Delay Discounting and Frontostriatal Fiber Tracts: A Combined DTI and MTR Study on Impulsive Choices in Healthy Young Adults
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Delay discounting, a measure of impulsive choice, has been associated with decreased control of the prefrontal cortex over striatum responses. The anatomical connectivity between both brain regions in delaying gratification remains unknown. Here, we investigate whether the quality of frontostriatal (FS) white matter tracts can predict individual differences in delay-discounting behavior. We use tract-based diffusion tensor imaging and magnetization transfer imaging to measure the microstructural properties of FS fiber tracts in 40 healthy young adults (from 18 to 25 years). We additionally explored whether internal sex hormone levels affect the integrity of FS tracts, based on the hypothesis that sex hormones modulate axonal density within prefrontal dopaminergic circuits. We calculated fractional anisotropy (FA), mean diffusivity (MD), longitudinal diffusivity, radial diffusivity (RD), and magnetization transfer ratio (MTR), a putative measure of myelination, for the FS tract. Results showed that lower integrity within the FS tract (higher MD and RD and lower FA), predicts faster discounting in both sexes. MTR was unrelated to delay-discounting performance. In addition, testosterone levels in males were associated with a lower integrity (higher RD) within the FS tract. Our study provides support for the hypothesis that enhanced structural integrity of white matter fiber bundles between prefrontal and striatal brain areas is associated with better impulse control.
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Discount rates depend on the strength of connections within and between valuation and control networks.
“discount rates are not only associated with regional changes within the valuation and control networks, but also depend on the strength of connections within and between these networks (31).”
From Adolescent impatience decreases with increased frontostriatal connectivity (2015) · cites this paper as [31]
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“SN frontostriatal circuit integrity may be associated with improved impulse control (Peper et al., 2013); conversely, improved top-down cognitive control over the striatum by prefrontal cortical regions may reduce impulsivity (Peters and Büchel, 2011).”
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- Authors
- Peper, J. S., Mandl, R. C. W., Braams, B. R., de Water, E., Heijboer, A. C., Koolschijn, P. C. M. P., & Crone, E. A.
- Affiliations
- Leiden University (NL)
- University Medical Center Utrecht (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Peper, J. S.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-06-12
- Volume
- 23
- Issue
- 7
- Pages
- 1695-1702
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC3673180
- OpenAlex
- W2168039639
- Cited by
- 144
- References
- 72
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 11 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 9 · 2018: 15 · 2017: 10 · 2016: 18 · 2015: 14 · 2014: 16 · 2013: 11 · 2012: 1
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Cerebral Cortex (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (451-10-007)
- FP7 Ideas: European Research Council (263234)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- delay discounting, impulsive choice, white matter microstructure, individual differences, sex hormones, testosterone, myelination, impulse control, prefrontal cortex, striatum, dopaminergic circuits, fractional anisotropy, radial diffusivity, mean diffusivity, magnetization transfer ratio
- MeSH terms
- Adolescent, Adult, Enzyme-Linked Immunosorbent Assay, Estradiol, Female, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Male, Nerve Fibers, Myelinated, Neural Pathways, Saliva, Sex Factors, Testosterone, Anisotropy, Young Adult, Diffusion Tensor Imaging
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