The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Hypervirulent Klebsiella pneumoniae – clinical and molecular perspectives
Open accessAbstract
Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a concerning global pathogen. hvKp is more virulent than classical K. pneumoniae (cKp) and capable of causing community‐acquired infections, often in healthy individuals. hvKp is carried in the gastrointestinal tract, which contributes to its spread in the community and healthcare settings. First recognized in Asia, hvKp arose as a leading cause of pyogenic liver abscesses. In the decades since, hvKp has spread globally and causes a variety of infections. In addition to liver abscesses, hvKp is distinct from cKp in its ability to metastasize to distant sites, including most commonly the eye, lung and central nervous system (CNS). hvKp has also been implicated in primary extrahepatic infections including bacteremia, pneumonia and soft tissue infections. The genetic determinants of hypervirulence are often found on large virulence plasmids as well as chromosomal mobile genetic elements which can be used as biomarkers to distinguish hvKp from cKp clinical isolates. These distinct virulence determinants of hvKp include up to four siderophore systems for iron acquisition, increased capsule production, K1 and K2 capsule types, and the colibactin toxin. Additionally, hvKp strains demonstrate hypermucoviscosity, a phenotypic description of hvKp in laboratory conditions that has become a distinguishing feature of many hypervirulent isolates. Alarmingly, multidrug‐resistant hypervirulent strains have emerged, creating a new challenge in combating this already dangerous pathogen.
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Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43
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Colibactin: More Than a New Bacterial Toxin
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Cited by
Virulence Factors in Hypervirulent Klebsiella pneumoniae
Zhu, J., Wang, T., Chen, L., & Du, H. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.642484 · Cited by 320
Klebsiella species: Taxonomy, hypervirulence and multidrug resistance
Dong, N., Yang, X., Chan, E. W.-C., Zhang, R., & Chen, S. (2022) · eBioMedicine · doi:10.1016/j.ebiom.2022.103998 · Cited by 313
Pu, D., Zhao, J., Chang, K., Zhuo, X., & Cao, B. (2023) · Science Bulletin · doi:10.1016/j.scib.2023.09.040 · Cited by 194
Neumann, B., Lippmann, N., Wendt, S., Karlas, T., Lübbert, C., Werner, G., Pfeifer, Y., & Schuster, C. F. (2022) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-022-00521-7 · Cited by 12
Metadata
- Authors
- Choby, J. E., Howard‐Anderson, J., & Weiss, D. S.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2019-11-21
- Volume
- 287
- Issue
- 3
- Pages
- 283-300
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2987013299
- Cited by
- 712
- References
- 9
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
