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MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Open accessAbstract
Commensals rule the MAITrix: Mucosal-associated invariant T (MAIT) cells play an important role in mucosal homeostasis. MAIT cells recognize microbial small molecules presented by the major histocompatibility complex class Ib molecule MR1. MAIT cells are absent in germ-free mice, and the mechanisms by which microbiota control MAIT cell development are unknown (see the Perspective by Oh and Unutmaz). Legoux et al. show that, in mice, development of MAIT cells within the thymus is governed by the bacterial product 5-(2-oxopropylideneamino)-6- d -ribitylaminouracil, which rapidly traffics from the mucosa to the thymus, where it is captured by MR1 and presented to developing MAIT cells. Constantinides et al. report that MAIT cell induction only occurs during a limited, early-life window and requires exposure to defined microbes that produce riboflavin derivatives. Continual interactions between MAIT cells and commensals in the skin modulates tissue repair functions. Together, these papers highlight how the microbiota can direct immune cell development and subsequent function at mucosal sites by secreting compounds that act like self-antigens. Science , this issue p. 494 , p. eaax6624 ; see also p. 419
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TL;DR
MAIT cells require a narrow early-life window of microbial exposure, especially riboflavin-synthesizing bacteria, to establish long-term tissue populations. In adult skin, these cells become a dominant IL-17A-producing, tissue-resident subset that responds to commensal antigens and cytokines and accelerates wound repair in mice.
Key findings
- MAIT cells were enriched in mouse skin, reaching up to 40% of αβ T cells, and averaged about 2% of CD3+ lymphocytes in human skin; germ-free mice had reduced MAIT cells across thymus, spleen, gut, skin, lungs, and liver.
- A defined five-species early-life community, or monocolonization with *Proteus mirabilis* alone, restored MAIT cell development in neonatal germ-free mice, whereas later-life exposure or adult conventionalization did not; topical 5-OP-RU also induced skin MAIT cells only when given early.
- Cutaneous MAIT cells were mostly double-negative, produced IL-17A rather than IFNγ, expressed type-17 genes including *Rorc*, *Il22*, *Il1r1*, and *Il23r*, and showed a tissue-repair transcriptional signature; IL-23 receptor deficiency reduced MAIT cell numbers, IL-18 blockade limited their expansion after *S. epidermidis*, and IL-1 receptor deficiency reduced IL-17A production.
- *S. epidermidis* lacking *ribD* failed to expand MAIT cells, while inducible MR1 deletion after development did not affect steady-state MAIT cells but prevented their response to *S. epidermidis*; in wounding experiments, MAIT-sufficient *Tcrd−/−* mice had longer epidermal tongues than MAIT-deficient *Mr1−/− Tcrd−/−* mice, and topical 5-OP-RU increased epidermal tongue length in wild-type mice.
Methods
- Mouse immunology study using SPF, germ-free, gnotobiotic, knockout, transgenic, parabiosis, and wound-healing models; early-life colonization was performed by oral gavage or topical skin association, with 16S rRNA sequencing and bacterial whole-genome sequencing to characterize communities and riboflavin synthesis genes.
- Immune populations were analyzed by flow cytometry, MR1 tetramer enrichment, confocal microscopy, RNA-sequencing, and single-cell RNA-sequencing; human skin specimens from elective surgery were digested and analyzed for MAIT cell frequency.
- Statistical comparisons used two-tailed unpaired Student’s t-tests; RNA-seq differential expression used DESeq2 with GO enrichment via Metascape, and scRNA-seq used Cell Ranger, CITE-seq-Count, and Seurat.
Limitations
- The paper states that how microbiota-derived riboflavin intermediates before and after birth contribute to human MAIT cell maturation and long-term tissue imprinting remains to be addressed.
- The functional wound-healing evidence is from murine punch-biopsy experiments, and MAIT cell function was tested in *Tcrd−/−* mice to reduce competition from γδ T cells, a setting the authors note is more relevant to human skin because human skin has fewer γδ T cells than mouse skin.
