Skeletal Muscle Wasting and Renewal: A Pivotal Role of Myokine IL-6
Open accessAbstract
Adult skeletal tissue is composed of heterogeneous population of cells that constantly self-renew by means of a controlled process of activation and proliferation of tissue-resident stem cells named satellite cells. Many growth factors, cytokines and myokines produced by skeletal muscle cells play critical roles in local regulation of the inflammatory process and skeletal muscle regeneration during different pathological conditions. IL-6 is a pleiotropic cytokine released in large amount during infection, autoimmunity and cancer. Low levels of IL-6 can promote activation of satellite cells and myotube regeneration while chronically elevated production promote skeletal muscle wasting. These distinct effects may be explained by a crosstalk of the IL-6/IL-6 receptor and gp130 trans-signaling pathway that oppose to regenerative and anti-inflammatory of the classical IL-6 receptor signaling pathway. Here we discuss on potential therapeutic strategies using monoclonal antibodies to IL-6R for the treatment of skeletal muscle wasting and cachexia. We also highlight on the IL-6/JAK/STAT and FGF/p38αβ MAPK signaling pathways in satellite cell activation and the use of protein kinase inhibitors for tailoring and optimizing satellite cell proliferation during the skeletal muscle renewal. Future investigations on the roles of the IL-6 classical and trans-signaling pathways in both immune and non-immune cells in skeletal muscle tissue will provide new basis for therapeutic approaches to reverse atrophy and degeneration of skeletal muscles in cancer and inflammatory diseases.
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IL-6 is considered as a double-edged sword with proinflammatory (catabolic) and anti-inflammatory (anabolic) effects according to local immune cells and the cytokines' microenvironment.
“Like TNF-α, IL-6 is considered as a “double-edged sword” with proinflammatory (catabolic) and anti-inflammatory (anabolic) effects (see the review in [46]) according to local immune cells and the cytokines’ microenvironment.”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [46]
The Background and Final remarks describe IL-6 as promoting muscle repair in some conditions and muscle wasting in others; the Satellite cells and skeletal muscle renewal section also identifies regenerative and anti-inflammatory roles. The review discusses local immune cells and cytokines, but does not establish that those cells and the cytokine microenvironment determine which of IL-6’s opposing effects occurs. It instead emphasizes IL-6 levels, duration of release, and signaling pathways. (LLM, conf=0.82)
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1 retracted
Myostatin is a novel tumoral factor that induces cancer cachexia
Lokireddy, S., Wijesoma, I. W., Bonala, S., Wei, M., Sze, S. K., McFarlane, C., Kambadur, R., & Sharma, M. (2012) · Biochemical Journal · doi:10.1042/bj20112024 · Cited by 96 · see citing works
RetractedCalcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,548 · see citing works
Definition and classification of cancer cachexia: an international consensus
Fearon, K., Strasser, F., Anker, S. D., Bosaeus, I. G., Bruera, E. D., Fainsinger, R. L., Jatoi, A., Loprinzi, C. L., Macdonald, N., Mantovani, G., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70218-7 · Cited by 5,800 · see citing works
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013 · see citing works
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · see citing works
The pro- and anti-inflammatory properties of the cytokine interleukin-6
Scheller, J., Chalaris, A., Schmidt-Arras, D., & Rose-John, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.034 · Cited by 3,212 · see citing works
Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012 · see citing works
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works
Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752 · see citing works
IL-6 as a keystone cytokine in health and disease
Hunter, C. A., & Jones, S. A. (2015) · Nature Immunology · doi:10.1038/ni.3153 · Cited by 2,511 · see citing works
Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345 · see citing works
Evans, W., Morley, J., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-zadeh, K., Lochs, H., Mantovani, G., et al. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.013 · Cited by 2,341 · see citing works
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166 · see citing works
Protein degradation and protection against misfolded or damaged proteins.
Goldberg, A. L. (2003) · Nature · doi:10.1038/nature02263 · Cited by 2,088 · see citing works
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084 · see citing works
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953 · see citing works
Borst, O., Walker, B., Münzer, P., Russo, A., Schmid, E., Faggio, C., Bigalke, B., Laufer, S., Gawaz, M., & Lang, F. J. W. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350110 · Cited by 1,867 · see citing works
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
Gomes, M. D., Lecker, S. H., Jagoe, R. T., Navon, A., & Goldberg, A. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251541198 · Cited by 1,774 · see citing works
Muscaritoli, M., Anker, S. D., Argilés, J., Aversa, Z., Bauer, J. M., Biolo, G., Boirie, Y., Bosaeus, I., Cederholm, T., Costelli, P., et al. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.12.004 · Cited by 1,732 · see citing works
Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., & Hill, C. S. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.65 · Cited by 1,636 · see citing works
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539 · see citing works
Cancer cachexia: understanding the molecular basis
Argilés, J. M. A., Busquets, S., Stemmler, B., & López-Soriano, F. J. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3829 · Cited by 1,518 · see citing works
Mechanisms regulating skeletal muscle growth and atrophy
Schiaffino, S., Dyar, K. A., Ciciliot, S., Blaauw, B., & Sandri, M. (2013) · The FEBS Journal · doi:10.1111/febs.12253 · Cited by 1,492 · see citing works
Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489 · see citing works
p38 MAP-Kinases pathway regulation, function and role in human diseases
Cuenda, A., & Rousseau, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.03.010 · Cited by 1,397 · see citing works
Targeted disruption of the mouse <i>Stat3</i> gene leads to early embryonic lethality
Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3801 · Cited by 1,323 · see citing works
Cellular and molecular mechanisms of muscle atrophy
Bonaldo, P., & Sandri, M. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010389 · Cited by 1,284 · see citing works
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states
Lecker, S. H., Goldberg, A. L., & Mitch, W. E. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006010083 · Cited by 1,234 · see citing works
Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways
Fearon, K. C. H., Glass, D. J., & D, D. C. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.011 · Cited by 1,203 · see citing works
Building Muscle: Molecular Regulation of MyogenesisPreprint
Bentzinger, C. F., Wang, Y. X., & Rudnicki, M. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008342 · Cited by 1,198 · see citing works
Tisdale, M. J. (2009) · Physiological Reviews · doi:10.1152/physrev.00016.2008 · Cited by 1,192 · see citing works
Hirano, T., Ishihara, K., & Hibi, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203551 · Cited by 1,187 · see citing works
Integrative Biology of Exercise
Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014) · Cell · doi:10.1016/j.cell.2014.10.029 · Cited by 1,152 · see citing works
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
Zhou, X., Wang, J. L., Lu, J., Song, Y., Kwak, K. S., Jiao, Q., Rosenfeld, R., Chen, Q., Boone, T. C., Simonet, W. S., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.011 · Cited by 941 · see citing works
Relaix, F., & Zammit, P. S. (2012) · Development · doi:10.1242/dev.069088 · Cited by 888 · see citing works
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875 · see citing works
Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy
Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.011 · Cited by 873 · see citing works
Inflammatory caspases and inflammasomes: master switches of inflammation
Martinon, F., & Tschopp, J. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402038 · Cited by 821 · see citing works
Signaling Pathways in Skeletal Muscle Remodeling
Bassel‐Duby, R., & Olson, E. N. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142622 · Cited by 799 · see citing works
Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?
