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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Open accessAbstract
Primitive Origins for Microglia: Microglia are the resident macrophages of the central nervous system and are associated with neurodegeneration and brain inflammatory diseases. Although the developmental origins of other tissue macrophage populations are well established, the origins of microglia remain controversial. Ginhoux et al. (p. 841 , published online 21 October) used in vivo lineage tracing studies to show that microglia arise early in mouse development and derive from primitive macrophages in the yolk sac. This is in contrast to other cells of the mononuclear phagocyte system, which arise later in development from a distinct progenitor population.
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“Two weeks after injection, CSF1R knockout brains had been partially repopulated with CD11b+ CD45+ cells (Fig. S7B), which are absent from non-engrafted brains (Ginhoux et al., 2010).”
From Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures (2017) · cites this paper as Ginhoux et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Importantly, microglia originate from the yolk sac during early embryonic development, whereas peripheral macrophages originate from hematopoietic stem cells in the bone marrow (19).”
From The role of microglia in multiple sclerosis: implications for treatment with Bruton’s tyrosine kinase inhibitors (2025) · cites this paper as [19]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“microglia are uniformly CX3CR1+ from early embryonic time points through adulthood (Cardona et al., 2006; Ginhoux et al., 2010; Schulz et al., 2012)”
From Differential roles of microglia and monocytes in the inflamed central nervous system (2014) · cites this paper as Ginhoux et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“It is believed that microglia arise from yolk sac erythromyeloid precursors and migrate into the brain parenchyma during early development [43,44,45].”
From The Cuprizone Model: Dos and Do Nots (2020) · cites this paper as [44]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Microglia share much of their genetic make-up, complement of proteins, and function, with other immune cells, particularly macrophages [129]”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [129]
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“aging, vascular dysfunction, and chronic neuroinflammation are known to compromise the integrity of the blood–brain barrier. This can lead to increased trafficking of peripheral immune cells as well as the above-mentioned microglial replacement of resident microglia by peripheral monocytes [24,36].”
From Clonal Hematopoiesis of Indeterminate Potential as an Emerging Interdisciplinary Risk Factor in Alzheimer’s Disease: Current Evidence and Future Directions (2026) · cites this paper as [36]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Microglia originate from primitive macrophage (M F ) progenitors that arise in the yolk sac (YS), infiltrate the developing brain and clonally expand 2,3 .”
From Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice (2025) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“In mice, two waves of embryonic macrophages are produced in the yolk sac blood islands at embryonic day 7.5 (E7.5) and E8.25, and the first wave migrate into the developing brain and differentiate to microglia (Ginhoux et al., 2010, Gomez Perdiguero et al., 2015, Hoeffel et al., 2015, Palis et al., 1999).”
From A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response (2017) · cites this paper as Ginhoux et al., 2010
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In the citing paper
“This lineage is mainly regulated by CSFR14 and its ligand, IL-347.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [4]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Our findings are consistent with reports that macrophage progenitors develop from the primitive ectoderm of the yolk sac4 and give rise to tissue macrophages that do not have a monocytic progenitor16,17.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [4]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“To provide this niche, we used CSF1R knockout animals, which lack microglia (Ginhoux et al., 2010) (schematic in Fig. 7A).”
From Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures (2017) · cites this paper as Ginhoux et al., 2010
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In the citing paper
“In mice, fate-mapping methods revealed that, unlike other glia cells with neuroectoderm origin, microglia in adults originate from yolk-sac (YS)-derived primitive macrophages, which colonize the developing brain rudiment during early embryogenesis (Ginhoux et al., 2010; Schulz et al., 2012).”
From Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals (2025) · cites this paper as Ginhoux et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“Microglia are the primary resident immune cells of the CNS parenchyma and are seeded during development from mesodermal progenitors”
From Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program (2019) · cites this paper as Ginhoux et al., 2010
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In the citing paper
“These cells arise from uncommitted KIT+ erythromyeloid precursors [181, 316], which seed the brain from the yolk sac at embryonic day 9.5 in the mouse [126], well before other glial cells and the formation of the blood–brain barrier (BBB) [130, 181].”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [126]
The cited source says what the claim attributes to it.
