Cited by 686Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

The DOI matches its Crossref record; 2,576 of the 2,576 references it cites were found in a registry or an index.

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Open access

Hansen, Kasper B., Wollmuth, Lonnie P., Bowie, Derek, Furukawa, Hiro, Menniti, Frank S., Sobolevsky, Alexander I., Swanson, Geoffrey T., Swanger, Sharon A., Greger, Ingo H., Nakagawa, Terunaga, McBain, Chris J., Jayaraman, Vasanthi, Low, Chian-Ming, Dell’Acqua, Mark L., Diamond, Jeffrey S., Camp, Chad R., Perszyk, Riley E., Yuan, Hongjie, Traynelis, Stephen F.·2021·Pharmacological Reviews

DOI 10.1124/pharmrev.120.000131PMC PMC8626789

Open this paper in CoChat — free account Open PDF

Abstract

Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs). These ligand-gated ion channels are critical to brain function and are centrally implicated in numerous psychiatric and neurologic disorders. There are different classes of iGluRs with a variety of receptor subtypes in each class that play distinct roles in neuronal functions. The diversity in iGluR subtypes, with their unique functional properties and physiologic roles, has motivated a large number of studies. Our understanding of receptor subtypes has advanced considerably since the first iGluR subunit gene was cloned in 1989, and the research focus has expanded to encompass facets of biology that have been recently discovered and to exploit experimental paradigms made possible by technological advances. Here, we review insights from more than 3 decades of iGluR studies with an emphasis on the progress that has occurred in the past decade. We cover structure, function, pharmacology, roles in neurophysiology, and therapeutic implications for all classes of receptors assembled from the subunits encoded by the 18 ionotropic glutamate receptor genes. SIGNIFICANCE STATEMENT: Glutamate receptors play important roles in virtually all aspects of brain function and are either involved in mediating some clinical features of neurological disease or represent a therapeutic target for treatment. Therefore, understanding the structure, function, and pharmacology of this class of receptors will advance our understanding of many aspects of brain function at molecular, cellular, and system levels and provide new opportunities to treat patients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1124/pharmrev.120.000131

Cites

2576 of 2576 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 201–400 of 2,576

