The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
An ingestible bacterial-electronic system to monitor gastrointestinal health
Open accessAbstract
Using bugs in the gut to detect blood: Bacteria are environmentally resilient and can be engineered to sense various biomolecules. Mimee et al. combined biosensor bacteria with a miniaturized wireless readout capsule to produce a minimally invasive device capable of in vivo biosensing in harsh, difficult-to-access environments (see the Perspective by Gibson and Burgell). The device successfully measured gastrointestinal bleeding in pigs. Science , this issue p. 915 ; see also p. 856
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The use of genetically engineered bacterial strains to assess the gut environment, release metabolites of interest at specific locations within the GI tract, and optimize drug metabolism appears to be on the horizon190, 191.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [191]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kearse, M., Moir, R., Wilson, A., Stones-Havas, S., Cheung, M., Sturrock, S., Buxton, S., Cooper, A., Markowitz, S., Duran, C., et al. (2012) · Bioinform. · doi:10.1093/bioinformatics/bts199 · Cited by 19,197
Enzymatic assembly of DNA molecules up to several hundred kilobases
Gibson, D. G., Young, L., Chuang, R.-Y., Venter, J. C., Hutchison, C. A., & Smith, H. O. (2009) · Nature Methods · doi:10.1038/nmeth.1318 · Cited by 10,088
Iddan, G., Meron, G., Glukhovsky, A., & Swain, P. (2000) · Nature · doi:10.1038/35013140 · Cited by 3,066
Automated design of synthetic ribosome binding sites to control protein expression
Salis, H. M., Mirsky, E. A., & Voigt, C. A. (2009) · Nature Biotechnology · doi:10.1038/nbt.1568 · Cited by 1,844
Chung, C. T., Niemelä, S., & Miller, R. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2172 · Cited by 1,602
Malfertheiner, P., Chan, F. K. L., & McColl, K. E. L. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60938-7 · Cited by 1,558
Lanas, Á., & Chan, F. K. L. (2017) · The Lancet · doi:10.1016/s0140-6736(16)32404-7 · Cited by 989
Principles of genetic circuit design
Brophy, J. A. N., & Voigt, C. A. (2014) · Nature Methods · doi:10.1038/nmeth.2926 · Cited by 965
Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness
Pickard, J. M., Maurice, C. F., Kinnebrew, M. A., Abt, M. C., Schenten, D., Golovkina, T. V., Bogatyrev, S. R., Ismagilov, R. F., Pamer, E. G., Turnbaugh, P. J., et al. (2014) · Nature · doi:10.1038/nature13823 · Cited by 550
Acyl-Homoserine Lactone Quorum Sensing: From Evolution to Application
Schuster, M., Sexton, D. J., Diggle, S. P., & Greenberg, E. P. (2013) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155635 · Cited by 549
Flagged first, then by citations
Cited by
Sorted by citations
Choi, K. R., Jang, W. D., Yang, D., Cho, J. S., Park, D., & Lee, S. Y. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.01.003 · Cited by 579
Engineered living biomaterials
Rodrigo‐Navarro, A., Sankaran, S., Dalby, M. J., del Campo, A., & Salmerón‐Sánchez, M. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00350-8 · Cited by 512
Connected healthcare: Improving patient care using digital health technologies
Awad, A., Trenfield, S. J., Pollard, T. D., Ong, J. J., Elbadawi, M., McCoubrey, L. E., Goyanes, A., Gaisford, S., & Basit, A. W. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113958 · Cited by 405
Artificial intelligence biosensors: Challenges and prospects
Jin, X., Liu, C., Xu, T., Su, L., & Zhang, X. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112412 · Cited by 399
Materials design by synthetic biology
Tang, T., An, B., Huang, Y., Vasikaran, S., Wang, Y., Jiang, X., Lu, T. K., & Zhong, C. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-00265-w · Cited by 406
Self-citationOpportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19
Bhalla, N., Pan, Y., Yang, Z., & Payam, A. F. (2020) · ACS Nano · doi:10.1021/acsnano.0c04421 · Cited by 392
Engineering living therapeutics with synthetic biology
Cubillos-Ruiz, A., Guo, T., Sokolovska, A., Miller, P., Collins, J. J., Lu, T. K., & Lora, J. M. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00285-3 · Cited by 387