In the citing paper
“Microglia and monocytes are ontogenetically distinct: microglia derive from yolk-sac progenitors during embryogenesis (Ginhoux et al., 2010; Schulz et al., 2012)”
From Differential roles of microglia and monocytes in the inflamed central nervous system (2014) · cites this paper as Ginhoux et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“In addition, IL-34 is newly identified ligand for CSF-1R, and it is reported to support maintenance of microglia [14].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [14]
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In the citing paper
“Peripheral immune cells may also replace microglial populations,5,23,30–32 though this is controversial.”
From TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice (2025) · cites this paper as [23]
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In the citing paper
“Studies in mice indicate that microglia are derived from yolk sac progenitor cells that populate the brain early in development (18, 19).”
From An environment-dependent transcriptional network specifies human microglia identity (2017) · cites this paper as [18]
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In the citing paper
“Our own work (Buchrieser et al., 2017) and that of others (Hoeffel et al., 2015) indicates that this protocol produces MYB-independent myeloid cells, recapitulating an embryonic ontogeny, and lineage-tracking studies in mouse have demonstrated that microglia derive from primitive, yolk sac macrophages that migrate into the developing brain (Ginhoux et al., 2010, Ginhoux et al., 2013).”
From A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response (2017) · cites this paper as Ginhoux et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“adult microglia derive from primitive macrophages4 in a Myb-independent manner5 via PU.1 and IRF8 dependent pathways6.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [4]
The cited source says what the claim attributes to it.
In the citing paper
“Thus, there is a resident pool of microglia that is separate from peripheral myeloid cells that infiltrate the nervous system.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [4]
The cited source says what the claim attributes to it.
In the citing paper
“Subsequent reports showed that microglia arise early during development from progenitors in the embryonic yolk sac4,38,39.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [4]
In the citing paper
“Bone marrow–derived myeloid precursors do not contribute to the microglia pool.”
From Microglia Function in the Central Nervous System During Health and Neurodegeneration (2017) · cites this paper as [1]
In the citing paper
“Fate-mapping studies have demonstrated that microglia originate from early myeloid progenitors in the embryonic yolk sac that migrate into the developing neural tube, where they proliferate, colonize the entire parenchyma, and subsist throughout the life span of the organism by slow division (1, 2).”
From Microglia Function in the Central Nervous System During Health and Neurodegeneration (2017) · cites this paper as [1]
In the citing paper
“Normal blood circulation is required for YS macrophage seeding of the CNS.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [42]
In the citing paper
“This observation supports the idea that the recruitment of YS progenitors into the brain is mediated by blood circulation.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [42]
In the citing paper
“it is now well-established that microglia are derived from yolk sac (YS) erythromyeloid precursors (EMPs).”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [42]
In the citing paper
“The origin of microglia has now been clearly defined and shown to relate to the early colonization of the CNS by mesodermal progenitors6 that arise from the yolk sac7,8”
From Microglial signatures and their role in health and disease (2018) · cites this paper as [8]
In the citing paper
“the cytokine CSF1, acting via its receptor CSF1R, is important for microglial development8.”
From Microglial signatures and their role in health and disease (2018) · cites this paper as [8]
In the citing paper
“Microglia arise from yolk sac-derived precursors that populate the brain during early development21.”
From Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke (2016) · cites this paper as [21]
In the citing paper
“Several groups have attempted different cell culture conditions to maintain homeostatic microglia signature and ramified morphology In vitro using a variety of cytokines, such as CSF1, GM-CSF, TGFβ, and IL-34 [73-76].”
From Transcriptional and Epigenetic Regulation of Microglia in Health and Disease (2019) · cites this paper as [73]
In the citing paper
“However, generation of microglia-like cells matching the recently identified signatures of acutely isolated microglia 10,11, and following their non-monocytic yolk sac ontogeny 4, has not been reported from pluripotent human cells.”
From Efficient derivation of microglia-like cells from human pluripotent stem cells (2016) · cites this paper as [4]
In the citing paper
“They emigrate as erythromyeloid precursors or primitive macrophages from the yolk sac, before further hematopoiesis takes place in the periphery.”