- Evident from the text: human data are limited mainly to skin MAIT cell frequency, and the study relies heavily on specific mouse models, defined bacterial strains, and early-life colonization conditions, so direct human causal tests of MAIT cell function are not provided.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The colonization of neonatal GF mice with our early-life microbial community induced MAIT cell development to the same extent observed in SPF mice harboring high MAIT cell frequencies (Fig. 1I).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Early-life exposure to riboflavin-synthesizing commensals is required for MAIT cell development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Indeed, the monocolonization of neonatal GF mice with P. mirabilis, but not L. johnsonii, was sufficient to drive MAIT cell development (Fig. 1K).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Early-life exposure to riboflavin-synthesizing commensals is required for MAIT cell development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In agreement with our observation that adult microbial colonization was insufficient to promote MAIT cell development (Fig. 1I), topical application of 5-OP-RU to the skin of adult GF mice failed to induce MAIT cells (Fig. 1L).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Early-life exposure to riboflavin-synthesizing commensals is required for MAIT cell development
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Cutaneous MAIT cells displayed a markedly different transcriptional profile (Figs. 2I–J & S2F–G).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Cutaneous MAIT cells express a type-17 transcriptional program and require homeostatic IL-23
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Gene ontology (GO) enrichment analysis revealed that cutaneous MAIT cells express a transcriptional profile consistent with T cell activation, including leukocyte differentiation, migration and cell adhesion, cytokine production, and the ERK1/2 cascade, which is downstream of TCR signaling (Fig. 2C).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Cutaneous MAIT cells express a type-17 transcriptional program and require homeostatic IL-23
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“IL-23 receptor-deficient mice (Il23rgfp/gfp) exhibited fewer MAIT cells than WT animals (Figs. 2F–G & S2D–E)”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Cutaneous MAIT cells express a type-17 transcriptional program and require homeostatic IL-23
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“their ability to produce IL-17A was significantly decreased (Fig. 3N–O).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Skin-resident MAIT cells respond to cutaneous microbes in an IL-1- and IL-18-dependent manner
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Additionally, scRNA-seq confirmed that cutaneous MAIT cells express multiple genes associated with tissue repair, including Lgals3, F2r, Sdc1, and Npnt (Fig. 2J).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Cutaneous MAIT cells express a type-17 transcriptional program and require homeostatic IL-23
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“S. epidermidis association promoted the expression of genes associated specifically with angiogenesis, including angiogenin (Ang) and Hgf (47, 48), as well as genes that more broadly promote tissue repair, like Ceacam1, Grn, Hmox1, Igf1, and Pdgfa (49–53) (Fig. 3R).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Skin-resident MAIT cells respond to cutaneous microbes in an IL-1- and IL-18-dependent manner
What the sources say
- Not checked yetcites [47] Bussolino F, Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 119, 629– 641 (1992). 1383237 PMC2289675 source
- Not checked yetcites [48] Miyake M, Goodison S, Lawton A, Gomes-Giacoia E, Rosser CJ, Angiogenin promotes tumoral growth and angiogenesis by regulating matrix metallopeptidase-2 expression via the ERK1/2 pathway. Oncogene 34, 890– 901 (2015). 24561529 PMC4317372 source
- Not checked yetcites [49] Toulon A, A role for human skin-resident T cells in wound healing. J Exp Med 206, 743– 750 (2009). 19307328 PMC2715110 source
- Not checked yetcites [50] He Z, Ong CH, Halper J, Bateman A, Progranulin is a mediator of the wound response. Nat Med 9, 225– 229 (2003). 12524533 source
- Not checked yetcites [51] LeBlanc S, CEACAM1 deficiency delays important wound healing processes. Wound Repair Regen 19, 745– 752 (2011). 22092845 source
- Not checked yetcites [52] Demaria M, An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell 31, 722– 733 (2014). 25499914 PMC4349629 source
- Not checked yetcites [53] Grochot-Przeczek A, Heme oxygenase-1 accelerates cutaneous wound healing in mice. PLoS One 4, e5803 (2009). 19495412 PMC2686151 source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Conversely, exposure later in life failed to promote MAIT cell development and accumulation within tissues (Fig. 1H–I)”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Early-life exposure to riboflavin-synthesizing commensals is required for MAIT cell development
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- It may state two separate claims as one. 16
- Probably not a substantial claim. 7
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although MAIT cells were highly abundant within the skin, WT SPF mice housed in distinct cages showed striking variability in the proportion of MAIT cells among genetically identical animals, ranging from <5%−40% of αβ T cells (Fig. 1D–E). In contrast, animals in the same cage had similar frequencies of MAIT cells in the skin and other organs (Fig. 1E)”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Early-life exposure to riboflavin-synthesizing commensals is required for MAIT cell development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This analysis revealed that MAIT cells were highly enriched in the skin (Fig. 1B–C), where they comprised up to 40% of αβ T cells (Fig. 1D–E).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Early-life exposure to riboflavin-synthesizing commensals is required for MAIT cell development
