Cited by 855Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsGenetic and phenotypic traits in livestock

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Finding genes that underlie complex traits.

Glazier, Anne M., Nadeau, Joseph H., Aitman, Timothy J.·2002·Science

DOI 10.1126/science.1076641

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Abstract

Phenotypic variation among organisms is central to evolutionary adaptations underlying natural and artificial selection, and also determines individual susceptibility to common diseases. These types of complex traits pose special challenges for genetic analysis because of gene-gene and gene-environment interactions, genetic heterogeneity, low penetrance, and limited statistical power. Emerging genome resources and technologies are enabling systematic identification of genes underlying these complex traits. We propose standards for proof of gene discovery in complex traits and evaluate the nature of the genes identified to date. These proof-of-concept studies demonstrate the insights that can be expected from the accelerating pace of gene discovery in this field.

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Authors: Glazier, A. M., Nadeau, J. H., & Aitman, T. J.
Affiliations: Hammersmith Hospital (GB)
Case Western Reserve University (US)
Corresponding author: Nadeau, Joseph H.
Aitman, Timothy J.
ORCID: Nadeau, Joseph H.
Aitman, Timothy J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2002-12-20
Volume: 298
Issue: 5602
Pages: 2345-2349
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1076641
OpenAlex: W1838763289
Cited by: 855
References: 57
Citations by year: 2026: 6 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 17 · 2021: 14 · 2020: 12 · 2019: 12 · 2018: 15 · 2017: 10 · 2016: 19 · 2015: 33 · 2014: 19 · 2013: 42 · 2012: 38
FWCI: 8.75
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Keywords: complex traits, gene discovery, phenotypic variability, gene-environment interaction, genetic heterogeneity, low penetrance, statistical power, genomic resources, common diseases, natural selection, selective breeding
MeSH terms: Alleles, Animals, Chromosome Mapping, Humans, Genetic Linkage, Mutation, Phenotype, Plants, Saccharomyces cerevisiae, Genetic Variation, Sequence Analysis, DNA, Quantitative Trait, Heritable, Genetic Predisposition to Disease, Multifactorial Inheritance, Quantitative Trait Loci

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