Cited by 60Antifungal resistance and susceptibilityFungal Plant Pathogen ControlFungal and yeast genetics research

Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection

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Sharma, Dipti, Paul, Raees A., Rudramurthy, Shivaprakash M., Kashyap, Nisha, Bhattacharya, Sanjay, Soman, Rajeev, Shankarnarayan, Shamanth A., Chavan, Dipali +7 more·2022·Antimicrobial Agents and Chemotherapy

Abstract

Echinocandins are frontline antifungal agents in the management of invasive infections due to multidrug resistant Candida auris . The study aimed to evaluate echinocandin resistance in C. auris isolates of multicentric origin, identify the resistance mechanism, and analyze the pharmacodynamic response to caspofungin in a neutropenic mouse model of infection.

Integrity signals

Registry

Crossref · 10.1128/aac.01652-21

Cites

41 of 41 references verified0 citation errors · 0 not checkable

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  • Several amino acid substitutions in FKS1 have been associated with decreased echinocandin susceptibility in C. auris.

    “Several amino acid substitutions in FKS1 have also been associated with decreased echinocandin susceptibility in C. auris12,37–42.”

    From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [39]

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Authors
Sharma, D., Paul, R. A., Rudramurthy, S. M., Kashyap, N., Bhattacharya, S., Soman, R., Shankarnarayan, S. A., Chavan, D., Singh, S., Das, P., Kaur, H., Ghosh, A. K., Prasad, R., Sanyal, K., & Chakrabarti, A.
Affiliations
  • Post Graduate Institute of Medical Education and Research (IN)
  • Tata Medical Center (IN)
  • Jupiter Hospital, Pune, India
  • Amity University Gurugram (IN)
  • Jawaharlal Nehru Centre for Advanced Scientific Research (IN)
Corresponding author
  • Rudramurthy, Shivaprakash M.
  • Chakrabarti, Arunaloke
Venue
Antimicrobial Agents and Chemotherapy
Published
2022-01-18
Volume
66
Issue
1
Pages
e0165221-e0165221
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
OpenAlex
W3214482667
Cited by
60
References
41
Citations by year
2026: 11 · 2025: 15 · 2024: 8 · 2023: 18 · 2022: 7 · 2021: 1
FWCI
2.69
Type
journal article
Language
en
Open access
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University Grants Commission (21/12/2014(ii)EU-v)
  • Indian Council of Medical Research (AMR/149/2018-ECD-II)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
Candida auris, echinocandin resistance, caspofungin, antifungal susceptibility, resistance mechanisms, neutropenic mouse model, invasive candidiasis, multidrug resistance, pharmacodynamics
MeSH terms
Candida auris, Animals, Antifungal Agents, Candidiasis, Disease Models, Animal, Fungal Proteins, Genotype, Microbial Sensitivity Tests, Mutation, Drug Resistance, Fungal, Mice, Echinocandins

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