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Topical application of 5-OP-RU was sufficient to induce a significant increase in the number of MAIT cells within the skin (Fig. 1L), without promoting the accumulation of other T cell subsets (Fig. S1J).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Early-life exposure to riboflavin-synthesizing commensals is required for MAIT cell development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Furthermore, MAIT cells were also enriched in human skin compared to the reported ~1% in peripheral blood (20), averaging ~2% of CD3+ lymphocytes (Fig. 1F).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Early-life exposure to riboflavin-synthesizing commensals is required for MAIT cell development
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Following stimulation, skin MAIT cells robustly produced IL-17A, but not IFNγ (Fig. 2A)”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Cutaneous MAIT cells express a type-17 transcriptional program and require homeostatic IL-23
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“we observed that in both cases, topical association expanded the cutaneous DN MAIT cell population and increased their production of IL-17A (Figs. 3A–D & S3B–D).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Skin-resident MAIT cells respond to cutaneous microbes in an IL-1- and IL-18-dependent manner
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“association with the S. epidermidis ΔribD mutant failed to induce a MAIT cell response (Fig. 4C), even though the CD8+ and γδ T cell responses were conserved (Fig. S4B–C).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > MR1-mediated presentation of riboflavin metabolites is necessary and sufficient for MAIT cell recognition of skin commensals
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Thus, early-life exposure to commensals that produce defined metabolites, or to microbially derived metabolites alone, is required for MAIT cell development and their presence later in life.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Early-life exposure to riboflavin-synthesizing commensals is required for MAIT cell development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“supporting the idea that homeostatic IL-23 contributes to MAIT cell development and/or accumulation within tissues.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Cutaneous MAIT cells express a type-17 transcriptional program and require homeostatic IL-23
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“indicating that microbial exposure in early life is required for the development of tissue MAIT cells, but not the thymic developmental stages.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Early-life exposure to riboflavin-synthesizing commensals is required for MAIT cell development
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In the paper
“Unless otherwise noted, age- and sex-matched mice between 6 and 12 weeks of age were used for each experiment.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Materials and Methods > Mice
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In the paper
“Dead cells were excluded from live samples using 4′, 6-diamidino-2-phenylindol (DAPI; Sigma-Aldrich), whereas either LIVE/DEAD Fixable Blue Dead Cell Stain Kit (Invitrogen Life Technologies) or Ghost Dye Violet 510 (Tonbo Biosciences) was used in fixed samples.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Materials and Methods > Flow cytometric analysis
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In the paper
“HTO were read in and assigned to the single cells and only singlets were used for further analysis leaving 585 cells.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Materials and Methods > Single-cell RNA-sequencing and analysis
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Notably, we show that MAIT cells are induced during a specific early-life window in response to riboflavin-synthesizing commensals, a phenomenon that permanently imprints the abundance of this subset in tissues.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Discussion
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In the paper
“Successful knockouts were confirmed by colony PCR and sequencing.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Materials and Methods > Generation of S. epidermidis mutant
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
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In the paper
“All staining was performed in the presence of purified anti-mouse CD16/32 and purified rat gamma globulin (Jackson ImmunoResearch).”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Materials and Methods > Flow cytometric analysis
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, γδ T cells restrict the MAIT cell population at steady-state and constrain their response to commensals.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > MAIT cells promote tissue repair
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In the paper
“Cells with less than 900 or more than 3,000 gene counts, more than 5% mitochondrial contamination, or more than 10,000 RNA counts were filtered out, leaving 5,678 cells for downstream analysis.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Materials and Methods > Single-cell RNA-sequencing and analysis
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In conclusion, our work proposes that a central strategy utilized by the immune system to interact with the microbiota may be via the recognition of canonical microbially derived antigens by unconventional T cells, including MAIT cells, a dialogue that may play a dominant role in the control of host physiology.”
§ MAIT cells are imprinted by the microbiota in early life and promote tissue repair > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✗ Based: failsProbably not a substantial claim. The paper may give no reason why it holds. It may state two separate claims as one.
The paper relies on this without support.
Human T cells develop in utero.
“In contrast to mice, human T cells develop in utero supporting the hypothesis that such early MAIT cell imprinting may occur prior to birth.”