A Molecular Determinant for Submillisecond Desensitization in Glutamate Receptors
Mosbacher, J., Schoepfer, R., Monyer, H., Burnashev, N., SEEBURG, P. H., & Ruppersberg, J. P. (1994) · Science · doi:10.1126/science.7973663 · Cited by 610
The Postsynaptic Organization of Synapses
Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603
Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression
Price, R. B., Nock, M. K., Charney, D. S., & Mathew, S. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.029 · Cited by 600
Heterogeneous Release Properties of Visualized Individual Hippocampal Synapses
Murthy, V. N., B, T. J. S. A., & Stevens, C. F. (1997) · Neuron · doi:10.1016/s0896-6273(00)80301-3 · Cited by 596
Early-Onset Epilepsy and Postnatal Lethality Associated with an Editing-Deficient GluR-B Allele in Mice
Brusa, R., Zimmermann, F., Koh, D., Feldmeyer, D., Gass, P., Seeburg, P. H., & Sprengel, R. (1995) · Science · doi:10.1126/science.270.5242.1677 · Cited by 594
The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
Bats, C., Groc, L., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.030 · Cited by 590
Regulation of AMPA receptor trafficking and synaptic plasticity
Anggono, V., & Huganir, R. L. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.12.006 · Cited by 588
The mouse stargazer gene encodes a neuronal Ca2+-channel γ subunit
Letts, V. A., Felix, R., Biddlecome, G. H., Arikkath, J., Mahaffey, C. L., Valenzuela, A., Bartlett, F. S., Mori, Y., Campbell, K. P., & Frankel, W. N. (1998) · Nature Genetics · doi:10.1038/1228 · Cited by 586
Inflammation, glutamate, and glia: a trio of trouble in mood disorders
Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584
Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A
Partin, K. M., Patneau, D. K., Winters, C. A., Mayer, M. L., & Buonanno, A. (1993) · Neuron · doi:10.1016/0896-6273(93)90220-l · Cited by 583
Interneurons unbound
McBain, C. J., & Fisahn, A. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049047 · Cited by 581
Self-citation
Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block
Bowie, D., & Mayer, M. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90049-7 · Cited by 579
Self-citation
Two Distinct Forms of Long-Term Depression Coexist in CA1 Hippocampal Pyramidal Cells
Oliet, S. H. R., Malenka, R. C., & Nicoll, R. A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80336-0 · Cited by 578
Allosteric control of an ionotropic glutamate receptor with an optical switch
Volgraf, M., Gorostiza, P., Numano, R., Krämer, R., Isacoff, E. Y., & Trauner, D. H. (2005) · Nature Chemical Biology · doi:10.1038/nchembio756 · Cited by 573
Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons
Castillo, P. E., Malenka, R. C., & Nicoll, R. A. (1997) · Nature · doi:10.1038/40645 · Cited by 568
Glutamate-operated channels: Developmentally early and mature forms arise by alternative splicing
Monyer, H., Seeburg, P. H., & Wisden, W. (1991) · Neuron · doi:10.1016/0896-6273(91)90176-z · Cited by 568
Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders
Parsons, M. P., & Raymond, L. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.030 · Cited by 567
Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
Traynelis, S. F., & Cull-Candy, S. G. (1990) · Nature · doi:10.1038/345347a0 · Cited by 566
Self-citation
Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents
Lester, R. A. J., Clements, J. D., Westbrook, G. L., & Jahr, C. E. (1990) · Nature · doi:10.1038/346565a0 · Cited by 564
Augmentation of Exposure Therapy With D-Cycloserine for Social Anxiety Disorder
Hofmann, S. G., Meuret, A. E., Smits, J. A. J., Simon, N. M., Pollack, M. H., Eisenmenger, K., Shiekh, M., & Otto, M. W. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.298 · Cited by 560
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury
Salter, M. G., & Fern, R. F. (2005) · Nature · doi:10.1038/nature04301 · Cited by 556
Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene
Zuo, J., De Jager, P. L., Takahashi, K. A., Jiang, W., Linden, D. J., & Heintz, N. (1997) · Nature · doi:10.1038/42009 · Cited by 554
AMPA receptor subunits expressed by single purkinje cells
Lambolez, B., Audinat, É., Bochet, P., Crépel, F., & Rossier, J. (1992) · Neuron · doi:10.1016/0896-6273(92)90164-9 · Cited by 553
The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits
Herb, A., Burnashev, N., Werner, P., Sakmann, B. J., Wisden, W., & Seeburg, P. H. (1992) · Neuron · doi:10.1016/0896-6273(92)90098-x · Cited by 550
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
Tomita, S., Chen, L., Kawasaki, Y., Petralia, R. S., Wenthold, R. J., Nicoll, R. A., & Bredt, D. S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212116 · Cited by 545
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
Plant, K., Pelkey, K. A., Bortolotto, Z. A., Morita, D., Terashima, A., McBain, C. J., Collingridge, G. L., & Isaac, J. T. R. (2006) · Nature Neuroscience · doi:10.1038/nn1678 · Cited by 542
Self-citation
NMDA receptor structures reveal subunit arrangement and pore architecture
Lee, C.-H., Lü, W., Michel, J. J. C., Goehring, A. S., Du, J., Song, X., & Gouaux, E. (2014) · Nature · doi:10.1038/nature13548 · Cited by 538
Signaling pathways underlying the rapid antidepressant actions of ketamine
Duman, R. S., Li, N., Liu, R.-J., Duric, V., & Aghajanian, G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.044 · Cited by 537
Inactivation of NMDA Receptors by Direct Interaction of Calmodulin with the NR1 Subunit
Ehlers, M., Zhang, S., Bernhardt, J., & Huganir, R. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81052-1 · Cited by 537
Glutamate Released from Glial Cells Synchronizes Neuronal Activity in the Hippocampus
Angulo, M. C., Kozlov, A. S., Charpak, S., & Audinat, É. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0473-04.2004 · Cited by 534
Modulation of pH by neuronal activity
Chesler, M., & Kaila, K. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90191-a · Cited by 533
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
Krystal, J. H., D'Souza, D. C., Mathalon, D., Perry, E., Belger, A., & Hoffman, R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1582-z · Cited by 530
Ligands for Glutamate Receptors: Design and Therapeutic Prospects
Bräuner‐Osborne, H., Egebjerg, J., Nielsen, E. Ø., Madsen, U., & Krogsgaard‐Larsen, P. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000007r · Cited by 528
Ketamine for chronic pain: risks and benefits
Niesters, M., Martini, C., & Dahan, A. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12094 · Cited by 526
Synaptic AMPA receptor composition in development, plasticity and disease
Henley, J. M., & Wilkinson, K. A. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.37 · Cited by 526
N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
Cline, H. T., Debski, E. A., & Constantine‐Paton, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.12.4342 · Cited by 525
Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing
Sugihara, H., Moriyoshi, K., Ishii, T. M., Masu, M., & Nakanishi, S. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91701-q · Cited by 524
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand‐binding core
Furukawa, H., & Gouaux, E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg303 · Cited by 524
Self-citation
An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder
Preskorn, S., Baker, B., Kolluri, S., Menniti, F. S., Krams, M., & Landen, J. W. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31818a6cea · Cited by 524
Self-citation
Glycine transporters are differentially expressed among CNS cells
Zafra, F., Aragón, C., Olivares, L., Danbolt, N. C., Giménez, C., & Storm‐Mathisen, J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03952.1995 · Cited by 521
Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission
Heine, M., Groc, L., Frischknecht, R., Béïque, J.-C., Lounis, B., Rumbaugh, G., Huganir, R. L., Cognet, L., & Choquet, D. (2008) · Science · doi:10.1126/science.1152089 · Cited by 518
Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure
Clem, R. L., & Huganir, R. L. (2010) · Science · doi:10.1126/science.1195298 · Cited by 516
Dendritic integration: 60 years of progress
Stuart, G. J., & Spruston, N. (2015) · Nature Neuroscience · doi:10.1038/nn.4157 · Cited by 516
Subunit-Specific NMDA Receptor Trafficking to Synapses
Barria, A., & Malinow, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00776-6 · Cited by 515
FUNCTIONS AND MECHANISMS OF RNA EDITING
Gott, J. M., & Emeson, R. B. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.499 · Cited by 513
Differential expression of five N‐methyl‐D‐aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats
Akazawa, C., Shigemoto, R., Bessho, Y., Nakanishi, S., & Mizuno, N. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903470112 · Cited by 506
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
Micu, I., Jiang, Q., Coderre, E., Ridsdale, A., Zhang, L., Woulfe, J., Yin, X., Trapp, B. D., McRory, J. E., Rehak, R., et al. (2005) · Nature · doi:10.1038/nature04474 · Cited by 504
Clinical Experience With Excitatory Amino Acid Antagonist Drugs
Muir, K. W., & Lees, K. R. (1995) · Stroke · doi:10.1161/01.str.26.3.503 · Cited by 503
Calcium-induced actin depolymerization reduces NMDA channel activity
Rosenmund, C., & Westbrook, G. L. (1993) · Neuron · doi:10.1016/0896-6273(93)90197-y · Cited by 503
Neurotrophin Regulation of Cortical Dendritic Growth Requires Activity
McAllister, A. K., Katz, L. C., & Lo, D. C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80239-1 · Cited by 503
Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex
Iwasato, T., Datwani, A., Wolf, A. M., Nishiyama, H., Taguchi, Y., Tonegawa, S., Knöpfel, T., Erzurumlu, R. S., & Itohara, S. (2000) · Nature · doi:10.1038/35021059 · Cited by 501
AMPA Receptor Incorporation into Synapses during LTP: The Role of Lateral Movement and Exocytosis
Makino, H., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.035 · Cited by 501
Impairment of Suckling Response, Trigeminal Neuronal Pattern Formation, and Hippocampal LTD in NMDA Receptor ε2 Subunit Mutant Mice
Kutsuwada, T., Sakimura, K., Manabe, T., Takayama, C., Katakura, N., Kushiya, E., Natsume, R., Watanabe, M., Inoue, Y., Yagi, T., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80051-3 · Cited by 498
Effects of D-Cycloserine on Extinction: Translation From Preclinical to Clinical Work
Davis, M., Ressler, K., Rothbaum, B. O., & Richardson, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.084 · Cited by 498
Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum
Uemura, T., Lee, S.-J., Yasumura, M., Takeuchi, T., Yoshida, T., Ra, M., Taguchi, R., Sakimura, K., & Mishina, M. (2010) · Cell · doi:10.1016/j.cell.2010.04.035 · Cited by 496
DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke
Tu, W., Xu, X., Peng, L., Zhong, X., Zhang, W., Soundarapandian, M. M., Belal, C., Wang, M., Jia, N., Zhang, W., et al. (2010) · Cell · doi:10.1016/j.cell.2009.12.055 · Cited by 493
Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons
Rao, A., & Craig, A. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80962-9 · Cited by 492
Analysis of excitatory synaptic action in pyramidal cells using whole‐cell recording from rat hippocampal slices.
Hestrin, S., Nicoll, R. A., Perkel, D. J., & Sah, P. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp017980 · Cited by 491
Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death
Forrest, D., Yuzaki, M., Soares, H. D., Ng, L., Luk, D. C., Sheng, M., Stewart, C. L., Morgan, J. I., Connor, J. A., & Curran, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90350-6 · Cited by 491
Progress in achieving quantitative classification of psychopathology
Krueger, R. F., Kotov, R., Watson, D., Forbes, M. K., Eaton, N. R., Ruggero, C. J., Simms, L. J., Widiger, T. A., Achenbach, T. M., Bach, B., et al. (2018) · World Psychiatry · doi:10.1002/wps.20566 · Cited by 490
Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice
Planagumà, J., Leypoldt, F., Mannara, F., Cuesta, J., Martín‐García, E., Aguilar, E., Titulaer, M. J., Petit‐Pedrol, M., Jain, A., Balice‐Gordon, R. J., et al. (2014) · Brain · doi:10.1093/brain/awu310 · Cited by 489
Single-Channel Properties of Recombinant AMPA Receptors Depend on RNA Editing, Splice Variation, and Subunit Composition
Swanson, G. T., Kamboj, S. K., & Cull-Candy, S. G. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00058.1997 · Cited by 489
Self-citation
The mechanisms and functions of synaptic facilitation.
Jackman, S. L., & Regehr, W. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.047 · Cited by 489
Stargazin modulates AMPA receptor gating and trafficking by distinct domains
Tomita, S., Adesnik, H., Sekiguchi, M., Zhang, W., Wada, K., Howe, J. R., Nicoll, R. A., & Bredt, D. S. (2005) · Nature · doi:10.1038/nature03624 · Cited by 486
Evidence for a Tetrameric Structure of Recombinant NMDA Receptors
Laube, B., Kuhse, J., & Betz, H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02954.1998 · Cited by 482
Short-Term Presynaptic Plasticity
Regehr, W. G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005702 · Cited by 482
The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography
Monaghan, D. T., & Cotman, C. W. (1982) · Brain Research · doi:10.1016/0006-8993(82)90981-7 · Cited by 481
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice
Mulle, C., Sailer, A. W., Pérez‐Otaño, I., Dickinson-Anson, H., Castillo, P. E., Bureau, I., Maron, C., Gage, F. H., Mann, J. R., Bettler, B., et al. (1998) · Nature · doi:10.1038/33408 · Cited by 480
Ro 25–6981, a Highly Potent and Selective Blocker of N-Methyl-d-aspartate Receptors Containing the NR2B Subunit. Characterization in Vitro
