Use of Micafungin as a Surrogate Marker To Predict Susceptibility and Resistance to Caspofungin among 3,764 Clinical Isolates of Candida by Use of CLSI Methods and Interpretive Criteria

Pfaller, Michael A.; Messer, Shawn A.; Diekema, Daniel J.; Jones, Ronald N.; Castanheira, Mariana

doi:10.1128/jcm.02481-13

Cited by 74Antifungal resistance and susceptibilityFungal Plant Pathogen ControlYeasts and Rust Fungi Studies

Use of Micafungin as a Surrogate Marker To Predict Susceptibility and Resistance to Caspofungin among 3,764 Clinical Isolates of Candida by Use of CLSI Methods and Interpretive Criteria

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Pfaller, Michael A., Messer, Shawn A., Diekema, Daniel J., Jones, Ronald N., Castanheira, Mariana·2014·Journal of Clinical Microbiology

DOI 10.1128/jcm.02481-13PMC PMC3911432

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Abstract

Due to unacceptably high interlaboratory variation in caspofungin MIC values, we evaluated the use of micafungin as a surrogate marker to predict the susceptibility of Candida spp. to caspofungin using reference methods and species-specific interpretive criteria. The MIC results for 3,764 strains of Candida (eight species), including 73 strains with fks mutations, were used. Caspofungin MIC values and species-specific interpretive criteria were compared with those of micafungin to determine the percent categorical agreement (%CA) and very major error (VME), major error (ME), and minor error rates as well as their ability to detect fks mutant strains of Candida albicans (11 mutants), Candida tropicalis (4 mutants), Candida krusei (3 mutants), and Candida glabrata (55 mutants). Overall, the %CA was 98.8% (0.2% VMEs and MEs, 0.8% minor errors) using micafungin as the surrogate marker. Among the 60 isolates of C. albicans (9 isolates), C. tropicalis (5 isolates), C. krusei (2 isolates), and C. glabrata (44 isolates) that were nonsusceptible (either intermediate or resistant) to both caspofungin and micafungin, 54 (90.0%) contained a mutation in fks1 or fks2. An additional 10 C. glabrata mutants, two C. albicans mutants, and one mutant each of C. tropicalis and C. krusei were classified as susceptible to both antifungal agents. Using the epidemiological cutoff values (ECVs) of 0.12 μg/ml for caspofungin and 0.03 μg/ml for micafungin to differentiate wild-type (WT) from non-WT strains of C. glabrata, 80% of the C. glabrata mutants were non-WT for both agents (96% concordance). Micafungin may serve as an acceptable surrogate marker for the prediction of susceptibility and resistance of Candida to caspofungin.

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Treatment of Candida Glabrata With Micafungin: A Case Report and Brief Review of the Literature
Guleri, A., Gatt, D., Sharma, R., & Pettit, S. (2013) · Journal of Medical Cases · doi:10.4021//jmc.v4i6.1237 · Cited by 1 · see citing works
Treatment of Candida Glabrata With Micafungin: A Case Report and Brief Review of the Literature
Guleri (2013) · Journal of Medical Cases · doi:10.4021/jmc1237w · Cited by 1 · see citing works
The action of photodynamic therapy on Candida species (836.10)
Dória, A. C. O. C., Bevilacqua, I., Santos, T. B., et al. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.836.10

Authors: Pfaller, M. A., Messer, S. A., Diekema, D. J., Jones, R. N., & Castanheira, M.
Affiliations: University of Iowa (US)
JMI Laboratories (US)
ORCID: Pfaller, Michael A.
Messer, Shawn A.
Diekema, Daniel J.
Jones, Ronald N.
Castanheira, Mariana
Venue: Journal of Clinical Microbiology
Publisher: American Society for Microbiology
Published: 2014-01
Volume: 52
Issue: 1
Pages: 108-114
ISSN: 0095-1137 (ISSN-L)
1098-660X
DOI: 10.1128/jcm.02481-13
PMC: PMC3911432
OpenAlex: W2129541275
Cited by: 74
References: 48
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 4 · 2016: 15 · 2015: 8 · 2014: 7
FWCI: 7.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Clinical Microbiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Pfizer
Astellas Pharma
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords: micafungin, caspofungin, Candida, surrogate markers, antifungal susceptibility, antifungal resistance, Candida glabrata, Candida albicans, Candida tropicalis, Candida krusei, epidemiological cut-off values, inter-laboratory variability
MeSH terms: Caspofungin, Micafungin, Antifungal Agents, Candida, Fungal Proteins, Humans, Microbial Sensitivity Tests, Mutation, Biomarkers, Drug Resistance, Fungal, Echinocandins, Lipopeptides

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Use of Micafungin as a Surrogate Marker To Predict Susceptibility and Resistance to Caspofungin among 3,764 Clinical Isolates of Candida by Use of CLSI Methods and Interpretive Criteria

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