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In the citing paper
“The development and maturation of MAIT cells are dependent on microbiota, as demonstrated by reduced numbers of MAIT cells in GF mice, which can be restored through microbial colonization.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [693]
Citations
Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
DADA2: High–resolution sample inference from Illumina amplicon data
Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016) · Nature Methods · doi:10.1038/nmeth.3869 · Cited by 35,698
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
Enzymatic assembly of DNA molecules up to several hundred kilobases
Gibson, D. G., Young, L., Chuang, R.-Y., Venter, J. C., Hutchison, C. A., & Smith, H. O. (2009) · Nature Methods · doi:10.1038/nmeth.1318 · Cited by 10,088
Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
Self-citationInduction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806
Self-citationAn Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045
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Items 101–200 of 581
Emerging Role for MAIT Cells in Control of Antimicrobial Resistance
Leeansyah, E., Boulouis, C., Kwa, A. L., & Sandberg, J. K. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.11.008 · Cited by 45
The liver as an immunological barrier redefined by single‐cell analysis
Stamataki, Z., & Swadling, L. (2020) · Immunology · doi:10.1111/imm.13193 · Cited by 48
Souter, M. N. T., Awad, W., Li, S., Pediongco, T. J., Meehan, B. S., Meehan, L. J., Tian, Z., Zhao, Z., Wang, H., Nelson, A. G., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20210828 · Cited by 45
Frascoli, M., Ferraj, E., Miu, B., Malin, J., Spidale, N. A., Cowan, J. E., Shissler, S. C., Brink, R. A., Xu, Y., Cyster, J. G., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.025 · Cited by 49
Self-citationEarly life microbiome influences on development of the mucosal innate immune system
Ignácio, A., Czyz, S., & McCoy, K. D. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2024.101885 · Cited by 55
Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates
Sakai, S., Lora, N. E., Kauffman, K. D., Dorosky, D. E., Oh, S., Namasivayam, S., Gomez, F., Fleegle, J. D., Bleach, J. L., Butler, A. L., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00425-3 · Cited by 44
Jabeen, M., & Hinks, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127588 · Cited by 49
Osbelt, L., Almási, É. D. H., Wende, M., Kienesberger, S., Voltz, A., Lesker, T. R., Muthukumarasamy, U., Knischewski, N., Nordmann, E., Bielecka, A. A., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01710-0 · Cited by 46
Skin microbiome and dermatologic disorders
Scharschmidt, T. C., & Segre, J. A. (2025) · Journal of Clinical Investigation · doi:10.1172/jci184315 · Cited by 55
Self-citationAging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging
Kurioka, A., & Klenerman, P. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101816 · Cited by 48
Lange, J., Anderson, R. J., Marshall, A. J., Chan, S. T. S., Bilbrough, T., Gasser, O., González-López, C., Salio, M., Cerundolo, V., Hermans, I. F., et al. (2020) · ACS Chemical Biology · doi:10.1021/acschembio.9b00902 · Cited by 42
Wu, X., Kasmani, M. Y., Zheng, S., Khatun, A., Yao, C., Winkler, W., Zander, R., Burns, R., Taparowsky, E. J., Sun, J., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abc9934 · Cited by 43
Decoding the molecular landscape of keloids: new insights from single-cell transcriptomics
Xia, Y., Wang, Y., Shan, M., Yan, H., & Liang, Z. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad017 · Cited by 45
Lett, M. J., Mehta, H., Keogh, A., Jaeger, T., Jacquet, M., Powell, K., Meier, M., Fofana, I., Melhem, H., Vosbeck, J., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-324478 · Cited by 54
Tao, H., Pan, Y., Chu, S., Li, L., Xie, J., Wang, P., Zhang, S., Reddy, S., Sleasman, J. W., & Zhong, X. (2021) · Nature Communications · doi:10.1038/s41467-021-22162-8 · Cited by 42
Li, Y., Yang, Y., Wang, J., Cai, P., Li, M., Tang, X., Tan, Y. C., Wang, Y., Zhang, F., Wen, X., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00871-4 · Cited by 39
Self-citationThe impact of prenatal dog keeping on infant gut microbiota development
Panzer, A. R., Sitarik, A. R., Fadrosh, D., Havstad, S. L., Jones, K. J., Davidson, B., Finazzo, S., Wegienka, G., Woodcroft, K. J., Lukacs, N. W., et al. (2023) · Clinical & Experimental Allergy · doi:10.1111/cea.14303 · Cited by 42
The neuroimmune CGRP–RAMP1 axis tunes cutaneous adaptive immunity to the microbiota
Kulalert, W., Wells, A. C., Link, V. M., Lim, A. I., Bouladoux, N. J., Nagai, M., Harrison, O. J., Kamenyeva, O., Kabát, J., Enamorado, M., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322574121 · Cited by 53
Self-citationRuibal, P., Voogd, L., Joosten, S. A., et al. (2021) · Immunological Reviews · doi:10.1111/imr.12948 · Cited by 43
Dey, R. J., Dey, B., Harriff, M. J., Canfield, E. T., Lewinsohn, D. M., & Bishai, W. R. (2022) · mBio · doi:10.1128/mbio.03865-21 · Cited by 39
Kammann, T., Cai, C., Sekine, T., Mouchtaridi, E., Boulouis, C., Nilsén, V., Rivera‐Ballesteros, O., Müller, T. R., Gao, Y., Raineri, E. J. M., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adn2362 · Cited by 49
A three-stage developmental pathway for human Vγ9Vδ2 T cells within the postnatal thymus
Perriman, L., Tavakolinia, N., Jalali, S., Li, S., Hickey, P. F., Amann‐Zalcenstein, D., Ho, W. W. H., Baldwin, T. M., Piers, A. T., Konstantinov, I. E., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.abo4365 · Cited by 42
Hendriks, A., Mnich, M. E., Clemente, B., Cruz, A. R., Tavarini, S., Bagnoli, F., & Soldaini, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.642711 · Cited by 40
The human skin microbiome: from metagenomes to therapeutics
Oh, J., & Voigt, A. Y. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01211-9 · Cited by 50
Atopic dermatitis: Is innate or adaptive immunity in control? A clinical perspective
Ong, P. Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943640 · Cited by 44
Microbial modulation of intestinal T helper cell responses and implications for disease and therapy
Geuking, M. B., & Burkhard, R. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00335-w · Cited by 38
MAIT Cells: Partners or Enemies in Cancer Immunotherapy?
