Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways

Protective and pathogenic functions of macrophage subsets

Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269 · see citing works

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248 · see citing works

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

Kawai, T., & Akira, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.006 · Cited by 3,658 · see citing works

Complement: a key system for immune surveillance and homeostasis

Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · see citing works

The regulation of IL-10 production by immune cells

Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,185 · see citing works

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985 · see citing works

Nonresolving Inflammation

Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183 · see citing works

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008) · Nature · doi:10.1038/nature07383 · Cited by 2,020 · see citing works

Crosstalk in NF-κB Signaling Pathways

Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942 · see citing works

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

Belkaid, Y., Piccirillo, C. A., Méndez, S., Shevach, E. M., & Sacks, D. L. (2002) · Nature · doi:10.1038/nature01152 · Cited by 1,726 · see citing works

Negative regulation of Toll-like receptor-mediated immune responses

Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509 · see citing works

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483 · see citing works

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,464 · see citing works

The IL-1 family: regulators of immunity

Sims, J. E., & Smith, D. E. (2010) · Nature reviews. Immunology · doi:10.1038/nri2691 · Cited by 1,416 · see citing works

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409 · see citing works

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367 · see citing works

Gene-specific control of inflammation by TLR-induced chromatin modifications

Foster, S. L., Hargreaves, D. C., & Medzhitov, R. (2007) · Nature · doi:10.1038/nature05836 · Cited by 1,344 · see citing works

Endotoxin tolerance: new mechanisms, molecules and clinical significance

Biswas, S. K., & Lopez-Collazo, E. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.009 · Cited by 1,318 · see citing works

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling

Kobayashi, K. S., Hernandez, L. D., Galán, J. E., Janeway, C. A., Medzhitov, R. M., & Flavell, R. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00827-9 · Cited by 1,289 · see citing works

Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation

Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., et al. (2010) · Blood · doi:10.1182/blood-2009-10-249540 · Cited by 1,246 · see citing works

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils

Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80005-9 · Cited by 1,220 · see citing works

The JAK-STAT Signaling Pathway: Input and Output Integration

Murray, P. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2623 · Cited by 1,179 · see citing works

Immunomodulatory functions of type I interferons

González-Navajas, J. M., Lee, J., David, M., & Raz, E. (2012) · Nature reviews. Immunology · doi:10.1038/nri3133 · Cited by 1,003 · see citing works

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

Colotta, F., Re, F., Muzio, M., Bertini, R., Polentarutti, N., Sironi, M., Giri, J. G., Dower, S., Sims, J. E., & Mantovani, A. (1993) · Science · doi:10.1126/science.8332913 · Cited by 979 · see citing works

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Häcker, H., Redecke, V., Blagoev, B., Kratchmarova, I., Hsu, L.-C., Wang, G. G., Kamps, M. P., Raz, E., Wagner, H., Häcker, G. A., et al. (2005) · Nature · doi:10.1038/nature04369 · Cited by 962 · see citing works

microRNA Regulation of Inflammatory Responses

O’Connell, R. M., Rao, D. S., & Baltimore, D. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075013 · Cited by 957 · see citing works

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

Oganesyan, G., Saha, S. K., Guo, B., He, J. Q., Shahangian, A., Zarnegar, B. J., Perry, A. K., & Cheng, G. (2005) · Nature · doi:10.1038/nature04374 · Cited by 881 · see citing works

Cytokine Signaling Modules in Inflammatory Responses

O’Shea, J. J., & Murray, P. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.002 · Cited by 819 · see citing works

Antigen-presenting cell function in the tolerogenic liver environment

Thomson, A. W., & Knolle, P. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2858 · Cited by 804 · see citing works

Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4

Gilchrist, M., Thórsson, V., Li, B., Rust, A. G., Korb, M., Kennedy, K., Hai, T., Bolouri, H., & Aderem, A. A. (2006) · Nature · doi:10.1038/nature04768 · Cited by 796 · see citing works

The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response.

Alexander, W., & Hilton, D. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.091003.090312 · Cited by 774 · see citing works

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647 · see citing works

SOCS-1 Participates in Negative Regulation of LPS Responses

Nakagawa, R., Naka, T., Tsutsui, H., Fujimoto, M., Kimura, A., Abe, T., Seki, E., Sato, S., Takeuchi, O., Takeda, K., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00449-1 · Cited by 638 · see citing works

SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

Kinjyo, I., Hanada, T., Inagaki-Ohara, K., Mori, H., Aki, D., Ohishi, M., Yoshida, H., Kubo, M., & Yoshimura, A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00446-6 · Cited by 630 · see citing works

Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-10

Lang, R., Patel, D. H., Morris, J. J., Rutschman, R. L., & Murray, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2253 · Cited by 613 · see citing works

SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling

Wald, D. N., Qin, J., Zhao, Z., Qian, Y., Naramura, M., Tian, L., Towne, J. E., Sims, J. E., Stark, G. R., & Li, X. (2003) · Nature Immunology · doi:10.1038/ni968 · Cited by 606 · see citing works

Achieving Stability of Lipopolysaccharide-Induced NF-κB Activation

Covert, M. W., Leung, T., Gaston, J. E., & Baltimore, D. (2005) · Science · doi:10.1126/science.1112304 · Cited by 603 · see citing works

Negative Regulation of Toll-like Receptor-mediated Signaling by Tollip

Zhang, G., & Ghosh, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109537200 · Cited by 598 · see citing works

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

Ramirez-Carrozzi, V. R., Braas, D., Bhatt, D. M., Cheng, C. S., Hong, C., Doty, K. R., Black, J. C., Hoffmann, A., Carey, M., & Smale, S. T. (2009) · Cell · doi:10.1016/j.cell.2009.04.020 · Cited by 581 · see citing works

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

Chi, H., Barry, S. P., Flach, R. J. R., Wu, J. J., Jones, E. A., Bennett, A. M., & Flavell, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510965103 · Cited by 569 · see citing works

PI3K-mediated negative feedback regulation of IL-12 production in DCs

Fukao, T., Tanabe, M., Terauchi, Y., Ota, T., Matsuda, S., Asano, T., Kadowaki, T., Takeuchi, T., & Koyasu, S. (2002) · Nature Immunology · doi:10.1038/ni825 · Cited by 529 · see citing works