Self-citationFoundations of gastrointestinal-based drug delivery and future developments
Chu, J. N., & Traverso, G. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00539-w · Cited by 300
Self-citationApplications, challenges, and needs for employing synthetic biology beyond the lab
Brooks, S. M., & Alper, H. S. (2021) · Nature Communications · doi:10.1038/s41467-021-21740-0 · Cited by 292
Liu, X., Steiger, C., Lin, S., Parada, G. A., Liu, J., Chan, H. F., Yuk, H., Phan, N. V., Collins, J. E., Tamang, S. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08355-2 · Cited by 288
Self-citationGenetically stable CRISPR-based kill switches for engineered microbes
Rottinghaus, A. G., Ferreiro, A. L., Fishbein, S. R. S., Dantas, G. A., & Moon, T. S. (2022) · Nature Communications · doi:10.1038/s41467-022-28163-5 · Cited by 302
Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals
Wan, X., Volpetti, F., Petrova, E., French, C. E., Maerkl, S. J., & Wang, B. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0244-3 · Cited by 283
Ingestible electronics for diagnostics and therapy
Steiger, C., Abramson, A., Nadeau, P., Chandrakasan, A. P., Langer, R., & Traverso, G. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0070-3 · Cited by 281
Self-citationHydrogel-based biocontainment of bacteria for continuous sensing and computation
Tang, T., Tham, E., Liu, X., Yehl, K. M., Rovner, A. J., Yuk, H., de la Fuente‐Núñez, C., Isaacs, F. J., Zhao, X., & Lu, T. K. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00779-6 · Cited by 261
Self-citationEngineered Living Materials For Sustainability
An, B., Wang, Y., Huang, Y., Wang, X., Liu, Y., Xun, D., Church, G. M., Dai, Z., Yi, X., Tang, T., et al. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00512 · Cited by 256
Li, Z., Wang, Y., Liu, J., Rawding, P. A., Bu, J., Hong, S., & Hu, Q. (2021) · Advanced Materials · doi:10.1002/adma.202102580 · Cited by 247
Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials
Welch, E. C., Powell, J. M., Clevinger, T. B., Fairman, A. E., & Shukla, A. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202104126 · Cited by 249
Inorganic semiconductor biointerfaces
Jiang, Y., & Tian, B. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0062-3 · Cited by 244
Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics
Lynch, J. P., Goers, L., & Lesser, C. F. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.02.002 · Cited by 240
Real-time bioelectronic sensing of environmental contaminants
Atkinson, J. T., Su, L., Zhang, X., Bennett, G. N., Silberg, J. J., & Ajo-Franklin, C. M. (2022) · Nature · doi:10.1038/s41586-022-05356-y · Cited by 233
Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota
Lindell, A. E., Zimmermann‐Kogadeeva, M., & Patil, K. R. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00681-5 · Cited by 239
Liu, X., Inda, M. E., Lai, Y., Lu, T. K., & Zhao, X. (2022) · Advanced Materials · doi:10.1002/adma.202201326 · Cited by 231
Self-citationBiomolecular sensors for advanced physiological monitoring
Flynn, C. D., Chang, D., Mahmud, A., Yousefi, H., Das, J., Riordan, K. T., Sargent, E. H., & Kelley, S. O. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00067-z · Cited by 226
Microbial whole-cell biosensors: Current applications, challenges, and future perspectives
Moraskie, M., Roshid, M. H. O., O’Connor, G., Dikici, E., Zingg, J.-M., Deo, S. K., & Daunert, S. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113359 · Cited by 214
Terahertz band communication systems: Challenges, novelties and standardization efforts
Tekbıyık, K., Ekti, A. R., Kurt, G. K., & Görçin, A. (2019) · Physical Communication · doi:10.1016/j.phycom.2019.04.014 · Cited by 206
Engineered microbial consortia: strategies and applications
Duncker, K. E., Holmes, Z. A., & You, L. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01699-9 · Cited by 196
A Tissue‐Like Soft All‐Hydrogel Battery
Ye, T., Wang, J., Jiao, Y., Li, L., He, E., Wang, L., Li, Y., Yun, Y., Li, D., Jiang, L., et al. (2021) · Advanced Materials · doi:10.1002/adma.202105120 · Cited by 184
Powering implantable and ingestible electronics