Fischer, G., Mutel, V., Trube, G., Malherbe, P., Kew, J. N. C., MOHACSI, E., Heitz, M., & Kemp, J. A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37138-1 · Cited by 480
Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells
Werner, P., Voigt, M. M., KEINÄNEN, K. P., Wisden, W., & Seeburg, P. H. (1991) · Nature · doi:10.1038/351742a0 · Cited by 477
A complex mosaic of high-affinity kainate receptors in rat brain
Wisden, W., & Seeburg, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03582.1993 · Cited by 476
cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila
Roth, S., Neuman‐Silberberg, F. S., Barcelo, G., & Schüpbach, T. (1995) · Cell · doi:10.1016/0092-8674(95)90016-0 · Cited by 475
Vesicular glutamate release from axons in white matter
Kukley, M., Capetillo‐Zarate, E., & Dietrich, D. (2007) · Nature Neuroscience · doi:10.1038/nn1850 · Cited by 472
Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product narp.
O’Brien, R. J., Xu, D., Petralia, R. S., Steward, O., Huganir, R. L., & Worley, P. (1999) · Neuron · doi:10.1016/s0896-6273(00)80782-5 · Cited by 471
THE EFFECTS OF A SERIES OF ω‐PHOSPHONIC α‐CARBOXYLIC AMINO ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID‐INDUCED RESPONSES IN ISOLATED SPINAL CORD PREPARATIONS
Evans, R. H., Francis, A. A., Jones, A. W., Smith, D. A. S., & Watkins, J. C. (1982) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1982.tb08758.x · Cited by 467
Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice
Li, Y., Erzurumlu, R. S., Chen, C., Jhaveri, S., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90108-2 · Cited by 466
Autophosphorylation-dependent Targeting of Calcium/ Calmodulin-dependent Protein Kinase II by the NR2B Subunit of theN-Methyl- d-aspartate Receptor*
Strack, S., & Colbran, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.20689 · Cited by 466
Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes.
Burnashev, N., Zhou, Z., Neher, E., & Sakmann, B. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020738 · Cited by 465
Determinants of ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: Diversity by RNA editing
Köhler, M. G., Burnashev, N., Sakmann, B. J., & Seeburg, P. H. (1993) · Neuron · doi:10.1016/0896-6273(93)90336-p · Cited by 464
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation
Davies, J., Francis, A. A., Jones, A. W., & Watkins, J. C. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90061-6 · Cited by 464
Modulation of the N-methyl-D-aspartate channel by extracellular H+.
Tang, C. M., Dichter, M., & Morad, M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6445 · Cited by 463
Regulation of Ca2+-permeable AMPA receptors: synaptic plasticity and beyond
Cull-Candy, S. G., Kelly, L., & Farrant, M. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.05.012 · Cited by 462
Importance of the Intracellular Domain of NR2 Subunits for NMDA Receptor Function In Vivo
Sprengel, R., Suchanek, B., Amico, C., Brusa, R., Burnashev, N., Rozov, A. V., Hvalby, Ø., Jensen, V., Paulsen, O., Andersen, P. N., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80921-6 · Cited by 460
Cartography of neurexins: More than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons
Ullrich, B., Ushkaryov, Y. A., & Südhof, T. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90306-2 · Cited by 460
Desensitization of AMPA receptors upon multiquantal neurotransmitter release
Trussell, L. O., Zhang, S., & Ramant, I. M. (1993) · Neuron · doi:10.1016/0896-6273(93)90066-z · Cited by 460
Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA Receptor
Burnashev, N., Schoepfer, R., Monyer, H., Ruppersberg, J. P., Gunther, W. C., Seeburg, P. H., & Sakmann, B. J. (1992) · Science · doi:10.1126/science.1382314 · Cited by 455
Ketamine: A Paradigm Shift for Depression Research and Treatment
Krystal, J. H., Abdallah, C. G., Sanacora, G., Charney, D. S., & Duman, R. S. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.005 · Cited by 455
Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype
Liu, S. J., & Cull-Candy, S. G. (2000) · Nature · doi:10.1038/35013064 · Cited by 452
SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines
Ngo‐Anh, T. J., Bloodgood, B. L., Lin, M., Sabatini, B. L., Maylie, J., & Adelman, J. P. (2005) · Nature Neuroscience · doi:10.1038/nn1449 · Cited by 451
Mobile NMDA Receptors at Hippocampal Synapses
Tovar, K. R., & Westbrook, G. L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00658-x · Cited by 448
Tonic Activation of NMDA Receptors by Ambient Glutamate Enhances Excitability of Neurons
Sah, P., Hestrin, S., & Nicoll, R. A. (1989) · Science · doi:10.1126/science.2573153 · Cited by 443
Nanoscale Scaffolding Domains within the Postsynaptic Density Concentrate Synaptic AMPA Receptors
MacGillavry, H. D., Song, Y., Raghavachari, S., & Blanpied, T. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.009 · Cited by 442
NMDA Receptor Heterogeneity During Postnatal Development of the Rat Brain: Differential Expression of the NR2A, NR2B, and NR2C Subunit Proteins
Wenzel, A., Fritschy, J., Möhler, H., & Benke, D. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68020469.x · Cited by 442
Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function
Mannaioni, G., Marino, M. J., Valenti, O., Traynelis, S. F., & Conn, P. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-05925.2001 · Cited by 441
Self-citation
Hipposeq: a comprehensive RNA-seq database of gene expression in hippocampal principal neurons
Cembrowski, M. S., Wang, L., Sugino, K., Shields, B. C., & Spruston, N. (2016) · eLife · doi:10.7554/elife.14997 · Cited by 438
Postnatal synaptic potentiation: delivery of GluR4-containing AMPA receptors by spontaneous activity
Zhu, J. J., Esteban, J. A., Hayashi, Y., & Malinow, R. (2000) · Nature Neuroscience · doi:10.1038/80614 · Cited by 437
Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA
Laurie, D. J., & Seeburg, P. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-03180.1994 · Cited by 437
CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin
Opazo, P., Labrecque, S., Tigaret, C. M., Frouin, A., Wiseman, P. W., Koninck, P. D., & Choquet, D. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.007 · Cited by 434
The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine
Harvey, C. D., Yasuda, R., Zhong, H., & Svoboda, K. (2008) · Science · doi:10.1126/science.1159675 · Cited by 434
Conus Venom Peptide Pharmacology
Lewis, R. J., Dutertre, S., Vetter, I., & Christie, M. J. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005322 · Cited by 434
The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray
Tölle, T. R., Berthele, A., Zieglgänsberger, W., Seeburg, P. H., & Wisden, W. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05009.1993 · Cited by 433
High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes