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

Mansell, A. S., Smith, R., Doyle, S., Gray, P., Fenner, J. E., Crack, P. J., Nicholson, S. E., Hilton, D. J., O'Neill, L. A. J., & Hertzog, P. J. (2006) · Nature Immunology · doi:10.1038/ni1299 · Cited by 513 · see citing works

Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity

Werner, S. L., Barken, D. M., & Hoffmann, A. (2005) · Science · doi:10.1126/science.1113319 · Cited by 506 · see citing works

Interactions between coagulation and complement—their role in inflammation

Οικονομοπούλου, Κ., Ricklin, D., Ward, P. A., & Lambris, J. D. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0280-x · Cited by 489 · see citing works

The human Mi-2/NuRD complex and gene regulation

Denslow, S. A., & Wade, P. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210611 · Cited by 479 · see citing works

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.Preprint

Beg, A. A., Sha, W. C., Bronson, R. T., & Baltimore, D. (1995) · Genes & Development · doi:10.1101/gad.9.22.2736 · Cited by 473 · see citing works

The role of IL-10 in immune regulation during M. tuberculosis infection

Redford, P. S., Murray, P. J., & O’Garra, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.7 · Cited by 472 · see citing works

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

Han, C., Jin, J., Xu, S., Liu, H., Li, N., & Cao, X. (2010) · Nature Immunology · doi:10.1038/ni.1908 · Cited by 458 · see citing works

Metabolic checkpoints in activated T cells

Wang, R., & Green, D. R. (2012) · Nature Immunology · doi:10.1038/ni.2386 · Cited by 457 · see citing works

Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response.Preprint

Ramirez-Carrozzi, V., Nazarian, A. A., Li, C.-Y. C., Gore, S., Sridharan, R., Imbalzano, A., & Smale, S. (2006) · Genes & Development · doi:10.1101/gad.1383206 · Cited by 456 · see citing works

Accessory molecules for Toll-like receptors and their function

Lee, C. C., Avalos, A. M., & Ploegh, H. L. (2012) · Nature reviews. Immunology · doi:10.1038/nri3151 · Cited by 440 · see citing works

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

McAuley, J., Lindén, S. K., Png, C. W., King, R. M., Pennington, H. L., Gendler, S. J., Florin, T. H., Hill, G. R., Korolik, V., & McGuckin, M. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26705 · Cited by 437 · see citing works

Reflex principles of immunological homeostasis

Andersson, U., & Tracey, K. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075015 · Cited by 414 · see citing works

Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105

Divanovic, S., Trompette, A., Atabani, S., Madan, R., Golenbock, D., Visintin, A., Finberg, R., Tarakhovsky, A., Vogel, S., Belkaid, Y., et al. (2005) · Nature Immunology · doi:10.1038/ni1198 · Cited by 407 · see citing works

Innate Response Activator B Cells Protect Against Microbial Sepsis

Rauch, P. J., Chudnovskiy, A., Robbins, C. S., Weber, G. F., Etzrodt, M., Hilgendorf, I., Tiglao, E., Figueiredo, J., Iwamoto, Y., Theurl, I., et al. (2012) · Science · doi:10.1126/science.1215173 · Cited by 407 · see citing works

Negative regulation of Toll-like-receptor signaling by IRF-4

Negishi, H., Ohba, Y., Yanai, H., Takaoka, A., Honma, K., Yui, K., Matsuyama, T., Taniguchi, T., & Honda, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508327102 · Cited by 403 · see citing works

The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription

Murray, P. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500419102 · Cited by 394 · see citing works

MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock

Zhao, Q., Wang, X., Nelin, L. D., Yao, Y., Matta, R., Manson, M. E., Baliga, R. S., Meng, X., Smith, C. V., Bauer, J. A., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051794 · Cited by 370 · see citing works

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

Casanova, J., Abel, L., & Quintana‐Murci, L. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101335 · Cited by 369 · see citing works

Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis

Rakoff-Nahoum, S., Hao, L., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.010 · Cited by 343 · see citing works

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

Ananieva, O., Darragh, J., Johansen, C., Carr, J. M., McIlrath, J. M., Park, J. M., Wingate, A. D., Monk, C. E., Toth, R. L., Santos, S. G., et al. (2008) · Nature Immunology · doi:10.1038/ni.1644 · Cited by 329 · see citing works

Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock

Hammer, M., Mages, J., Dietrich, H., Servatius, A., Howells, N., Cato, A. C. B., & Lang, R. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051753 · Cited by 327 · see citing works

Return to homeostasis: downregulation of NF-κB responses

Ruland, J. (2011) · Nature Immunology · doi:10.1038/ni.2055 · Cited by 321 · see citing works

Selective Transcription in Response to an Inflammatory Stimulus

Smale, S. T. (2010) · Cell · doi:10.1016/j.cell.2010.01.037 · Cited by 318 · see citing works

Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12

Hamerman, J. A., Tchao, N. K., Lowell, C. A., & Lanier, L. L. (2005) · Nature Immunology · doi:10.1038/ni1204 · Cited by 318 · see citing works

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

Schroder, K., Irvine, K. M., Taylor, M. S., Bokil, N. J., Cao, K. L., Masterman, K., Labzin, L. I., Semple, C. A. M., Kapétanovic, R., Fairbairn, L., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110156109 · Cited by 306 · see citing works

Regulation of interferon and Toll‐like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

Hu, X., Chakravarty, S. D., & Ivashkiv, L. B. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00707.x · Cited by 303 · see citing works

Beyond pattern recognition: five immune checkpoints for scaling the microbial threat

Blander, J. M., & Sander, L. E. (2012) · Nature reviews. Immunology · doi:10.1038/nri3167 · Cited by 286 · see citing works

Post-transcriptional regulons coordinate the initiation and resolution of inflammation

Anderson, P. (2009) · Nature reviews. Immunology · doi:10.1038/nri2685 · Cited by 285 · see citing works

Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling

Woo, C. W., Cui, D., Arellano, J., Dorweiler, B., Harding, H. P., Fitzgerald, K. A., Ron, D., & Tabas, I. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1996 · Cited by 281 · see citing works

Crosstalk pathways between Toll-like receptors and the complement system

Hajishengallis, G., & Lambris, J. D. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.002 · Cited by 277 · see citing works

Suppressor of Cytokine Signaling (SOCS) Proteins Indirectly Regulate Toll-like Receptor Signaling in Innate Immune Cells

