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Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia
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Higher mTORC1/S6K activity in muscle of older mice, rats and humans is associated with sarcopenia.
“Higher mTORC1/S6K activity in muscle of older mice, rats and humans is associated with sarcopenia 97–101, and in brain is associated with Alzheimer’s disease 101–105.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [100]
The Results (‘Increased activation of the mTORC1 pathway with age’; page unavailable) and Discussion report that mTORC1/S6K1 signaling increased in aging rat muscle as muscle mass declined. The cited paper does not establish the same association in older mice or humans, so it supports the rat portion of the claim but not its full population scope. (LLM, conf=0.88)
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Cites
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
Gait speed and survival in older adults.
Studenski, S. (2011) · JAMA · doi:10.1001/jama.2010.1923 · Cited by 4,558 · cited 1×
“This loss of muscle is called sarcopenia, and it is associated with a decrease in the ability to move, leading to morbidity and ultimately to mortality (2); indeed, a decrease in walking speed is one of the strongest predictors of mortality in humans, and this finding is associated with sarcopenia (3, 4).”
BackgroundRapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521
Self-citationSandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012
Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752
Self-citationAgeing as a Risk Factor for Disease
Niccoli, T., & Partridge, L. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.024 · Cited by 1,831
mTOR is a key modulator of ageing and age-related disease
Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676 · cited 1×
“Among these signaling pathways, genetic or pharmacological inhibition of mammalian target of rapamycin complex 1 (mTORC1) is thus far the best-validated intervention to delay age-related pathophysiological changes (11).”
BackgroundRommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583
Self-citationAutophagy maintains stemness by preventing senescence
García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., et al. (2016) · Nature · doi:10.1038/nature16187 · Cited by 1,355
Autophagy is required to maintain muscle mass.
Masiero, E., Agatea, L., Mammucari, C., Blaauw, B., Loro, E., Komatsu, M., Metzger, D., Reggiani, C., Schiaffino, S., & Sandri, M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.008 · Cited by 1,282
Geriatric muscle stem cells switch reversible quiescence into senescence
Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A. L., et al. (2014) · Nature · doi:10.1038/nature13013 · Cited by 1,010
mTOR inhibition improves immune function in the elderly
Mannick, J. B., Del Giudice, G., Lattanzi, M., Valiante, N. M., Praestgaard, J., Huang, B., Lonetto, M. A., Maecker, H. T., Kovarik, J., Carson, S., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009892 · Cited by 786
Self-citationMilan, G., Romanello, V., Pescatore, F., Armani, A., Paik, J.-H., Frasson, L., Seydel, A., Zhao, J., Abraham, R., Goldberg, A. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7670 · Cited by 709
The role of skeletal muscle mTOR in the regulation of mechanical load‐induced growth
Goodman, C. A., Frey, J. W., Mabrey, D. M., Jacobs, B. L., Lincoln, H. C., You, J., & Hornberger, T. A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.218255 · Cited by 297
Reduced Expression of MYC Increases Longevity and Enhances Healthspan
Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.016 · Cited by 293
Ibebunjo, C., Chick, J. M., Kendall, T., Eash, J. K., Li, C., Zhang, Y., Vickers, C., Wu, Z., Clarke, B. A., Shi, J., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01036-12 · Cited by 267
Self-citationRedox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
Sarbassov, D. D., & Sabatini, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506096200 · Cited by 248
Musculoskeletal senescence: a moving target ready to be eliminated
Baar, M. P., Perdiguero, E., Muñoz-Cánoves, P., & de Keizer, P. L. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.05.007 · Cited by 83
Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength
Summermatter, S., Bouzan, A., Pierrel, E., Melly, S., Stauffer, D., Gutzwiller, S., Nolin, E., Dornelas, C., Fryer, C., Leighton-Davies, J., et al. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00305-16 · Cited by 66
Self-citationShavlakadze, T., Zhu, J., Wang, S., Zhou, W., Morin, B., Egerman, M. A., Fan, L., Wang, Y., Iartchouk, O., Meyer, A., et al. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx249 · Cited by 59
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Flagged first, then by citations
Research works printed but not linked: 39
- 10.3109/10409238.2013.857291 · DOI · Paper page
- 10.1111/j.1749-6632.2010.05809.x · DOI
- 10.1016/j.jamda.2011.04.014 · DOI · Paper page
- 10.1038/nm.4004 · DOI
- 10.1038/nature08980 · DOI · Paper page
- 10.1126/scisignal.2000559 · DOI · Paper page
- 10.1111/acel.12109 · DOI
- 10.1093/gerona/glq178 · DOI · Paper page
- 10.1111/acel.12194 · DOI
- 10.1093/gerona/glt056 · DOI
- 10.1016/j.bbrep.2018.12.009 · DOI
- 10.3389/fphys.2017.00788 · DOI · Paper page
- 10.1016/S0092-8674(02)00808-5 · DOI
- 10.1016/j.devcel.2006.10.007 · DOI
- 10.1016/j.cmet.2007.11.004 · DOI · Paper page
- 10.1016/j.cmet.2007.11.001 · DOI · Paper page
- 10.1152/ajpcell.00502.2008 · DOI
- 10.1074/jbc.M702039200 · DOI
- 10.1146/annurev-pharmtox-010510-100537 · DOI
- 10.1016/S1097-2765(04)00211-4 · DOI · Paper page
- 10.1073/pnas.251541198 · DOI · Paper page
- 10.1016/j.cmet.2007.09.009 · DOI · Paper page
- 10.1074/jbc.M411346200 · DOI
- 10.1083/jcb.200901052 · DOI
- 10.1016/j.tig.2008.10.002 · DOI · Paper page
- 10.1016/j.cell.2011.07.030 · DOI · Paper page
- 10.1016/j.cell.2010.10.007 · DOI · Paper page
- Sengupta P. 2013. The laboratory rat: relating its age with human's. Int J Prev Med 4:624–630.
- 10.1172/JCI64099 · DOI · Paper page
- 10.1016/j.cmet.2013.03.015 · DOI · Paper page
- 10.1073/pnas.1002220107 · DOI
- 10.1371/journal.pone.0034640 · DOI
- 10.1371/journal.pone.0028090 · DOI
- 10.1016/j.biocel.2016.06.012 · DOI · Paper page
- 10.1002/jcsm.12045 · DOI
- 10.1016/j.exger.2013.05.061 · DOI
- 10.1126/science.1196371 · DOI · Paper page
- 10.1016/j.cmet.2015.05.016 · DOI
- 10.1038/nrm2672 · DOI · Paper page
Cited by
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Control of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476
Targeting the biology of aging with mTOR inhibitors
Mannick, J. B., & Lamming, D. W. (2023) · Nature Aging · doi:10.1038/s43587-023-00416-y · Cited by 372
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
Palla, A. R., Ravichandran, M., Wang, Y. X., Alexandrova, L., Yang, A. V., Kraft, P., Holbrook, C. A., Schürch, C. M., Ho, A. T. V., & Blau, H. M. (2021) · Science · doi:10.1126/science.abc8059 · Cited by 232
Christian, C. J., & Benian, G. M. (2020) · Aging Cell · doi:10.1111/acel.13223 · Cited by 113
Börsch, A., Ham, D. J., Mittal, N., Tintignac, L. A., Migliavacca, E., Feige, J. N., Rüegg, M. A., & Zavolan, M. (2021) · Communications Biology · doi:10.1038/s42003-021-01723-z · Cited by 85
A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved
Moreira-Pais, A., Ferreira, R., Oliveira, P. A., & Duarte, J. A. (2022) · GeroScience · doi:10.1007/s11357-021-00510-2 · Cited by 74
Senolytic treatment rescues blunted muscle hypertrophy in old mice
Dungan, C. M., Figueiredo, V. C., Wen, Y., VonLehmden, G. L., Zdunek, C. J., Thomas, N. T., Mobley, C. B., Murach, K. A., Brightwell, C. R., Long, D. E., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00542-2 · Cited by 65
Caloric restriction: implications for sarcopenia and potential mechanisms
Xie, W.-Q., Xiao, W.-F., Tang, K., Wu, Y.-X., Hu, P.-W., Li, Y.-S., Duan, Y., & Lv, S. (2020) · Aging · doi:10.18632/aging.103987 · Cited by 46
Metadata
- Authors
- Joseph, G. A., Wang, S. X., Jacobs, C. E., Zhou, W., Kimble, G. C., Tse, H. W., Eash, J. K., Shavlakadze, T., & Glass, D. J.
- Affiliations
- Novartis Institutes for Biomedical Research
- ORCID
- Glass, David J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2019-10-01
- Volume
- 39
- Issue
- 19
- ISSN
- 1098-5549
- PMC
- PMC6751631
- Cited by
- 158
- References
- 22
- Language
- en
- Funders
- Novartis
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