Schwenk, J., Harmel, N., Brechet, A., Zolles, G., Berkefeld, H., Müller, C. S., Bildl, W., Baehrens, D., Hüber, B., Kulik, A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.034 · Cited by 433
Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases
Sin, W. C., Haas, K. Z., Ruthazer, E. S., & Cline, H. T. (2002) · Nature · doi:10.1038/nature00987 · Cited by 433
GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction
Lesca, G., Rudolf, G., Bruneau, N., Lozovaya, N., Labalme, A., Boutry‐Kryza, N., Salmi, M., Tsintsadze, T. S., Addis, L., Motte, J. E., et al. (2013) · Nature Genetics · doi:10.1038/ng.2726 · Cited by 433
Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins
Stern-Bach, Y., Bettler, B., Hartley, M., Sheppard, P. O., O’Hara, P. J., & Heinemann, S. F. (1994) · Neuron · doi:10.1016/0896-6273(94)90420-0 · Cited by 432
Glutamate and GABA receptor signalling in the developing brain
Luján, R., Shigemoto, R., & López‐Bendito, G. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.042 · Cited by 429
Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo
Smith, S. L., Smith, I. T., Branco, T., & Häusser, M. (2013) · Nature · doi:10.1038/nature12600 · Cited by 429
The synaptic activation of kainate receptors
Vignes, M., & Collingridge, G. L. (1997) · Nature · doi:10.1038/40639 · Cited by 428
Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes
Lemke, J. R., Lal, D., Reinthaler, E. M., Steiner, I., Nothnagel, M., Alber, M., Geider, K., Laube, B., Schwake, M., Finsterwalder, K., et al. (2013) · Nature Genetics · doi:10.1038/ng.2728 · Cited by 428
Potentiation of NMDA receptor currents by arachidonic acid
Miller, B., Sarantis, M., Traynelis, S. F., & Attwell, D. (1992) · Nature · doi:10.1038/355722a0 · Cited by 425
Self-citation
GABAergic Interneurons Shape the Functional Maturation of the Cortex
Le Magueresse, C., & Monyer, H. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.011 · Cited by 425
Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking
Herring, B. E., & Nicoll, R. A. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071753 · Cited by 425
Diversity in NMDA Receptor Composition
Sanz-Clemente, A., Nicoll, R. A., & Roche, K. W. (2012) · The Neuroscientist · doi:10.1177/1073858411435129 · Cited by 424
Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics
Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-053013-062946 · Cited by 422
N‐methyl‐ D ‐aspartate receptor antibodies in herpes simplex encephalitis
Prüss, H., Finke, C., Höltje, M., Hofmann, J., Klingbeil, C., Probst, C., Borowski, K., Ahnert‐Hilger, G., Harms, L., Schwab, J. M., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23689 · Cited by 422
Glutamate receptor channels in rat DRG neurons: Activation by kainate and quisqualate and blockade of desensitization by con A
Huettner, J. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90163-a · Cited by 421
N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1
Hollmann, M., Maron, C., & Heinemann, S. (1994) · Neuron · doi:10.1016/0896-6273(94)90419-7 · Cited by 421
Subunit‐specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles
Erreger, K., Dravid, S. M., Banke, T. G., Wyllie, D. J. A., & Traynelis, S. F. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080028 · Cited by 421
Self-citation
Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain
Sucher, N. J., Akbarian, S., Chi, C.-L., Leclerc, C., Awobuluyi, M., Deitcher, D. L., Wu, M., Yuan, J., Jones, E. G., & Lipton, S. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06509.1995 · Cited by 420
De Novo Mutations in Moderate or Severe Intellectual Disability
Hamdan, F. F., Srour, M., Capo-Chichi, J.-M., Daoud, H., Nassif, C., Patry, L., Massicotte, C., Ambalavanan, A., Spiegelman, D., Diallo, O., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004772 · Cited by 419
An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing
Scott, D. B., Blanpied, T. A., Swanson, G. T., Zhang, C., & Ehlers, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03063.2001 · Cited by 418
Modulation of N -methyl- d -aspartate receptor function by glycine transport
Bergeron, R., Meyer, T. M., Coyle, J. T., & Greene, R. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15730 · Cited by 418
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission
Clarke, V. R. J., Ballyk, B. A., Hoo, K. H., Mandelzys, A., Pellizzari, A., Bath, C. P., Thomas, J., Sharpe, E. F., Davies, C. H., Ornstein, P. L., et al. (1997) · Nature · doi:10.1038/39315 · Cited by 416
Extrasynaptic Glutamate Spillover in the Hippocampus: Dependence on Temperature and the Role of Active Glutamate Uptake
Asztély, F., Erdemli, G., & Kullmann, D. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80268-8 · Cited by 416
Control of Proton Sensitivity of the NMDA Receptor by RNA Splicing and Polyamines
Traynelis, S. F., Hartley, M., & Heinemann, S. F. (1995) · Science · doi:10.1126/science.7754371 · Cited by 416
Self-citation
Postsynaptic Membrane Fusion and Long-Term Potentiation
Lledo, P.-M., Zhang, X., Südhof, T. C., Malenka, R. C., & Nicoll, R. A. (1998) · Science · doi:10.1126/science.279.5349.399 · Cited by 413
Multiple-conductance channels activated by excitatory amino acids in cerebellar neurons
Cull-Candy, S. G., & Usowicz, M. M. (1987) · Nature · doi:10.1038/325525a0 · Cited by 412
Human lupus autoantibodies against NMDA receptors mediate cognitive impairment
Kowal, C., DeGiorgio, L. A., Lee, J. Y., Edgar, M. A., Huerta, P. T., Volpe, B. T., & Diamond, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608397104 · Cited by 412
Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy
Hanada, T., Hashizume, Y., Tokuhara, N., Takenaka, O., Kohmura, N., Ogasawara, A., Hatakeyama, S., Ohgoh, M., Ueno, M., & Nishizawa, Y. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2011.03109.x · Cited by 411
The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits
Jackson, A. C., & Nicoll, R. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.007 · Cited by 410
Bipolar Cells Use Kainate and AMPA Receptors to Filter Visual Information into Separate Channels
DeVries, S. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)00158-6 · Cited by 407
Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse
Geiger, J. R. P., Lübke, J., Roth, A., Frotscher, M., & Jonas, P. (1997) · Neuron · doi:10.1016/s0896-6273(00)80339-6 · Cited by 407
Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond
Krystal, J. H., Sanacora, G., & Duman, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.026 · Cited by 406
Cognition and Immunity
Kowal, C., DeGiorgio, L. A., Nakaoka, T., Hetherington, H. P., Huerta, P. T., Diamond, B., & Volpe, B. T. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.011 · Cited by 405
Synaptic plasticity of NMDA receptors: mechanisms and functional implications
Hunt, D. L., & Castillo, P. E. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.01.007 · Cited by 405
