Cited by 1,257Epigenetics and DNA MethylationGenomics and Chromatin DynamicsDNA and Nucleic Acid Chemistry

The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Open access

Abstract

Positives and negatives of methylated CpG: When the DNA bases cytosine and guanine are next to each other, a methyl group is generally added to the pyrimidine, generating a mCpG dinucleotide. This modification alters DNA structure but can also affect function by inhibiting transcription factor (TF) binding. Yin et al. systematically analyzed the effect of CpG methylation on the binding of 542 human TFs (see the Perspective by Hughes and Lambert). In addition to inhibiting binding of some TFs, they found that mCpGs can promote binding of others, particularly TFs involved in development, such as homeodomain proteins. Science , this issue p. eaaj2239 ; see also p. 489

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.aaj2239

Cites

97 of 97 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Cited by

Sorted by citations

See all 1,257

Metadata

Authors
Yin, Y., Morgunova, E., Jolma, A., Kaasinen, E., Sahu, B., Khund-Sayeed, S., Das, P. K., Kivioja, T., Dave, K., Zhong, F., Nitta, K. R., Taipale, M., Popov, A., Ginno, P. A., Domcke, S., Yan, J., Schübeler, D., Vinson, C., & Taipale, J.
Affiliations
  • Karolinska Institutet (SE)
  • University of Helsinki (FI)
  • National Institutes of Health (US)
  • European Synchrotron Radiation Facility (FR)
  • Friedrich Miescher Institute (CH)
  • University of Basel (CH)
Corresponding author
Taipale, Jussi
Venue
Science
Published
2017-05-05
Volume
356
Issue
6337
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2610903912
Cited by
1,257
References
97
Citations by year
2026: 92 · 2025: 138 · 2024: 148 · 2023: 159 · 2022: 166 · 2021: 150 · 2020: 125 · 2019: 125 · 2018: 113 · 2017: 37
FWCI
44.66
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Academy of Finland Center of Excellence in Cancer Genetics
  • European Research Area SynBio
  • Center for Innovative Medicine at Karolinska Institutet
  • Knut and Alice Wallenberg Foundation
  • Göran Gustafsson Foundation
  • Vetenskapsrådet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords
cytosine methylation, CpG methylation, transcription factor binding specificity, DNA methylation, homeodomain transcription factor, 5-methylcytosine, hydrophobic interactions, epigenetic regulation, gene regulatory elements
MeSH terms
Protein Domains, Cytosine, DNA, Humans, Protein Binding, Transcription Factors, Dinucleoside Phosphates, Genome, Human, CpG Islands, DNA Methylation, Epigenesis, Genetic, SELEX Aptamer Technique

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review