From Efficient derivation of microglia-like cells from human pluripotent stem cells (2016) · cites this paper as [4]
In the citing paper
“recent genetic lineage tracing in the mouse determined that microglia take up residence in the developing neural tube shortly before closure of the blood-brain barrier 4.”
From Efficient derivation of microglia-like cells from human pluripotent stem cells (2016) · cites this paper as [4]
In the citing paper
“Elegant lineage tracing studies show that microglia originate from yolk sac erythromyeloid progenitors (EMP) generated during primitive hematopoiesis (Ginhoux et al., 2010; Kierdorf et al., 2013; Schulz et al., 2012).”
From iPSC-derived human microglia-like cells to study neurological diseases (2017) · cites this paper as Ginhoux et al., 2010
In the citing paper
“We identified eleven TFs upregulated in PS19 mice that are implicated in mediating the inflammatory responses (Stat1, Stat3, Stat5a, Stat5b, Nfkb1, Nfe2l2, Fli1), microglia proliferation and differentiation (Irf8, Spi1, Runx1), and astrocyte maturation and neurogenesis (Pax6) (Ginhoux et al., 2010; Kierdorf et al., 2013; Zamanian et al., 2012; Zusso et al., 2012).”
From Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease (2018) · cites this paper as Ginhoux et al., 2010
In the citing paper
“They are derived from embryonic yolk sac (YS) precursors and maintain their CNS population via local self-renewal, with little contribution from bone marrow-derived monocytes12,13.”
From Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight (2018) · cites this paper as [12]
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Cites
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570
Microglial physiology: unique stimuli, specialized responses
Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643
THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES
van Furth, R., & Cohn, Z. A. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.128.3.415 · Cited by 1,564
Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265
Harrison, J. K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R. K., Streit, W. J., Salafranca, M. N., Adhikari, S., Thompson, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10896 · Cited by 1,176
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience · doi:10.1038/nn2015 · Cited by 1,089
In Vivo Analysis of Dendritic Cell Development and Homeostasis
Liu, K., Victora, G. D., Schwickert, T. A., Guermonprez, P., Meredith, M. M., Yao, K.-H., Chu, F.-F., Randolph, G. J., Rudensky, A. Y., & Nussenzweig, M. C. (2009) · Science · doi:10.1126/science.1170540 · Cited by 1,001
Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
Alliot, F., Godin, I., & Pessac, B. (1999) · Developmental Brain Research · doi:10.1016/s0165-3806(99)00113-3 · Cited by 884
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Gautier, E. L., Chow, A. T., Spanbroek, R., Marcelin, G., Greter, M., Jakubzick, C., Bogunovic, M., Leboeuf, M., van Rooijen, N., Habenicht, A. J. R., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200495 · Cited by 175
Self-citationVlaminck, K. D., Hove, H. V., Kancheva, D., Scheyltjens, I., Antunes, A. R. P., Bastos, J., Vara‐Pérez, M., Ali, L., Mampay, M., Deneyer, L., et al. (2021) · Immunity · doi:10.1016/j.immuni.2022.09.005 · Cited by 169
Learning and memory … and the immune system
Marin, I., & Kipnis, J. (2013) · Learning & Memory · doi:10.1101/lm.028357.112 · Cited by 166
Yao, A., Liu, F., Chen, K., Tang, L. V., Liu, L., Zhang, K., Yu, C., Bian, G., Guo, H., Zheng, J., et al. (2014) · Neurotherapeutics · doi:10.1007/s13311-013-0254-x · Cited by 163
Bone Marrow Cell Recruitment to the Brain in the Absence of Irradiation or Parabiosis Bias
Kierdorf, K., Katzmarski, N., Haas, C. A., & Prinz, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058544 · Cited by 165
Mammana, S., Fagone, P., Cavalli, E., Basile, M. S., Petralia, M. C., Nicoletti, F., Bramanti, P., & Mazzon, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030831 · Cited by 171
Lung Interstitial Macrophages: Past, Present, and Future
Schyns, J., Bureau, F., & Marichal, T. (2018) · Journal of Immunology Research · doi:10.1155/2018/5160794 · Cited by 166
Copper induces microglia-mediated neuroinflammation through ROS/NF-κB pathway and mitophagy disorder
Zhou, Q., Zhang, Y., Lu, L., Zhang, H., Zhao, C., Pu, Y., & Yin, L. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113369 · Cited by 172
Differential Requirement for irf8 in Formation of Embryonic and Adult Macrophages in Zebrafish
Shiau, C. E., Kaufman, Z., Meireles, A. M., & Talbot, W. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117513 · Cited by 156
Chemokines in the balance: maintenance of homeostasis and protection at CNS barriers
Williams, J. L., Holman, D. W., & Klein, R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00154 · Cited by 165
Neuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”
Wohleb, E. S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00544 · Cited by 170
Niche signals and transcription factors involved in tissue-resident macrophage development
T’Jonck, W., Guilliams, M., & Bonnardel, J. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.02.005 · Cited by 173
Microglia and Astrocyte Function and Communication: What Do We Know in Humans?