Muñoz‐Cánoves, P., Scheele, C., Pedersen, B. K., & Serrano, A. L. (2013) · The FEBS Journal · doi:10.1111/febs.12338 · Cited by 774 · see citing works
Interleukin-6 stimulates lipolysis and fat oxidation in humans
van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., Hiscock, N., Møller, K., Saltin, B., Febbraio, M. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021687 · Cited by 767 · see citing works
Human Caspases: Activation, Specificity, and Regulation
Pop, C., & Salvesen, G. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800084200 · Cited by 757 · see citing works
Proteasomes and their kin: proteases in the machine age
Pickart, C. M., & Cohen, R. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1336 · Cited by 735 · see citing works
Du, J., Wang, X., Miereles, C., Bailey, J. L., Debigaré, R., Zheng, B., Price, S. R., & Mitch, W. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18330 · Cited by 730 · see citing works
MyoD is required for myogenic stem cell function in adult skeletal muscle
Megeney, L. A., Kablar, B., Garrett, K., Anderson, J. E., & Rudnicki, M. A. (1996) · Genes & Development · doi:10.1101/gad.10.10.1173 · Cited by 724 · see citing works
Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome
Sandri, M. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.04.023 · Cited by 689 · see citing works
The Skeletal Muscle Satellite Cell: The Stem Cell That Came in From the Cold
Zammit, P. S., Partridge, T. A., & Yablonka‐Reuveni, Z. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6r6995.2006 · Cited by 684 · see citing works
Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668 · see citing works
Tumors secreting human TNF/cachectin induce cachexia in mice
Oliff, A. I., Defeo-Jones, D., BOYER, M. E., Martinez, D., KIEFER, D. M., Vuocolo, G. A., Wolfe, A. L., & Socher, S. H. (1987) · Cell · doi:10.1016/0092-8674(87)90028-6 · Cited by 640 · see citing works
Interleukin-6 and its receptors: a highly regulated and dynamic system
Wolf, J., Rose-John, S., & Garbers, C. (2014) · Cytokine · doi:10.1016/j.cyto.2014.05.024 · Cited by 618 · see citing works
IL-6-induced skeletal muscle atrophy
Haddad, F., Zaldivar, F., Cooper, D. M., & Adams, G. R. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01026.2004 · Cited by 612 · see citing works
Muscle‐derived interleukin‐6: possible biological effects
Pedersen, B. K., Steensberg, A., & Schjerling, P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0329c.xd · Cited by 599 · see citing works
A New Look at the Origin, Function, and “Stem-Cell” Status of Muscle Satellite Cells
Seale, P., & Rudnicki, M. A. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9565 · Cited by 590 · see citing works
Cohen, S., Brault, J. J., Gygi, S. P., Glass, D. J., Valenzuela, D. M., Gartner, C. A., Latres, E., & Goldberg, A. L. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200901052 · Cited by 584 · see citing works
Bernet, J. D., Doles, J. D., Hall, J. K., Kelly Tanaka, K., Carter, T. A., & Olwin, B. B. (2014) · Nature Medicine · doi:10.1038/nm.3465 · Cited by 573 · see citing works
Muscle stem cells in development, regeneration, and diseasePreprint
Shi, X., & Garry, D. J. (2006) · Genes & Development · doi:10.1101/gad.1419406 · Cited by 502 · see citing works
Exercise as an anti-inflammatory therapy for rheumatic diseases—Myokine regulation
Benatti, F. B., & Pedersen, B. K. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.193 · Cited by 474 · cited 3× · see citing works
“…License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.”
BackgroundInfluentialBonetto, A., Aydogdu, T., Jin, X., Zhang, Z., Zhan, R., Puzis, L., Koniaris, L. G., & Zimmers, T. A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2012 · Cited by 463 · see citing works
Cancer cachexia: Developing multimodal therapy for a multidimensional problem
Fearon, K. C. H. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.02.033 · Cited by 444 · see citing works
Steensberg, A., Febbraio, M. A., Osada, T., Schjerling, P., van Hall, G., Saltin, B., & Pedersen, B. K. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00633.x · Cited by 444 · see citing works
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
Galdo, N. A. R., Lu, K., Ai, X., Haines, G. M., & Emerson, C. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504337103 · Cited by 441 · see citing works
The central role of muscle stem cells in regenerative failure with aging
Blau, H. M., Cosgrove, B. D., & Ho, A. T. V. (2015) · Nature Medicine · doi:10.1038/nm.3918 · Cited by 437 · see citing works
Tsujinaka, T., Fujita, J., Ebisui, C., Yano, M., Kominami, E., Suzuki, K., Tanaka, K., Katsume, A., Ohsugi, Y., Shiozaki, H., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118398 · Cited by 421 · see citing works
Byfield, S. D., Major, C. D., Laping, N. J., & Roberts, A. B. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.3.744 · Cited by 417 · see citing works
Centner, T., Yano, J., Kimura, E., McElhinny, A., Pelin, K., Witt, C. C., Bang, M., Trombitás, K., Granzier, H., Gregorio, C. C., et al. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4448 · Cited by 402 · see citing works
STAT3 signaling controls satellite cell expansion and skeletal muscle repair
Tierney, M. T., Aydogdu, T., Sala, D., Malecova, B., Gatto, S., Puri, P. L., Latella, L., & Sacco, A. (2014) · Nature Medicine · doi:10.1038/nm.3656 · Cited by 401 · see citing works
Intracellular signaling during skeletal muscle atrophy
Kandarian, S. C., & Jackman, R. W. (2005) · Muscle & Nerve · doi:10.1002/mus.20442 · Cited by 393 · see citing works
Major cell death pathways at a glance
Duprez, L., Wirawan, E., Berghe, T. V., & Vandenabeele, P. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.08.013 · Cited by 382 · see citing works
Looking back to the embryo: defining transcriptional networks in adult myogenesis
Parker, M. H., Seale, P., & Rudnicki, M. A. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1109 · Cited by 366 · see citing works
Signaling pathways perturbing muscle mass.
Glass, D. J. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833862df · Cited by 359 · see citing works
Cancer anorexia-cachexia syndrome: are neuropeptides the key?
Inui, A. (1999) · PubMed · Cited by 338 · see citing works
PI3 kinase regulation of skeletal muscle hypertrophy and atrophy.
