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Generation and Analysis of Interleukin-4 Deficient Mice
Abstract
Interleukin-4 (IL-4) promotes the growth and differentiation of many hematopoietic cells in vitro; in particular, it directs the immunoglobulin (Ig) class switch to IgG1 and IgE. Mice homozygous for a mutation that inactivates the IL-4 gene were generated to test the requirement for IL-4 in vivo. In the mutant mice T and B cell development was normal, but the serum levels of IgG1 and IgE were strongly reduced. The IgG1 dominance in a T cell-dependent immune response was lost, and IgE was not detectable upon nematode infection. Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo.
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Metadata
- Authors
- Kühn, R., Rajewsky, K., & Müller, W.
- Venue
- Science
- Published
- 1991-11
- Volume
- 254
- Issue
- 5032
- Pages
- 707-710
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997531619
- Cited by
- 1,248
- References
- 0
- FWCI
- 28.68
- Type
- journal article
- Language
- en
- Open access
- closed
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