Cogswell, D. T., Gapin, L., Tobin, H., McCarter, M. D., & Tobin, R. P. (2021) · Cancers · doi:10.3390/cancers13071502 · Cited by 37
Regulation of tissue-resident memory T cells by the Microbiota
Overacre-Delgoffe, A. E., & Hand, T. W. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00491-1 · Cited by 40
MR1-Restricted T Cells Are Unprecedented Cancer Fighters
Vacchini, A., Chancellor, A., Spagnuolo, J., Mori, L., & Libero, G. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00751 · Cited by 34
Early life host-microbe interactions in skin
Dwyer, L. R., & Scharschmidt, T. C. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.02.016 · Cited by 40
Self-citationMAIT cells in liver inflammation and fibrosis
Mehta, H., Lett, M. J., Klenerman, P., & Sinnreich, M. F. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00949-1 · Cited by 43
Establishment and Stability of the Murine Oral Microbiome
Abusleme, L., O'Gorman, H., Dutzan, N., Greenwell‐Wild, T., & Moutsopoulos, N. M. (2020) · Journal of Dental Research · doi:10.1177/0022034520915485 · Cited by 37
The Wound MicrobiomePreprint
White, E. K., & Grice, E. A. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041218 · Cited by 36
Tourret, M., Talvard-Balland, N., Lambert, M., Youssef, G. B., Chevalier, M. F., Bohineust, A., Yvorra, T., Morin, F., Azarnoush, S., Lantz, O. J., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003123 · Cited by 37
Cobamide Sharing Is Predicted in the Human Skin Microbiome
Swaney, M. H., Sandstrom, S., & Kalan, L. (2022) · mSystems · doi:10.1128/msystems.00677-22 · Cited by 31
Early development of the skin microbiome: therapeutic opportunities
Casterline, B. W., & Paller, A. S. (2020) · Pediatric Research · doi:10.1038/s41390-020-01146-2 · Cited by 39
MAIT cells: Conserved watchers on the wall
Germain, L., Veloso, P., Lantz, O. J., & Legoux, F. P. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20232298 · Cited by 37
MAIT Cells Come to the Rescue in Cancer Immunotherapy?
Łukasik, Z. M., Elewaut, D. S., & Venken, K. (2020) · Cancers · doi:10.3390/cancers12020413 · Cited by 37
Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models
Chesko, D. M., & Wilgus, T. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052444 · Cited by 34
Lamichhane, R., Munro, F. M., Harrop, T. W. R., de la Harpe, S. M., Dearden, P. K., Vernall, A. J., McCall, J. L., & Ussher, J. E. (2020) · European Journal of Immunology · doi:10.1002/eji.202048830 · Cited by 39
Baby’s skin bacteria: first impressions are long-lasting
Dhariwala, M. O., & Scharschmidt, T. C. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.10.005 · Cited by 32
Self-citationThe burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease
Crowther, M. D., & Sewell, A. K. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.12.002 · Cited by 36
Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier
Akuzum, B., & Lee, J. (2022) · Immune Network · doi:10.4110/in.2022.22.e46 · Cited by 36
Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammation
Cha, J., Kim, T., Bhae, E., Gwak, H., Ju, Y., Choe, Y. H., Jang, I.-H., Jung, Y., Moon, S., Kim, T. H., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2023.12.006 · Cited by 36
Chemical Modulators of Mucosal Associated Invariant T Cells
Mak, J. Y. W., Liu, L., & Fairlie, D. P. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00359 · Cited by 35
White, E. K., Uberoi, A., Pan, J. T.-C., Ort, J. T., Campbell, A. E., Murga-Garrido, S. M., Harris, J. C., Bhanap, P., Wei, M. H., Robles, N. Y., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj2020 · Cited by 39
Yiğit, M., Basoglu, O. F., & Unutmaz, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1369236 · Cited by 34
Gut immune microenvironment and autoimmunity
Wang, Q., Lu, Q., Jia, S., & Zhao, M. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110842 · Cited by 33
New insights into MAIT cells in autoimmune diseases
Fan, Q., Nan, H., Li, Z., Li, B., Zhang, F., & Bi, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114250 · Cited by 33
The Emerging Role of MAIT Cell Responses in Viral Infections
Sandberg, J. K., Leeansyah, E., Eller, M. A., Shacklett, B. L., & Paquin‐Proulx, D. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300147 · Cited by 31
Early-life microbiota-immune homeostasis
Reynolds, H. M., & Bettini, M. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1266876 · Cited by 39
Mucosal Associated Invariant T Cells in Cancer-Friend or Foe?