Baetz, A., Frey, M., Heeg, K. M., & Dalpke, A. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410992200 · Cited by 270 · see citing works

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response

Ashida, H., Kim, M., Schmidt‐Supprian, M., Ma, A. I., Ogawa, M., & Sasakawa, C. (2009) · Nature Cell Biology · doi:10.1038/ncb2006 · Cited by 264 · see citing works

NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance

Liu, T. F., Yoza, B. K., Gazzar, M. E., Vachharajani, V., & McCall, C. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.196790 · Cited by 264 · see citing works

IL-10 Inhibits miR-155 Induction by Toll-like Receptors

McCoy, C. E., Sheedy, F. J., Qualls, J. E., Doyle, S., Quinn, S. R., Murray, P. J., & O'Neill, L. A. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.102111 · Cited by 256 · see citing works

Bcl-6 and NF-κB cistromes mediate opposing regulation of the innate immune responsePreprint

Barish, G. D., Yu, R. T., Karunasiri, M. S., Ocampo, C. B., Dixon, J. R., Benner, C. W., Dent, A. L., Tangirala, R. K., & Evans, R. M. (2010) · Genes & Development · doi:10.1101/gad.1998010 · Cited by 256 · see citing works

Immune dysregulation in TGF- beta 1-deficient mice.

Christ, M., McCartney-Francis, N. L., Kulkarni, A. B., Ward, J. M., Mizel, D. E., Mackall, C. L., Gress, R. E., Hines, K. L., Tian, H., Karlsson, S., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.5.1936 · Cited by 229 · see citing works

Interleukin-10 and Immunity against Prokaryotic and Eukaryotic Intracellular Pathogens

Cyktor, J. C., & Turner, J. (2011) · Infection and Immunity · doi:10.1128/iai.00047-11 · Cited by 227 · see citing works

General nature of the STAT3-activated anti-inflammatory response.

El Kasmi, K. C., Holst, J., Coffre, M., Mielke, L., de Pauw, A., Lhocine, N., Smith, A. M., Rutschman, R., Kaushal, D., Shen, Y., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7880 · Cited by 225 · see citing works

Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K

Conley, M. E., Dobbs, K., Quintana, A. M., Bosompem, A., Wang, Y., Coustan‐Smith, E., Smith, A. M., Pérez, E., & Murray, P. J. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112533 · Cited by 215 · see citing works

Negative Regulation of TLR-Signaling Pathways by Activating Transcription Factor-3

Whitmore, M., Iparraguirre, A., Kubelka, L., Weninger, W., Hai, T., & Williams, B. R. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3622 · Cited by 214 · see citing works

Cross-regulation of signaling by ITAM-associated receptors

Ivashkiv, L. B. (2009) · Nature Immunology · doi:10.1038/ni.1706 · Cited by 212 · see citing works

Gene-specific control of the TLR-induced inflammatory response

Foster, S. L., & Medzhitov, R. M. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.08.015 · Cited by 205 · see citing works

Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor α, cyclooxygenase 2, and inflammatory arthritis

Phillips, K., Kedersha, N., Shen, L., Blackshear, P. J., & Anderson, P. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400148101 · Cited by 199 · see citing works

Human genetics of infectious diseases: between proof of principle and paradigm

Alcaïs, A., Abel, L., & Casanova, J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38111 · Cited by 182 · see citing works

Cutting Edge: A Transcriptional Repressor and Corepressor Induced by the STAT3-Regulated Anti-Inflammatory Signaling Pathway

El Kasmi, K. C., Smith, A. M., Williams, L., Neale, G., Panopolous, A., Watowich, S. S., Häcker, H., Foxwell, B. M. J., & Murray, P. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7215 · Cited by 182 · see citing works

Tumor necrosis factor induces GSK3 kinase–mediated cross-tolerance to endotoxin in macrophages

Park, S. H., Park‐Min, K., Chen, J., Hu, X., & Ivashkiv, L. B. (2011) · Nature Immunology · doi:10.1038/ni.2043 · Cited by 176 · see citing works

The C5a Receptor Impairs IL-12–Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss

Liang, S., Krauss, J. L., Domon, H., McIntosh, M. L., Hosur, K. B., Qu, H., Li, F., Τζέκου, Α., Lambris, J. D., & Hajishengallis, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1003252 · Cited by 173 · see citing works

MUC1 Mucin Is a Negative Regulator of Toll-Like Receptor Signaling

Ueno, K., Koga, T., Kato, K., Golenbock, D. T., Gendler, S. J., Kai, H., & Kim, K. C. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0336rc · Cited by 172 · see citing works

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

Oshima, S., Turer, E. E., Callahan, J. A., Chai, S., Advincula, R., Barrera, J., Shifrin, N. T., Lee, B. L., Yen, B. C., Woo, T. T., et al. (2008) · Nature · doi:10.1038/nature07575 · Cited by 169 · see citing works

Inflammatory signaling in macrophages: Transitions from acute to tolerant and alternative activation states

Ivashkiv, L. B. (2011) · European Journal of Immunology · doi:10.1002/eji.201141783 · Cited by 161 · see citing works

TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils

Alagbala, A. A., Wang, Q., Cui, J., Zou, J., Xia, X., Wang, M., Tong, Y., Hui, W., Liu, D., Su, B., et al. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.010 · Cited by 159 · see citing works

IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling

Chen, J., & Ivashkiv, L. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007816107 · Cited by 154 · see citing works

Re-examination of the Role of Suppressor of Cytokine Signaling 1 (SOCS1) in the Regulation of Toll-like Receptor Signaling

Gingras, S., Parganas, E., Pauw, A. D., Ihle, J. N., & Murray, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411043200 · Cited by 148 · see citing works

Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum

Martinon, F., & Glimcher, L. H. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.10.016 · Cited by 144 · see citing works

IL-13Rα2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice

Wilson, M. S., Elnekave, E., Mentink-Kane, M. M., Hodges, M. G., Pesce, J. T., Ramalingam, T. R., Thompson, R. W., Kamanaka, M., Flavell, R. A., Keane-Myers, A., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31546 · Cited by 137 · see citing works

CD44 Is a Negative Regulator of Acute Pulmonary Inflammation and Lipopolysaccharide-TLR Signaling in Mouse Macrophages