Yang, S., Sencadas, V., You, S. S., Jia, N. Z., Srinivasan, S. S., Huang, H., Ahmed, A. E., Liang, J. Y., & Traverso, G. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009289 · Cited by 183
Self-citationApplications of synthetic biology in medical and pharmaceutical fields
Yan, X., Liu, X., Zhao, C., & Chen, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01440-5 · Cited by 191
Magnetic Living Hydrogels for Intestinal Localization, Retention, and Diagnosis
Liu, X., Yang, Y., Inda, M. E., Lin, S., Wu, J., Kim, Y., Chen, X., Ma, D., Lu, T. K., & Zhao, X. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202010918 · Cited by 175
Self-citationBardhan, I. R., Chen, H., & Karahanna, E. (2020) · MIS Quarterly · doi:10.25300/misq/2020/14644 · Cited by 192
Robotic wireless capsule endoscopy: recent advances and upcoming technologies
Cao, Q., Deng, R., Pan, Y., Liu, R., Chen, Y., Gong, G., Zou, J. T., Yang, H., & Han, D. (2024) · Nature Communications · doi:10.1038/s41467-024-49019-0 · Cited by 168
Edible Electronics: The Vision and the Challenge
Sharova, A. S., Melloni, F., Lanzani, G., Bettinger, C. J., & Caironi, M. (2020) · Advanced Materials Technologies · doi:10.1002/admt.202000757 · Cited by 172
The gut Microbiome in adult and pediatric functional gastrointestinal disorders
Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163
Lu, T., Ji, S., Jin, W., Yang, Q., Luo, Q., & Ren, T. (2023) · Sensors · doi:10.3390/s23062991 · Cited by 183
Self-citationZou, Z., Du, Y., Fang, T.-T., Zhou, Y. Q., & Ye, B. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.12.004 · Cited by 161
Engineering probiotics for therapeutic applications: recent examples and translational outlook
Aggarwal, N., Breedon, A. M. E., Davis, C. M., Hwang, I. Y., & Chang, M. W. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.02.016 · Cited by 158
Stretchable and Fully Degradable Semiconductors for Transient Electronics
Tran, H., Feig, V. R., Liu, K., Wu, H., Chen, R., Xu, J., Deisseroth, K. A., & Bao, Z. (2019) · ACS Central Science · doi:10.1021/acscentsci.9b00850 · Cited by 159
Synthetic Biology Enables Programmable Cell‐Based Biosensors
Hicks, M., Bachmann, T. T., & Wang, B. (2019) · ChemPhysChem · doi:10.1002/cphc.201900739 · Cited by 153
la Paz, E. D., Maganti, N. H., Trifonov, A., Jeerapan, I., Mahato, K., Yin, L., Sonsa‐ard, T., Ma, N., Jung, W., Burns, R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35074-y · Cited by 151
Integration of personalized drug delivery systems into digital health
Raijada, D. K., Wac, K., Greisen, E., Rantanen, J., & Genina, N. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113857 · Cited by 142
Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics
Tan, X., Letendre, J. H., Collins, J. J., & Wong, W. W. (2021) · Cell · doi:10.1016/j.cell.2021.01.017 · Cited by 134
Self-citationEngineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut
Lynch, J. P., González-Prieto, C., Reeves, A. Z., Bae, S., Powale, U., Godbole, N. P., Tremblay, J. M., Schmidt, F. I., Ploegh, H. L., Kansra, V. V., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.007 · Cited by 132
Light-degradable hydrogels as dynamic triggers for gastrointestinal applications
Raman, R., Hua, T., Gwynne, D., Collins, J. E., Tamang, S. M., Zhou, J., Esfandiary, T., Soares, V. V., Pajovic, S., Hayward, A. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay0065 · Cited by 129
Self-citationTheranostic cells: emerging clinical applications of synthetic biology
McNerney, M. P., Doiron, K. E., Ng, T. L., Chang, T. Z., & Silver, P. A. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00383-3 · Cited by 131
Stimuli-responsive engineered living materials
Rivera‐Tarazona, L. K., Campbell, Z. T., & Ware, T. H. (2020) · Soft Matter · doi:10.1039/d0sm01905d · Cited by 132
Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
Liu, G. W., Pickett, M. J., Kuosmanen, J. L. P., Ishida, K., Madani, W. A. M., White, G. N., Jenkins, J. A., Park, S., Feig, V. R., Jiménez, M., et al. (2024) · Nature Materials · doi:10.1038/s41563-024-01811-5 · Cited by 126
Self-citationNext generation probiotics: Engineering live biotherapeutics
