Genetics of Human Social Behavior
Open accessAbstract
Human beings are an incredibly social species and along with eusocial insects engage in the largest cooperative living groups in the planet's history. Twin and family studies suggest that uniquely human characteristics such as empathy, altruism, sense of equity, love, trust, music, economic behavior, and even politics are partially hardwired. The leap from twin studies to identifying specific genes engaging the social brain has occurred in the past decade, aided by deep insights accumulated about social behavior in lower mammals. Remarkably, genes such as the arginine vasopressin receptor and the oxytocin receptor contribute to social behavior in a broad range of species from voles to man. Other polymorphic genes constituting the "usual suspects"--i.e., those encoding for dopamine reward pathways, serotonergic emotional regulation, or sex hormones--further enable elaborate social behaviors.
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Genetic makeup is thought to play a key role in the phenotypical manifestation of social behaviours.
“Similarly, genetic makeup is thought to play a key role in the phenotypical manifestation of social behaviours38.”
From Shank3 mutant mice display autistic-like behaviours and striatal dysfunction (2011) · cites this paper as [38]
Interactions with the oxytocin system extend beyond the opioid pathway, including the dopaminergic and muscarinic acetylcholine circuits, with possible implications for social behavior and psychiatric disorders.
“The interactions with the oxytocin system extend beyond the opioid pathway, including the dopaminergic17,18 and muscarinic acetylcholine12,19 circuits, with possible implications for social behavior and psychiatric disorders.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [18]
A smaller number of OXTR SNPs were found to be linked to measures of wider social engagement.
“a smaller number of OXTR SNPs were found to be linked to measures of wider social engagement (corroborating some previous findings) (50)”
From Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality (2017) · cites this paper as [50]
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- Authors
- Ebstein, R. P., Israel, S., Chew, S. H., Zhong, S., & Knafo, A.
- Affiliations
- National University of Singapore (SG)
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Ebstein, Richard P.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 65
- Issue
- 6
- Pages
- 831-844
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2005171996
- Cited by
- 323
- References
- 207
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 17 · 2023: 14 · 2022: 16 · 2021: 16 · 2020: 15 · 2019: 17 · 2018: 14 · 2017: 15 · 2016: 27 · 2015: 31 · 2014: 23 · 2013: 32 · 2012: 31
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- National University of Singapore (submittedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Wellcome Trust
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Keywords
- human social behavior, twin studies, family studies, empathy, altruism, trust, social brain, arginine vasopressin receptor, oxytocin receptor, dopamine reward pathway, serotonergic regulation, sex hormones, eusociality
- MeSH terms
- Altruism, Animals, Choice Behavior, Games, Experimental, Humans, Social Behavior, Social Perception, Species Specificity, Twins, Receptors, Vasopressin, Genetic Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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