Liang, J., Jiang, D., Griffith, J. W., Yu, S., Fan, J., Zhao, X., Bucala, R., & Noble, P. W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2469 · Cited by 137 · see citing works

Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages

Hutchins, A. P., Poulain, S., & Miranda‐Saavedra, D. (2012) · Blood · doi:10.1182/blood-2011-09-381483 · Cited by 134 · see citing works

Pig Bone Marrow-Derived Macrophages Resemble Human Macrophages in Their Response to Bacterial Lipopolysaccharide

Kapétanovic, R., Fairbairn, L., Beraldi, D., Sester, D. P., Archibald, A. L., Tuggle, C. K., & Hume, D. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102649 · Cited by 123 · see citing works

Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis

Yiakouvaki, A., Dimitriou, M., Karakasiliοtis, I., Eftychi, C., Theocharis, S., & Kontoyiannis, D. L. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45021 · Cited by 123 · see citing works

Cytokines, virokines and the evolution of immunity

Dower, S. (2000) · Nature Immunology · doi:10.1038/80799 · Cited by 120 · see citing works

Autophagy in regulation of Toll-like receptor signaling

Into, T., Inomata, M., Takayama, E., & Takigawa, T. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.020 · Cited by 119 · see citing works

NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity

Kobayashi, T., Matsuoka, K., Sheikh, S. Z., Elloumi, H. Z., Kamada, N., Hisamatsu, T., Hansen, J. J., Doty, K. R., Pope, S. D., Smale, S. T., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003888 · Cited by 118 · see citing works

IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages

Smallie, T., Ricchetti, G., Horwood, N. J., Feldmann, M., Clark, A. R., & Williams, L. M. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100414 · Cited by 117 · see citing works

Interleukin-10 Inhibits Interleukin-12 p40 Gene Transcription by Targeting a Late Event in the Activation Pathway

Zhou, L., Nazarian, A. A., & Smale, S. T. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2385-2396.2004 · Cited by 113 · see citing works

A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease

Zhou, J., Wu, R., High, A. A., Slaughter, C. A., Finkelstein, D., Rehg, J. E., Redecke, V., & Häcker, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106232108 · Cited by 111 · see citing works

Tristetraprolin‐driven regulatory circuit controls quality and timing of mRNA decay in inflammation

Kratochvill, F., Machacek, C., Vogl, C., Ebner, F., Sedlyarov, V., Gruber, A. R., Hartweger, H., Vielnascher, R. M., Karaghiosoff, M., Rülicke, T., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.93 · Cited by 111 · see citing works

Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes

Colotta, F., Saccani, S., Giri, J. G., Dower, S., Sims, J. E., Introna, M., & Mantovani, A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.7.2534 · Cited by 108 · see citing works

Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids

Chinenov, Y. V., Gupte, R., Dobrovolná, J., Flammer, J. R., Liu, B., Michelassi, F. E., & Rogatsky, I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206059109 · Cited by 106 · see citing works

Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-10

Schaljo, B., Kratochvill, F., Gratz, N., Sadzak, I., Sauer, I., Hammer, M., Vogl, C., Strobl, B., Müller, M. M., Blackshear, P. J., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803883 · Cited by 101 · see citing works

Shigella

Marteyn, B., Gazi, A. D., & Sansonetti, P. J. (2012) · Gut Microbes · doi:10.4161/gmic.19325 · Cited by 101 · see citing works

Integration of cytokine and heterologous receptor signaling pathways

Bezbradica, J. S., & Medzhitov, R. M. (2009) · Nature Immunology · doi:10.1038/ni.1713 · Cited by 96 · see citing works

Tumor suppressor CYLD: negative regulation of NF-κB signaling and more

Courtois, G. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7465-4 · Cited by 81 · see citing works

Negative regulation of Toll‐like receptor signaling plays an essential role in homeostasis of the intestine

Biswas, A., Wilmanski, J., Forsman, H. F., Hrnčíř, T., Hao, L., Tlaskalová-Hogenová, H., & Kobayashi, K. S. (2010) · European Journal of Immunology · doi:10.1002/eji.201040479 · Cited by 78 · see citing works

A Distal Enhancer in Il12b Is the Target of Transcriptional Repression by the STAT3 Pathway and Requires the Basic Leucine Zipper (B-ZIP) Protein NFIL3

Smith, A. M., Qualls, J. E., O’Brien, K., Balouzian, L., Johnson, P. F., Schultz‐Cherry, S., Smale, S. T., & Murray, P. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.249235 · Cited by 75 · see citing works

Interpreting mixed signals: the cell's cytokine conundrum

Delgoffe, G. M., Murray, P. J., & Vignali, D. A. A. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.013 · Cited by 66 · see citing works

Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice

Yanada, M., Kojima, T., Ishiguro, K., Nakayama, Y., Yamamoto, K., Matsushita, T., Kadomatsu, K., Nishimura, M., Muramatsu, T., & Saito, H. (2002) · Blood · doi:10.1182/blood.v99.7.2455 · Cited by 56 · see citing works

An Inducible Enhancer Required forIl12bPromoter Activity in an Insulated Chromatin Environment

Zhou, L., Nazarian, A. A., Xu, J., Tantin, D. R., Corcoran, L. M., & Smale, S. T. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00788-06 · Cited by 48 · see citing works

MARCKS as a Negative Regulator of Lipopolysaccharide Signaling

Manček‐Keber, M., Benčina, M., Japelj, B., Panter, G., Andrä, J., Brandenburg, K., Triantafilou, M., Triantafilou, K., & Jerala, R. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1003605 · Cited by 24 · see citing works

Regulation of pattern recognition receptor signalling in plants

Couto, D., & Zipfel, C. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.77 · Cited by 1,400 · see citing works

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

Carpenter, S. B., Aiello, D. A., Atianand, M., Ricci, E. P., Gandhi, P., Hall, L. L., Byron, M., Monks, B. G., Henry-Bezy, M., Lawrence, J. B., et al. (2013) · Science · doi:10.1126/science.1240925 · Cited by 946 · see citing works

Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor

Wu, J.-Y., Huang, T., Hsieh, Y.-T., Wang, Y., Yen, C.-C., Lee, G.-L., Yeh, C., Peng, Y., Kuo, Y.-Y., Wen, H.-T., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.023 · Cited by 542 · see citing works

Toll-like receptors: Activation, signalling and transcriptional modulation

Nardo, D. D. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.025 · Cited by 459 · see citing works

