Mouse Social Network Dynamics and Community Structure are Associated with Plasticity-Related Brain Gene Expression
Open accessAbstract
Laboratory studies of social behavior have typically focused on dyadic interactions occurring within a limited spatiotemporal context. However, this strategy prevents analyses of the dynamics of group social behavior and constrains identification of the biological pathways mediating individual differences in behavior. In the current study, we aimed to identify the spatiotemporal dynamics and hierarchical organization of a large social network of male mice. We also sought to determine if standard assays of social and exploratory behavior are predictive of social behavior in this social network and whether individual network position was associated with the mRNA expression of two plasticity-related genes, DNA methyltransferase 1 and 3a. Mice were observed to form a hierarchically organized social network and self-organized into two separate social network communities. Members of both communities exhibited distinct patterns of socio-spatial organization within the vivaria that was not limited to only agonistic interactions. We further established that exploratory and social behaviors in standard behavioral assays conducted prior to placing the mice into the large group was predictive of initial network position and behavior but were not associated with final social network position. Finally, we determined that social network position is associated with variation in mRNA levels of two neural plasticity genes, DNMT1 and DNMT3a, in the hippocampus but not the mPOA. This work demonstrates the importance of understanding the role of social context and complex social dynamics in determining the relationship between individual differences in social behavior and brain gene expression.
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In the laboratory, mice are more often than rats kept in large groups (more than 10 animals), which facilitates studying high-order social behaviors such as emergence of social networks.
“Finally, in the laboratory, mice are more often than rats kept in large groups (ie, more than 10 animals), which facilitates studying high-order social behaviors which cannot be reduced to interactions within dyads, for example, emergence of social networks.1,2,72”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [72]
Social dominance can be reliably found in mice kept in captivity, both laboratory mice and wild ones.
“Keeping this limitation in mind, social dominance can be reliably found in mice kept in captivity.This is true both for laboratory mice 72,92,96,135,136 and wild ones.80,137”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [72]
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Chen, X., Winiarski, M., Puścian, A., Knapska, E., Mora, T., & Walczak, A. M. (2025) · eLife · doi:10.7554/elife.94999.2
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- Authors
- Williamson, C. M., Franks, B., & Curley, J. P.
- Affiliations
- Columbia University (US)
- University of British Columbia (CA)
- Corresponding author
- Curley, James P.
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2016-08-04
- Volume
- 10
- Pages
- 152-152
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC4972826
- OpenAlex
- W2475757115
- Cited by
- 64
- References
- 107
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 11 · 2020: 5 · 2019: 4 · 2018: 9 · 2017: 3
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Columbia Academic Commons (Columbia University)
- Funders
- National Science Foundation (2016203784)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- social network dynamics, community structure, social hierarchy, network position, exploratory behavior, social behavior, DNMT1, DNMT3A, neuroplasticity, hippocampus, medial preoptic area, gene expression, male mice
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