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An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Abstract
Familial advanced sleep phase syndrome (FASPS) is an autosomal dominant circadian rhythm variant; affected individuals are "morning larks" with a 4-hour advance of the sleep, temperature, and melatonin rhythms. Here we report localization of the FASPS gene near the telomere of chromosome 2q. A strong candidate gene (hPer2), a human homolog of the period gene in Drosophila, maps to the same locus. Affected individuals have a serine to glycine mutation within the casein kinase Iepsilon (CKIepsilon) binding region of hPER2, which causes hypophosphorylation by CKIepsilon in vitro. Thus, a variant in human sleep behavior can be attributed to a missense mutation in a clock component, hPER2, which alters the circadian period.
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“Herein, specific mutations in circadian clock regulators that affect human circadian behavior and the period of the underlying clock have been identified (38, 39).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [38]
In the citing paper
“Examples of circadian clock gene mutations which impact circadian function include familial advanced sleep phase syndrome in humans and the many clock gene mutations in experimental animals”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Toh et al., 2001
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A comprehensive genetic map of the human genome based on 5,264 microsatellites
Dib, C., Fauré, S., Fizames, C., Samson, D. S., Drouot, N., Alain Vignal, A., Millasseau, P., Marc, S., Kazan, J., Seboun, E., et al. (1996) · Nature · doi:10.1038/380152a0 · Cited by 2,927
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
Clock Mutants of Drosophila melanogaster
Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287
Interacting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367
A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light
Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80495-x · Cited by 879
Zylka, M. J., Shearman, L. P., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80492-4 · Cited by 865
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860
double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation
Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81224-6 · Cited by 839
The mPer2 gene encodes a functional component of the mammalian circadian clock
Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., & Bradley, A. (1999) · Nature · doi:10.1038/22118 · Cited by 718
The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε
Kloss, B., Price, J. L., Sáez, L., Blau, J., Rothenfluh, A., Wesley, C. S., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81225-8 · Cited by 682
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- Individuals who did not meet either the conservative affected or unaffected criteria were classified as unknown. Venous blood samples were gathered from individuals from ASPS families who were likely to contribute to linkage information. Participants signed a “Consent of Participation” form which was approved by the Institutional Review Board for Human Research at the University of Utah School of Medicine. High–molecular weight genomic DNA was isolated from whole-blood lysates and lymphoblastoid cell lines were transformed with Epstein-Barr virus as described (36).
- Klerman E. B., et al., Am. J. Physiol. 270, R271 (1996).
- Web text is available at Science Online at www.sciencemag.org/cgi/content/full/1057499/DC1.
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Zhu, L., & Zee, P. C. (2012) · Neurologic Clinics · doi:10.1016/j.ncl.2012.08.011 · Cited by 182
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Albrecht, U. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00759.2001 · Cited by 159
Pack, A. I. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2401008 · Cited by 163
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Chiu, J. C., Vanselow, J. T., Kramer, A., & Edery, I. (2008) · Genes & Development · doi:10.1101/gad.1682708 · Cited by 157
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Mansour, H. A., Talkowski, M. E., Wood, J., Chowdari, K. V., McClain, L., Prasad, K., Montrose, D., Fagiolini, A., Friedman, E. S., Allen, M. H., et al. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00756.x · Cited by 161
Leloup, J., & Goldbeter, A. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.04.040 · Cited by 164
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The circadian clock: a framework linking metabolism, epigenetics and neuronal function
