Cited by 465Neural dynamics and brain functionMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Theta Phase Segregation of Input-Specific Gamma Patterns in Entorhinal-Hippocampal Networks

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Schomburg, Erik W., Fernández-Ruiz, Antonio, Mizuseki, Kenji, Berényi, Antal, Anastassiou, Costas A., Koch, Christof, Buzsáki, György·2014·Neuron

Abstract

Precisely how rhythms support neuronal communication remains obscure. We investigated interregional coordination of gamma oscillations using high-density electrophysiological recordings in the rat hippocampus and entorhinal cortex. We found that 30-80 Hz gamma dominated CA1 local field potentials (LFPs) on the descending phase of CA1 theta waves during navigation, with 60-120 Hz gamma at the theta peak. These signals corresponded to CA3 and entorhinal input, respectively. Above 50 Hz, interregional phase-synchronization of principal cell spikes occurred mostly for LFPs in the axonal target domain. CA1 pyramidal cells were phase-locked mainly to fast gamma (>100 Hz) LFP patterns restricted to CA1, which were strongest at the theta trough. While theta phase coordination of spiking across entorhinal-hippocampal regions depended on memory demands, LFP gamma patterns below 100 Hz in the hippocampus were consistently layer specific and largely reflected afferent activity. Gamma synchronization as a mechanism for interregional communication thus rapidly loses efficacy at higher frequencies.

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Authors
Schomburg, E. W., Fernández-Ruiz, A., Mizuseki, K., Berényi, A., Anastassiou, C. A., Koch, C., & Buzsáki, G.
Affiliations
  • California Institute of Technology (US)
  • Allen Institute for Brain Science (US)
  • University of Szeged (HU)
  • New York University (US)
Corresponding author
Buzsáki, György
Venue
Neuron
Publisher
Elsevier BV
Published
2014-10
Volume
84
Issue
2
Pages
470-485
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2170430044
Cited by
465
References
110
Citations by year
2026: 22 · 2025: 48 · 2024: 30 · 2023: 40 · 2022: 40 · 2021: 42 · 2020: 42 · 2019: 53 · 2018: 33 · 2017: 34 · 2016: 54 · 2015: 21 · 2014: 3
FWCI
20.82
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders
  • National Institute of Mental Health (R01MH054671, R01MH102840, MH54671)
  • National Institute of Neurological Disorders and Stroke (NS074015, R01NS034994, R01NS074015, NS-34994)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
gamma oscillations, theta oscillations, entorhinal cortex, hippocampus, CA1, CA3, local field potentials, phase synchronization, interregional communication, memory demand, navigation, afferent input
MeSH terms
Action Potentials, Animals, Hippocampus, Interneurons, Male, Models, Neurological, Theta Rhythm, Pyramidal Cells, Entorhinal Cortex, Rats, Long-Evans, Gamma Rhythm

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