The DOI matches its Crossref record.
HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family
Abstract
In contrast to other members of the Eag family of voltage-gated, outwardly rectifying potassium channels, the human eag -related gene ( HERG ) has now been shown to encode an inwardly rectifying potassium channel. The properties of HERG channels are consistent with the gating properties of Eag-related and other outwardly rectifying, S4-containing potassium channels, but with the addition of an inactivation mechanism that attenuates potassium efflux during depolarization. Because mutations in HERG cause a form of long-QT syndrome, these properties of HERG channel function may be critical to the maintenance of normal cardiac rhythmicity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 39
- ARMSTRONG, C.M., ANOMALOUS RECTIFICATION IN SQUID GIANT AXON INJECTED WITH TETRAETHYLAMMONIUM CHLORIDE, JOURNAL OF GENERAL PHYSIOLOGY 48: 859 (1965). · DOI · Paper page
- ARMSTRONG, C.M., INACTIVATION OF POTASSIUM CONDUCTANCE AND RELATED PHENOMENA CAUSED BY QUATERNARY AMMONIUM ION INJECTION IN SQUID AXONS, JOURNAL OF GENERAL PHYSIOLOGY 54: 553 (1969). · DOI · Paper page
- 10.1126/science.1857984 · DOI · Paper page
- 10.1038/365445a0 · DOI · Paper page
- BUCHANAN, L.V., COMPARATIVE-ASSESSMENT OF IBUTILIDE, D-SOTALOL, CLOFILIUM, E-4031, AND UK-68,798 IN A RABBIT MODEL OF PROARRHYTHMIA, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 22: 540 (1993).
- Cranefield, P. F., Cardiac Arrhythmias: The Role of Triggered Activity and Other Arrhythmias: 553 (1988).
- CURRAN, M.E., A MOLECULAR-BASIS FOR CARDIAC-ARRHYTHMIA - HERG MUTATIONS CAUSE LONG QT SYNDROME, CELL 80: 795 (1995). · DOI · Paper page
- DIFRANCESCO, D, A MODEL OF CARDIAC ELECTRICAL-ACTIVITY INCORPORATING IONIC PUMPS AND CONCENTRATION CHANGES, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 307: 353 (1985).
- 10.1126/science.7973666 · DOI · Paper page
- GANETZKY, B, J NEUROGENET 1: 17 (1983). · DOI · Paper page
- Hagiwara, S., Journal of General Physiology 67: 621 (1976). · DOI · Paper page
- HAGIWARA, S, JOURNAL OF PHYSIOLOGY-LONDON 279: 167 (1978). · DOI · Paper page
- HO, K, CLONING AND EXPRESSION OF AN INWARDLY RECTIFYING ATP-REGULATED POTASSIUM CHANNEL, NATURE 362: 31 (1993). · DOI · Paper page
- 10.1016/0896-6273(91)90367-9 · DOI · Paper page
- 10.1126/science.2122519 · DOI · Paper page
- KAPLAN, W.D., BEHAVIOR OF 4 NEUROLOGICAL MUTANTS OF DROSOPHILA, GENETICS 61: 399 (1969). · DOI · Paper page
- 10.1038/362127a0 · DOI · Paper page
- LANDT, O, A GENERAL-METHOD FOR RAPID SITE-DIRECTED MUTAGENESIS USING THE POLYMERASE CHAIN-REACTION, GENE 96: 125 (1990). · DOI · Paper page
- LIMAN, E.R., VOLTAGE-SENSING RESIDUES IN THE S4 REGION OF A MAMMALIAN K+ CHANNEL, NATURE 353: 752 (1991). · DOI · Paper page
- LIMAN, E.R., SUBUNIT STOICHIOMETRY OF A MAMMALIAN K+ CHANNEL DETERMINED BY CONSTRUCTION OF MULTIMERIC CDNAS, NEURON 9: 861 (1992). · DOI · Paper page
- 10.1038/372366a0 · DOI · Paper page
- LUDWIG, J, FUNCTIONAL EXPRESSION OF A RAT HOMOLOG OF THE VOLTAGE-GATED ETHER A GO-GO POTASSIUM CHANNEL REVEALS DIFFERENCES IN SELECTIVITY AND ACTIVATION KINETICS BETWEEN THE DROSOPHILA CHANNEL AND ITS MAMMALIAN COUNTERPART, EMBO JOURNAL 13: 4451 (1994). · DOI · Paper page
- MAKHINA, E.N., CLONING AND EXPRESSION OF A NOVEL HUMAN BRAIN INWARD RECTIFIER POTASSIUM CHANNEL, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 20468 (1994). · DOI
- MATSUDA, H, OHMIC CONDUCTANCE THROUGH THE INWARDLY RECTIFYING K-CHANNEL AND BLOCKING BY INTERNAL MG-2+, NATURE 325: 156 (1987). · DOI · Paper page
- 10.1038/349305a0 · DOI · Paper page
- 10.1126/science.2441470 · DOI · Paper page
- PERIER, F, PRIMARY STRUCTURE AND CHARACTERIZATION OF A SMALL-CONDUCTANCE INWARDLY RECTIFYING POTASSIUM CHANNEL FROM HUMAN HIPPOCAMPUS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 6240 (1994).
