Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, Florent, Greter, Melanie, Leboeuf, Marylene, Nandi, Sayan, See, Peter, Gokhan, Solen, Mehler, Mark F., Conway, Simon J., Ng, Lai Guan, Stanley, E. Richard, Samokhvalov, Igor M., Merad, Miriam·2010·Science
Cited by (1,135)
Items 901–1,000 of 1,135
- Macrophage functions in wound healingMałgorzata Kloc, Rafik Mark Ghobrial, Jarek Wosik, Aneta Lewicka, Sławomir Lewicki, Jacek Z. Kubiak · 2018 · Journal of Tissue Engineering and Regenerative Medicine
- Histamine, Neuroinflammation and Neurodevelopment: A ReviewElliott R. Carthy, Tommas J. Ellender · 2021 · Frontiers in Neuroscience
- Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunitiesGuoqing Wang, Kunhong Zhong, Zeng Wang, Zongliang Zhang, Xin Tang, Aiping Tong, Liangxue Zhou · 2022 · Frontiers in Immunology
- Molecular and metabolic heterogeneity of astrocytes and microgliaPhilip Hasel, William H. Aisenberg, F. Chris Bennett, Shane Antony Liddelow · 2023 · Cell Metabolism
- Differential Location and Distribution of Hepatic Immune CellsFreitas-Lopes, Maria, Mafra, Kassiana, David, Bruna, Carvalho-Gontijo, Raquel, Menezes, Gustavo · 2017 · Cells
- Adenosine Augments IL-10 Production by Microglial Cells through an A2B Adenosine Receptor-Mediated ProcessBalázs Koscsó, Balázs Csóka, Zsolt Selmeczy, Leonóra Himer, Pál Pacher, László Virág, György Haskó · 2011 · The Journal of Immunology
- CNS sterile injury: just another wound healing?Ravid Shechter, Michal Schwartz · 2012 · Trends in Molecular Medicine
- A Lifespan Approach to Neuroinflammatory and Cognitive Disorders: A Critical Role for GliaStaci D. Bilbo, Susan Harless Smith, Jaclyn M. Schwarz · 2011 · Journal of Neuroimmune Pharmacology
- Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseasesColleen M. McClean, David M. Tobin · 2016 · Pathogens and Disease
- Neonatal Subventricular Zone Neural Stem Cells Release Extracellular Vesicles that Act as a Microglial MorphogenMorton, Mary C., Neckles, Victoria N., Seluzicki, Caitlin M., Holmberg, Jennie C., Feliciano, David M. · 2018 · Cell Reports
- Prenatal Immune and Endocrine Modulators of Offspring's Brain Development and Cognitive Functions Later in LifeSteven Ngandeu Schepanski, Claudia Buß, Ileana L. Hanganu‐Opatz, Petra Arck · 2018 · Frontiers in Immunology
- The influence of environment and origin on brain resident macrophages and implications for therapyMariko L. Bennett, F. Chris Bennett · 2019 · Nature Neuroscience
- Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastomaApeng Chen, Yinan Jiang, Zhengwei Li, Lingxiang Wu, Ulises Santiago, Han Zou, Chunhui Cai, Vaibhav Sharma, Yongchang Guan, Lauren H. McCarl et al. · 2021 · Journal of Clinical Investigation
- Innate Immune Response in Retinal Homeostasis and Inflammatory DisordersMurakami, Yusuke, Ishikawa, Keijiro, Nakao, Shintaro, Sonoda, Koh-Hei · 2020 · Progress in Retinal and Eye Research
- Sex differences in neuroinflammation and neuroprotection in ischemic strokeSpychala, Monica S., Honarpisheh, Pedram, McCullough, Louise D. · 2017 · Journal of Neuroscience Research
- The brain’s best friend: microglial neurotoxicity revisitedHellwig, Sabine, Heinrich, Annette, Biber, Knut · 2013 · Frontiers in Cellular Neuroscience
- Cardioprotective function of cardiac macrophagesKatsuhito Fujiu, Jingjing Wang, R Nagai · 2014 · Cardiovascular Research
- The ubiquitin proteasome system in glia and its role in neurodegenerative diseasesAnne H. P. Jansen, Eric A. Reits, Elly M. Hol · 2014 · Frontiers in Molecular Neuroscience
- Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cellsAlison E. Mungenast, Sandra Siegert, Li‐Huei Tsai · 2015 · Molecular and Cellular Neuroscience
- Macrophages and Cardiovascular HealthVanessa Frodermann, Matthias Nahrendorf · 2018 · Physiological Reviews