The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges

Hutchins, A. P., Díez, D., & Miranda‐Saavedra, D. (2013) · Briefings in Functional Genomics · doi:10.1093/bfgp/elt028 · Cited by 419 · see citing works

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

Banchereau, J., Pascual, V., & O’Garra, A. (2012) · Nature Immunology · doi:10.1038/ni.2406 · Cited by 401 · see citing works

Contribution of metabolic reprogramming to macrophage plasticity and function

Kasmi, K. C. E., & Stenmark, K. R. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.09.001 · Cited by 276 · see citing works

Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease

Golpich, M., Amini, E., Hemmati, F., Ibrahim, N. M., Rahmani, B., Mohamed, Z., Raymond, A. A., Dargahi, L., Ghasemi, R., & Ahmadiani, A. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.03.010 · Cited by 276 · see citing works

The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation

Du, M., Yuan, L., Tan, X., Huang, D., Wang, X., Zheng, Z., Mao, X., Li, X., Yang, L., Huang, K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02229-1 · Cited by 264 · see citing works

The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection

Harding, A. T., & Heaton, N. S. (2022) · Cancers · doi:10.3390/cancers14040909 · Cited by 261 · see citing works

Exacerbated and prolonged inflammation impairs wound healing and increases scarring

Qian, L., Fourcaudot, A. B., Yamane, K., You, T., Chan, R. K., & Leung, K. P. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12381 · Cited by 197 · see citing works

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

Rajbhandari, P., Thomas, B. J., Feng, A., Hong, C., Wang, J., Vergnes, L., Sallam, T., Wang, B., Sandhu, J., Seldin, M. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.019 · Cited by 190 · see citing works

Roles of Macrophages in the Development and Treatment of Gut Inflammation

Han, X., Ding, S., Jiang, H., & Liu, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.625423 · Cited by 187 · see citing works

TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients

Hossain, D. M. S., Pal, S. K., Moreira, D., Duttagupta, P. A., Zhang, Q., Won, H., Jones, J. O., D’Apuzzo, M., Forman, S. J., & Kortylewski, M. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3145 · Cited by 189 · see citing works

Circulating inflamma-miRs in aging and age-related diseases

Olivieri, F., Rippo, M. R., Procopio, A. D., & Fazioli, F. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00121 · Cited by 179 · see citing works

Anti‐inflammatory cytokines and risk of type 2 diabetes

Herder, C., Carstensen, M., & Ouwens, D. M. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12155 · Cited by 171 · see citing works

Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease

Hoang, L. T., Shimizu, C., Ling, L., Naim, A. N. M., Khor, C. C., Tremoulet, A. H., Wright, V. J., Levin, M., Hibberd, M. L., & Burns, J. C. (2014) · Genome Medicine · doi:10.1186/s13073-014-0102-6 · Cited by 167 · see citing works

The price of immunity

Goldszmid, R. S., & Trinchieri, G. (2012) · Nature Immunology · doi:10.1038/ni.2422 · Cited by 164 · see citing works

Lipopolysaccharide: Basic Biochemistry, Intracellular Signaling, and Physiological Impacts in the Gut

Rhee, S. H. (2014) · Intestinal Research · doi:10.5217/ir.2014.12.2.90 · Cited by 162 · see citing works

Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway

Ng, W. L., Marinov, G. K., Liau, E. S., Lam, Y. L., Lim, Y., & Ea, C.-K. (2016) · RNA Biology · doi:10.1080/15476286.2016.1207036 · Cited by 155 · see citing works

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation

Kang, K., Bachu, M., Park, S. H., Kang, K., Bae, S., Park‐Min, K., & Ivashkiv, L. B. (2019) · Nature Communications · doi:10.1038/s41467-019-11147-3 · Cited by 139 · see citing works

Toll like receptor signaling in “inflammaging”: microRNA as new players

Olivieri, F., Rippo, M. R., Prattichizzo, F., Babini, L., Graciotti, L., Recchioni, R., & Procopio, A. D. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-11 · Cited by 137 · see citing works

miR-27a regulates inflammatory response of macrophages by targeting IL-10

Xie, N., Cui, H., Banerjee, S., Tan, Z., Salomao, R., Fu, M., Abraham, E., Thannickal, V. J., & Liu, G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400203 · Cited by 120 · see citing works

A critical role for interleukin-1β in the progression of autoimmune diseases

Zhao, R., Zhou, H., & Su, S. B. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.08.012 · Cited by 123 · see citing works

STAT3 in Tumor-Associated Myeloid Cells: Multitasking to Disrupt Immunity

Su, Y., Banerjee, S., White, S. V., & Kortylewski, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061803 · Cited by 123 · see citing works

miRNA-124 in Immune System and Immune Disorders

Qin, Z., Wang, P., Su, D., & Liu, X. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00406 · Cited by 116 · see citing works

Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis

Gao, M., Tang, M., Ho, W., Teng, Y., Chen, Q., Bu, L., Xu, X., & Zhang, X. (2023) · ACS Nano · doi:10.1021/acsnano.3c00958 · Cited by 106 · see citing works

Long non-coding RNAs in innate and adaptive immunity

Aune, T. M., & Spurlock, C. F. (2015) · Virus Research · doi:10.1016/j.virusres.2015.07.003 · Cited by 103 · see citing works

Essential role of IL-10/STAT3 in chronic stress-induced immune suppression

Hu, D., Wan, L., Chen, M., Caudle, Y., LeSage, G., Li, Q., & Yin, D. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.016 · Cited by 97 · see citing works

The vaccine adjuvant alum promotes IL‐10 production that suppresses Th1 responses

Oleszycka, E., McCluskey, S., Sharp, F. A., Muñoz‐Wolf, N., Hams, E., Gorman, A. L., Fallon, P. G., & Lavelle, E. C. (2018) · European Journal of Immunology · doi:10.1002/eji.201747150 · Cited by 95 · see citing works

Pristane-induced lupus: considerations on this experimental model

Freitas, E. C., de Oliveira, M. S., & Monticielo, O. A. (2017) · Clinical Rheumatology · doi:10.1007/s10067-017-3811-6 · Cited by 93 · see citing works

Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis

Mahajan, S., Saini, A., Chandra, V., Nanduri, R., Kalra, R., Bhagyaraj, E., Khatri, N., & Gupta, P. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.638064 · Cited by 90 · see citing works