- ROBERTSON, G.A., BIOPHYSICAL JOURNAL 64: A340 (1993).
- Robertson, G.A., Biophysical Journal 68: A363 (1995).
- RUDY, B, METHODS IN ENZYMOLOGY 207: 225 (1992). · DOI
- SANGUINETTI, M.C., A MECHANISTIC LINK BETWEEN AN INHERITED AND AN ACQUIRED CARDIAC-ARRHYTHMIA - HERG ENCODES THE I-KR POTASSIUM CHANNEL, CELL 81: 299 (1995). · DOI · Paper page
- SANGUINETTI, M.C., 2 COMPONENTS OF CARDIAC DELAYED RECTIFIER K+ CURRENT - DIFFERENTIAL SENSITIVITY TO BLOCK BY CLASS-III ANTIARRHYTHMIC AGENTS, JOURNAL OF GENERAL PHYSIOLOGY 96: 195 (1990). · DOI · Paper page
- 10.1126/science.8966547 · DOI · Paper page
- 10.1038/339597a0 · DOI · Paper page
- Trudeau, M. C., Biophysical Journal 68: A32 (1995).
- VANDENBERG, C.A., INWARD RECTIFICATION OF A POTASSIUM CHANNEL IN CARDIAC VENTRICULAR CELLS DEPENDS ON INTERNAL MAGNESIUM-IONS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 2560 (1987).
- 10.1126/science.1840699 · DOI · Paper page
- WARMKE, J.W., A FAMILY OF POTASSIUM CHANNEL GENES RELATED TO EAG IN DROSOPHILA AND MAMMALS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 3438 (1994).
- Zei, P. C., Biophysical Journal 68: A32 (1995).
Cited by
Membrane potential and cancer progression
Yang, M., & Brackenbury, W. J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00185 · Cited by 614
Schönherr, R., & Heinemann, S. H. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021410 · Cited by 320
Cellular mechanisms underlying the long QT syndrome
Antzelevitch, C., & Shimizu, W. (2002) · Current Opinion in Cardiology · doi:10.1097/00001573-200201000-00007 · Cited by 313
(1998) · PubMed · Cited by 262
The sigma-1 receptor: roles in neuronal plasticity and disease
Kourrich, S., Su, T.-P., Fujimoto, M., & Bonci, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.09.007 · Cited by 245
Metadata
- Authors
- Trudeau, M. C., Warmke, J. W., Ganetzky, B., & Robertson, G. A.
- Venue
- Science
- Published
- 1995-07-07
- Volume
- 269
- Issue
- 5220
- Pages
- 92-95
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021438486
- Cited by
- 1,239
- References
- 0
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family. https://app.cochat.ai/papers/10.1126/science.7604285
- The paper
- Trudeau, M. C., Warmke, J. W., Ganetzky, B., & Robertson, G. A. (1995). HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family. Science. https://doi.org/10.1126/science.7604285
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