Glass, D. (2010) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2010_78 · Cited by 330 · see citing works
Pedersen, B. K. (2000) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2000.t01-11-.x · Cited by 325 · see citing works
Transforming growth factor-β and myostatin signaling in skeletal muscle
Kollias, H. D., & McDermott, J. C. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01091.2007 · Cited by 307 · see citing works
Lach-Trifilieff, E., Minetti, G. C., Sheppard, K., Ibebunjo, C., Feige, J. N., Hartmann, S., Brachat, S., Rivet, H., Koelbing, C., Morvan, F., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01307-13 · Cited by 306 · see citing works
KUSANO, K. F., Pola, R., Murayama, T., Curry, C., Kawamoto, A., Iwakura, A., Shintani, S., Ii, M., Asai, J., Tkebuchava, T., et al. (2005) · Nature Medicine · doi:10.1038/nm1313 · Cited by 304 · see citing works
The soluble Interleukin 6 receptor: generation and role in inflammation and cancer.
Chalaris, A., Garbers, C., Rabe, B., Rose-John, S., & Scheller, J. (2011) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.10.007 · Cited by 302 · see citing works
Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair
Kharraz, Y., Guerra, J., Mann, C. J., Serrano, A. L., & Muñoz‐Cánoves, P. (2013) · Mediators of Inflammation · doi:10.1155/2013/491497 · Cited by 302 · see citing works
Interleukin‐6 Trans‐Signalling in Chronic Inflammation and Cancer
Scheller, J., Ohnesorge, N., & Rose‐John, S. (2006) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2006.01750.x · Cited by 301 · see citing works
The genetics of vertebrate myogenesis
Bryson‐Richardson, R. J., & Currie, P. D. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2369 · Cited by 285 · see citing works
Interleukin-6 and cachexia in ApcMin/+ mice.
Baltgalvis, K. A., Berger, F. G., Peña, M., Davis, J. M., Muga, S., & Carson, J. A. (2008) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00716.2007 · Cited by 281 · see citing works
Baracos, V., DeVivo, C., Hoyle, D., & Goldberg, A. (1995) · American Journal of Physiology · doi:10.1152/ajpendo.1995.268.5.e996 · Cited by 275 · see citing works
The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor?
Pedersen, B. K., Steensberg, A., Fischer, C. P., Keller, C., Keller, P., Plomgaard, P., Petersen, E. W., & Febbraio, M. A. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004338 · Cited by 273 · see citing works
Regulation of Muscle Mass by Follistatin and Activins
Lee, S.-J., Lee, Y.-S., Zimmers, T. A., Soleimani, A., Matzuk, M. M., Tsuchida, K., Cohn, R. D., & Barton, E. R. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0127 · Cited by 273 · see citing works
Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins
Fong, Y., Moldawer, L. L., Marano, M. A., Wei, H., Barber, A. E., Manogue, K., Tracey, K. J., Kuo, G., Fischman, D. A., Cerami, A., et al. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.256.3.r659 · Cited by 266 · see citing works
Cachexia: prevalence and impact in medicine
Tan, B. H. L., & Fearon, K. C. H. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328300ecc1 · Cited by 266 · see citing works
Stem Cell Review Series: Aging of the skeletal muscle stem cell niche
Gopinath, S. D., & Rando, T. A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00399.x · Cited by 262 · see citing works
From cytokine to myokine: The emerging role of interleukin-6 in metabolic regulation
Pal, M., Febbraio, M. A., & Whitham, M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2014.16 · Cited by 258 · see citing works
Muscle satellite cell heterogeneity and self-renewal
Motohashi, N., & Asakura, A. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00001 · Cited by 251 · see citing works
Lysosomal proteolysis in skeletal muscle
Béchet, D., Tassa, A., Taillandier, D., Combaret, L., & Attaix, D. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.02.029 · Cited by 241 · see citing works
A role for the myogenic determination gene Myf5 in adult regenerative myogenesis
Gayraud-Morel, B., Chrétien, F. C., Flamant, P., Gomès, D., Zammit, P. S., & Tajbakhsh, S. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.059 · Cited by 240 · see citing works
Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids
Baehr, L. M., Furlow, J. D., & Bodine, S. C. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.212845 · Cited by 234 · see citing works
Loss of stem cell regenerative capacity within aged niches
Carlson, M. E., & Conboy, I. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00286.x · Cited by 233 · see citing works
Silva, K. A. S., Dong, J., Dong, Y., Dong, Y., Schor, N., Tweardy, D. J., Zhang, L., & Mitch, W. E. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.641514 · Cited by 229 · see citing works
The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases
Kallen, K. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00325-7 · Cited by 205 · see citing works
Role of interleukin-6 in cachexia
Narsale, A. A., & Carson, J. A. (2014) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000091 · Cited by 205 · see citing works
Chang, N. C., & Rudnicki, M. A. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00006-8 · Cited by 180 · see citing works
Consensus on Cachexia Definitions
Argilés, J. M. A., Anker, S. D., Evans, W. J., Morley, J. E., Fearon, K., Strasser, F., Muscaritoli, M., & Baracos, V. E. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.02.004 · Cited by 174 · see citing works
Do, D. V., Ueda, J., Messerschmidt, D. M., Lorthongpanich, C., Zhou, Y., Feng, B., Guo, G., Lin, P. J., Hossain, M. Z., Zhang, W., et al. (2013) · Genes & Development · doi:10.1101/gad.221176.113 · Cited by 172 · see citing works
Lee, S., Huynh, T. V., Lee, Y., Sebald, S. M., Wilcox‐Adelman, S. A., Iwamori, N., Lepper, C., Matzuk, M. M., & Fan, C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206410109 · Cited by 167 · see citing works
The ins and outs of muscle stem cell aging
Brack, A. S., & Muñoz-Cánoves, P. (2015) · Skeletal Muscle · doi:10.1186/s13395-016-0072-z · Cited by 166 · see citing works
Tsujinaka, T., Ebisui, C., Fujita, J., Kishibuchi, M., Morimoto, T., Ogawa, A., Katsume, A., Ohsugi, Y., Kominami, E., & Monden, M. (1995) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.1995.1168 · Cited by 159 · see citing works
Toth, K., McKay, B. R., Lisio, M. D., Little, J. P., Tarnopolsky, M. A., & Parise, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017392 · Cited by 155 · see citing works
Ca2+-dependent proteolysis in muscle wasting
Costelli, P., Reffo, P., Penna, F., Autelli, R., Bonelli, G., & Baccino, F. M. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.03.010 · Cited by 151 · see citing works
Elia, D., Madhala, D., Ardon, E., Reshef, R., & Halevy, O. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.06.006 · Cited by 145 · see citing works
The pivotal role of cytokines in muscle wasting during cancer
Argilés, J. M. A., Busquets, S., & López-Soriano, F. J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.03.014 · Cited by 142 · see citing works
Defining the transcriptional signature of skeletal muscle stem cells1,2
Yablonka‐Reuveni, Z., Day, K. R., Vine, A. L., & Shefer, G. (2007) · Journal of Animal Science · doi:10.2527/jas.2007-0473 · Cited by 141 · see citing works
Weigert, C., Hennige, A. M., Lehmann, R., Brodbeck, K., Baumgärtner, F., Schaüble, M., Häring, H. U., & Schleicher, E. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509782200 · Cited by 140 · see citing works
Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
Sangiuliano, B. A., Pérez-Sosa, M., Moreira, D., & Belizário, J. E. (2014) · Mediators of Inflammation · doi:10.1155/2014/821043 · Cited by 136 · see citing works
Self-citationSonic hedgehog regulates angiogenesis and myogenesis during post‐natal skeletal muscle regeneration
Straface, G., Aprahamian, T. R., Flex, A., Gaetani, E., Biscetti, F., Smith, R. C., Pecorini, G., Pola, E., Angelini, F., Stigliano, E., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00440.x · Cited by 134 · see citing works
Cantini, M., Massimino, M. L., Rapizzi, E., Rossini, K., Catani, C., Dallalibera, L., & Carraro, U. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2590 · Cited by 129 · see citing works
Proteasome substrate degradation requires association plus extended peptide
Takeuchi, J. S., Chen, H., & Coffino, P. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601476 · Cited by 128 · see citing works
Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc Min/+ mouse
Baltgalvis, K. A., Berger, F. G., Peña, M. M. O., Davis, J. M., White, J. P., & Carson, J. A. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0574-6 · Cited by 125 · see citing works
Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor
Koeberle, S. C., Romir, J., Fischer, S., Koeberle, A., Schattel, V., Albrecht, W., Grütter, C., Werz, O., Rauh, D., Stehle, T., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.761 · Cited by 123 · see citing works
Tocilizumab, a Proposed Therapy for the Cachexia of Interleukin6-Expressing Lung Cancer
Ando, K., Takahashi, F., Kato, M., Kaneko, N., Doi, T., Ohe, Y., Koizumi, F., Nishio, K., & Takahashi, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102436 · Cited by 120 · see citing works
CNTO 328, a monoclonal antibody to IL‐6, inhibits human tumor‐induced cachexia in nude mice
Zaki, M. H., Nemeth, J. A., & Trikha, M. (2004) · International Journal of Cancer · doi:10.1002/ijc.20270 · Cited by 118 · see citing works
Belizário, J. E., Lorite, M. J., & Tisdale, M. J. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1700 · Cited by 116 · see citing works
Self-citationCiechanover, A. J. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310474 · Cited by 116 · see citing works
The Muscle Stem Cell Niche: Regulation of Satellite Cells During Regeneration
Boonen, K. J. M., & Post, M. J. (2008) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2008.0045 · Cited by 114 · see citing works
Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex
Skiniotis, G., Lupardus, P. J., Martick, M. M., Walz, T., & García, K. C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.011 · Cited by 112 · see citing works
Physiological mechanisms contributing to increased interleukin-1 secretion
Cannon, J. G., Evans, W. J., HUGHES, V. A., Meredith, C. N., & Dinarello, C. A. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.5.1869 · Cited by 112 · see citing works
Kwak, K. S., Zhou, X., Solomon, V., Baracos, V. E., Davis, J. G., Bannon, A. W., Boyle, W. J., Lacey, D. L., & Han, H. Q. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2102 · Cited by 111 · see citing works
Judge, S. M., Wu, C.-L., Beharry, A. W., Roberts, B. M., Ferreira, L. F., Kandarian, S. C., & Judge, A. R. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-997 · Cited by 111 · see citing works
IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-6
Müllberg, J., Geib, T., Jostock, T., Hoischen, S. H., Vollmer, P., Voltz, N., Heinz, D. W., Galle, P. R., Klouche, M., & Rose‐John, S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.9.4672 · Cited by 110 · see citing works
Luz, M. A. M., Marques, M. J., & Neto, H. S. (2002) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2002000600009 · Cited by 109 · see citing works
Interleukin-6: a villain in the drama of pancreatic cancer development and progression
Holmer, R., Goumas, F. A., Waetzig, G. H., Rose‐John, S., & Kalthoff, H. (2014) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(14)60259-9 · Cited by 108 · see citing works
Investigations of Branched-Chain Amino Acids and Their Metabolites inAnimal Models of Cancer1–3
Baracos, V. E., & Mackenzie, M. L. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.237s · Cited by 104 · see citing works
Context matters: In vivo and in vitro influences on muscle satellite cell activity
Cornelison, D. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21892 · Cited by 101 · see citing works
Cachexia: a problem of energetic inefficiency
Argilés, J. M. A., de Oliveira, C. C. F., Toledo, M., López-Soriano, F. J., & Busquets, S. (2014) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-014-0154-x · Cited by 93 · see citing works
Cancer cachexia: Its correlations and causes
Rubin, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931260100 · Cited by 89 · see citing works
Wang, X. H., Zhang, L., Mitch, W. E., LeDoux, J. M., Hu, J., & Du, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041707 · Cited by 89 · see citing works
Discovery and characterization of olokizumab
Shaw, S., Bourne, T., Meier, C., Carrington, B., Gelinas, R., Henry, A. J., Popplewell, A. G., Adams, R., BAKER, T. S., Rapecki, S., et al. (2014) · mAbs · doi:10.4161/mabs.28612 · Cited by 86 · see citing works
Tisdale, M. J. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20246 · Cited by 84 · see citing works
Muscle wasting from kidney failure—A model for catabolic conditions
Wang, X. H., & Mitch, W. E. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.027 · Cited by 82 · see citing works
Association of IL-1beta gene polymorphism with cachexia from locally advanced gastric cancer
Zhang, D., Zheng, H., Zhou, Y., Tang, X., Baojun, Y., & Li, J. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-45 · Cited by 81 · see citing works
Molecular regulation of skeletal muscle mass
Russell, A. P. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05265.x · Cited by 80 · see citing works
Matsushita, K., Iwanaga, S., Oda, T., Kimura, K., Shimada, M., Sano, M., Umezawa, A., Hata, J., & Ogawa, S. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700322 · Cited by 77 · see citing works
Keller, G., Grimm, V., Vogelsang, H., Bischoff, P., Mueller, J., Siewert, J. R., & Höfler, H. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19961127)68:5 · Cited by 76 · see citing works
Role of NF-κB and cytokine in experimental cancer cachexia
Zhou, W., Jiang, Z.-W., Tian, J., Jiang, J., Li, N., & Li, J.-S. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i7.1567 · Cited by 74 · see citing works
Apoptotic signaling in skeletal muscle fibers during atrophy
Sandri, M. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200205000-00003 · Cited by 70 · see citing works
Pelosi, M., Rossi, M. D., Barberi, L., & Musarò, A. (2014) · BioMed Research International · doi:10.1155/2014/206026 · Cited by 67 · see citing works
Halevy, O., Hodik, V., & Mett, A. (1996) · General and Comparative Endocrinology · doi:10.1006/gcen.1996.0006 · Cited by 67 · see citing works
Coupling Caspase Cleavage and Proteasomal Degradation of Proteins Carrying PEST Motif
Belizário, J. E., Alves, J. V., Garay-Malpartida, M., & Occhiucci, J. M. (2008) · Current Protein and Peptide Science · doi:10.2174/138920308784534023 · Cited by 66 · see citing works
Self-citationInflammation in cancer cachexia: To resolve or not to resolve (is that the question?)
