DNA Methylation and Its Implications and Accessibility for Neuropsychiatric Therapeutics
Open accessAbstract
In this review, we discuss the potential pharmacological targeting of a set of powerful epigenetic mechanisms: DNA methylation control systems in the central nervous system (CNS). Specifically, we focus on the possible use of these targets for novel future treatments for learning and memory disorders. We first describe several unique pharmacological attributes of epigenetic mechanisms, especially DNA cytosine methylation, as potential drug targets. We then present an overview of the existing literature regarding DNA methylation control pathways and enzymes in the nervous system, particularly as related to synaptic function, plasticity, learning and memory. Lastly, we speculate upon potential categories of CNS cognitive disorders that might be amenable to methylomic targeting.
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Animal models such as mouse fear conditioning suggest a role for 5mC in regulating learning and memory.
“Animal models, such as mouse fear conditioning, suggests a role for 5mC in regulating learning and memory (62).”
From Dynamic DNA methylation: In the right place at the right time (2018) · cites this paper as [62]
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Dynamic DNA methylation: In the right place at the right time
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Existing and future drugs for the treatment of the dark side of addiction
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- Authors
- Day, J. J., Kennedy, A. J., & Sweatt, J. D.
- Affiliations
- University of Alabama at Birmingham (US)
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2015-01-06
- Volume
- 55
- Issue
- 1
- Pages
- 591-611
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- PMC
- PMC4768530
- OpenAlex
- W2163781262
- Cited by
- 78
- References
- 121
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 9 · 2019: 3 · 2018: 10 · 2017: 14 · 2016: 14 · 2015: 6
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Annual Review of Pharmacology and Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Brain Research Foundation
- McKnight Foundation
- Civitan International
- Evelyn F. McKnight Brain Research Foundation
- Johns Hopkins University
- University of Pittsburgh
- National Institute of Mental Health (MH091122, MH 57014, R01MH091122, R01MH057014)
- National Institute on Drug Abuse (K99DA034681, R00DA034681, DA034681)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- DNA methylation, epigenetics, epigenetic drug targets, central nervous system, synaptic plasticity, DNA methyltransferases, DNA demethylation, cognitive disorders
- MeSH terms
- Animals, Mental Disorders, Central Nervous System Agents, Cognition, Enzyme Inhibitors, Humans, Memory, Nucleic Acid Conformation, Protein Conformation, Structure-Activity Relationship, DNA Modification Methylases, DNA Methylation, Gene Silencing, Epigenesis, Genetic, Drug Discovery, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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