Cited by 78Epigenetics and DNA MethylationNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

DNA Methylation and Its Implications and Accessibility for Neuropsychiatric Therapeutics

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Day, Jeremy J., Kennedy, Andrew J., Sweatt, J. David·2015·Annual Review of Pharmacology and Toxicology

Abstract

In this review, we discuss the potential pharmacological targeting of a set of powerful epigenetic mechanisms: DNA methylation control systems in the central nervous system (CNS). Specifically, we focus on the possible use of these targets for novel future treatments for learning and memory disorders. We first describe several unique pharmacological attributes of epigenetic mechanisms, especially DNA cytosine methylation, as potential drug targets. We then present an overview of the existing literature regarding DNA methylation control pathways and enzymes in the nervous system, particularly as related to synaptic function, plasticity, learning and memory. Lastly, we speculate upon potential categories of CNS cognitive disorders that might be amenable to methylomic targeting.

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Authors
Day, J. J., Kennedy, A. J., & Sweatt, J. D.
Affiliations
University of Alabama at Birmingham (US)
Venue
Annual Review of Pharmacology and Toxicology
Published
2015-01-06
Volume
55
Issue
1
Pages
591-611
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
OpenAlex
W2163781262
Cited by
78
References
121
Citations by year
2026: 4 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 9 · 2019: 3 · 2018: 10 · 2017: 14 · 2016: 14 · 2015: 6
FWCI
1.07
Type
journal article
Language
en
Open access
Locations
  • The Annual Review of Pharmacology and Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Brain Research Foundation
  • McKnight Foundation
  • Civitan International
  • Evelyn F. McKnight Brain Research Foundation
  • Johns Hopkins University
  • University of Pittsburgh
  • National Institute of Mental Health (MH091122, MH 57014, R01MH091122, R01MH057014)
  • National Institute on Drug Abuse (K99DA034681, R00DA034681, DA034681)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
DNA methylation, epigenetics, epigenetic drug targets, central nervous system, synaptic plasticity, DNA methyltransferases, DNA demethylation, cognitive disorders
MeSH terms
Animals, Mental Disorders, Central Nervous System Agents, Cognition, Enzyme Inhibitors, Humans, Memory, Nucleic Acid Conformation, Protein Conformation, Structure-Activity Relationship, DNA Modification Methylases, DNA Methylation, Gene Silencing, Epigenesis, Genetic, Drug Discovery, Molecular Targeted Therapy

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