Seelaender, M. C. L., Júnior, M. L. B., Lira, F. S., Silvério, R., & Fanelli, F. R. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.01.011 · Cited by 65 · see citing works
Conditional gp130 deficient mouse mutants
Fasnacht, N., & Müller, W. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.001 · Cited by 60 · see citing works
Brien, P., Pugazhendhi, D., Woodhouse, S., Oxley, D., & Pell, J. M. (2013) · Stem Cells · doi:10.1002/stem.1399 · Cited by 58 · see citing works
Brooks, N. E., Cadena, S. M., Vannier, E. G., Cloutier, G. J., Carámbula, S. F., Myburgh, K. H., Roubenoff, R., & Castaneda‐Sceppa, C. (2010) · Muscle & Nerve · doi:10.1002/mus.21780 · Cited by 56 · see citing works
Self-citationExercise, Cachexia, and Cancer Therapy: A Molecular Rationale
Ardies, C. M. (2002) · Nutrition and Cancer · doi:10.1207/s15327914nc422_1 · Cited by 56 · see citing works
FOXOphagy path to inducing stress resistance and cell survival
Sandri, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2550 · Cited by 53 · see citing works
The Role of Inflammatory Pathways in Cancer-Associated Cachexia and Radiation Resistance
Laine, A. M., Iyengar, P., & Pandita, T. K. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0189 · Cited by 51 · see citing works
Cross-talk among gp130 Cytokines in Adipocytes*
Zvonić, S., Baugh, J., Arbour-Reily, P., Mynatt, R., & Stephens, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508020200 · Cited by 50 · see citing works
Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress
Sacheck, J. M., Cannon, J. G., Hamada, K., Vannier, E. G., Blumberg, J. B., & Roubenoff, R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00052.2005 · Cited by 48 · see citing works
Self-citationBelizário, J. E., Katz, M., Chenker, E., & Raw, I. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.159 · Cited by 47 · see citing works
Self-citationEndurance exercise training in myostatin null mice
Savage, K. J., & McPherron, A. C. (2010) · Muscle & Nerve · doi:10.1002/mus.21688 · Cited by 45 · see citing works
Interleukin-6 family cytokines: signaling and effects in human airway smooth muscle cells
Lahiri, T., Laporte, J. D., Moore, P. E., Panettieri, R. A., & Shore, S. A. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.6.l1225 · Cited by 39 · see citing works
FoxO3 Controls Dangerous Proteolytic Liaisons
Attaix, D., & Béchet, D. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.005 · Cited by 36 · see citing works
Jablons, D. M., McIntosh, J. K., Mulé, J. J., Nordan, R. P., Rudikoff, S., & Lotze, M. T. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb24008.x · Cited by 35 · see citing works
Biomarkers for cancer cachexia: is there also a genetic component to cachexia?
Tan, B. H. L., Deans, D. A. C., Skipworth, R. J. E., Ross, J. A., & Fearon, K. C. H. (2007) · Supportive Care in Cancer · doi:10.1007/s00520-007-0367-z · Cited by 30 · see citing works
Effects of leucine supplemented diet on intestinal absorption in tumor bearing pregnant rats
Ventrucci, G., de Mello, M. A. R., & Gomes‐Marcondes, M. C. C. (2002) · BMC Cancer · doi:10.1186/1471-2407-2-7 · Cited by 24 · see citing works
Caspase-mediated cleavage of the signal-transducing IL-6 receptor subunit gp130
Graf, D., Haselow, K., Münks, I., Bode, J. G., & Häussinger, D. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.06.009 · Cited by 14 · see citing works
Shibata, M., Nagata, Y., Kimura, T., Kanou, H., Nezu, T., Takekawa, M., & Fukuzawa, M. (2000) · International Journal of Clinical Oncology · doi:10.1007/s101470050101 · Cited by 9 · see citing works
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Skeletal muscle: A review of molecular structure and function, in health and disease
Mukund, K., & Subramaniam, S. (2019) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1462 · Cited by 680 · see citing works
Tuttle, C. S. L., Thang, L. A. N., & Maier, A. B. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101185 · Cited by 664 · see citing works
Biomarkers shared by frailty and sarcopenia in older adults: A systematic review and meta-analysis
Picca, A., Coelho‐Júnior, H. J., Calvani, R., Marzetti, E., & Vetrano, D. L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101530 · Cited by 372 · see citing works
Inflammation: Roles in Skeletal Muscle Atrophy
Ji, Y., Li, M., Chang, M., Liu, R., Qiu, J., Wang, K., Deng, C., Shen, Y., Zhu, J., Wang, W., et al. (2022) · Antioxidants · doi:10.3390/antiox11091686 · Cited by 311 · see citing works
Inflammation and sarcopenia: A focus on circulating inflammatory cytokines
Pan, L., Xie, W., Fu, X., Lu, W., Jin, H., Lai, J., Zhang, A., Yu, Y., Li, Y., & Xiao, W. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111544 · Cited by 307 · see citing works
Myokines: The endocrine coupling of skeletal muscle and bone
Gomarasca, M., Banfi, G., & Lombardi, G. (2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.010 · Cited by 274 · see citing works
Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise
Safdar, A., & Tarnopolsky, M. A. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029827 · Cited by 203 · see citing works
VanderVeen, B. N., Fix, D. K., & Carson, J. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3292087 · Cited by 182 · see citing works
The JAK/STAT Pathway in Skeletal Muscle Pathophysiology
Moresi, V., Adamo, S., & Berghella, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00500 · Cited by 141 · see citing works
Inflammaging: The ground for sarcopenia?