Maintaining system homeostasis: the third law of Newtonian immunology

Germain, R. N. (2012) · Nature Immunology · doi:10.1038/ni.2404 · Cited by 88 · see citing works

TLR9 Signaling in the Tumor Microenvironment Initiates Cancer Recurrence after Radiotherapy

Gao, C., Kozłowska, A. K., Nechaev, S., Li, H., Zhang, Q., Hossain, D. M. S., Kowolik, C. M., Chu, P. G., Swiderski, P. M., Diamond, D. J., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1314 · Cited by 88 · see citing works

Limiting of the Innate Immune Response by SF3A-Dependent Control of MyD88 Alternative mRNA Splicing

Arras, L. D., & Alper, S. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003855 · Cited by 84 · see citing works

Lactobacillus paracasei modulates LPS-induced inflammatory cytokine release by monocyte-macrophages via the up-regulation of negative regulators of NF-kappaB signaling in a TLR2-dependent manner

Sun, K., Xu, D., Xie, C., Plummer, S., Tang, J. Z., Yang, X. F., & Ji, X. H. (2017) · Cytokine · doi:10.1016/j.cyto.2017.01.003 · Cited by 85 · see citing works

Toll-like receptor 2 in host defense against Mycobacterium tuberculosis: to be or not to be — that is the question

Gopalakrishnan, A., & Salgame, P. R. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.06.003 · Cited by 85 · see citing works

Zinc finger protein ZBTB20 promotes toll-like receptor-triggered innate immune responses by repressing IκBα gene transcription

Liu, X., Zhang, P., Bao, Y., Han, Y., Wang, Y., Zhang, Q., Zhan, Z., Meng, J., Li, Y., Li, N., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301257110 · Cited by 80 · see citing works

Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus

Zhuang, H., Han, S., Lee, P. Y., Khaybullin, R. N., Shumyak, S. P., Lu, L., Chatha, A., Afaneh, A. B., Zhang, Y., Xie, C., et al. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40077 · Cited by 78 · see citing works

Cerebrospinal fluid and serum cytokine profiling to detect immune control of infectious and inflammatory neurological and psychiatric diseases

Maxeiner, H., Schneider, E. M., Kurfiss, S.-T., Brettschneider, J., Tumani, H., & Bechter, K. (2014) · Cytokine · doi:10.1016/j.cyto.2014.05.008 · Cited by 78 · see citing works

MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

Bae, S., Park, P. S. U., Lee, Y., Mun, S. H., Γιαννοπούλου, Ε., Fujii, T., Lee, K. P., Violante, S. N., Cross, J. R., & Park‐Min, K. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109264 · Cited by 79 · see citing works

Airway structural cells regulate TLR5-mediated mucosal adjuvant activity

Maele, L. V., Fougeron, D., Janot, L., Didierlaurent, A., Cayet, D., Tabareau, J., Rumbo, M., Corvo-Chamaillard, S., Boulenouar, S., Jeffs, S., et al. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.66 · Cited by 78 · see citing works

IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms

Mishra, B., Bachu, M., Yuan, R., Wingert, C. K., Chaudhary, V., Brauner, C., Bell, R. D., & Ivashkiv, L. B. (2025) · Nature Immunology · doi:10.1038/s41590-025-02137-3 · Cited by 80 · see citing works

MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response

Yu, L., Fang, F., Dai, X. J., Xu, H., Qi, X., Fang, M., & Xu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-00301-w · Cited by 71 · see citing works

Macrophages employ quorum licensing to regulate collective activation

Muldoon, J. J., Chuang, Y., Bagheri, N., & Leonard, J. N. (2020) · Nature Communications · doi:10.1038/s41467-020-14547-y · Cited by 68 · see citing works

Glycogen synthase kinase 3 is part of the molecular machinery regulating the adaptive response to LPS stimulation in microglial cells

Ajmone‐Cat, M. A., D’Urso, M. C., di Blasio, G., Brignone, M. S., Simone, R. D., & Minghetti, L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.11.012 · Cited by 70 · see citing works

Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts

Crowley, T., O’Neil, J. D., Adams, H., Thomas, A. M. C., Filer, A. D., Buckley, C. D., & Clark, A. R. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1248-6 · Cited by 67 · see citing works

Genomic analysis of LPS-stimulated myeloid cells identifies a common pro-inflammatory response but divergent IL-10 anti-inflammatory responses

Hutchins, A. P., Takahashi, Y., & Miranda‐Saavedra, D. (2015) · Scientific Reports · doi:10.1038/srep09100 · Cited by 64 · see citing works

Polyethyleneimine-coated MXene quantum dots improve cotton tolerance to Verticillium dahliae by maintaining ROS homeostasis

Qiu, P., Li, J., Zhang, L., Chen, K., Shao, J., Zheng, B., Yuan, H., Qi, J., Yue, L., Hu, Q., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43192-4 · Cited by 63 · see citing works

Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex

O’Connor, B. P., Danhorn, T., Arras, L. D., Flatley, B. R., Marcus, R. A., Farias‐Hesson, E., Leach, S. M., & Alper, S. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004932 · Cited by 62 · see citing works

TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells

Moreira, D., Zhang, Q., Hossain, D. M. S., Nechaev, S., Li, H., Kowolik, C. M., D’Apuzzo, M., Forman, S. J., Jones, J. O., Pal, S. K., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4029 · Cited by 62 · see citing works

A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes

Zugasti, O., Thakur, N., Belougne, J., Squiban, B., Kurz, C. L., Soulé, J., Omi, S., Tichit, L., Pujol, N., & Ewbank, J. J. (2016) · BMC Biology · doi:10.1186/s12915-016-0256-3 · Cited by 56 · see citing works

β-Arrestin 2 Negatively Regulates Toll-like Receptor 4 (TLR4)-triggered Inflammatory Signaling via Targeting p38 MAPK and Interleukin 10

Li, H. Z., Hu, D., Fan, H., Zhang, Y., LeSage, G., Caudle, Y., Stuart, C. A., Liu, Z., & Yin, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.591495 · Cited by 55 · see citing works

Involvement of MyD88 in zinc oxide nanoparticle-induced lung inflammation

Han, C. L., Ho, C.-C., Yang, C. S., Chang, W., Tsai, M., Tsai, H.-T., & Lin, P. (2013) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2013.01.001 · Cited by 55 · see citing works