O’Neill, C. A., Cassidy, F. C., O'Shea, D. B., & Hogan, A. E. (2021) · Cancers · doi:10.3390/cancers13071582 · Cited by 29
Escherichia coli O157:H7 senses microbiota-produced riboflavin to increase its virulence in the gut
Liu, B., Liu, Y., Yang, B., Wang, Q., Liu, X., Qin, J., Zhao, K., Li, F., Feng, X., Li, L., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212436119 · Cited by 33
Clonal tracing reveals diverse patterns of response to immune checkpoint blockade
Gu, S. S., Wang, X., Hu, X. S., Jiang, P., Li, Z., Traugh, N. C., Bu, X., Tang, Q., Wang, C., Zeng, Z., et al. (2020) · Genome biology · doi:10.1186/s13059-020-02166-1 · Cited by 29
MicroRNA miR-181—A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function
Grewers, Z., & Krueger, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176200 · Cited by 30
Boulouis, C., Kammann, T., Cuapio, A., Parrot, T., Gao, Y., Mouchtaridi, E., Wullimann, D., Lange, J., Chen, P., Akber, M., et al. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00484-7 · Cited by 29
On developmental programming of the immune system
Hong, J. Y., & Medzhitov, R. M. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.09.004 · Cited by 30
Jackson, C. L., Frank, D. N., Robertson, C. E., Ir, D., Kofonow, J. M., Montlha, M. P., Mutsaerts, E. A. M. L., Nunes, M. C., Madhi, S. A., Ghosh, D., et al. (2022) · mBio · doi:10.1128/mbio.01229-22 · Cited by 28
Innate-like T cells in liver disease
Yang, A. Y.-P., Wistuba‐Hamprecht, K., Greten, T. F., & Ruf, B. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.05.008 · Cited by 36
Innate and Innate-like Effector Lymphocytes in Health and Disease
Kaer, L. V., Postoak, J. L., Song, W., & Wu, L. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200074 · Cited by 32
Early life imprinting of intestinal immune tolerance and tissue homeostasis
Iza, Y. A. P., & Brown, C. C. (2024) · Immunological Reviews · doi:10.1111/imr.13321 · Cited by 33
Riboflavin for women’s health and emerging microbiome strategies
Dricot, C. E. M. K., Erreygers, I., Cauwenberghs, E., Paz, J. D., Spacova, I., Verhoeven, V., Ahannach, S., & Lebeer, S. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00579-5 · Cited by 34
From microbes to mind: germ-free models in neuropsychiatric research
Delgado‐Ocaña, S., & Cuesta, S. (2024) · mBio · doi:10.1128/mbio.02075-24 · Cited by 38
The skin mycobiome and intermicrobial interactions in the cutaneous niche
Tuor, M., & LeibundGut-Landmann, S. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2023.102381 · Cited by 30
Boulouis, C., Mouchtaridi, E., Müller, T. R., Mak, J. Y. W., Fairlie, D. P., Bergman, P., Michaëlsson, J., Halfvarson, J., Mjösberg, J., Buggert, M., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2414230122 · Cited by 29
Interleukin 23 receptor: Expression and regulation in immune cells
Mezghiche, I., Yahia‐Cherbal, H., Rogge, L., & Bianchi, E. (2023) · European Journal of Immunology · doi:10.1002/eji.202250348 · Cited by 32
The dialogue between unconventional T cells and the microbiota
Lin, Q., Kuypers, M., Philpott, D. J., & Mallevaey, T. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0326-2 · Cited by 30
Yin, Z., Wang, Y., Feng, X., Liu, C., Guan, X., Liu, S., Long, Z. H., Miao, Z., He, F., Cheng, R., et al. (2024) · Microbial Biotechnology · doi:10.1111/1751-7915.70031 · Cited by 29
Self-citationExpansion of MAIT cells in the combined absence of NKT and γδ-T cells
Xu, C., Li, S., Fulford, T. S., Christo, S. N., Mackay, L. K., Gray, D. H. D., Uldrich, A. P., Pellicci, D. G., Godfrey, D. I., & Koay, H. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.05.003 · Cited by 28
Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans
Swarbrick, G. M., Gela, A., Cansler, M. E., Null, M. D., Duncan, R. B., Nemes, E., Shey, M. S., Nsereko, M., Mayanja‐Kizza, H., Kiguli, S., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.556695 · Cited by 26
Quantifying the Impact of Human Leukocyte Antigen on the Human Gut Microbiota
Andeweg, S. P., Keşmir, C., & Dutilh, B. E. (2021) · mSphere · doi:10.1128/msphere.00476-21 · Cited by 34
Khuzwayo, S., Mthembu, M., Meermeier, E. W., Prakadan, S. M., Kazer, S. W., Bassett, T., Nyamande, K., Khan, D. F., Maharaj, P., Mitha, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631410 · Cited by 24