Liang, Z., Zhang, T., Liu, H., Li, Z., Peng, L., Wang, C., & Wang, T. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111931 · Cited by 141 · see citing works
Chronic stress and body composition disorders: implications for health and disease
Stefanaki, C., Pervanidou, P., Boschiero, D., & Chrousos, G. P. (2018) · HORMONES · doi:10.1007/s42000-018-0023-7 · Cited by 135 · see citing works
Role of Pro-inflammatory Cytokines in Regulation of Skeletal Muscle Metabolism: A Systematic Review
Sharma, B., & Dabur, R. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867326666181129095309 · Cited by 127 · see citing works
Immune system and sarcopenia: Presented relationship and future perspective
Zhang, X., Li, H., He, M., Wang, J., Wu, Y., & Li, Y. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111823 · Cited by 112 · see citing works
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs
Rodgers, B. D., & Ward, C. W. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab030 · Cited by 111 · see citing works
Out of Control: The Role of the Ubiquitin Proteasome System in Skeletal Muscle during Inflammation
Haberecht-Müller, S., Krüger, E., & Fielitz, J. (2021) · Biomolecules · doi:10.3390/biom11091327 · Cited by 108 · see citing works
Zhou, S., Zhang, W., Cai, G., Ding, Y., Wei, C., Li, S., Yu, Y., Qin, J., Liu, D., Zhang, H., et al. (2020) · Cell Research · doi:10.1038/s41422-020-00393-6 · Cited by 104 · see citing works
Irazoki, A., Gordaliza‐Alaguero, I., Frank, E., Giakoumakis, N.-N., Seco, J., Palacı́n, M., Gumà, A., Sylow, L., Sebastián, D., & Zorzano, A. (2023) · Nature Communications · doi:10.1038/s41467-022-35732-1 · Cited by 104 · see citing works
Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions
Jun, L., Robinson, M., Geetha, T., Broderick, T. L., & Babu, J. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032973 · Cited by 101 · see citing works
de Sire, R., Rizzatti, G., Ingravalle, F., Pizzoferrato, M., Petito, V., Lopetuso, L. R., Graziani, C., Alessandro de, S. I. R. E., Mentella, M. C., Mele, M. C., et al. (2018) · Minerva Gastroenterologica e Dietologica · doi:10.23736/s1121-421x.18.02511-4 · Cited by 93 · see citing works
Muscle Wasting Diseases: Novel Targets and Treatments
Furrer, R., & Handschin, C. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021041 · Cited by 93 · see citing works
Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control
Peris-Moreno, D., Cussonneau, L., Combaret, L., Polge, C., & Taillandier, D. (2021) · Molecules · doi:10.3390/molecules26020407 · Cited by 87 · see citing works
Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85 · see citing works
The hormetic and hermetic role of IL-6
Forcina, L., Franceschi, C., & Musarò, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101697 · Cited by 85 · see citing works
Nidadavolu, L. S., & Walston, J. D. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa209 · Cited by 84 · see citing works
Musculoskeletal senescence: a moving target ready to be eliminated
Baar, M. P., Perdiguero, E., Muñoz-Cánoves, P., & de Keizer, P. L. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.05.007 · Cited by 83 · see citing works
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works
Dantas, W. S., Zunica, E. R. M., Heintz, E. C., Vandanmagsar, B., Floyd, Z. E., Yu, Y., Fujioka, H., Hoppel, C. L., Belmont, K. P., Axelrod, C. L., et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12982 · Cited by 82 · see citing works
Álvarez, Á. M., DeOcesano-Pereira, C., Teixeira, C., & Moreira, V. (2020) · Cells · doi:10.3390/cells9092005 · Cited by 78 · see citing works
Mechanisms of exercise as a preventative measure to muscle wasting
Graham, Z., Lavin, K. M., O’Bryan, S. M., Thalacker‐Mercer, A. E., Buford, T. W., Ford, K. M., Broderick, T. J., & Bamman, M. M. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00056.2021 · Cited by 78 · see citing works
Muscle Atrophy: Present and Future
Cao, R. Y., Li, J., Dai, Q., Li, Q. X., & Yang, J. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1435-3_29 · Cited by 75 · see citing works
Sheng, R., Cao, M., Song, M., Wang, M., Zhang, Y., Shi, L., Xie, T., Li, Y., Wang, J., & Rui, Y. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.09.007 · Cited by 74 · see citing works
Khalafi, M., Akbari, A., Symonds, M. E., Pourvaghar, M. J., Rosenkranz, S. K., & Tabari, E. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156303 · Cited by 69 · see citing works
Emerging Targets and Treatments for Sarcopenia: A Narrative Review
Cacciatore, S., Calvani, R., Esposito, I., Massaro, C., Gava, G., Picca, A., Tosato, M., Marzetti, E., & Landi, F. (2024) · Nutrients · doi:10.3390/nu16193271 · Cited by 71 · see citing works
Picca, A., Calvani, R., Coelho‐Júnior, H. J., Marini, F., Landi, F., & Marzetti, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214006 · Cited by 65 · see citing works
Fan, J., Fan, J., & Khanzada, Z. (2025) · Muscles · doi:10.3390/muscles4030026 · Cited by 64 · see citing works
MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice
Cheng, N., Liu, C., Li, Y., Gao, S., Han, Y., Wang, X., Du, J., & Zhang, C. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012263 · Cited by 60 · see citing works
Shi, L., Zhang, L., Zhang, D., & Chen, Z. (2023) · BMC Public Health · doi:10.1186/s12889-023-16338-8 · Cited by 59 · see citing works
Marinho, R., de Alcântara, P. S. M., Otoch, J. P., & Seelaender, M. C. L. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00069 · Cited by 56 · see citing works
Blackwell, T. A., Červenka, I., Khatri, B., Brown, J. L., Rosa‐Caldwell, M. E., Lee, D. E., Perry, R. A., Brown, L. A., Haynie, W. S., Wiggs, M. P., et al. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00061.2018 · Cited by 56 · see citing works
IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight
Smith, J. K. (2018) · npj Microgravity · doi:10.1038/s41526-018-0057-9 · Cited by 56 · see citing works
Identification of microRNAs in skeletal muscle associated with lung cancer cachexia
van de Worp, W. R. P. H., Schols, A. M. W. J., Dingemans, A. C., den Kamp, C. M. O., Degens, J. H. R. J., KELDERS, M. C. J. M., Coort, S. L., Woodruff, H. C., Kratassiouk, G., Harel‐Bellan, A., et al. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12512 · Cited by 55 · see citing works
Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing
Borja-Gonzalez, M., Casas-Martinez, J. C., McDonagh, B., & Goljanek‐Whysall, K. (2020) · Antioxidants · doi:10.3390/antiox9040345 · Cited by 53 · see citing works
Cirillo, F., Resmini, G., Ghiroldi, A., Piccoli, M., Bergante, S., Tettamanti, G., & Anastasia, L. (2017) · The FASEB Journal · doi:10.1096/fj.201600878r · Cited by 53 · see citing works
Baranova, A. V., Maltseva, D. V., & Tonevitsky, A. (2018) · Obesity Reviews · doi:10.1111/obr.12765 · Cited by 52 · see citing works
Campos, F., Ábrigo, J., Aguirre, F. S., Garcés, B., Arrese, M. A., Karpen, S. J., Cabrera, D., Andía, M. E., Simón, F., & Cabello‐Verrugio, C. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2167-3 · Cited by 51 · see citing works
Quorum sensing molecules as a novel microbial factor impacting muscle cells
Spiegeleer, A. D., Elewaut, D. S., Noortgate, N. V. D., Janssens, Y., Debunne, N., Langenhove, S. V., Govindarajan, S., Spiegeleer, B. M. J. D., & Wynendaele, E. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165646 · Cited by 51 · see citing works
Anderson, J. E. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04865-4 · Cited by 52 · see citing works
Cancer cachexia: lessons from Drosophila
Liu, Y., Saavedra, P. H. V., & Perrimon, N. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049298 · Cited by 43 · see citing works
Feng, Z., Xia, J., Yu, J., Wang, J. P., Yin, S., Yang, H. J., Wu, T., Zhang, Z., Yan, W., Wang, S., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115113 · Cited by 47 · see citing works
Berdeaux, R., & Hutchins, C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00535 · Cited by 46 · see citing works
Wang, Y., Zhang, J., Wang, J., Zhang, Y., Sun, J., Gong, J., Yao, X., & Sun, H. (2026) · Pharmaceuticals · doi:10.3390/ph19060868 · Cited by 45 · see citing works
Andrich, D. E., Melbouci, L., Ou, Y., Auclair, N., Mercier, J., Grenier, J., Lira, F., Barreiro, L. B., Danialou, G., Comtois, A., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00372 · Cited by 39 · see citing works
Targeting the JAK2/STAT3 Pathway—Can We Compare It to the Two Faces of the God Janus?