- Il34-Csf1r Pathway Regulates the Migration and Colonization of Microglial PrecursorsShuting Wu, Rongtao Xue, Shaoli Hassan, Thi My Linh Nguyen, Tienan Wang, Hongru Pan, Jin Xu, Qifa Liu, Wenqing Zhang, Zilong Wen · 2018 · Developmental Cell
- Physiology of MicrogliaOlga Garaschuk, Alexei Verkhratsky · 2019 · Methods in molecular biology
- Microglia and sexual differentiation of the developing brain: A focus on ontogeny and intrinsic factorsBordt, Evan A., Ceasrine, Alexis M., Bilbo, Staci D. · 2020 · Glia
- Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic DriversAnna S. Warden, Sarah A. Wolfe, Sophia Khom, Florence P. Varodayan, Reesha R. Patel, Michael Q. Steinman, Michal Bajo, Sarah E. Montgomery, Roman Vlkolinský, Tali Nadav et al. · 2020 · Biological Psychiatry
- Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomicsRatz, Michael, von Berlin, Leonie, Larsson, Ludvig, Martin, Marcel, Westholm, Jakub Orzechowski, La Manno, Gioele, Lundeberg, Joakim, Frisén, Jonas · 2022 · Nature Neuroscience
- Targeting innate immunity for neurodegenerative disorders of the central nervous systemAndreasson, Katrin I., Bachstetter, Adam D., Colonna, Marco, Ginhoux, Florent, Holmes, Clive, Lamb, Bruce, Landreth, Gary, Lee, Daniel C., Low, Donovan, Lynch, Marina A. et al. · 2016 · Journal of Neurochemistry
- Nuclear receptors as therapeutic targets for Alzheimer's diseaseMandrekar-Colucci, Shweta, Landreth, Gary E · 2011 · Expert Opinion on Therapeutic Targets
- Microglia: unique and common features with other tissue macrophagesPrinz, Marco, Tay, Tuan Leng, Wolf, Yochai, Jung, Steffen · 2014 · Acta Neuropathologica
- Neurovascular Coupling in Development and Disease: Focus on AstrocytesTeresa L. Stackhouse, Anusha Mishra · 2021 · Frontiers in Cell and Developmental Biology
- Immunotherapies for malignant gliomaVassiliki A. Boussiotis, Alain Charest · 2017 · Oncogene
- Microglial activation after ischaemic strokeShengxiang Zhang · 2019 · Stroke and Vascular Neurology
- An Overview of the Intrinsic Role of Citrullination in Autoimmune DisordersMohammed A. Alghamdi, Doaa Alasmari, Amjad Assiri, Ehab H. Mattar, Abdullah A. Aljaddawi, Sana Ghazi Alattas, Elrashdy M Moustafa Mohamed Redwan · 2019 · Journal of Immunology Research
- Human mononuclear phagocyte system reunitedMuzlifah A. Haniffa, Venetia Bigley, Matthew P. Collin · 2015 · Seminars in Cell and Developmental Biology
- Treatment of a genetic brain disease by CNS-wide microglia replacementYohei Shibuya, Kevin K. Kumar, Marius Marc-Daniel Mader, Yongjin Yoo, L Angel Ayala, Mu Zhou, Manuel Alexander Mohr, Gernot Neumayer, Ishan Kumar, Ryō Yamamoto et al. · 2022 · Science Translational Medicine
- Myocardial infarction: a critical role of macrophages in cardiac remodelingTobias Weinberger, Christian Schulz · 2015 · Frontiers in Physiology
- Microglia in development: linking brain wiring to brain environmentRosa Chiara Paolicelli, Cornelius Thilo Gross · 2011 · Neuron Glia Biology
- Differential contribution of microglia and monocytes in neurodegenerative diseasesCaroline Baufeld, Elaine K. O'Loughlin, Narghes Calcagno, Charlotte Madore, Oleg Butovsky · 2017 · Journal of Neural Transmission
- Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucomaYanying Miao, Guoli Zhao, Shuo Cheng, Zhongfeng Wang, Xiong-Li Yang · 2023 · Progress in Retinal and Eye Research
- Microglia at the blood brain barrier in health and diseaseMeredith G. Mayer, Tracy Fischer · 2024 · Frontiers in Cellular Neuroscience
- CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organNegi, Neema, Das, Bimal K. · 2018 · International Reviews of Immunology
- Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brainColes, Jonathan A., Myburgh, Elmarie, Brewer, James M., McMenamin, Paul G. · 2017 · Progress in Neurobiology
- Microglial diversity by responses and respondersGertig, Ulla, Hanisch, Uwe-Karsten · 2014 · Frontiers in Cellular Neuroscience
- A Hitchhiker’s Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification SystemMartin Guilliams, Lianne van de Laar · 2015 · Frontiers in Immunology
- A deficiency in CCR2+ monocytes: the hidden side of Alzheimer’s diseaseNaert, Gaëlle, Rivest, Serge · 2013 · Journal of Molecular Cell Biology
- Microglia and Neonatal Brain InjuryCarina E. Mallard, Marie‐Ève Tremblay, Zinaida S. Vexler · 2018 · Neuroscience
- Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug moleculesSeetha Harilal, Jobin Jose, Della Grace Thomas Parambi, Rajesh Kumar, Mazhuvancherry Kesavan Unnikrishnan, Md. Sahab Uddin, Githa Elizabeth Mathew, Rahul Pratap, Akash Marathakam, Bijo Mathew · 2020 · Brain Research Bulletin
- Microglia in Alzheimer’s Disease in the Context of Tau PathologyJuan Ramón Perea, Marta Bolós, Jesús Ávila · 2020 · Biomolecules
- SARS-CoV-2 promotes microglial synapse elimination in human brain organoidsSamudyata Samudyata, Ana Osório Oliveira, Susmita Malwade, Nuno Rufino de Sousa, Sravan Kumar Goparaju, Jessica Gracias, Funda Orhan, Laura Steponaviciute, Martin Schalling, Steven D. Sheridan et al. · 2022 · Molecular Psychiatry
- The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditionsMartins-Ferreira, Ricardo, Calafell-Segura, Josep, Leal, Bárbara, Rodríguez-Ubreva, Javier, Martínez-Saez, Elena, Mereu, Elisabetta, Pinho E Costa, Paulo, Laguna, Ariadna, Ballestar, Esteban · 2025 · Nature Communications
- Microglia in prion diseasesAguzzi, Adriano, Zhu, Caihong · 2017 · Journal of Clinical Investigation
- Environment matters: microglia function and dysfunction in a changing worldHanamsagar, Richa, Bilbo, Staci D · 2017 · Current Opinion in Neurobiology
- TGF‐β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environmentAbutbul, Shai, Shapiro, Jenny, Szaingurten‐Solodkin, Irit, Levy, Nitzan, Carmy, Yaron, Baron, Rona, Jung, Steffen, Monsonego, Alon · 2012 · Glia
- Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survivalChiot, Aude, Zaïdi, Sakina, Iltis, Charlène, Ribon, Matthieu, Berriat, Félix, Schiaffino, Lorenzo, Jolly, Ariane, de la Grange, Pierre, Mallat, Michel, Bohl, Delphine et al. · 2020 · Nature Neuroscience
- Interferon regulatory factor 7 participates in the M 1‐like microglial polarization switchTatsuhide Tanaka, Koichi Murakami, Yoshio Bandô, Shigetaka Yoshida · 2014 · Glia
- Alveolar macrophages and type I IFN in airway homeostasis and immunityMaziar Divangahi, Irah L. King, Erwan Pernet · 2015 · Trends in Immunology
- Macrophages and Dendritic CellsMyron I. Cybulsky, Cheolho Cheong, Clinton S. Robbins · 2016 · Circulation Research
- The Role of Microglia in the Spread of Tau: Relevance for TauopathiesJuan Ramón Perea, María Llorens-Martín, Jesús Ávila, Marta Bolós · 2018 · Frontiers in Cellular Neuroscience
- Analysis of Myeloid Cells in Mouse Tissues with Flow CytometryZhaoyuan Liu, Yaqi Gu, Amanda Shin, Shuangyan Zhang, Florent Ginhoux · 2020 · STAR Protocols
- Microglia in neurodegenerative diseasesYu Xu, Ming-Zhu Jin, Zeyong Yang, Ming-Zhu Jin · 2020 · Neural Regeneration Research
- Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptorAmin Sherafat, Friederike Pfeiffer, Alexander Reiss, William M. Wood, Akiko Nishiyama · 2021 · Nature Communications
- Microglia-like Cells Promote Neuronal Functions in Cerebral OrganoidsIlkka Fagerlund, Antonios Dougalis, Anastasia Shakirzyanova, Mireia Gómez‐Budia, Anssi Pelkonen, Henna Konttinen, Sohvi Ohtonen, Mohammad Feroze Fazaludeen, Marja Koskuvi, Johanna Kuusisto et al. · 2021 · Cells