Murali, S. K., & Mansell, T. J. (2024) · Biotechnology Advances · doi:10.1016/j.biotechadv.2024.108336 · Cited by 140
Sub-1.4 cm3 capsule for detecting labile inflammatory biomarkers in situ
Inda, M. E., Jiménez, M., Liu, Q., Phan, N. V., Ahn, J., Steiger, C., Wentworth, A. J., Riaz, A., Zirtiloglu, T., Wong, K., et al. (2023) · Nature · doi:10.1038/s41586-023-06369-x · Cited by 149
Self-citationSingle-Nucleotide-Resolution Computing and Memory in Living Cells
Farzadfard, F., Gharaei, N., Higashikuni, Y., Jung, G., Cao, J., & Lu, T. K. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.011 · Cited by 122
Self-citationKoltes, J. E., Cole, J. B., Clemmens, R., Dilger, R. N., Kramer, L., Lunney, J. K., McCue, M. E., McKay, S., Mateescu, R. G., Murdoch, B. M., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01197 · Cited by 120
Eco-friendly, sustainable, and safe energy storage: a nature-inspired materials paradigm shift
Bertaglia, T., Costa, C. M., Lanceros-Méndez, S., & Crespilho, F. N. (2024) · Materials Advances · doi:10.1039/d4ma00363b · Cited by 127
Bacterial therapies at the interface of synthetic biology and nanomedicine
Hahn, J., Ding, S., Im, J., Harimoto, T., Leong, K. W., & Danino, T. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00119-4 · Cited by 125
Electroactive material-based biosensors for detection and drug delivery
Olvera, D., & Monaghan, M. G. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.09.011 · Cited by 120
Location-aware ingestible microdevices for wireless monitoring of gastrointestinal dynamics
Sharma, S., Ramadi, K. B., Poole, N., Srinivasan, S. S., Ishida, K., Kuosmanen, J. L. P., Jenkins, J. A., Aghlmand, F., Swift, M., Shapiro, M. G., et al. (2023) · Nature Electronics · doi:10.1038/s41928-023-00916-0 · Cited by 112
Self-citationMaguire, M., & Maguire, G. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0024 · Cited by 114
Disentangling host–microbiota complexity through hologenomics
Alberdi, A., Andersen, S. B., Limborg, M. T., Dunn, R. R., & Gilbert, M. T. P. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00421-0 · Cited by 110
Stretchable Thermoelectrics: Strategies, Performances, and Applications
Hao, Y., He, X., Wang, L., Qin, X., Chen, G., & Yu, J. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202109790 · Cited by 106
Mucosa-interfacing electronics
Nan, K., Feig, V. R., Ying, B., Howarth, J. G., Kang, Z., Yang, Y., & Traverso, G. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00477-2 · Cited by 105
Self-citation3D‐Printed Gastric Resident Electronics
Kong, Y. L., Zou, X., McCandler, C. A., Kirtane, A. R., Ning, S., Zhou, J., Abid, A., Jafari, M., Rogner, J., Minahan, D. J., et al. (2018) · Advanced Materials Technologies · doi:10.1002/admt.201800490 · Cited by 101
Self-citationRewiring bacterial two-component systems by modular DNA-binding domain swapping
Schmidl, S. R., Ekness, F., Sofjan, K., Daeffler, K. N.-M., Brink, K. R., Landry, B. P., Gerhardt, K. P., Dyulgyarov, N., Sheth, R. U., & Tabor, J. J. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0286-6 · Cited by 101
Terrell, J. L., Tschirhart, T., Jahnke, J. P., Stephens, K., Liu, Y., Dong, H., Hurley, M. M., Pozo, M. R., McKay, R., Tsao, C. Y., et al. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00878-4 · Cited by 101
Continuous health monitoring: An opportunity for precision health
Gambhir, S. S., Ge, T. J., Vermesh, O., Spitler, R., & Gold, G. E. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe5383 · Cited by 106
Engineered Probiotics for Detection and Treatment of Inflammatory Intestinal Diseases
Barra, M., Danino, T., & Garrido, D. A. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00265 · Cited by 100
Synthetic biology-inspired cell engineering in diagnosis, treatment and drug development
Zhao, N., Song, Y., Xie, X., Zhu, Z., Duan, C., Nong, C., Wang, H., & Bao, R. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01375-x · Cited by 107
An Analysis Review of Detection Coronavirus Disease 2019 (COVID-19) Based on Biosensor Application
Taha, B. A., Mashhadany, Y. I. M. A., Bakar, A. A. A., Zan, M. S. D., & Arsad, N. (2020) · Sensors · doi:10.3390/s20236764 · Cited by 99
Next-Generation Probiotics for Inflammatory Bowel Disease