Jaśkiewicz, A., Domoradzki, T., & Pająk, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218261 · Cited by 42 · see citing works
What Role Do Inflammatory Cytokines Play in Cancer Cachexia?
Malla, J., Zahra, A., Venugopal, S., Selvamani, T. Y., Shoukrie, S. I., Selvaraj, R., Dhanoa, R. K., Hamouda, R. K., & Mostafa, J. A. (2022) · Cureus · doi:10.7759/cureus.26798 · Cited by 41 · see citing works
Fielding, R. A., Atkinson, E. J., Aversa, Z., White, T. A., Heeren, A. A., Mielke, M. M., Cummings, S. R., Pahor, M., Leeuwenburgh, C., & LeBrasseur, N. K. (2024) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glad257 · Cited by 38 · see citing works
Corey‐Bloom, J., Fischer, R. S., Kim, A., Snell, C. M., Parkin, G. M., Granger, D. A., Granger, S. W., & Thomas, E. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176363 · Cited by 38 · see citing works
Skeletal muscle atrophy after sciatic nerve damage: Mechanistic insights
Yadav, A., & Dabur, R. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176506 · Cited by 38 · see citing works
Gros, M., Nunes, A. M., Daoudlarian, D., Pini, J., Martinuzzi, E., Barbosa, S., Ramirez, M., Puma, A. R., Villa, L., Cavalli, M., et al. (2021) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-210711 · Cited by 37 · see citing works
Heitman, K., Alexander, M. S., & Faul, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105117 · Cited by 38 · see citing works
Ding, J., Yang, G., Sun, W., Li, Y., Wang, N., Wang, J., & Zhao, Y. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2384664 · Cited by 36 · see citing works
Advances in research on cell models for skeletal muscle atrophy
Li, L., Huang, C., Pang, J., Huang, Y., Chen, X., & Chen, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115517 · Cited by 34 · see citing works
Muscle–bone interactions: movement in the field of mechano–humoral coupling of muscle and bone
Cardozo, C. P., & Graham, Z. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13411 · Cited by 33 · see citing works
Spaans, O. K., Kuhn‐Sherlock, B., Hickey, A. J., Crookenden, M. A., Heiser, A., Burke, C. R., Phyn, C. V. C., & Roche, J. R. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-20883 · Cited by 33 · see citing works
Guo, Q., Luo, Q., & Song, G. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13440 · Cited by 32 · see citing works
Collins, J. J. P., Lithopoulos, M. A., dos Santos, C. C., Issa, N. G., Möbius, M. A., Ito, C. Y., Zhong, S., Vadivel, A., & Thébaud, B. (2018) · Stem Cells and Development · doi:10.1089/scd.2017.0145 · Cited by 32 · see citing works
Cenni, V., Kojić, S., Capanni, C., Faulkner, G., & Lattanzi, G. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7318796 · Cited by 32 · see citing works
Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle
Klymenko, O., Brecklinghaus, T., Dille, M., Springer, C., de Wendt, C., Altenhofen, D., Binsch, C., Knebel, B., Scheller, J., Hardt, C., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101062 · Cited by 25 · see citing works
Au, E., Desai, A., Koniaris, L., & Zimmers, T. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2016.00682 · Cited by 27 · see citing works
Invernizzi, M., Alessandro de, S. I. R. E., Carda, S., Venetis, K., Renò, F., Cisari, C., & Fusco, N. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00601-7 · Cited by 29 · see citing works
Mageriu, V., Manole, E., Bastian, A. E., & Stăniceanu, F. (2020) · Journal of Immunology Research · doi:10.1155/2020/9079083 · Cited by 28 · see citing works
Dupont, J., Vercauteren, L., Amini, N., Lapauw, L., Schaepdryver, M. D., Poesen, K., Dedeyne, L., Verschueren, S., Tournoy, J., Koppo, K., et al. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112196 · Cited by 27 · see citing works
Activated dendritic cells modulate proliferation and differentiation of human myoblasts
Ladislau, L., Portilho, D. M., Courau, T., Solares-Pérez, A., Négroni, E., Lainé, J., Klatzmann, D., Bonomo, A. C., Allenbach, Y., Benvéniste, O., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0426-z · Cited by 26 · see citing works
Systemic inflammatory markers in individuals with cerebral palsy
Pingel, J., Barber, L. A., Andersen, I. T., von Walden, F., Wong, C., Døssing, S., & Nielsen, J. B. (2019) · European Journal of Inflammation · doi:10.1177/2058739218823474 · Cited by 26 · see citing works
Invernizzi, M., Alessandro de, S. I. R. E., & Fusco, N. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.02.003 · Cited by 26 · see citing works
Hodgson, J. A., Parvy, J.-P., Yu, Y., Vidal, M., & Cordero, J. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158317 · Cited by 23 · see citing works
Rinninella, E., Cintoni, M., Raoul, P., Pozzo, C., Strippoli, A., Ponziani, F., Pompili, M., Bria, E., Tortora, G., Gasbarrini, A., et al. (2020) · Nutrients · doi:10.3390/nu12103101 · Cited by 26 · see citing works
Ludovico, A. D., Bella, S. L., Ciarelli, F., Chiarelli, F., Breda, L., & Mohn, A. (2024) · Journal of Ultrasound · doi:10.1007/s40477-024-00917-5 · Cited by 25 · see citing works
Liang, Z., & Zhang, L. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1733798 · Cited by 26 · see citing works
Shi, L. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112296 · Cited by 25 · see citing works
Osaka, T., Hashimoto, Y., Okamura, T., Fukuda, T., Yamazaki, M., Hamaguchi, M., & Fukui, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122175 · Cited by 25 · see citing works