Garland, E. F., Hartnell, I. J., & Boche, D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.824888 · Cited by 165
Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy
Tang, Y., Chaillon, A., Gianella, S., Wong, L. M., Li, D., Simermeyer, T. L., Porrachia, M., Ignacio, C. C., Woodworth, B., Zhong, D., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci167417 · Cited by 165
The microglial component of amyotrophic lateral sclerosis
Clarke, B. E., & Patani, R. (2020) · Brain · doi:10.1093/brain/awaa309 · Cited by 164
Tumor-Associated Macrophages in Glioma: Friend or Foe?
Kennedy, B. C., Showers, C. R., Anderson, D. E., Anderson, L., Canoll, P., Bruce, J. N., & Anderson, R. C. E. (2013) · Journal of Oncology · doi:10.1155/2013/486912 · Cited by 164
Pinton, L., Masetto, E., Vettore, M., Solito, S., Magri, S., D'Andolfi, M., Bianco, P. D., Lollo, G., Benoît, J., Okada, H., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0536-x · Cited by 161
Origins, Biology, and Diseases of Tissue Macrophages
Cox, N., Pokrovskii, M. V., Vicario, R., & Geissmann, F. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-111748 · Cited by 171
Han, J., Chiţu, V., Stanley, E. R., Wszołek, Z. K., Karrenbauer, V. D., & Harris, R. A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04225-1 · Cited by 169
Self-citationZhan, L., Krabbe, G., Du, F., Jones, I., Reichert, M. C., Telpoukhovskaia, M., Kodama, L., Wang, C., Cho, S.-H., Sayed, F., et al. (2019) · PLOS Biology · doi:10.1371/journal.pbio.3000134 · Cited by 163
“leave the blood island and travel from the yolk sac to colonize the developing fetal brain [10, 13, 14].”
BackgroundMicroglia and lipids: how metabolism controls brain innate immunity
Chausse, B., Kakimoto, P. A., & Kann, O. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.08.001 · Cited by 181
Metchnikoff's policemen: macrophages in development, homeostasis and regeneration
Stefater, J. A., Ren, S., Lang, R. A., & Duffield, J. S. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.07.009 · Cited by 169
Silva, M. C., Videira, P. A., & Sackstein, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01878 · Cited by 170
Okunuki, Y., Mukai, R., Pearsall, E., Klokman, G., Husain, D., Park, D.-H., Korobkina, E. D., Weiner, H. L., Butovsky, O., Ksander, B. R., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719601115 · Cited by 165
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges
Silva, H. M., Báfica, A. L. B., Rodrigues-Luiz, G. F., Chi, J., Santos, P. D. A., Reis, B. S., van Konijnenburg, D. P. H., Crane, A., Arifa, R. D. D. N., Martin, P. K., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181049 · Cited by 168
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
Fellner, L., Jellinger, K. A., Wenning, G. K., & Stefanova, N. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0833-z · Cited by 162
ATP receptors gate microglia signaling in neuropathic pain
Trang, T., Beggs, S., & Salter, M. W. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.012 · Cited by 165
Richner, M., Ulrichsen, M., Elmegaard, S. L., Dieu, R. S., Pallesen, L. T., & Vægter, C. B. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8706-9 · Cited by 167
Xu, J., Wang, T., Wu, Y., Jin, W., & Wen, Z. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.018 · Cited by 169
Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor
Chiţu, V., & Stanley, E. R. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.10.004 · Cited by 163
Self-citationMicroglia: Neuroimmune-sensors of stress
Frank, M. G., Fonken, L. K., Watkins, L. R., & Maier, S. F. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.001 · Cited by 165
Folate-targeted nanoparticles for rheumatoid arthritis therapy
Nogueira, E., Gomes, A. C., Preto, A., & Cavaco-Paulo, A. M. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.12.365 · Cited by 163
