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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

Open access
Feng, Yu, Broder, Christopher C., Kennedy, Paul E., Berger, Edward A.·1996·Science

Abstract

A cofactor for HIV-1 (human immunodeficiency virus-type 1) fusion and entry was identified with the use of a novel functional complementary DNA (cDNA) cloning strategy. This protein, designated “fusin,” is a putative G protein-coupled receptor with seven transmembrane segments. Recombinant fusin enabled CD4-expressing nonhuman cell types to support HIV-1 Env-mediated cell fusion and HIV-1 infection. Antibodies to fusin blocked cell fusion and infection with normal CD4-positive human target cells. Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophage-tropic HIV-1 isolates.

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Crossref · 10.1126/science.272.5263.872

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Metadata

Authors
Feng, Y., Broder, C. C., Kennedy, P. E., & Berger, E. A.
Venue
Science
Published
1996-05-10
Volume
272
Issue
5263
Pages
872-877
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W82820957
Cited by
4,172
References
0
FWCI
110.35
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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