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Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction
Abstract
The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-β (TGF-β). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-β and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-β superfamily members.
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Metadata
- Authors
- Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T., Nishida, E., & Matsumoto, K.
- Venue
- Science
- Published
- 1995-12-22
- Volume
- 270
- Issue
- 5244
- Pages
- 2008-2011
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005792688
- Cited by
- 1,343
- References
- 1
- FWCI
- 19.30
- Type
- journal article
- Language
- en
- Open access
- closed
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