Cited by 875Resilience and Mental HealthPosttraumatic Stress Disorder ResearchStress Responses and Cortisol

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The Science of Resilience: Implications for the Prevention and Treatment of Depression

Southwick, Steven M., Charney, Dennis S.·2012·Science

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Abstract

Human responses to stress and trauma vary widely. Some people develop trauma-related psychological disorders, such as posttraumatic stress disorder (PTSD) and depression; others develop mild to moderate psychological symptoms that resolve rapidly; still others report no new psychological symptoms in response to traumatic stress. Individual variability in how animals and humans respond to stress and trauma depends on numerous genetic, developmental, cognitive, psychological, and neurobiological risk and protective factors.

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Mecha, P., Martín-García, Ó., Blanco, I., & Sánchez-López, Á. (2026) · Cognitive Therapy and Research · doi:10.1007/s10608-026-10786-3
Psychological Adaptation During Prolonged War‐Related Stress in Ukraine: A Narrative Review
Nekrasova, N. O., Solovyova, Y., Butov, D., Uwishema, O., & Kauk, O. I. (2026) · Health Science Reports · doi:10.1002/hsr2.73284
“…rumination, helplessness, and externally focused control beliefs are associated with poorer psychological adaptation, whereas self‐compassion, meaning‐making, and response‐focused agency are more consistently associated with adaptive functioning [9, 10, 12, 13, 15–17, 19–22, 33–36, 46, 47].”
Association of Taiyin personality traits with sleep quality among college students: parallel indirect effects through resilience and rumination
Pan, G., Zhang, R., Wang, X., Zhai, Y., Wang, A., & Zhu, H. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2026.1854838
“As one such personality trait, psychological resilience can regulate the levels of stress hormones like cortisol, consequently reducing emotional volatility (Southwick and Charney, 2012).”
Adaptive regulation over adversity: Noradrenergic scaling and psychological resources differentiate attentional performance
Fabar, C., Bosch, T., Gerin, M. I., Cholakis, F., Carrasco, X., Aguirre, R., Aboitiz, F., & Ossandón, T. (2026) · Acta Psychologica · doi:10.1016/j.actpsy.2026.107939

Authors: Southwick, S. M., & Charney, D. S.
Affiliations: United States Department of Veterans Affairs (US)
Mount Sinai Hospital (US)
Corresponding author: Charney, Dennis S.
ORCID: Southwick, Steven M.
Charney, Dennis S.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2012-10-05
Volume: 338
Issue: 6103
Pages: 79-82
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1222942
OpenAlex: W1996620918
Cited by: 875
References: 19
Citations by year: 2026: 40 · 2025: 86 · 2024: 90 · 2023: 62 · 2022: 95 · 2021: 78 · 2020: 73 · 2019: 79 · 2018: 57 · 2017: 51 · 2016: 45 · 2015: 45 · 2014: 38 · 2013: 28 · 2012: 2
FWCI: 41.03
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: resilience, depression, depression prevention, depression treatment, stress response, trauma, post-traumatic stress disorder, interindividual variability, risk and protective factors, genetic factors, neurobiology of stress
MeSH terms: Animals, Depressive Disorder, Humans, Stress Disorders, Post-Traumatic, Resilience, Psychological

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The Science of Resilience: Implications for the Prevention and Treatment of Depression

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