Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection
Open accessAbstract
Echinocandins are frontline antifungal agents in the management of invasive infections due to multidrug resistant Candida auris . The study aimed to evaluate echinocandin resistance in C. auris isolates of multicentric origin, identify the resistance mechanism, and analyze the pharmacodynamic response to caspofungin in a neutropenic mouse model of infection.
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Several amino acid substitutions in FKS1 have been associated with decreased echinocandin susceptibility in C. auris.
“Several amino acid substitutions in FKS1 have also been associated with decreased echinocandin susceptibility in C. auris12,37–42.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [39]
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- Authors
- Sharma, D., Paul, R. A., Rudramurthy, S. M., Kashyap, N., Bhattacharya, S., Soman, R., Shankarnarayan, S. A., Chavan, D., Singh, S., Das, P., Kaur, H., Ghosh, A. K., Prasad, R., Sanyal, K., & Chakrabarti, A.
- Affiliations
- Post Graduate Institute of Medical Education and Research (IN)
- Tata Medical Center (IN)
- Jupiter Hospital, Pune, India
- Amity University Gurugram (IN)
- Jawaharlal Nehru Centre for Advanced Scientific Research (IN)
- Corresponding author
- Rudramurthy, Shivaprakash M.
- Chakrabarti, Arunaloke
- ORCID
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2022-01-18
- Volume
- 66
- Issue
- 1
- Pages
- e0165221-e0165221
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC8765266
- OpenAlex
- W3214482667
- Cited by
- 60
- References
- 41
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 8 · 2023: 18 · 2022: 7 · 2021: 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission (21/12/2014(ii)EU-v)
- Indian Council of Medical Research (AMR/149/2018-ECD-II)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida auris, echinocandin resistance, caspofungin, antifungal susceptibility, resistance mechanisms, neutropenic mouse model, invasive candidiasis, multidrug resistance, pharmacodynamics
- MeSH terms
- Candida auris, Animals, Antifungal Agents, Candidiasis, Disease Models, Animal, Fungal Proteins, Genotype, Microbial Sensitivity Tests, Mutation, Drug Resistance, Fungal, Mice, Echinocandins
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