Gouveia-Freitas, K., & de Bastos-Leite, A. J. (2021) · Neuroradiology · doi:10.1007/s00234-021-02718-7 · Cited by 166
When encephalitogenic T cells collaborate with microglia in multiple sclerosis
Dong, Y., & Yong, V. W. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0253-6 · Cited by 169
Wang, P. L., Yim, A. K., Kim, K.-W., Avey, D. R., Czepielewski, R. S., Colonna, M., Milbrandt, J., Randolph, G. J., & The Immunological Genome Project (2020) · Nature Communications · doi:10.1038/s41467-020-16355-w · Cited by 168
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia
Ndoja, A., Reja, R., Lee, S.-H., Webster, J. D., Ngu, H., Rose, C. M., Kirkpatrick, D. S., Modrusan, Z. D., Chen, Y.-J. J., Dugger, D. L., et al. (2020) · Cell · doi:10.1016/j.cell.2020.07.011 · Cited by 161
Tissue-Resident Macrophage Development and Function
Wu, Y., & Hirschi, K. K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.617879 · Cited by 169
Cai, L., Gong, Q., Qi, L., Xu, T., Suo, Q., Li, X., Wang, W., Yao, J., Yang, D., Xu, Z., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00862-y · Cited by 166
Resolution of acute inflammation bridges the gap between innate and adaptive immunity
Newson, J., Stables, M. J., Karra, E., Vargas, F. A., Quezada, S. A., Motwani, M. P., Mack, M., Yona, S., Audzevich, T., & Gilroy, D. W. (2014) · Blood · doi:10.1182/blood-2014-03-562710 · Cited by 159
Neuroimmune Basis of Alcoholic Brain Damage
Crews, F. T., & Vetreno, R. P. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00010-5 · Cited by 165
Ryan, K. J., White, C. C., Patel, K. R., Xu, J., Olah, M., Replogle, J. M., Frangieh, M., Cimpean, M., Winn, P. A., McHenry, A., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai7635 · Cited by 159
Neuroinflammation During RNA Viral Infections
Klein, R. S., Garber, C., Funk, K. E., Salimi, H., Soung, A., Kanmogne, M., Manivasagam, S., Agner, S., & Cain, M. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041417 · Cited by 160
Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases
Barbalace, M. C., Malaguti, M., Giusti, L., Lucacchini, A., Hrelia, S., & Angeloni, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123061 · Cited by 163
Microglia activation states and cannabinoid system: Therapeutic implications
Mecha, M., Carrillo-Salinas, F. J., Feliú, A., Mestre, L., & Guaza, C. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.06.011 · Cited by 165
Macrophage: Key player in the pathogenesis of autoimmune diseases
Yang, S. C., Zhao, M., & Jia, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1080310 · Cited by 165
Glia in the pathogenesis of neurodegenerative diseases
Verkhratsky, A., Parpura, V., Pekna, M., Pekny, M., & Sofroniew, M. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140107 · Cited by 141
Macrophages and cellular immunity in Drosophila melanogaster
Gold, K. S., & Brückner, K. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2016.03.010 · Cited by 158
Guruswamy, R., & ElAli, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030496 · Cited by 166
Astrocytes and microglia: Models and tools
Guttenplan, K. A., & Liddelow, S. A. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180200 · Cited by 162
Zhou, M., Xu, R., Kaelber, D. C., & Gurney, M. E. (2020) · PLOS ONE · doi:10.1371/journal.pone.0229819 · Cited by 157
Glia Crosstalk in Neuroinflammatory Diseases
Bernaus, A., Blanco, S., & Sevilla, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00209 · Cited by 157
Microglia and neuronal cell death
Marín‐Teva, J. L., Cuadros, M. Á., Martín‐Oliva, D., & Navascués, J. (2011) · Neuron Glia Biology · doi:10.1017/s1740925x12000014 · Cited by 158
Toll-like receptor signaling and stages of addiction