Zareie, P., Weiss, E. S., Kaplan, D. H., & Mackay, L. K. (2025) · Nature Immunology · doi:10.1038/s41590-025-02145-3 · Cited by 29
Biological functions and therapeutic applications of human mucosal-associated invariant T cells
Fang, Y., Chen, Y., Niu, S., Lyu, Z., Tian, Y., Shen, X., Li, Y.-R., & Yang, L. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01125-x · Cited by 31
Self-citationMAIT cell plasticity enables functional adaptation that drives antibacterial immune protection
Wang, H., Souter, M. N. T., Moreira, M. L., Li, S., Zhou, Y., Nelson, A. G., Yu, J., Meehan, L. J., Meehan, B. S., Eckle, S. B. G., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adp9841 · Cited by 27
Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities
Al-Taweel, R., Hammad, A. S., Tajammul, A., Crovella, S., & Al‐Asmakh, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311365 · Cited by 35
Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature
Dhariwala, M. O., Karthikeyan, D., Vasquez, K. S., Farhat, S., Weckel, A., Taravati, K., Leitner, E. G., Clancy, S., Pauli, M. L., Piper, M. L., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100132 · Cited by 26
Self-citationMaladaptive consequences of inflammatory events shape individual immune identity
Halper-Stromberg, A., & Jabrì, B. (2022) · Nature Immunology · doi:10.1038/s41590-022-01342-8 · Cited by 31
Naidoo, K., Woods, K., Pellefigues, C., Cait, A., O’Sullivan, D., Gell, K., Marshall, A. J., Anderson, R. J., Li, Y., Schmidt, A., et al. (2021) · Allergy · doi:10.1111/all.14994 · Cited by 26
The promise of endogenous and exogenous riboflavin in anti-infection
Lei, J., Xin, C., Xiao, W., Chen, W., & Song, Z. (2021) · Virulence · doi:10.1080/21505594.2021.1963909 · Cited by 26
Gnirck, A.-C., Philipp, M., Waterhölter, A., Wunderlich, M., Shaikh, N., Adamiak, V., Henneken, L., Kautz, T., Xiong, T., Klaus, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43269-0 · Cited by 26
Dissecting skin microbiota and microenvironment for the development of therapeutic strategies
Ito, Y., & Amagai, M. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2023.102311 · Cited by 29
Convergence and divergence of individual immune responses over the life course
Metcalf, C. J. E., Graham, A. L., Yates, A. J., & Cummings, D. A. T. (2025) · Science · doi:10.1126/science.ady9543 · Cited by 26
MAIT cell activation is reduced by direct and microbiota-mediated exposure to bisphenols
Krause, J. L., Engelmann, B., da Rocha, U. N., Pierzchalski, A., Chang, H., Zenclussen, A. C., von Bergen�, M., Rolle-Kampczyk, U. E., & Herberth, G. (2021) · Environment International · doi:10.1016/j.envint.2021.106985 · Cited by 28
Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections
Edmans, M. D., Connelley, T., Jayaraman, S., Vrettou, C., Vordermeier, M. H., Mak, J. Y. W., Liu, L., Fairlie, D. P., Maze, E. A., Chrun, T., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.627173 · Cited by 25
Biological functions of MAIT cells in tissues
Klenerman, P., Hinks, T., & Ussher, J. E. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.12.017 · Cited by 26
Luo, J., Wu, G. G., Alonso, S., Zhao, C., Lemenze, A. D., Lam, Y. Y., Zhao, L., & Edelblum, K. L. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00522-x · Cited by 22
Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes
Cox, J. R., Cruickshank, S. M., & Saunders, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.670471 · Cited by 26
MAIT cell development in mice and humans
Salou, M., Legoux, F. P., & Lantz, O. J. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.12.003 · Cited by 25
Leeansyah, E., Hey, Y. Y., Sia, W. R., Ng, J. H. J., Gulam, M. Y., Boulouis, C., Zhu, F., Ahn, M., Mak, J. Y. W., Fairlie, D. P., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101876 · Cited by 24
Valestrand, L., Zheng, F., Hansen, S. H., Øgaard, J., Hov, J. R., Björkström, N. K., Karlsen, T. H., Jiang, X., & Melum, E. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.12.008 · Cited by 31
MAIT Cells and Microbiota in Multiple Sclerosis and Other Autoimmune Diseases
Mechelli, R., Romano, S., Romano, C., Morena, E., Buscarinu, M. C., Bigi, R., Bellucci, G., Reniè, R., Pellicciari, G., Salvetti, M., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9061132 · Cited by 24
