A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

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Acetylcholine Receptor: An Allosteric Protein

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Desensitization of neuronal nicotinic receptors

Quick, M. W., & Lester, R. A. J. (2002) · Journal of Neurobiology · doi:10.1002/neu.10109 · Cited by 456

Nicotine addiction and nicotinic receptors: lessons from genetically modified mice

Changeux, J.-P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2849 · Cited by 453

Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function

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Desensitization of nicotinic ACh receptors: shaping cholinergic signaling

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Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction

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Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine

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Nicotinic excitation of rat ventral tegmental neurones in vitro studied by intracellular recording

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Nicotine addiction: the possible role of functional upregulation

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Neuronal nicotinic receptors: A perspective on two decades of drug discovery research

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Upregulation of Surface α4β2 Nicotinic Receptors Is Initiated by Receptor Desensitization after Chronic Exposure to Nicotine

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Chronic Nicotine Exposure Upregulates Nicotinic Receptors by a Novel Mechanism

Vallejo, Y. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5240-04.2005 · Cited by 201

Desensitized nicotinic receptors in brain

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Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement

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A gating mechanism of pentameric ligand-gated ion channels

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Sazetidine-A, A Novel Ligand That Desensitizes α4β2 Nicotinic Acetylcholine Receptors without Activating Them

Xiao, Y., Fan, H., Musachio, J. L., Wei, Z.-L., Chellappan, S. K., Kozikowski, A. P., & Kellar, K. J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027318 · Cited by 141

Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method

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Effects of chronic nicotine treatment on expression of diverse nicotinic acetylcholine receptor subtypes. I. Dose‐ and time‐dependent effects of nicotine treatment

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A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions.

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Acute and long-term changes in the mesolimbic dopamine pathway after systemic or local single nicotine injections

Ferrari, R., Le Novère, N., Picciotto, M. R., Changeux, J. P., & Zoli, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.02009.x · Cited by 132

Desensitization of Nicotine‐Stimulated [3H]Dopamine Release from Mouse Striatal Synaptosomes

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Properties of vertebrate glutamate receptors: Calcium mobilization and desensitization

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Effects of sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats

Rezvani, A. H., Slade, S., Wells, C., Petro, A., Lumeng, L., Li, T.-K., Xiao, Y., Brown, M. L., Paige, M. A., McDowell, B. E., et al. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1878-8 · Cited by 88

Dependence of Nicotinic Acetylcholine Receptor Recovery from Desensitization on the Duration of Agonist Exposure

Reitstetter, R., Lukas, R. J., & Gruener, R. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38184-4 · Cited by 87

Agonist-Induced Up-Regulation of α4β2 Nicotinic Acetylcholine Receptors in M10 Cells: Pharmacological and Spatial Definition

Whiteaker, P., Sharples, C. G. V., & Wonnacott, S. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13263-4 · Cited by 152

Sazetidine-A, a Selective α4β2 Nicotinic Receptor Desensitizing Agent and Partial Agonist, Reduces Nicotine Self-Administration in Rats

Levin, E. D., Rezvani, A. H., Xiao, Y., Slade, S., Cauley, M., Wells, C., Hampton, D., Petro, A., Rose, J. E., Brown, M. L., et al. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.162073 · Cited by 65

Long-lasting inactivation of nicotinic receptor function in vitro by treatment with high concentrations of nicotine

Rowell, P. P., & Duggan, D. S. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(97)00193-7 · Cited by 52

Increases in α4* but not α3*/α6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment

McCallum, S. E., Parameswaran, N., Bordia, T., Fan, H., Tyndale, R. F., Langston, J. W., McIntosh, J. M., & Quik, M. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03646.x · Cited by 44

Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats

Johnson, J. E., Slade, S., Wells, C., Petro, A., Sexton, H., Rezvani, A. H., Brown, M. L., Paige, M. A., McDowell, B. E., Xiao, Y., et al. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2642-z · Cited by 35

Differential effect of chronic nicotine treatment on nicotinic receptor numbers in various brain regions of mice

Collins, A. C., Marks, M. J., & Pauly, J. R. (1989) · Journal of Substance Abuse · doi:10.1016/s0899-3289(18)30004-x · Cited by 17