Masri, S., & Sassone‐Corsi, P. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3393 · Cited by 161
Archer, S. N., Viola, A., Kyriakopoulou, V., von Schantz, M., & Dijk, D. (2008) · SLEEP · doi:10.1093/sleep/31.5.608 · Cited by 156
Yu, W., Nomura, M., & Ikeda, M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6300 · Cited by 152
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Liu, S., Lamaze, A., Liu, Q., Tabuchi, M., Yang, Y. R., Fowler, M. A., Bharadwaj, R., Zhang, J., Bedont, J. L., Blackshaw, S., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.040 · Cited by 146
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Huang, J. H., Zhong, Z., Wang, M., Chen, X., Tan, Y., Zhang, S., He, W., He, X., Huang, G., Lu, H., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2551-14.2015 · Cited by 161
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Ohdo, S. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.01.006 · Cited by 146
Cyran, S. A., Yiannoulos, G., Buchsbaum, A. M., Sáez, L., Young, M. W., & Blau, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0263-05.2005 · Cited by 148
The times they’re a-changing: Effects of circadian desynchronization on physiology and disease
Golombek, D. A., Casiraghi, L. P., Agostino, P. V., Paladino, N., Duhart, J. M., Plano, S. A., & Chiesa, J. J. (2013) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2013.03.007 · Cited by 150
Regulation of the Mammalian Circadian Clock by Cryptochrome
Sancar, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400016200 · Cited by 148
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Dong, D., Yang, D., Lin, L., Wang, S., & Wu, B. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114045 · Cited by 148
Steinlechner, S., Jacobmeier, B., Scherbarth, F., Dernbach, H., Kruse, F., & Albrecht, U. (2002) · Journal of Biological Rhythms · doi:10.1177/074873040201700303 · Cited by 148
Barclay, N. L., & Gregory, A. M. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.01.008 · Cited by 143
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Yang, Y., Cheng, P., & Liu, Y. (2002) · Genes & Development · doi:10.1101/gad.965102 · Cited by 144
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Maury, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071597 · Cited by 148
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Pandi-Perumal, S. R., Trakht, I., Spence, D. W., Srinivasan, V., Dagan, Y., & Cardinali, D. P. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0847 · Cited by 140
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Kurabayashi, N., Hirota, T., Sakai, M., Sanada, K., & Fukada, Y. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01047-09 · Cited by 136
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Archer, S. N., Carpen, J. D., Gibson, M., Lim, G. H., Johnston, J. D., Skene, D. J., & von Schantz, M. (2010) · SLEEP · doi:10.1093/sleep/33.5.695 · Cited by 134
Hida, A., Kitamura, S., Katayose, Y., Kato, M., Ono, H., Kadotani, H., Uchiyama, M., Ebisawa, T., Inoue, Y., Kamei, Y., et al. (2014) · Scientific Reports · doi:10.1038/srep06309 · Cited by 131
Takano, A., Uchiyama, M., Kajimura, N., Mishima, K., Inoue, Y., Kamei, Y., Kitajima, T., Shibui, K., Katoh, M., Watanabe, T., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300503 · Cited by 129
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Ribas‐Latre, A., & Eckel‐Mahan, K. L. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2015.12.006 · Cited by 139
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Serón‐Ferré, M., Valenzuela, G. J., & Torres‐Farfan, C. (2007) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20101 · Cited by 135
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Merikangas, K. R., Chakravarti, A., Moldin, S. O., Araj, H., Blangero, J., Burmeister, M., Crabbe, J. C., Depaulo, J. R., Foulks, E., Freimer, N. B., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01471-3 · Cited by 128
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Huang, G., Chen, S., Li, S., Cha, J., Long, C., Li, L. Y., He, Q., & Liu, Y. (2007) · Genes & Development · doi:10.1101/gad.1610207 · Cited by 126
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Genetic Differences in Human Circadian Clock Genes among Worldwide Populations
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Clayton, J. D., Kyriacou, C. P., & Reppert, S. M. (2001) · Nature · doi:10.1038/35057006 · Cited by 127
Fustin, J., Kojima, R., Itoh, K., Chang, H., Ye, S., Zhuang, B., Oji, A., Gibo, S., Narasimamurthy, R., Virshup, D. M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721371115 · Cited by 124