Tissue-resident and innate-like T cells in patients with advanced chronic liver disease
Ibidapo-Obe, O., & Bruns, T. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100812 · Cited by 25
A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells
Lim, H. J., Wubben, J. M., Garcia, C. P., Cruz-Gomez, S., Deng, J., Mak, J. Y. W., Hachani, A., Anderson, R. J., Painter, G. F., Goyette, J., et al. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202110125 · Cited by 23
Kim, K., Jang, H., Kim, E., Kim, H., & Sung, G. Y. (2023) · Experimental Dermatology · doi:10.1111/exd.14940 · Cited by 24
Rashu, R., Ninkov, M., Wardell, C. M., Benoit, J. M., Wang, N. I., Meilleur, C. E., D’Agostino, M. R., Zhang, A., Feng, E., Saeedian, N., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011485 · Cited by 28
Xiao, M.-H., Wu, S., Liang, P., Ma, D., Zhang, J., Chen, H., Zhong, Z., Liu, J., Jiang, H., Feng, X., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105138 · Cited by 27
A Role for MAIT Cells in Colorectal Cancer
Berzins, S. P., Wallace, M. E., Kannourakis, G., & Kelly, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00949 · Cited by 25
Blackburn, N. B., Leandro, A. C., Nahvi, N., Devlin, M. A., Leandro, M., Escobedo, I. M., Peralta, J. M., George, J., Stacy, B. A., deMaar, T. W., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.630988 · Cited by 25
Drashansky, T. T., Helm, E. Y., Curkovic, N. B., Cooper, J. N., Cheng, P., Chen, X., Gautam, N., Meng, L., Kwiatkowski, A. J., Collins, W. O., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102307 · Cited by 22
Metadata
- Authors
- Constantinides, M. G., Link, V. M., Tamoutounour, S., Wong, A. C., Perez-Chaparro, P. J., Han, S.-J., Chen, Y. E., Li, K., Farhat, S., Weckel, A., Krishnamurthy, S. R., Vujkovic-Cvijin, I., Linehan, J. L., Bouladoux, N., Merrill, E. D., Roy, S., Cua, D. J., Adams, E. J., Bhandoola, A., Scharschmidt, T. C., Aubé, J., Fischbach, M. A., & Belkaid, Y.
- Affiliations
- National Institutes of Health (US)
- University of Pennsylvania (US)
- NIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- Stanford University (US)
- University of North Carolina at Chapel Hill (US)
- University of California, San Francisco (US)
- University of Chicago (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Corresponding author
- Belkaid, Yasmine
- ORCID
- Constantinides, Michael G.
- Link, Verena M.
- Wong, Andrea C.
- Perez-Chaparro, P. Juliana
- Chen, Y. Erin
- Li, Kelin
- Weckel, Antonin
- Krishnamurthy, Siddharth R.
- Vujkovic-Cvijin, Ivan
- Linehan, Jonathan L.
- Bouladoux, Nicolas
- Merrill, E. Dean
- Roy, Sobhan
- Adams, Erin J.
- Bhandoola, Avinash
- Scharschmidt, Tiffany C.
- Aubé, Jeffrey
- Fischbach, Michael A.
- Belkaid, Yasmine
- Venue
- Science
- Published
- 2019-10-25
- Volume
- 366
- Issue
- 6464
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7603427
- OpenAlex
- W2981494076
- Cited by
- 567
- References
- 81
- Citations by year
- 2026: 57 · 2025: 93 · 2024: 82 · 2023: 81 · 2022: 92 · 2021: 76 · 2020: 80 · 2019: 4
- FWCI
- 25.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (R01-DK110174, DP1-DK113598, U19-AI111143)
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences
- Chan Zuckerberg Biohub
- Cancer Research Institute
- European Molecular Biology Organization
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases (ZIA-AI001115, ZIA-AI001132)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- mucosal-associated invariant T cells, gut microbiota, MR1, riboflavin derivatives, thymus development, commensal bacteria, tissue repair, skin, mucosal immunity, microbial metabolites, germ-free mice
- MeSH terms
- Mucosal-Associated Invariant T Cells, Animals, Bacteria, Germ-Free Life, Humans, Interleukin-1, Mice, Inbred BALB C, Mice, Inbred C57BL, Riboflavin, Skin, Specific Pathogen-Free Organisms, Wound Healing, Histocompatibility Antigens Class I, Minor Histocompatibility Antigens, Mice, Knockout, Interleukin-17, Interleukin-18, Mice, Interleukin-23, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-06, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-06 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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