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Cited by 162Neuroscience of respiration and sleepMotor Control and AdaptationNeural and Behavioral Psychology Studies

Regional cerebral blood flow during volitional expiration in man: a comparison with volitional inspiration

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Ramsay, S C, Adams, L, Murphy, K, Corfield, D R, Grootoonk, S, Bailey, D L, Frackowiak, R S, Guz, A·1993·The Journal of Physiology
DOI 10.1113/jphysiol.1993.sp019503PMC PMC1175247
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Abstract

1. Positron emission tomographic (PET) imaging of regional cerebral blood flow (rCBF), using a new 3-dimensional technique of data collection, was used to identify areas of neuronal activation associated with volitional inspiration and separately with volitional expiration in five normal male subjects. A comparison of the activated areas was also undertaken to isolate regions specific for one or other active task. 2. Scans were performed during intravenous infusion of H2(15)O under conditions of (a) volitional inspiration with passive expiration, (b) passive inspiration with volitional expiration and (c) passive inspiration with passive expiration. Four measurements in these three conditions were performed in each subject. Breathing pattern was well matched between conditions. 3. Regional increases in brain blood flow, due to increased neural activity associated with either active inspiration or active expiration, were derived using a pixel by pixel comparison of images obtained during the volitional and passive ventilation phases. Data were pooled from all runs in all subjects and were then processed to detect statistically significant (P < 0.05) increases in rCBF comparing active inspiration with passive inspiration and active expiration with passive expiration. 4. During active inspiration significant increases in rCBF were found bilaterally in the primary motor cortex dorsally just lateral to the vertex, in the supplementary motor area, in the right lateral pre-motor cortex and in the left ventrolateral thalamus. 5. In active expiration significant increases in rCBF were found in the right and left primary motor cortices dorsally just lateral to the vertex, the right and left primary motor cortices more ventrolaterally, the supplementary motor area, the right lateral pre-motor cortex, the ventrolateral thalamus bilaterally, and the cerebellum. 6. Using this modified and more sensitive PET technique, these findings essentially replicate those for volitional inspiration obtained in a previous study. For volitional expiration the areas activated are more extensive, but overlap with those involved in volitional inspiration. 7. The technique used has been successful in demonstrating the regions of the brain involved in the generation of volitional breathing, and probably in the volitional modulation of automatic breathing patterns such as would be required for the production of speech.

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  • There is a striking overlap between areas activated during articulation of speech, vocalisation, and control of volitional breathing in the absence of vocalisation.

    “There was, nevertheless, a striking overlap between the areas activated during the articulation of speech, vocalisation (Hirano et al., 1996) and the control of volitional breathing in the absence of vocalisation (Ramsay et al., 1993; Fink et al., 1996).”

    From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Ramsay et al., 1993

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Authors
Ramsay, S. C., Adams, L., Murphy, K., Corfield, D. R., Grootoonk, S., Bailey, D. L., Frackowiak, R. S., & Guz, A.
Affiliations
Hammersmith Hospital (GB)
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
1993-02
Volume
461
Issue
1
Pages
85-101
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.1993.sp019503
PMC
PMC1175247
OpenAlex
W2038079001
Cited by
162
References
24
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 9
FWCI
3.16
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
regional cerebral blood flow, respiratory control, primary motor cortex, supplementary motor area, premotor cortex, ventrolateral thalamic nucleus, cerebellum, neuronal activation, speech production
MeSH terms
Abdominal Muscles, Adult, Inhalation, Brain, Cerebrovascular Circulation, Electromyography, Humans, Male, Middle Aged, Motor Cortex, Neurons, Respiration, Thalamus, Tomography, Emission-Computed

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