Crews, F. T., Walter, T. J., Coleman, L. G., & Vetreno, R. P. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4560-6 · Cited by 163
The origins and homeostasis of monocytes and tissue‐resident macrophages in physiological situation
Zhao, Y., Zou, W., Du, J., & Zhao, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26461 · Cited by 190
The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis
Muñoz-García, J., Cochonneau, D., Télétchéa, S., Moranton, E., Lanoé, D., Brion, R., Lézot, F., Heymann, M., & Heymann, D. (2020) · Theranostics · doi:10.7150/thno.50683 · Cited by 161
Monocyte Regulation in Homeostasis and Malignancy
Robinson, A., Han, C. Z., Glass, C. K., & Pollard, J. W. (2021) · Trends in Immunology · doi:10.1016/j.it.2020.12.001 · Cited by 162
CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis
Funk, K. E., & Klein, R. S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1397-4 · Cited by 156
MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia
Plastira, I., Bernhart, E. M., Joshi, L., Koyani, C. N., Strohmaier, H. M., Reicher, H., Malle, E., & Sattler, W. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01809-1 · Cited by 157
Microglia-mediated neuroinflammation and neuroplasticity after stroke
Wang, Y., Leak, R. K., & Cao, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.980722 · Cited by 164
Kaffes, I., Szulzewsky, F., Chen, Z., Herting, C. J., Gabanic, B., Vega, J. E. V., Shelton, J., Switchenko, J. M., Ross, J., McSwain, L., et al. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1655360 · Cited by 151
Good News–Bad News: The Yin and Yang of Immune Privilege in the Eye
Forrester, J. V., & Xu, H. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00338 · Cited by 153
Zusso, M., Methot, L., Lo, R., Greenhalgh, A. D., David, S., & Stifani, S. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6182-11.2012 · Cited by 163
Macrophages in gastrointestinal homeostasis and inflammation
Grainger, J. R., Konkel, J. E., Zangerle-Murray, T., & Shaw, T. N. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1958-2 · Cited by 157
Pereira, J. D., DuBreuil, D. M., Devlin, A., Held, A., Sapir, Y., Berezovski, E., Hawrot, J., Dorfman, K., Chander, V., & Wainger, B. J. (2021) · Nature Communications · doi:10.1038/s41467-021-24776-4 · Cited by 159
The promising role of tumor-associated macrophages in the treatment of cancer
Wang, H., Wang, X., Zhang, X., & Xu, W. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2023.101041 · Cited by 163
Microglial dysfunction connects depression and Alzheimer’s disease
Santos, L. E., Beckman, D., & Ferreira, S. T. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.011 · Cited by 154
Cellular and Molecular Characterization of Microglia: A Unique Immune Cell Population
Sousa, C., Biber, K. P. H., & Michelucci, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00198 · Cited by 159
Epigenetics Control Microglia Plasticity
Cheray, M., & Joseph, B. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00243 · Cited by 157
Santa, F. D., Vitiello, L., Torcinaro, A., & Ferraro, E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7420 · Cited by 157
Wang, Z., Wu, Z., Wang, H., Feng, R., Wang, G., Li, M., Wang, S.-Y., Chen, X., Su, Y., Wang, J., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.019 · Cited by 158
Self-citationDysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation
Chu, E., Mychasiuk, R., Hibbs, M. L., & Semple, B. D. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02325-6 · Cited by 152
Innate and adaptive immune responses in the CNS
Waisman, A., Liblau, R., & Becher, B. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00141-6 · Cited by 158
Jones, C. V., & Ricardo, S. D. (2013) · Organogenesis · doi:10.4161/org.25676 · Cited by 152
Immunoadolescence: Neuroimmune development and adolescent behavior