- Murine macrophage chemokine receptor CCR2 plays a crucial role in macrophage recruitment and regulated inflammation in wound healingAnna E. Boniakowski, Andrew Kimball, Amrita Joshi, Matt Schaller, Frank M. Davis, Aaron D. denDekker, Andrea T Obi, Bethany B. Moore, Steven L. Kunkel, Katherine Ann Gallagher · 2018 · European Journal of Immunology
- New perspectives on the origins and heterogeneity of mast cellsAshley L. St. John, Abhay P. S. Rathore, Florent Ginhoux · 2022 · Nature reviews. Immunology
- Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s diseaseMezö, Charlotte, Dokalis, Nikolaos, Mossad, Omar, Staszewski, Ori, Neuber, Jana, Yilmaz, Bahtiyar, Schnepf, Daniel, de Agüero, Mercedes Gomez, Ganal-Vonarburg, Stephanie C., Macpherson, Andrew J. et al. · 2020 · Acta Neuropathologica Communications
- The microglia in healthy and diseased retinaLi, Lu, Eter, Nicole, Heiduschka, Peter · 2015 · Experimental Eye Research
- Chemotherapy and tumor microenvironment of pancreatic cancerLiu, Qiaofei, Liao, Quan, Zhao, Yupei · 2017 · Cancer Cell International
- Langerhans cell origin and regulationCollin, Matthew, Milne, Paul · 2016 · Current Opinion in Hematology
- Role of Microglia in Autism: Recent AdvancesTomoyuki Takano · 2015 · Developmental Neuroscience
- Adult Neurogenesis Transiently Generates Oxidative StressNoah M. Walton, Rick S. Shin, Katsunori Tajinda, Carrie L Heusner, Jeffrey H. Kogan, Shinichi Miyake, Qian Chen, Kouichi Tamura, Mitsuyuki Matsumoto · 2012 · PLoS ONE
- Microglia depletion in early life programs persistent changes in social, mood-related, and locomotor behavior in male and female ratsLars H. Nelson, Kathryn M. Lenz · 2016 · Behavioural Brain Research
- Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environmentSang Hun Lee, Mélanie Charmoy, Audrey Romano, Andrea Paun, Mariana Martins Chaves, Frederick O. Cope, David A. Ralph, David L. Sacks · 2017 · The Journal of Experimental Medicine
- Leveraging preclinical models for the development of Alzheimer disease therapeuticsKimberly A. Scearce-Levie, Pascal E. Sanchez, Joseph W. Lewcock · 2020 · Nature Reviews Drug Discovery
- Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic originsFengming Liu, Shen Dai, Dechun Feng, Zhongnan Qin, Xiao Peng, Siva S. V. P. Sakamuri, Mi Ren, Li Huang, Min Cheng, Kabir E. Mohammad et al. · 2020 · Nature Communications
- The Role of Microglia in Modulating Neuroinflammation after Spinal Cord InjurySydney T. Brockie, James Hong, Michael George Fehlings · 2021 · International Journal of Molecular Sciences
- Advances in Biomaterial‐Based Spinal Cord Injury RepairHe Shen, Caixia Fan, Zhifeng You, Zhifeng Xiao, Yannan Zhao, Jianwu Dai · 2021 · Advanced Functional Materials
- Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)Chitu, Violeta, Gokhan, Solen, Gulinello, Maria, Branch, Craig A., Patil, Madhuvati, Basu, Ranu, Stoddart, Corrina, Mehler, Mark F., Stanley, E. Richard · 2015 · Neurobiology of Disease
- Microglia: A Central Player in DepressionDeng, Si-long, Chen, Jian-guo, Wang, Fang · 2020 · Current Medical Science
- Transcriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brainParakalan Rangarajan, Boran Jiang, Nimmi Baby, Janani Manivannan, Manikandan Jayapal, Jia Lu, Samuel Sam Wah Tay, Eng‐Ang Ling, Shaikali Thameem Dheen · 2012 · BMC Neuroscience
- Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in ZebrafishGiuliano Ferrero, Christopher B. Mahony, Eléonore Dupuis, Laurent Yvernogeau, Elodie Di Ruggiero, Magali Miserocchi, Marianne Caron, Catherine Robin, David J. Traver, Julien Y. Bertrand et al. · 2018 · Cell Reports
- Microglia: Brain cells on the moveSophie Smolders, Sofie Kessels, Tim Vangansewinkel, Jean‐Michel Rigo, Pascal Legendre, Bert Brône · 2019 · Progress in Neurobiology
- Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer’s Disease and Multiple SclerosisAdham Fani Maleki, Serge Rivest · 2019 · Frontiers in Cellular Neuroscience
- Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte systemKIM M. SUMMERS, Stephen J. Bush, David Arthur Hume · 2020 · PLoS Biology
- Niche-specific functional heterogeneity of intestinal resident macrophagesMaria Francesca Viola, Guy E. Boeckxstaens · 2020 · Gut
- Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillanceMcMenamin, Paul G., Saban, Daniel R., Dando, Samantha J. · 2019 · Progress in Retinal and Eye Research
- Convergence between microglia and peripheral macrophages phenotype during development and neuroinflammationGrassivaro, Francesca, Menon, Ramesh, Acquaviva, Massimo, Ottoboni, Linda, Ruffini, Francesca, Bergamaschi, Andrea, Muzio, Luca, Farina, Cinthia, Martino, Gianvito · 2020 · The Journal of Neuroscience
- Genetic targeting of microgliaPeter Wieghofer, Klaus‐Peter Knobeloch, Marco Prinz · 2014 · Glia
- Quantification of Entry Phenotypes of Macrophage-Tropic HIV-1 across a Wide Range of CD4 DensitiesSarah Joseph, Kathryn T. Arrildt, Adrienne E. Swanstrom, Gretja Schnell, Benhur Lee, James A. Hoxie, Ronald I. Swanstrom · 2013 · Journal of Virology
- Regulation of brain microglia by female gonadal steroidsHabib, Pardes, Beyer, Cordian · 2015 · The Journal of Steroid Biochemistry and Molecular Biology
- Aging enhances classical activation but mitigates alternative activation in the central nervous systemDaniel C. Lee, Claudia R. Ruiz, Lori A. Lebson, Maj‐Linda B. Selenica, Justin Rizer, Jerry B. Hunt, Rahil Rojiani, Patrick Reid, Sidharth Kammath, Kevin R. Nash et al. · 2013 · Neurobiology of Aging
- Inhomogeneous distribution of Iba‐1 characterizes microglial pathology in Alzheimer's diseaseJasmin Tischer, Martin Krueger, Wolf C. Mueller, Ori Staszewski, Marco Prinz, Wolfgang J. Streit, Ingo Bechmann · 2016 · Glia
- Salt, Hypertension, and ImmunityA. Justin Rucker, Nathan P. Rudemiller, Steven D. Crowley · 2017 · Annual Review of Physiology
- Studying tissue macrophages in vitro: are iPSC-derived cells the answer?Christopher Lee, Tatsuya Kozaki, Florent Ginhoux · 2018 · Nature reviews. Immunology
- Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic miceMichael Stefan Unger, P. Schernthaner, Julia Marschallinger, Heike Mrowetz, Ludwig Aigner · 2018 · Journal of Neuroinflammation
- Isolation and Culture of MicrogliaChristopher J. Bohlen, F. Chris Bennett, Mariko L. Bennett · 2018 · Current Protocols in Immunology
- The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic reviewHossein Bagheri, Faezeh Ghasemi, George Emilio Barreto, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar · 2019 · BioFactors
- The role of tumor-associated macrophages in osteosarcoma progression – therapeutic implicationsHuang, Qingshan, Liang, Xin, Ren, Tingting, Huang, Yi, Zhang, Hongliang, Yu, Yiyang, Chen, Chenglong, Wang, Wei, Niu, Jianfang, Lou, Jingbing et al. · 2021 · Cellular Oncology
- Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and GlaucomaToth, Reka P., Atkin, Julie D. · 2018 · Frontiers in Immunology
- Aging microgliaAntignano, Ignazio, Liu, Yingxiao, Offermann, Nina, Capasso, Melania · 2023 · Cellular and Molecular Life Sciences
- Origin, development, and homeostasis of tissue‐resident macrophagesMalay Haldar, KENNETH M. M. MURPHY · 2014 · Immunological Reviews
- Temporal Characterization of Microglia/Macrophage Phenotypes in a Mouse Model of Neonatal Hypoxic-Ischemic Brain InjuryNina Hellström Erkenstam, Peter L. P. Smith, Bobbi Fleiss, Syam Nair, Pernilla Svedin, Wei Wang, Martina Boström, Pierre Gressèns, Henrik Hagberg, Kelly L. Brown et al. · 2016 · Frontiers in Cellular Neuroscience