The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains
Abstract
Although dispensable, costimulation through CD28 facilitates activation of naı̈ve T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down-regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.
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Citations
Cites
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Metadata
- Authors
- Viola, A., Schroeder, S., Sakakibara, Y., & Lanzavecchia, A.
- Venue
- Science
- Published
- 1999-01-29
- Volume
- 283
- Issue
- 5402
- Pages
- 680-682
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072122733
- Cited by
- 938
- References
- 1
- FWCI
- 40.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