The Majority of N-Methyl-d-Aspartate Receptor Complexes in Adult Rat Cerebral Cortex Contain at Least Three Different Subunits (NR1/NR2A/NR2B)
Luo, J., Wang, Y., Yasuda, R. P., Dunah, A. W., & Wolfe, B. B. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.1.79 · Cited by 399
Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine
Mayer, M. L., Vyklický, L., & Clements, J. (1989) · Nature · doi:10.1038/338425a0 · Cited by 398
Bipolar I Disorder and Schizophrenia: A 440–Single-Nucleotide Polymorphism Screen of 64 Candidate Genes among Ashkenazi Jewish Case-Parent Trios
Fallin, M. D., Lasseter, V. K., Avramopoulos, D., Nicodemus, K. K., Wolyniec, P. S., McGrath, J. A., Steel, G., Nestadt, G., Liang, K., Huganir, R. L., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/497703 · Cited by 398
The BCM theory of synapse modification at 30: interaction of theory with experiment
Cooper, L. N., & Bear, M. F. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3353 · Cited by 395
Kainate receptor gene expression in the developing rat brain
Bahn, S., Volk, B., & Wisden, W. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05525.1994 · Cited by 394
Regulation of glutamate release by presynaptic kainate receptors in the hippocampus
Chittajallu, R., Vignes, M., Dev, K. K., Barnes, J. M., Collingridge, G. L., & Henley, J. M. (1996) · Nature · doi:10.1038/379078a0 · Cited by 394
NMDA Receptor Losses in Putamen from Patients with Huntington's Disease
Young, A. B., Greenamyre, J. T., Hollingsworth, Z. R., Albin, R. L., D’Amato, C. J., Shoulson, I., & Penney, J. B. (1988) · Science · doi:10.1126/science.2841762 · Cited by 394
Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins
Greger, I. H., Watson, J. F., & Cull-Candy, S. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.009 · Cited by 392
Self-citation
Roles and rules of kainate receptors in synaptic transmission
Lerma, J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1118 · Cited by 391
Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390
Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors
Schwenk, J., Harmel, N., Zolles, G., Bildl, W., Kulik, Á., Heimrich, B., Chisaka, O., Jónás, P., Schulte, U., Fakler, B., et al. (2009) · Science · doi:10.1126/science.1167852 · Cited by 388
Effects of D-cycloserine on extinction of conditioned freezing.
Ledgerwood, L., Richardson, R., & Cranney, J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.341 · Cited by 388
KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent Manner
Bortone, D., & Polleux, F. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.034 · Cited by 387
Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept
Rodriguez, C. I., Kegeles, L. S., Levinson, A., Feng, T., Marcus, S. M., Vermes, D., Flood, P., & Simpson, H. B. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.150 · Cited by 386
A Role of Actin Filament in Synaptic Transmission and Long-Term Potentiation
Kim, C.-H., & Lisman, J. E. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04314.1999 · Cited by 386
Calcium/calmodulin-dependent protein kinase II is associated with the N -methyl- d -aspartate receptor
Leonard, A. S., Lim, I. A., Hemsworth, D. E., Horne, M. C., & Hell, J. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3239 · Cited by 385
GRIN2A mutations cause epilepsy-aphasia spectrum disorders
Carvill, G. L., Regan, B. M., Yendle, S. C., O’Roak, B. J., Lozovaya, N., Bruneau, N., Burnashev, N., Khan, A., Cook, J., Geraghty, E., et al. (2013) · Nature Genetics · doi:10.1038/ng.2727 · Cited by 385
Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium
Legendre, P., Rosenmund, C., & Westbrook, G. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00674.1993 · Cited by 384
D-Cycloserine Augmented Exposure Therapy for Obsessive-Compulsive Disorder
Kushner, M. G., Kim, S. W., Donahue, C. B., THURAS, P. D., Adson, D. E., Kotlyar, M., McCabe, J., Peterson, J., & Foa, E. B. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.020 · Cited by 384
Stabilization of Dendritic Arbor Structure in Vivo by CaMKII
Wu, G., & Cline, H. T. (1998) · Science · doi:10.1126/science.279.5348.222 · Cited by 377
Cloning of a putative glutamate receptor: A low affinity kainate-binding subunit
Bettler, B., Egebjerg, J., Sharma, G., Pecht, G., Hermans‐Borgmeyer, I., Moll, C., Stevens, C. F., & Heinemann, S. F. (1992) · Neuron · doi:10.1016/0896-6273(92)90292-l · Cited by 377
Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions
Suzuki, H., Nishizawa, T., Tani, K., Yamazaki, Y., Tamura, A., Ishitani, R., Dohmae, N., Tsukita, S., Nureki, O., & Fujiyoshi, Y. (2014) · Science · doi:10.1126/science.1248571 · Cited by 377
Multivesicular Release at Climbing Fiber-Purkinje Cell Synapses
Wadiche, J. I., & Jahr, C. E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00488-3 · Cited by 374
Organization of N‐methyl‐D‐aspartate glutamate receptor gene expression in the basal ganglia of the rat
Standaert, D. G., Testa, C. M., Young, A. B., & Penney, J. B. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903430102 · Cited by 373
Acute mechanisms underlying antibody effects in anti–N‐methyl‐D‐aspartate receptor encephalitis
Moscato, E. H., Peng, X., Jain, A., Parsons, T. D., Dalmau, J. O., & Balice‐Gordon, R. J. (2014) · Annals of Neurology · doi:10.1002/ana.24195 · Cited by 371
Intracellular spermine confers rectification on rat calcium‐permeable AMPA and kainate receptors.
Kamboj, S. K., Swanson, G. T., & Cull-Candy, S. G. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020812 · Cited by 370
Self-citation
Presynaptic glutamate receptors: physiological functions and mechanisms of action
Pinheiro, P. S., & Mulle, C. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2379 · Cited by 368
Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses in situ
Silver, R. A., Traynelis, S. F., & Cull-Candy, S. G. (1992) · Nature · doi:10.1038/355163a0 · Cited by 368
Self-citation
Glutamate induces de novo growth of functional spines in developing cortex
Kwon, H.-B., & Sabatini, B. L. (2011) · Nature · doi:10.1038/nature09986 · Cited by 368
Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons
Paternain, A. V., Morales, M., & Lerma, J. (1995) · Neuron · doi:10.1016/0896-6273(95)90253-8 · Cited by 367
Structural basis for partial agonist action at ionotropic glutamate receptors
Jin, R., Banke, T. G., Mayer, M. L., Traynelis, S. F., & Gouaux, E. (2003) · Nature Neuroscience · doi:10.1038/nn1091 · Cited by 367
Self-citation
Glutamate-receptor genes in plants
Lam, H., Chiu, J. C., Hsieh, M., Meisel, L. A., Oliveira, I. C., Shin, M. J., & Coruzzi, G. M. (1998) · Nature · doi:10.1038/24066 · Cited by 366
Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures
Giffard, R. G., Monyer, H., Christine, C. W., & Choi, D. W. (1990) · Brain Research · doi:10.1016/0006-8993(90)91276-m · Cited by 366
