Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Lieberman-Aiden, Erez, van Berkum, Nynke L., Williams, Louise, Imakaev, Maxim, Ragoczy, Tobias, Telling, Agnes, Amit, Ido, Lajoie, Bryan R. +11 more·2009·Science

Cited by (244)

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  13. Crossed wires: 3D genome misfolding in human disease
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  21. 3D hotspots of recurrent retroviral insertions reveal long-range interactions with cancer genes
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  22. Mapping genome-wide transcription factor binding sites in frozen tissues
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  25. ‘Generating chromosome geometries in a minimal cell from cryo-electron tomograms and chromosome conformation capture maps’
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  26. Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals
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    Zhao, Jingru, Faryabi, Robert B. · 2023 · Trends in Cancer
  28. The first enhancer in an enhancer chain safeguards subsequent enhancer-promoter contacts from a distance
    Song, Wei, Sharan, Roded, Ovcharenko, Ivan · 2019 · Genome Biology
  29. Glucocorticoid receptor-regulated enhancers play a central role in the gene regulatory networks underlying drug addiction
    Duttke, Sascha H., Montilla-Perez, Patricia, Chang, Max W., Li, Hairi, Chen, Hao, Carrette, Lieselot L. G., Guglielmo, Giordano de, George, Olivier, Palmer, Abraham A., Benner, Christopher et al. · 2022 · Frontiers in Neuroscience
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    McGeachie, Michael J., Yates, Katherine P., Zhou, Xiaobo, Guo, Feng, Sternberg, Alice L., Van Natta, Mark L., Wise, Robert A., Szefler, Stanley J., Sharma, Sunita, Kho, Alvin T. et al. · 2016 · American Journal of Respiratory and Critical Care Medicine
  31. Exogenous artificial DNA forms chromatin structure with active transcription in yeast
    Zhou, Jianting, Zhang, Chao, Wei, Ran, Han, Mingzhe, Wang, Songduo, Yang, Kaiguang, Zhang, Lihua, Chen, Weigang, Wen, Mingzhang, Li, Cheng et al. · 2022 · Science China Life Sciences
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  34. HiC-GNN: A Generalizable Model for 3D Chromosome Reconstruction Using Graph Convolutional Neural Networks
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  36. Single-cell damagenome profiling unveils vulnerable genes and functional pathways in human genome toward DNA damage
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  38. Genomic properties of chromosomal bands are linked to evolutionary rearrangements and new centromere formation in primates
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  39. Predicting gene expression from histone marks using chromatin deep learning models depends on histone mark function, regulatory distance and cellular states
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  40. The Chromatin Organization Close to SNP rs12913832, Involved in Eye Color Variation, Is Evolutionary Conserved in Vertebrates
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  42. Interpreting noncoding genetic variation in complex traits and human disease
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  43. Topological Approaches in Animal Comparative Genomics
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  44. Epigenetic Rewiring of Enhancer–Promoter Interactions in Cancer: Mechanisms and Therapeutic Implications
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