Cheong, J. K., Hung, N. T., Wang, H., Tan, P. B. O., Voorhoeve, P. M., Lee, S. H., & Virshup, D. M. (2011) · Oncogene · doi:10.1038/onc.2010.627 · Cited by 123
Yang, Y., Cheng, P., Zhi, G., & Liu, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106905200 · Cited by 120
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Sleep and circadian rhythm disturbances: multiple genes and multiple phenotypes
Wulff, K., Porcheret, K., Cussans, E., & Foster, F. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.03.007 · Cited by 121
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Okawa, M., & Uchiyama, M. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.08.001 · Cited by 116
McCarthy, M. J., Wei, H., Nievergelt, C. M., Stautland, A., Maihofer, A. X., Welsh, D. K., Shilling, P. D., Alda, M., Alliey‐Rodriguez, N., Anand, A., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0273-8 · Cited by 112
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Kopp, C., Albrecht, U., Zheng, B., & Tobler, I. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02156.x · Cited by 114
Kim, E. Y., Ko, H. W., Yu, W., Hardin, P. E., & Edery, I. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02339-06 · Cited by 114
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Newcombe, E. A., Delaforge, E., Hartmann‐Petersen, R., Skriver, K., & Kragelund, B. B. (2022) · Essays in Biochemistry · doi:10.1042/ebc20220060 · Cited by 111
Signaling in the mammalian circadian clock: the NO/cGMP pathway
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Genetic contributions to behavioural diversity at the gene-environment interface
Bendesky, A., & Bargmann, C. I. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3065 · Cited by 103
Utge, S., Soronen, P., Loukola, A., Kronholm, E., Ollila, H. M., Pirkola, S. P., Porkka‐Heiskanen, T., Partonen, T., & Paunio, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009259 · Cited by 110
The genetics of sleep disorders
Taheri, S., & Mignot, E. J.-M. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00103-5 · Cited by 111
Mortality risk factors in sleep apnoea: a matched case–control study
Lavie, P., Herer, P., & Lavie, L. (2007) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2007.00578.x · Cited by 111
The days and nights of cancer cells.
Canaple, L., Kakizawa, T., & Laudet, V. (2003) · PubMed · Cited by 108
Circadian Rhythm Sleep-Wake Disorders
Abbott, S. M., Reid, K. J., & Zee, P. C. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.012 · Cited by 111
Systems biology of cellular rhythms
Goldbeter, A., Gérard, C., Gonze, D., Leloup, J., & Dupont, G. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.07.041 · Cited by 114
Circadian Rhythms in the CNS and Peripheral Clock Disorders: Human Sleep Disorders and Clock Genes
Ebisawa, T. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fmj06003x5 · Cited by 109
Molecular aspects of circadian pharmacology and relevance for cancer chronotherapy
Ozturk, N., Ozturk, D., Kavakli, I. H., & Okyar, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102168 · Cited by 106
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Metadata
- Authors
- Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H.
- Affiliations
- Department of Human Genetics,
- Department of Neurology,
- Department of Neurobiology and Anatomy,
- Huntsman Cancer Institute (US)
- Corresponding author
- Toh, Kong L.
- Jones, Christopher R.
- Venue
- Science
- Published
- 2001-02-09
- Volume
- 291
- Issue
- 5506
- Pages
- 1040-1043
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990192893
- Cited by
- 1,460
- References
- 24
- Citations by year
- 2026: 20 · 2025: 44 · 2024: 46 · 2023: 34 · 2022: 52 · 2021: 46 · 2020: 55 · 2019: 57 · 2018: 51 · 2017: 57 · 2016: 50 · 2015: 58 · 2014: 63 · 2013: 72 · 2012: 63
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL/HD 59596)
- National Center for Research Resources (M01RR000064)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- casein kinase I epsilon, circadian rhythm, clock genes, chromosome 2q, sleep timing, melatonin rhythm
- MeSH terms
- Amino Acid Sequence, Animals, Binding Sites, Biological Clocks, Chromosome Mapping, Chromosomes, Human, Pair 2, Circadian Rhythm, Exons, Female, Glycine, Humans, Genetic Linkage, Male, Molecular Sequence Data, Nuclear Proteins, Pedigree, Phosphorylation, Protein Kinases, Proteins, Serine, Transcription Factors, Polymorphism, Single-Stranded Conformational, Amino Acid Substitution, Mutation, Missense, Sleep Disorders, Circadian Rhythm, Casein Kinases, Period Circadian Proteins
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