Dopaminergic Network Differences in Human Impulsivity

Buckholtz, Joshua W.; Treadway, Michael T.; Cowan, Ronald L.; Woodward, Neil D.; Li, Rui; Ansari, M. Sib; Baldwin, Ronald M.; Schwartzman, Ashley N.; Shelby, Evan S.; Smith, Clarence E.; Kessler, Robert M.; Zald, David H.

doi:10.1126/science.1185778

Cited by 600Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSchizophrenia research and treatment

Dopaminergic Network Differences in Human Impulsivity

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Buckholtz, Joshua W., Treadway, Michael T., Cowan, Ronald L., Woodward, Neil D., Li, Rui, Ansari, M. Sib, Baldwin, Ronald M., Schwartzman, Ashley N. +4 more·2010·Science

DOI 10.1126/science.1185778PMC PMC3161413

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Abstract

Highly impulsive individuals have diminished regulatory control of dopamine release.

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Amphetamine increases dopamine release across multiple brain regions in healthy humans, including dorsal and ventral striatum, substantia nigra, and cortex.
“Reductions in ligand binding in PET (130-132, 134, 136, 144-146, 148-154, 157, 159, 161, 162, 164) and SPECT (140, 142, 143, 156) studies in healthy humans indicate that AMP increases DA release across multiple brain regions, including the dorsal and ventral striatum, substantia nigra, and regions of the cortex.”
From The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities (2018) · cites this paper as [131]
The paper reports PET evidence of amphetamine-induced dopamine release in the striatum of healthy volunteers (Abstract; page unavailable). It does not establish release in the cortex or substantia nigra: its substantia nigra/ventral tegmental area finding concerns D2/D3 receptor availability. The passages also do not distinguish dorsal from ventral striatal release. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Converging evidence that effects of L-tyrosine depend on baseline dopaminergic state comes from a recent study in healthy older adults showing that L-tyrosine's effect on willingness to exert cognitive control was predicted by individual trait impulsivity, a correlate of dopamine activity in the basal ganglia.
“Converging evidence that effects of L-tyrosine depend on baseline dopaminergic state in particular comes from a recent (preprinted) study in healthy older adults showing that L-tyrosine’s effect on the willingness to exert cognitive control was predicted by individual trait impulsivity (Froböse, Westbrook, Bloemendaal, Aarts, & Cools, 2019), a correlate of dopamine activity in BG (Buckholtz et al.”
From Baseline-dependent effect of dopamine’s precursor L-tyrosine on working memory gating but not updating (2020) · cites this paper as Buckholtz et al., 2011
The same reduction in D2R is also seen in obesity, internet addiction, and trait impulsivity.
“This same reduction in D2R is also seen in obesity, internet addiction, and trait impulsivity (Wang et al 2001; Buckholtz et al 2010; Kim et al 2011).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Buckholtz et al 2010
Imaging studies of impulsive behavior in healthy controls report mixed results on the relationship between impulsivity or response inhibition and D2 BPND/delta BPND.
“Imaging studies of impulsive behavior in healthy controls report mixed results. While some studies found an inverse relationship between measures of impulsivity or response inhibition and D2 BPND and delta BPND, other studies showed the opposite (Buckholtz et al., 2010; Ghahremani et al., 2012; Oswald et al., 2007; Reeves et al., 2012).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Buckholtz et al., 2010
Experimental data suggest an association between risky and impulsive behavior, characteristic of ADHD, and dopamine release or dopamine-dependent BOLD response to rewards in the striatum.
“Additionally, experimental data suggest an association between risky and impulsive behavior, which is characteristic of ADHD,14–16 and dopamine release or dopamine-dependent BOLD response to rewards in the striatum.11,17–20”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [11]

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Dopaminergic Network Differences
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2821 – Dopamine D2/3 Receptor Availability and Human Cognitive Impulsivity: A High-Resolution Pet Imaging Study with [11C]Raclopride
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Authors: Buckholtz, J. W., Treadway, M. T., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Shelby, E. S., Smith, C. E., Kessler, R. M., & Zald, D. H.
Affiliations: Vanderbilt University (US)
Corresponding author: Buckholtz, Joshua W.
Treadway, Michael T.
ORCID: Buckholtz, Joshua W.
Treadway, Michael T.
Cowan, Ronald L.
Woodward, Neil D.
Li, Rui
Zald, David H.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-07-30
Volume: 329
Issue: 5991
Pages: 532-532
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1185778
PMC: PMC3161413
OpenAlex: W1992615559
Cited by: 600
References: 8
Citations by year: 2026: 15 · 2025: 15 · 2024: 17 · 2023: 27 · 2022: 25 · 2021: 34 · 2020: 40 · 2019: 42 · 2018: 44 · 2017: 42 · 2016: 51 · 2015: 54 · 2014: 50 · 2013: 45 · 2012: 61
FWCI: 18.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (T32MH018921)
National Institute on Drug Abuse (R01DA019670)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: impulsivity, dopamine, midbrain, striatal dopamine release, amphetamine, [18F]fallypride, trait impulsivity
MeSH terms: Adolescent, Adult, Benzamides, Corpus Striatum, Dextroamphetamine, Dopamine, Female, Humans, Impulsive Behavior, Ligands, Male, Pyrrolidines, Substantia Nigra, Tegmentum Mesencephali, Signal Transduction, Receptors, Dopamine D2, Ventral Tegmental Area, Autoreceptors, Amphetamine-Related Disorders, Positron-Emission Tomography, Receptors, Dopamine D3, Young Adult

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Dopaminergic Network Differences in Human Impulsivity

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