Pesce, M., Seguella, L., Re, A., Lu, J., Palenca, I., Corpetti, C., Rurgo, S., Sanseverino, W., Sarnelli, G., & Esposito, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105466 · Cited by 105
End-to-end design of ingestible electronics
Abdigazy, A., Arfan, M., Lazzi, G., Sideris, C., Abramson, A., & Khan, Y. (2024) · Nature Electronics · doi:10.1038/s41928-024-01122-2 · Cited by 106
Lopreside, A., Wan, X., Michelini, E., Roda, A., & Wang, B. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04444 · Cited by 96
Bioelectronic Implantable Devices for Physiological Signal Recording and Closed‐Loop Neuromodulation
Oh, S., Jekal, J., Jia Liu, B., Kim, J., Park, J., Lee, T., & Jang, K. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202403562 · Cited by 104
Activity-Based Diagnostics: An Emerging Paradigm for Disease Detection and Monitoring
Soleimany, A. P., & Bhatia, S. N. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.01.013 · Cited by 94
Temperature-responsive biometamaterials for gastrointestinal applications
Babaee, S., Pajovic, S., Kirtane, A. R., Shi, J., Caffarel–Salvador, E., Hess, K., Collins, J. E., Tamang, S. M., Wahane, A. V., Hayward, A. M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau8581 · Cited by 95
Self-citationEngineered bacteria detect tumor DNA
Cooper, R. M., Wright, J. A., Ng, J. Q., Goyne, J. M., Suzuki, N., Lee, Y.-K., Ichinose, M., Radford, G., Ryan, F. J., Kumar, S., et al. (2023) · Science · doi:10.1126/science.adf3974 · Cited by 92
Beardslee, L. A., Banis, G., Chu, S., Liu, S., Chapin, A. A., Stine, J. M., Pasricha, P. J., & Reza Ghodssi, A. (2020) · ACS Sensors · doi:10.1021/acssensors.9b02263 · Cited by 95
Orally ingestible medical devices for gut engineering
Mandsberg, N. K., Christfort, J. F., Kamguyan, K., Boisen, A., & Srivastava, S. K. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.05.004 · Cited by 93
A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy
Hou, B., Yi, L., Hu, D., Luo, Z., Gao, D., Li, C., Xing, B., Wang, J., Lee, C. N., Zhang, R., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01024-2 · Cited by 102
High-density soft bioelectronic fibres for multimodal sensing and stimulation
Khatib, M., Zhao, E. T., Wei, S., Park, J., Abramson, A., Bishop, E. S., Thomas, A.-L. A., Chen, C.-H., Emengo, P. O., Xu, C., et al. (2025) · Nature · doi:10.1038/s41586-025-09481-2 · Cited by 91
Synthetic bacteria for the detection and bioremediation of heavy metals
Thai, T. D., Lim, W., & Na, D. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1178680 · Cited by 89
Robust direct digital-to-biological data storage in living cells.
Yim, S. S., McBee, R. M., Song, A. M., Huang, Y., Sheth, R. U., & Wang, H. H. (2021) · Nature Chemical Biology · doi:10.1038/s41589-020-00711-4 · Cited by 83
Yang, B., Kong, J., & Fang, X. (2019) · Talanta · doi:10.1016/j.talanta.2019.06.031 · Cited by 83
CRISPR Tools To Control Gene Expression in Bacteria
Vigouroux, A., & Bikard, D. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00077-19 · Cited by 84
Bacterial two-component systems as sensors for synthetic biology applications
Lazar, J. T., & Tabor, J. J. (2021) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2021.100398 · Cited by 84
Engineering the gut microbiome
Bai, X., Huang, Z., Duraj‐Thatte, A., Ebert, M., Zhang, F., Burgermeister, E., Liu, X., Scott, B. M., Li, G., & Zuo, T. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00072-2 · Cited by 85
Recent advances in the analytical strategies of microbial biosensor for detection of pollutants
Ma, Z., Meliana, C., Munawaroh, H. S. H., Karaman, C., Karimi‐Maleh, H., Low, S. S., & Show, P. L. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135515 · Cited by 80
Programming Living Glue Systems to Perform Autonomous Mechanical Repairs
An, B., Wang, Y., Jiang, X., Ma, C., Mimee, M., Moser, F., Li, K., Wang, X., Tang, T., Huang, Y., et al. (2020) · Matter · doi:10.1016/j.matt.2020.09.006 · Cited by 77
Self-citationDesigning Artificial Cells towards a New Generation of Biosensors
Boyd, M. A., & Kamat, N. P. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.12.002 · Cited by 79
