Cited by 449Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Deficit in Attachment Behavior in Mice Lacking the µ-Opioid Receptor Gene

Moles, Anna, Kieffer, Brigitte L., D'Amato, Francesca R.·2004·Science

Abstract

Endogenous opioid binding to μ receptors is hypothesized to mediate natural rewards and has been proposed to be the basis of infant attachment behavior. Here, we report that μ-opioid receptor knockout mouse pups emit fewer ultrasonic vocalizations when removed from their mothers but not when exposed to cold or male mice odors. Moreover these knockout pups do not show a preference toward their mothers' cues and do not show ultrasonic calls potentiation after brief maternal exposure. Results from this study may indicate a molecular mechanism for diseases characterized by deficits in attachment behavior, such as autism or reactive attachment disorder.

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Crossref · 10.1126/science.1095943

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Authors
Moles, A., Kieffer, B. L., & D'Amato, F. R.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
D'Amato, Francesca R.
Venue
Science
Published
2004-06-25
Volume
304
Issue
5679
Pages
1983-1986
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2014102714
Cited by
449
References
25
Citations by year
2026: 4 · 2025: 13 · 2024: 14 · 2023: 16 · 2022: 16 · 2021: 20 · 2020: 28 · 2019: 18 · 2018: 14 · 2017: 27 · 2016: 32 · 2015: 20 · 2014: 17 · 2013: 26 · 2012: 28
FWCI
34.70
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
mu-opioid receptor, knockout mice, attachment behavior, ultrasonic vocalizations, maternal separation, infant attachment, autism spectrum disorder, reactive attachment disorder, endogenous opioids, natural reward
MeSH terms
Animals, Animals, Newborn, Bedding and Linens, Behavior, Animal, Cold Temperature, Cues, Female, Genotype, Male, Maternal Behavior, Maternal Deprivation, Mothers, Mutation, Object Attachment, Odorants, Reward, Vocalization, Animal, Receptors, Opioid, mu, Mice, Knockout, Mice

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