1542341 · Cited by 36 · see citing works
Association of genes with phenotype in autism spectrum disorder
Nisar, S., Hashem, S., Bhat, A. A., Syed, N., Yadav, S. K., Azeem, M. W., Shahab Uddin, M. S., Bagga, P., Reddy, R. D., & Haris, M. (2019) · Aging · doi:10.18632/aging.102473 · Cited by 37 · see citing works
Yaseen, A., Shrivastava, K., Zuri, Z., Hatoum, O. A., & Maroun, M. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy070 · Cited by 35 · see citing works
Oxytocin Increases Phasic and Tonic GABAergic Transmission in CA1 Region of Mouse Hippocampus
Maniezzi, C., Talpo, F., Spaiardi, P., Toselli, M., & Biella, G. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00178 · Cited by 35 · see citing works
Moerkerke, M., Bonte, M.-L., Daniëls, N., Chubar, V., Alaerts, K., Steyaert, J. G., & Boets, B. (2021) · Research in Autism · doi:10.1016/j.rasd.2021.101785 · Cited by 33 · see citing works
Interplay between the oxytocin and opioid systems in regulating social behaviour
Putnam, P. T., & Chang, S. W. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0050 · Cited by 33 · see citing works
van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12355 · Cited by 34 · see citing works
Quintana, D. S. (2020) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2020.100014 · Cited by 34 · see citing works
Li, Y., Zhang, X., & Li, Y. (2019) · CNS Spectrums · doi:10.1017/s1092852919001603 · Cited by 33 · see citing works
Structure-function relationships of the disease-linked A218T oxytocin receptor variant
Meyer, M., Jurek, B., Alfonso‐Prieto, M., Ribeiro, R. P., Milenkovic, V. M., Winter, J. J., Hoffmann, P., Wetzel, C. H., Giorgetti, A., Carloni, P., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01241-8 · Cited by 33 · see citing works
Pădurariu, M., Antioch, I., Balmuș, I.-M., Ciobica, A. S., El-lethey, H. S., & Kamel, M. M. (2017) · International Journal of Veterinary Science and Medicine · doi:10.1016/j.ijvsm.2017.08.003 · Cited by 32 · see citing works
Masi, A., Lampit, A., DeMayo, M. M., Glozier, N., Hickie, I. B., & Guastella, A. J. (2017) · Psychological Medicine · doi:10.1017/s0033291716003457 · Cited by 29 · see citing works
Self-citationQuantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism
Owada, K., Okada, T., Munesue, T., Kuroda, M., Fujioka, T., Uno, Y., Matsumoto, K., Kuwabara, H., Mori, D., Okamoto, Y., et al. (2019) · Brain · doi:10.1093/brain/awz126 · Cited by 29 · see citing works
Recent progress in understanding skills and impairments in social cognition
Happe, F. G. E., & Conway, J. R. (2016) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000417 · Cited by 29 · see citing works
Aggression: Perspectives from social and systems neuroscience
Kelly, A. M., & Wilson, L. C. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.04.010 · Cited by 27 · see citing works
Wiśniewski, K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9504-2_11 · Cited by 28 · see citing works
Guastella, A. J., Cooper, M., White, C. R. H., White, M. K., Pennell, C. E., & Whitehouse, A. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12924 · Cited by 29 · see citing works
Self-citationLeithead, A. B., Tasker, J. G., & Harony‐Nicolas, H. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13061 · Cited by 26 · see citing works
Popow, C., Ohmann, S., & Plener, P. L. (2021) · Neuropsychiatrie · doi:10.1007/s40211-021-00395-9 · Cited by 36 · see citing works
Opportunities and challenges for intranasal oxytocin treatment studies in nonhuman primates
Bauman, M. D., Murai, T., Hogrefe, C. E., & Platt, M. L. (2018) · American Journal of Primatology · doi:10.1002/ajp.22913 · Cited by 25 · see citing works
- Authors
- Guastella, A. J., & Hickie, I. B.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Guastella, Adam J.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 79
- Issue
- 3
- Pages
- 234-242
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W812470321
- Semantic Scholar
- 6c0b662be91c0e09c0caf039cb7c80bdb01d7198
- Cited by
- 223
- References
- 123
- Citations by year
- 2026: 18 · 2025: 15 · 2024: 15 · 2023: 9 · 2022: 25 · 2021: 23 · 2020: 16 · 2019: 21 · 2018: 20 · 2017: 27 · 2016: 24 · 2015: 8
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council project (1043664)
- Simons Foundation
- Career Development Fellowship (1061922)
- Australia Fellowship (494914)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- oxytocin, autism spectrum disorder, social dysfunction, oxytocin therapy, personalized treatment, clinical translation, social motivation, reward processing
- MeSH terms
- Autistic Disorder, Humans, Interpersonal Relations, Oxytocin, Social Behavior, Treatment Outcome
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