Brenhouse, H. C., & Schwarz, J. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.035 · Cited by 163
Bolton, J. L., Marinero, S., Hassanzadeh, T., Natesan, D., Le, D., Belliveau, C., Mason, S. N., Auten, R. L., & Bilbo, S. D. (2017) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2017.00010 · Cited by 159
Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment
Lahmar, Q., Keirsse, J., Laoui, D., Movahedi, K., Overmeire, E. V., & Ginderachter, J. A. V. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.06.009 · Cited by 161
Primary Phagocytosis of Neurons by Inflamed Microglia: Potential Roles in Neurodegeneration
Neher, J. J., Neniškytė, U., & Brown, G. C. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00027 · Cited by 157
The Role of TGFβ Signaling in Microglia Maturation and Activation
Spittau, B., Dokalis, N., & Prinz, M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.003 · Cited by 157
From the Reticuloendothelial to Mononuclear Phagocyte System – The Unaccounted Years
Yona, S., & Gordon, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00328 · Cited by 151
Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer
Bosurgi, L., Bernink, J. H., Cuevas, V. D., Gagliani, N., Joannas, L. D., Schmid, E. T., Booth, C. J., Ghosh, S., & Rothlin, C. V. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302507110 · Cited by 152
Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells
Sprangers, S., de Vries, T. J., & Everts, V. E. (2016) · Journal of Immunology Research · doi:10.1155/2016/1475435 · Cited by 164
Microglia and Monocyte-Derived Macrophages in Stroke
Kim, E., & Cho, S. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0463-1 · Cited by 159
A Developmental Analysis of Juxtavascular Microglia Dynamics and Interactions with the Vasculature
Mondo, E., Becker, S. C., Kautzman, A. G., Schifferer, M., Baer, C. E., Chen, J., Huang, E. J., Simons, M., & Schafer, D. P. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.3006-19.2020 · Cited by 153
Programs, origins and immunomodulatory functions of myeloid cells in glioma
Miller, T. E., Farran, C. A. E., Couturier, C., Chen, Z., D’Antonio, J. P., Verga, J. A., Villanueva, M. A., Castro, L. N. G., Tong, Y. E., Al-Saadi, T. D., et al. (2025) · Nature · doi:10.1038/s41586-025-08633-8 · Cited by 171
Wlodarczyk, A., Løbner, M., Cédile, O., & Owens, T. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-57 · Cited by 149
Clinical landscape of macrophage-reprogramming cancer immunotherapies
Rannikko, J. H., & Hollmén, M. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02715-6 · Cited by 169
Beyond the gut: decoding the gut–immune–brain axis in health and disease
Park, J. C., Chang, L., Kwon, H.-K., & Im, S.-H. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01333-3 · Cited by 149
Blaho, V. A., & Hla, T. (2011) · Chemical Reviews · doi:10.1021/cr200273u · Cited by 151
Mutant huntingtin impairs immune cell migration in Huntington disease
Kwan, W., Träger, U., Davalos, D., Chou, A., Bouchard, J. J., André, R., Miller, A., Weiss, A., Giorgini, F., Cheah, C. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64484 · Cited by 145
P2X4 receptors and neuropathic pain
Tsuda, M., Masuda, T., Tozaki‐Saitoh, H., & Inoue, K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00191 · Cited by 154
Brain Microglia and Microglial Markers
Korzhevsky, D. E., & Kirik, O. V. (2016) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-016-0231-z · Cited by 148
The multifaceted link between inflammation and human diseases
Rajendran, P., Chen, Y., Chen, Y., Chung, L.-C., Tamilselvi, S., Shen, C.-Y., Day, C. H., Chen, R., Viswanadha, V. P., Kuo, W., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26479 · Cited by 157
Placental formation in early pregnancy: how is the centre of the placenta made?