Han, Y.-H., Mun, J.-G., Jeon, H. D., Yoon, D. H., Choi, B.-M., Kee, J.-Y., & Hong, S.-H. (2020) · Nutrients · doi:10.3390/nu12103195 · Cited by 24 · see citing works
Lopes, K. G., Farinatti, P., Bottino, D. A., de Souza, M. D. G. C., Maranhao, P. A., Bouskela, E., Lourenço, R. A., & Oliveira, R. B. (2021) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-211202 · Cited by 24 · see citing works
Kays, J. K., Koniaris, L. G., Cooper, C. A., Пили, Р., Jiang, G., Liu, Y., & Zimmers, T. A. (2020) · Cancers · doi:10.3390/cancers12061605 · Cited by 24 · see citing works
Beavers, D. P., Kritchevsky, S. B., Gill, T. M., Ambrosius, W. T., Anton, S. D., Fielding, R. A., King, A. C., Rejeski, W. J., Lovato, L., McDermott, M. M., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab093 · Cited by 23 · see citing works
Decreased miR-497-5p Suppresses IL-6 Induced Atrophy in Muscle Cells
Freire, P., Cury, S., Lopes, L. O., Fernandez, G., Liu, J., de Moraes, L. N., de Oliveira, G. D., Oliveira, J., de Moraes, D., Cabral-Marques, O., et al. (2021) · Cells · doi:10.3390/cells10123527 · Cited by 18 · see citing works
Deng, Y., Zhao, L., Huang, X., Zeng, Y., Xiong, Z., & Zuo, M. (2022) · Nutrition · doi:10.1016/j.nut.2022.111829 · Cited by 23 · see citing works
The dichotomic role of single cytokines: Fine-tuning immune responses
Silva, R. C. M. C., Travassos, L. H., & Dutra, F. F. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156408 · Cited by 25 · see citing works
Inflammatory cytokines and sarcopenia in Iranian adults-results from SARIR study
Asoudeh, F., Dashti, F., Raeesi, S., Heshmat, R., Bidkhori, M., Jalilian, Z., & Hashemi, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-09139-3 · Cited by 22 · see citing works
Pedraza-Vázquez, G., Mena‐Montes, B., Hernández-Álvarez, D., Gómez-Verján, J. C., Toledo-Pérez, R., López-Teros, M. T., Königsberg, M., Gómez-Quiroz, L. E., & Luna‐López, A. (2022) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2022.104856 · Cited by 22 · see citing works
Ono, Y., Saito, M., Sakamoto, K., Maejima, Y., Misaka, S., Shimomura, K., Nakanishi, N., Inoue, S., & Kotani, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1031906 · Cited by 22 · see citing works
Aging, Physical Exercise, Telomeres, and Sarcopenia: A Narrative Review
Hernández-Álvarez, D., Rosado-Pérez, J., Gavia-García, G., Arista-Ugalde, T. L., Aguíñiga-Sánchez, I., Santiago‐Osorio, E., & Mendoza-Núñez, V. M. (2023) · Biomedicines · doi:10.3390/biomedicines11020598 · Cited by 22 · see citing works
Inflammation—Insulin Resistance Crosstalk and the Central Role of Myokines
Dobre, M.-Z., Vîrgolici, B., Stefan, D. C. A., Doicin, I.-C., & Stănescu-Spînu, I.-I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010060 · Cited by 21 · see citing works
Schmitt, A., Herzog, P., Röchner, F., Brändle, A.-L., Fragasso, A., & Munz, B. (2020) · Physiological Reports · doi:10.14814/phy2.14609 · Cited by 20 · see citing works
Relationship between adiponectin and muscle mass in patients with metabolic syndrome and obesity
de Luis, D. A., Primo, D., Izaola, O., & Gómez, J. J. L. (2024) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2024.108706 · Cited by 21 · see citing works
Fontelonga, T. M., Jordan, B., Nunes, A. M., Barraza-Flores, P., Bolden, N., Wuebbles, R., Griner, L. A. M., Hu, X., Ferrer, M., Marugan, J., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz044 · Cited by 17 · see citing works
Rosales-Antequera, C., Viscor, G., & Araneda, O. F. (2022) · Biology · doi:10.3390/biology11040550 · Cited by 20 · see citing works
Anderson, M. R., Easthausen, I. J., Gallagher, G. B., Udupa, J. K., Tong, Y., Torigian, D. A., Diamond, J. M., Porteous, M. K., Palmer, S. M., Snyder, L. D., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2019-214461 · Cited by 19 · see citing works
Palmquist, C., Dehlendorff, C., Calatayud, D., Hansen, C. P., Hasselby, J. P., & Johansen, J. S. (2019) · Pancreas · doi:10.1097/mpa.0000000000001466 · Cited by 19 · see citing works
Filippi, M., MOCK, D., Fuentes, J., Michelis, M. Y., Balciunaite, A., Paniagua, P., Hopf, R., Barteld, A., Eng, S., Badolato, A., et al. (2025) · Science Advances · doi:10.1126/sciadv.adv2628 · Cited by 18 · see citing works
Wang, J., Zhou, X., Qiu, S., Deng, L., Li, J., Yang, L., Wei, Q., & Dong, B. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.937087 · Cited by 19 · see citing works
- Authors
- Belizário, J. E., Fontes-Oliveira, C. C., Borges, J. P., Kashiabara, J. A., & Vannier, E.
- Affiliations
- Universidade de São Paulo (BR)
- Tufts Medical Center (US)
- Corresponding author
- Vannier, Edouard
- Venue
- SpringerPlus
- Published
- 2016-05-13
- Volume
- 5
- Issue
- 1
- Pages
- 619-619
- ISSN
- 2193-1801 (ISSN-L)
- PMC
- PMC4870483
- OpenAlex
- W2388738573
- Cited by
- 244
- References
- 161
- Citations by year
- 2026: 22 · 2025: 28 · 2024: 36 · 2023: 32 · 2022: 32 · 2021: 23 · 2020: 23 · 2019: 21 · 2018: 18 · 2017: 8 · 2016: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- SpringerPlus (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2001/0100-7)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (486048/2011)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- skeletal muscle atrophy, cachexia, interleukin-6, myokines, satellite cells, muscle regeneration, JAK/STAT signaling, protein kinase inhibitors, muscle atrophy, muscle degeneration, cancer cachexia, inflammatory diseases
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