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Neural Mechanisms of a Genome-Wide Supported Psychosis Variant
Abstract
A genetic polymorphism associated with schizophrenia conveys a risk for abnormal connectivity between brain regions.
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“To ensure that the connectivity matrices are not dominated by simple coactivation during the task blocks, we have regressed out the task activation using a general linear model (GLM), consistent with our prior work (23, 35, 47, 52).”
From Dynamic reconfiguration of frontal brain networks during executive cognition in humans (2015) · cites this paper as [35]
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Metadata
- Authors
- Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., Haddad, L., Mier, D., Opitz von Boberfeld, C., Raab, K., Witt, S. H., Rietschel, M., Cichon, S., & Meyer-Lindenberg, A.
- Affiliations
- Heidelberg University (DE)
- University of Bonn (DE)
- Department of Psychiatry and Psychotherapy, University of Bonn, 53105 Bonn, Germany.
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany.
- Corresponding author
- Esslinger, Christine
- Walter, Henrik
- Kirsch, Peter
- ORCID
- Venue
- Science
- Published
- 2009-05
- Volume
- 324
- Issue
- 5927
- Pages
- 605-605
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990436516
- Cited by
- 400
- References
- 6
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 10 · 2020: 12 · 2019: 12 · 2018: 16 · 2017: 19 · 2016: 19 · 2015: 34 · 2014: 46 · 2013: 42 · 2012: 51
- FWCI
- 35.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- schizophrenia, ZNF804A, rs1344706, genetic risk variants, imaging genetics, gene dosage, functional connectivity, dorsolateral prefrontal cortex, hippocampus, amygdala, linkage disequilibrium, endophenotypes, psychosis
- MeSH terms
- Adult, Affective Symptoms, Bipolar Disorder, Brain Mapping, Female, Genotype, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Mental Processes, Phenotype, Schizophrenia, Prefrontal Cortex, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Kruppel-Like Transcription Factors, Genome-Wide Association Study
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