Boss, A. L., Chamley, L., & James, J. L. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy030 · Cited by 147
The Skin-Resident Immune Network
Tay, S. S., Roediger, B., Tong, P. L., Tikoo, S., & Weninger, W. (2014) · Current Dermatology Reports · doi:10.1007/s13671-013-0063-9 · Cited by 147
Activated microglia drive demyelination via CSF1R signaling
Marzan, D. E., Brügger‐Verdon, V., West, B. L., Liddelow, S., Samanta, J., & Salzer, J. L. (2021) · Glia · doi:10.1002/glia.23980 · Cited by 147
“…highly dynamic cells derive from yolk sac precursors that colonize the brain early during embryonic development and are maintained autonomously throughout adult life by clonal expansion (Ajami, Bennett, Krieger, Tetzlaff, & Rossi, 2007; Davalos et al., 2005; Ginhoux et al., 2010; Tay et al., 2017).”
BackgroundMolecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer’s Disease
Franco-Bocanegra, D. K., McAuley, C., Nicoll, J. A. R., & Boche, D. (2019) · Cells · doi:10.3390/cells8060639 · Cited by 147
Ohgidani, M., Kato, T. A., Setoyama, D., Sagata, N., Hashimoto, R., Shigenobu, K., Yoshida, T., Hayakawa, K., Shimokawa, N., Miura, D., et al. (2014) · Scientific Reports · doi:10.1038/srep04957 · Cited by 150
The importance of microglia in the development of the vasculature in the central nervous system
Arnold, T., & Betsholtz, C. (2013) · Vascular Cell · doi:10.1186/2045-824x-5-4 · Cited by 157
Post-mortem analysis of neuroinflammatory changes in human Alzheimer’s disease
Gomez-Nicola, D., & Boche, D. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0126-1 · Cited by 147
Microglia: Key players in neurodevelopment and neuronal plasticity
Sominsky, L., Luca, S. N. D., & Spencer, S. J. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.11.012 · Cited by 155
Metadata
- Authors
- Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., Samokhvalov, I. M., & Merad, M.
- Affiliations
- Singapore Immunology Network (SG)
- Icahn School of Medicine at Mount Sinai (US)
- Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.
- Albert Einstein College of Medicine (US)
- Institute for Brain Disorders and Neural Regeneration, Rose F. Kennedy Center for Research on Intellectual and Developmental Disabilities, and Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.
- Indiana University Indianapolis (US)
- RIKEN (JP)
- Corresponding author
- Ginhoux, Florent
- ORCID
- Venue
- Science
- Published
- 2010-11-05
- Volume
- 330
- Issue
- 6005
- Pages
- 841-845
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3719181
- OpenAlex
- W2148898943
- Cited by
- 5,175
- References
- 32
- Citations by year
- 2026: 286 · 2025: 360 · 2024: 447 · 2023: 369 · 2022: 443 · 2021: 483 · 2020: 425 · 2019: 382 · 2018: 363 · 2017: 328 · 2016: 279 · 2015: 279 · 2014: 271 · 2013: 219 · 2012: 137
- FWCI
- 87.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- National Science Foundation
- National Institutes of Health (CA26504)
- RIKEN
- National Heart, Lung, and Blood Institute (HL086899, R01HL086899, R01HL060714)
- National Institute of Mental Health (R01MH066290, MH66290)
- National Cancer Institute (CA-32551, R01CA032551, R37CA026504, R01CA112100, CA26504, CA112100, R01CA026504)
- National Institute of Allergy and Infectious Diseases (AI080884, R01AI080884)
- National Institute of Neurological Disorders and Stroke (NS38902, R01NS038902)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- myeloid progenitor cells, CSF-1, CSF-1 receptor, reticuloendothelial system, hematopoietic progenitor cells, lineage tracing, neuroinflammation, neurodegenerative diseases
- MeSH terms
- Animals, Brain, Cell Differentiation, Embryo, Mammalian, Female, Hematopoiesis, Hematopoietic Stem Cells, Homeostasis, Macrophages, Mice, Inbred C57BL, Yolk Sac, Macrophage Colony-Stimulating Factor, Receptor, Macrophage Colony-Stimulating Factor, Microglia, Cell Lineage, Myeloid Progenitor Cells, Cell Proliferation, Core Binding Factor Alpha 2 Subunit, Mice, Gene Knock-In Techniques
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