Protein Tyrosine Phosphatase 1B Is a Regulator of the Interleukin-10–Induced Transcriptional Program in Macrophages

Pike, K. A., Hutchins, A. P., Vinette, V., Théberge, J.-F., Sabbagh, L., Tremblay, M. L., & Miranda‐Saavedra, D. (2014) · Science Signaling · doi:10.1126/scisignal.2005020 · Cited by 54 · see citing works

Stroma: the forgotten cells of innate immune memory

Crowley, T., Buckley, C. D., & Clark, A. R. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13149 · Cited by 53 · see citing works

Single-Cell Secretion Analysis Reveals a Dual Role for IL-10 in Restraining and Resolving the TLR4-Induced Inflammatory Response

Alexander, A. F., Kelsey, I., Forbes, H., & Miller‐Jensen, K. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.109728 · Cited by 51 · see citing works

Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections

Hulme, K. D., Noye, E. C., Short, K. R., & Labzin, L. I. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.770066 · Cited by 51 · see citing works

Dendritic cells from the elderly display an intrinsic defect in the production of IL-10 in response to Lithium Chloride

Agrawal, S., Gollapudi, S. V. S., Gupta, S., & Agrawal, A. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.08.006 · Cited by 47 · see citing works

Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo

O’Neil, J. D., Ross, E. A., Ridley, M. L., Ding, Q., Tang, T., Rosner, D. R., Crowley, T., Malhi, D., Dean, J. L. E., Smallie, T., et al. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00536-16 · Cited by 46 · see citing works

CITED2 Restrains Proinflammatory Macrophage Activation and Response

Kim, G.-D., Das, R., Rao, X., Zhong, J., Deiuliis, J. A., Ramírez‐Bergeron, D. L., Rajagopalan, S., & Mahabeleshwar, G. H. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00452-17 · Cited by 45 · see citing works

Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure

Zhou, H., Gao, S., Duan, X., Liang, S., Scott, D. A., Lamont, R. J., & Wang, H. (2015) · The FASEB Journal · doi:10.1096/fj.15-270462 · Cited by 40 · see citing works

Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ1–42 in BV-2 cells

Zhang, Z., Wu, Z., Zhu, X., Hui, X.-C., Pan, J., & Xu, Y. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.01.005 · Cited by 40 · see citing works

Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages

Howes, A., Taubert, C., Blankley, S., Spink, N., Wu, X., Graham, C. M., Zhao, J., Saraiva, M., Ricciardi‐Castagnoli, P., Bancroft, G. J., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501923 · Cited by 41 · see citing works

Identification and characterization of a novel adiponectin receptor agonist adipo anti‐inflammation agonist and its anti‐inflammatory effects in vitro and in vivo

Qiu, W., Wu, H., Hu, Z., Wu, X., Tu, M., Fang, F., Zhu, X., Liu, Y., Lian, J., Valverde, P., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15277 · Cited by 40 · see citing works

A resident stromal cell population actively restrains innate immune response in the propagation phase of colitis pathogenesis in mice

Gao, L., Yu, Q., Zhang, H., Wang, Z., Zhang, T., Xiang, J., Yu, S., Zhang, S., Wu, H., Xu, Y., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb5071 · Cited by 40 · see citing works

GHK and DNA: Resetting the human genome to health

Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014) · BioMed Research International · doi:10.1155/2014/151479 · Cited by 39 · see citing works

TLR9 Ligands Induce S100A8 in Macrophages via a STAT3-Dependent Pathway which Requires IL-10 and PGE2

Hsu, K., Chung, Y. M., Endoh, Y., & Geczy, C. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103629 · Cited by 38 · see citing works

Immunopathology and immune homeostasis during viral infection in insects

González‐González, A., & Wayne, M. L. (2020) · Advances in virus research · doi:10.1016/bs.aivir.2020.06.001 · Cited by 35 · see citing works

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism

Menzfeld, C., John, M., van Rossum, D., Regen, T., Scheffel, J., Jáňová, H., Götz, A. A., Ribes, S., Nau, R., Borisch, A., et al. (2015) · Glia · doi:10.1002/glia.22803 · Cited by 36 · see citing works

Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release

Tran, T. A. T., Grievink, H. W., Lipinska, K., Kluft, C., Burggraaf, J., Moerland, M., Tasev, D., & Malone, K. E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214999 · Cited by 35 · see citing works

Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-κB activation

Liu, J., Zhang, Z., Chai, L., Che, Y., Min, S., & Yang, R. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.071 · Cited by 35 · see citing works

Macrophage production and activation are dependent on TRIM33

Gallouët, A.-S., Ferri, F., Petit, V., Parcelier, A., Lewandowski, D., Gault, N., Barroca, V., Gras, S. L., Soler, É., Grosveld, F. G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13872 · Cited by 35 · see citing works

TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling

Yang, D., Li, S., Duan, X., Ren, J., Liang, S., Yakoumatos, L., Kang, Y., Uriarte, S. M., Shang, J., Li, W., et al. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.12.013 · Cited by 32 · see citing works

Clinical applications of oligonucleotides for cancer therapy

DeFranciscis, V., Amabile, G., & Kortylewski, M. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.02.045 · Cited by 32 · see citing works

STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor–Induced Inflammatory Cytokines, and STAT3 / STAT5 Disease Variants Modulate These Outcomes

Hedl, M., Sun, R., Huang, C. L., & Abraham, C. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900031 · Cited by 32 · see citing works

The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling

Wei, J., Wei, C., Wang, M., Xiao, Q., Li, Y., Yuan, Y., Jin, C., Leng, L., Wang, J., Yang, X., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309218111 · Cited by 32 · see citing works

B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors

Zhao, X., Zhang, Z., Moreira, D., Su, Y., Won, H., Adamus, T., Dong, Z., Liang, Y., Yin, H. H., Swiderski, P. M., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.01.007 · Cited by 32 · see citing works

Coordinated Post-Transcriptional Regulation of the Chemokine System: Messages from CCL2

Panganiban, R. P., Vonakis, B. M., Ishmael, F. T., & Stellato, C. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2013.0149 · Cited by 31 · see citing works

Genomic and computational approaches to dissect the mechanisms of STAT3’s universal and cell type-specific functions