A GIT1/PIX/Rac/PAK Signaling Module Regulates Spine Morphogenesis and Synapse Formation through MLC
Zhang, H., Webb, D. J., Asmussen, H., Niu, S., & Horwitz, A. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3553-04.2005 · Cited by 365
Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate
Patneau, D. K., Vyklický, L., & Mayer, M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03496.1993 · Cited by 361
Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors
Karakaş, E., Simorowski, N., & Furukawa, H. (2011) · Nature · doi:10.1038/nature10180 · Cited by 360
Self-citation
GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses
Donevan, S. D., & Rogawski, M. A. (1993) · Neuron · doi:10.1016/0896-6273(93)90241-i · Cited by 359
NMDA receptor function: subunit composition versus spatial distribution
Köhr, G. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0273-6 · Cited by 357
Mechanism and Regulation of Calcium/Calmodulin-dependent Protein Kinase II Targeting to the NR2B Subunit of the N-Methyl-d-aspartate Receptor
Strack, S., McNeill, R. B., & Colbran, R. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001471200 · Cited by 356
Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma
Tüzün, E., Zhou, L., Baehring, J. M., Bannykh, S., Rosenfeld, M. R., & Dalmau, J. O. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0582-4 · Cited by 355
Subunit composition at the single-cell level explains functional properties of a glutamate-gated channel
Bochet, P., Audinat, É., Lambolez, B., Crépel, F., Rossier, J., Iino, M., Tsuzuki, K., & Ozawa, S. (1994) · Neuron · doi:10.1016/0896-6273(94)90279-8 · Cited by 353
Transcellular Nanoalignment of Synaptic Function
Biederer, T., Kaeser, P. S., & Blanpied, T. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.006 · Cited by 352
RNA Editing at Arg607 Controls AMPA Receptor Exit from the Endoplasmic Reticulum
Greger, I. H., Khatri, L., & Ziff, E. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00693-1 · Cited by 350
Self-citation
Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability
Hamdan, F. F., Gauthier, J., Araki, Y., Lin, D.-T., Yoshizawa, Y., Higashi, K., Park, A.-R., Spiegelman, D., Dobrzeniecka, S., Piton, A., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.02.001 · Cited by 349
The rat delta‐1 and delta‐2 subunits extend the excitatory amino acid receptor family
Lomelı́, H., Sprengel, R., Laurie, D., Köhr, G., Herb, A., Seeburg, P. H., & Wisden, W. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81186-4 · Cited by 348
Translational control in synaptic plasticity and cognitive dysfunction
Buffington, S. A., Huang, W., & Costa-Mattioli, M. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014100 · Cited by 348
Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation
Lin, D.-T., Makino, Y., Sharma, K., Hayashi, T., Neve, R., Takamiya, K., & Huganir, R. L. (2009) · Nature Neuroscience · doi:10.1038/nn.2351 · Cited by 347
Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C.
Durand, G. M., Bennett, M. V. L., & Zukin, R. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6731 · Cited by 347
Kainate Receptor Modulation of GABA Release Involves a Metabotropic Function
Moreno, A. R., & Lerma, J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80501-2 · Cited by 345
Mechanism of differential control of NMDA receptor activity by NR2 subunits
Gielen, M. C., Retchless, B. S., Mony, L., Johnson, J. W., & Paoletti, P. (2009) · Nature · doi:10.1038/nature07993 · Cited by 344
Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs
Tomita, S., Stein, V., Stocker, T. J., Nicoll, R. A., & Bredt, D. S. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.009 · Cited by 343
Long-lasting facilitation of a synaptic potential following tetanization in thein vitro hippocampal slice
Schwartzkroin, P. A., & Wester, K. G. (1975) · Brain Research · doi:10.1016/0006-8993(75)90138-9 · Cited by 343
A glutamate receptor channel with high affinity for domoate and kainate.
Sommer, B., Burnashev, N., Verdoorn, T. A., KEINÄNEN, K. P., Sakmann, B. J., & Seeburg, P. H. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05211.x · Cited by 342
Differential effects of enrichment on learning and memory function in NR2B transgenic mice
Tang, Y., Wang, H., Feng, R., Kyin, M., & Tsien, J. Z. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00122-8 · Cited by 342
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood–brain barrier integrity
Hammer, C., Stepniak, B., Schneider, A., Papiol, S., Tantra, M., Begemann, M., Sirén, A.-L., Pardo, L. A., Sperling, S., Mohd Jofrry, S., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.110 · Cited by 342
Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis
Mikasova, L., De Rossi, P., Bouchet, D., Georges, F., Rogemond, V., Didelot, A., Meissirel, C., Honnorat, J., & Groc, L. (2012) · Brain · doi:10.1093/brain/aws092 · Cited by 341
AMPA Receptor Flip/Flop Mutants Affecting Deactivation, Desensitization, and Modulation by Cyclothiazide, Aniracetam, and Thiocyanate
Partin, K. M., Fleck, M. W., & Mayer, M. L. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06634.1996 · Cited by 341
Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior
Basu, A. C., Tsai, G. E., Ma, C.-L., Ehmsen, J. T., Mustafa, A. K., Han, L., Jiang, Z. I., Benneyworth, M. A., Froimowitz, M., LANGE, N. D., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.130 · Cited by 340
Functional characterization of a potassium-selective prokaryotic glutamate receptor
Chen, G., Cui, C., Mayer, M. L., & Gouaux, E. (1999) · Nature · doi:10.1038/45568 · Cited by 333
NMDA spikes enhance action potential generation during sensory input
Palmer, L. M., Shai, A. S., Reeve, J. E., Anderson, H. L., Paulsen, O., & Larkum, M. E. (2014) · Nature Neuroscience · doi:10.1038/nn.3646 · Cited by 333
Esketamine for Treatment-Resistant Depression — First FDA-Approved Antidepressant in a New Class
Kim, J., Farchione, T., Potter, A., Chen, Q., & Temple, R. (2019) · New England Journal of Medicine · doi:10.1056/nejmp1903305 · Cited by 333
Glutamate and Parkinson’s disease
Blandini, F., Porter, R. H. P., & Greenamyre, J. T. (1996) · Molecular Neurobiology · doi:10.1007/bf02740748 · Cited by 332
Cbln1 Is a Ligand for an Orphan Glutamate Receptor δ2, a Bidirectional Synapse Organizer
Matsuda, K., Miura, E., Miyazaki, T., Kakegawa, W., Emi, K., Narumi, S., Fukazawa, Y., Ito-Ishida, A., Kondo, T., Shigemoto, R., et al. (2010) · Science · doi:10.1126/science.1185152 · Cited by 332
Kainate receptors are involved in synaptic plasticity
Bortolotto, Z. A., Clarke, V. R. J., Delany, C. M., Parry, M., Smolders, I. J., Vignes, M., Ho, K. H., Miu, P., Brinton, B. T., Fantaske, R. P., et al. (1999) · Nature · doi:10.1038/46290 · Cited by 332
Extracellular Glutamate Concentration in Hippocampal Slice
Herman, M. A., & Jahr, C. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3009-07.2007 · Cited by 331

