Cited by 1,952T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

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Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

Masopust, David, Vezys, Vaiva, Marzo, Amanda L., Lefrançois, Leo·2001·Science

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Abstract

Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.

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The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes
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The transcription factor ELF4 controls proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2
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Background
Tumor-Specific CD4+ T Cells Render the Tumor Environment Permissive for Infiltration by Low-Avidity CD8+ T Cells
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Cell and fluid sampling microneedle patches for monitoring skin-resident immunity
Mandal, A., Boopathy, A. V., Lam, L. K. W., Moynihan, K. D., Welch, M., Bennett, N. R., Turvey, M. E., Thai, N., Van, J. H., Love, J. C., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aar2227 · Cited by 161
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Local Inflammatory Cues Regulate Differentiation and Persistence of CD8+ Tissue-Resident Memory T Cells
Bergsbaken, T., Bevan, M. J., & Fink, P. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.031 · Cited by 163
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“, lung, gut, and liver), as well as the blood and spleen (18,19).”
BackgroundMethod
Non-Hematopoietic Cells in Lymph Nodes Drive Memory CD8 T Cell Inflation during Murine Cytomegalovirus Infection
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Human Papillomavirus 16-Associated Cervical Intraepithelial Neoplasia in Humans Excludes CD8 T Cells from Dysplastic Epithelium
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Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation
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Background
Tissue-Resident Memory T Cells and Fixed Immune Surveillance in Nonlymphoid Organs
Carbone, F. R. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500515 · Cited by 131
“Because TEM cells were expected to recirculate through the periphery, and the tissue cells showed enhanced effector function (16), memory cells in the nonlymphoid”
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Rapid host immune response and viral dynamics in herpes simplex virus-2 infection
Schiffer, J. T., & Corey, L. (2013) · Nature Medicine · doi:10.1038/nm.3103 · Cited by 118
Dissecting the human immunologic memory for pathogens
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“Studies in the mouse system confirmed the differential distribution of TCM and TEM in lymphoid versus peripheral tissues in the steady state (42, 43).”
Background
IL-17 Is a Critical Component of Vaccine-Induced Protection against Lung Infection by Lipopolysaccharide-Heterologous Strains of Pseudomonas aeruginosa
Priebe, G. P., Walsh, R. L., Cederroth, T., Kamei, A., Coutinho-Sledge, Y. S., Goldberg, J. B., & Pier, G. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4965 · Cited by 123
“Lung leukocytes were isolated after perfusion of the lungs in situ with PBS containing heparin (10 U/ml) followed by incubation with EDTA, then digestion with collagenase and DNase, and then sedimentation over a discontinuous Percoll gradient, all as previously reported (11).”
Method
Staged development of long-lived T-cell receptor αβ TH17 resident memory T-cell population to Candida albicans after skin infection
Park, C. O., Fu, X., Jiang, X., Pan, Y., Teague, J. E., Collins, N., Tian, T., O'Malley, J. T., Emerson, R. O., Kim, J. H., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.042 · Cited by 125
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Background
Transcriptional programming of tissue-resident memory CD8+ T cells
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Background
The CTLA-4 and PD-1/PD-L1 Inhibitory Pathways Independently Regulate Host Resistance to Plasmodium-induced Acute Immune Pathology
Hafalla, J., Claser, C., Couper, K. N., Grau, G., Rénia, L., de Souza, J. D., & Riley, E. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002504 · Cited by 119
“Furthermore, T cells from C57BL/6 mice expressed significantly higher levels of effector and activation markers: CD11a, a surrogate marker for polyclonal, antigen-experienced CD8 T cells [53,54] and CD62L, a commonly used marker of effector cells [53,55] (Figure S2 in Text S1).”
Background
Diet-Induced Obesity in Mice Reduces the Maintenance of Influenza-Specific CD8+ Memory T Cells ,
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“Although the exact definitions are still controversial, memory T cells established after infection can be divided into 2 subsets: TCM, which preferentially localize to the lymphoid tissues, and TEM, which are found mainly in peripheral sites of infection (37,38).”
Background

Authors: Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L.
Affiliations: UConn Health (US)
Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
ORCID: Masopust, David
Vezys, Vaiva
Marzo, Amanda L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2001-03-23
Volume: 291
Issue: 5512
Pages: 2413-2417
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1058867
OpenAlex: W2081097093
Cited by: 1,952
References: 0
Citations by year: 2026: 23 · 2025: 42 · 2024: 39 · 2023: 36 · 2022: 52 · 2021: 55 · 2020: 67 · 2019: 71 · 2018: 76 · 2017: 65 · 2016: 52 · 2015: 53 · 2014: 69 · 2013: 80 · 2012: 60
FWCI: 42.95
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI41576, T32 AI 07080, R01AI041576, T32AI007080)
National Institute of Diabetes and Digestive and Kidney Diseases (DK45260, R01DK045260)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: effector memory T cells, non-lymphoid tissues, CD8+ T cells, T cell migration, intracellular pathogens, viral infection, bacterial infection, lytic activity
MeSH terms: Animals, Cell Movement, Cells, Cultured, Flow Cytometry, H-2 Antigens, Immunologic Memory, Intestine, Small, Listeriosis, Listeria monocytogenes, Liver, Lung, Lymphocyte Activation, Lymphoid Tissue, Mice, Inbred C57BL, Ovalbumin, Phenotype, Vesicular stomatitis Indiana virus, T-Lymphocyte Subsets, Rhabdoviridae Infections, CD8-Positive T-Lymphocytes, Mice

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Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

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