Hutchins, A. P., Diez, D., & Miranda-Saavedra, D. (2013) · JAK-STAT · doi:10.4161/jkst.25097 · Cited by 31 · see citing works

MicroRNAs Associated With a Good Prognosis of Acute Myeloid Leukemia and Their Effect on Macrophage Polarization

Neaga, A., Bagacean, C., Tempescul, A., Jimbu, L., Mesaros, O., Blag, C., Tomuleasa, C., Bocsan, C., Gaman, M., & Zdrenghea, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.582915 · Cited by 30 · see citing works

Inhibition of Interleukin 1β (IL-1β) Expression by Anthrax Lethal Toxin (LeTx) Is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages

Ha, S.-D., Reid, C., Meshkibaf, S., & Kim, S. O. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.695809 · Cited by 29 · see citing works

Epigenetic Regulation of Myeloid Cells

Ivashkiv, L. B., & Park, S. H. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0010-2015 · Cited by 26 · see citing works

SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity

Han, X., Ren, J., Lohner, H., Yakoumatos, L., Liang, R., & Wang, H. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102036 · Cited by 28 · see citing works

DietaryArtemisia ordosicaextract alleviating immune stress in broilers exposed to lipopolysaccharide

Li, K., Zhang, P., Shi, B., Su, J., Yue, Y., Tong, M., & Yan, S. (2017) · Italian Journal of Animal Science · doi:10.1080/1828051x.2016.1274242 · Cited by 28 · see citing works

Suppressor of Cytokine Signaling 3 (SOCS3) Degrades p65 and Regulate HIV-1 Replication

Sood, V., Lata, S., Ramachandran, V. G., & Banerjea, A. C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00114 · Cited by 26 · see citing works

MTDH Promotes Intestinal Inflammation by Positively Regulating TLR Signalling

Wang, L., Zhang, N., Han, D., Su, P., Chen, B., Zhao, W., Liu, Y., Zhang, H., Hu, G., & Yang, Q. (2021) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjab086 · Cited by 26 · see citing works

MicroRNAs as Regulators of Phagocytosis

Gierlikowski, W., & Gierlikowska, B. (2022) · Cells · doi:10.3390/cells11091380 · Cited by 25 · see citing works

Azithromycin Affords Neuroprotection in Rat Undergone Transient Focal Cerebral Ischemia

Amantea, D., Petrelli, F., Greco, R., Tassorelli, C., Corasaniti, M. T., Tonin, P., & Bagetta, G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01256 · Cited by 25 · see citing works

Pattern-Recognition Receptor Signaling Regulator mRNA Expression in Humans and Mice, and in Transient Inflammation or Progressive Fibrosis

Günthner, R., Kumar, V., Lorenz, G., Anders, H., & Lech, M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140918124 · Cited by 24 · see citing works

Gene Trap Mice Reveal an Essential Function of Dual Specificity Phosphatase Dusp16/MKP-7 in Perinatal Survival and Regulation of Toll-like Receptor (TLR)-induced Cytokine Production

Niedzielska, M., Bodendorfer, B., Münch, S., Eichner, A., Derigs, M., da Costa, O., Schweizer, A., Neff, F., Nitschke, L., Sparwasser, T. D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.535245 · Cited by 24 · see citing works

Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems

Buchwald, Z. S., & Aurora, R. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/429373 · Cited by 24 · see citing works

Issues with the Specificity of Immunological Reagents for Murine IDO1

de Velde, L.-A. V., Gingras, S., Pelletier, S. W., & Murray, P. J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.004 · Cited by 24 · see citing works

Transcriptome analysis of porcine PBMCs reveals lipopolysaccharide-induced immunomodulatory responses and crosstalk of immune and glucocorticoid receptor signaling

Li, Z., Trakooljul, N., Hadlich, F., Ponsuksili, S., Wimmers, K., & Muráni, E. (2021) · Virulence · doi:10.1080/21505594.2021.1948276 · Cited by 22 · see citing works

Effects of betaine on growth performance, intestinal health, and immune response of goslings challenged with lipopolysaccharide

Yang, Z., Yang, J., Zhu, P. J., Han, H. M., Wan, X., Yang, H., & Wang, Z. Y. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102153 · Cited by 22 · see citing works

JAK3 restrains inflammatory responses and protects against periodontal disease through Wnt3a signaling

Lü, L., Yakoumatos, L., Ren, J., Duan, X., Zhou, H., Gu, Z., Mohammed, M., Uriarte, S. M., Liang, S., Scott, D. A., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902697rr · Cited by 21 · see citing works

Coadministration of Polyinosinic:Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity

Quinn, K. M., Yamamoto, A., Costa, A. D. S., Darrah, P. A., Lindsay, R. W. B., Hegde, S. T., Johnson, T. R., Flynn, B. J., Loré, K., & Seder, R. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301730 · Cited by 20 · see citing works

Endotoxin tolerance induction in human periodontal ligament fibroblasts stimulated with different bacterial lipopolysaccharides

Wu, X., Zhang, G., Wang, X., Zhang, P., & Tan, Y. (2014) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2014.10.005 · Cited by 20 · see citing works

The Genetics of Innate Immunity Sensors and Human Disease

Pothlichet, J., & Quintana‐Murci, L. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.777064 · Cited by 20 · see citing works

Establishment and characterization of Yellow River carp (Cyprinus carpio haematopterus) muscle cell line and its application to fish virology and immunology

Zhi, S., Wang, J., Wang, Y., Yang, L., Qin, C., Yan, X., Zhao, M., Liu, M., Qu, L., & Nie, G. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.108859 · Cited by 19 · see citing works

Negative regulatory approaches to the attenuation of Toll-like receptor signaling

Anwar, M. A., Basith, S., & Choi, S. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.28 · Cited by 139 · see citing works

Negative Regulation of Toll-like Receptors Signaling Pathways*

Bing, S. U. N., & Dai-Shu, H. A. N. (2010) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2009.00213 · Cited by 4 · see citing works

Negative regulation of Toll-like receptor-mediated immune responses

Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509 · see citing works

The negative regulation of Toll‐like receptor and associated pathways

Lang, T., & Mansell, A. S. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100094 · Cited by 133 · see citing works

Toll-like receptors activation, signaling, and targeting: an overview

El-Zayat, S. R., Sibaii, H., & Mannaa, F. A. E. (2019) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-019-0227-2 · Cited by 560 · see citing works