Recent Advances in Hydrogel-Based Biosensors for Cancer Detection
Sun, S., & Chen, J. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c02317 · Cited by 84
Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging
Li, B., Ji, P., Peng, S., Pan, P., Zheng, D., Li, C., Sun, Y., & Zhang, X. (2020) · Advanced Materials · doi:10.1002/adma.202000376 · Cited by 76
Nazir, A., Hussain, F. H. N., & Raza, A. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1511149 · Cited by 81
Tian, L., Min, Y., Li, W., Chen, J., Zhou, N., Zhu, T., Li, D., Ma, J., An, P., Zheng, L., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01581 · Cited by 75
Edible and Nutritive Electronics: Materials, Fabrications, Components, and Applications
Wu, Y., Ye, D., Shan, Y., He, S., Su, Z., Liang, J., Zheng, J., Yang, Z., Yang, H., Xu, W., et al. (2020) · Advanced Materials Technologies · doi:10.1002/admt.202000100 · Cited by 78
Jin, X., Wei, C., Wu, C., & Zhang, W. (2022) · Composites Part B Engineering · doi:10.1016/j.compositesb.2022.109816 · Cited by 75
Min, J., Yang, Y., Wu, Z., & Gao, W. F. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900125 · Cited by 81
Bhokisham, N., VanArsdale, E. S., Stephens, K., Hauk, P., Payne, G. F., & Bentley, W. E. (2020) · Nature Communications · doi:10.1038/s41467-020-16249-x · Cited by 74
Zuo, F., Chen, S., & Marcotte, H. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107654 · Cited by 72
Smart pills for gastrointestinal diagnostics and therapy
Cummins, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113931 · Cited by 77
Ingestible transiently anchoring electronics for microstimulation and conductive signaling
Abramson, A., Dellal, D., Kong, Y. L., Zhou, J., Gao, Y., Collins, J. E., Tamang, S. M., Wainer, J., McManus, R., Hayward, A. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz0127 · Cited by 72
Self-citationEngineered microbial systems for advanced drug delivery
Shen, H., Aggarwal, N., Wun, K. S., Lee, Y. S., Hwang, I. Y., & Chang, M. W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114364 · Cited by 74
Integrated Sensors for Soft Medical Robotics
Qiu, Y., Ashok, A., Nguyen, C. C., Yamauchi, Y., Do, T. N., & Phan, H. (2024) · Small · doi:10.1002/smll.202308805 · Cited by 74
Emerging Frontiers in Microbiome Engineering
Inda, M. E., Broset, E., Lu, T. K., & de la Fuente‐Núñez, C. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.08.007 · Cited by 74
Self-citation
Metadata
- Authors
- Mimee, M., Nadeau, P., Hayward, A., Carim, S., Flanagan, S., Jerger, L., Collins, J., McDonnell, S., Swartwout, R., Citorik, R. J., Bulović, V., Langer, R., Traverso, G., Chandrakasan, A. P., & Lu, T. K.
- Affiliations
- Massachusetts Institute of Technology (US)
- Koch Institute for Integrative Cancer Research At MIT (US)
- Harvard University (US)
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.
- Brigham and Women's Hospital (US)
- Corresponding author
- Mimee, Mark
- Nadeau, Phillip
- Chandrakasan, Anantha P.
- Lu, Timothy K.
- ORCID
- Venue
- Science
- Published
- 2018-05-25
- Volume
- 360
- Issue
- 6391
- Pages
- 915-918
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6430580
- OpenAlex
- W2803662842
- Cited by
- 606
- References
- 35
- Citations by year
- 2026: 58 · 2025: 106 · 2024: 75 · 2023: 81 · 2022: 76 · 2021: 84 · 2020: 67 · 2019: 42 · 2018: 17
- FWCI
- 20.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- PMC
- Funders
- National Institutes of Health (EB-000244)
- Office of Naval Research Global (N00014-13-1-0424)
- National Science Foundation (1522074)
- Hong Kong Innovation and Technology Fund (ITS/195/14FP)
- Center for Microbiome Informatics and Therapeutics (15127713)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › bioluminescence and chemiluminescence research
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Keywords
- gastrointestinal bleeding diagnosis, gastrointestinal disease diagnosis, porcine model, implantable electronics
- MeSH terms
- Animals, Gastrointestinal Diseases, Heme, Gastrointestinal Hemorrhage, Monitoring, Physiologic, Swine, Biosensing Techniques, Probiotics, Gastrointestinal Tract, Electrical Equipment and Supplies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