Flagged first, then by citations

Sorted by citations

Mechanisms of ketamine and its metabolites as antidepressants
Hess, E. M., Riggs, L. M., Michaelides, M., & Gould, T. D. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114892 · Cited by 175
A gain‐of‐function GRIA2 variant associated with neurodevelopmental delay and seizures: Functional characterization and targeted treatment
Coombs, I. D., Ziobro, J., Krotov, V., Surtees, T., Cull‐Candy, S. G., & Farrant, M. (2022) · Epilepsia · doi:10.1111/epi.17419 · Cited by 32
Cryo-EM structure of the human Asc-1 transporter complex
Li, Y., Guo, Y., Bröer, A., Dai, L., Brӧer, S., & Yan, R. (2024) · Nature Communications · doi:10.1038/s41467-024-47468-1 · Cited by 12
Glutamate receptor 4 as a fluid biomarker for the diagnosis of psychiatric disorders
Gómez de San José, N., Goossens, J., Al Shweiki, M. R., Halbgebauer, S., Oeckl, P., Steinacker, P., Danzer, K. M., Graf, H., Schönfeldt-Lecuona, C., Belbin, O., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.010 · Cited by 9

See all 686

Authors: Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., McBain, C. J., Jayaraman, V., Low, C.-M., Dell’Acqua, M. L., Diamond, J. S., Camp, C. R., Perszyk, R. E., Yuan, H., & Traynelis, S. F.
Affiliations: Northwestern University (US)
Corresponding author: Traynelis, Stephen F.
ORCID: Hansen, Kasper B.
Wollmuth, Lonnie P.
Bowie, Derek
Furukawa, Hiro
Menniti, Frank S.
Sobolevsky, Alexander I.
Swanson, Geoffrey T.
Swanger, Sharon A.
Greger, Ingo H.
Nakagawa, Terunaga
McBain, Chris J.
Jayaraman, Vasanthi
Low, Chian-Ming
Dell’Acqua, Mark L.
Diamond, Jeffrey S.
Camp, Chad R.
Perszyk, Riley E.
Yuan, Hongjie
Traynelis, Stephen F.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2021-10
Volume: 73
Issue: 4
Pages: 1469-1658
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pharmrev.120.000131
PMC: PMC8626789
OpenAlex: W3214054678
Cited by: 686
References: 2,576
Citations by year: 2026: 123 · 2025: 198 · 2024: 160 · 2023: 115 · 2022: 81 · 2021: 9
FWCI: 13.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders: National Institutes of Health (5f31ns113530-02)
Biotechnology and Biological Sciences Research Council (BB/N002113/1)
National Institute of Mental Health (R56MH123474, R21MH127404, R01MH085926, R01MH123474)
National Cancer Institute (R01CA206573)
National Institute of General Medical Sciences (P20GM103546, R35GM122528)
National Institute of Neurological Disorders and Stroke (F31‐NS113530, R01NS105804, R56NS040701, R01NS083660, R01NS040701, R01NS088479, R01NS111745, RF1NS113632, R01NS105502, R01NS107253, R35NS111619, R37NS083660, R01NS116055, R01NS097536)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD082373)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: ionotropic glutamate receptors, ligand-gated ion channels, glutamate, receptor subtypes, receptor structure, receptor pharmacology, excitatory neurotransmission, neurophysiology, neurological disorders, mental illness, therapeutic target
MeSH terms: Animals, Central Nervous System, Humans, Receptors, Glutamate, Neurotransmitter Agents, Glutamic Acid, Receptors, Ionotropic Glutamate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks