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Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE
Abstract
Maternal IgE activates fetal mast cells: Mast cells (MCs) are immune cells that participate in allergic reactions through their activation by immunoglobulin E (IgE) antibodies. MCs arise early during mammalian development, but it is unclear whether IgE-mediated activation occurs in fetal tissues and what the source of IgE stimulation is. Msallam et al. show that human and mouse fetal MCs can be sensitized by IgE of maternal origin, which crosses the placental barrier through the fetal neonatal Fc receptor (see the Perspective by Rothenberg). Prenatal maternal sensitization conferred transient allergen sensitivity after birth and resulted in the development of postnatal skin and airway inflammation in the offspring after their first exposure to allergen. Thus, both maternal IgE and fetal MCs may influence mother-to-child transmission of allergic disease during gestation. Science , this issue p. 941 ; see also p. 907
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“which is also expressed by fetal mast cells and their progenitors. 53 , 63”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [63]
In the citing paper
“While surface expression of FcεR1 is only upregulated perinatally, 53 , 63 fetal mast cells express other receptors through which they can sense the environment, such as the IL‐33 receptor. 53 , 54 , 63 They can also respond to environmental signals and stressors already in utero. 63”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [63]
In the citing paper
“At least on transcript level, fetal mast cells also express key effectors like proteases. 53 , 54 , 63 This is also true for human fetal mast cells, which express, for example, TPSAB1, the gene encoding tryptase, and carry granules. 59 , 60 , 63”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [63]
In the citing paper
“Their ontogeny may make mast cells particularly susceptible to developmental programming: They are already present and phenotypically plastic at fetal stages and can sense environmental perturbations. 63 , 170 They are also long‐lived and many fetal‐derived mast cells persist postnatally.”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [63]
In the citing paper
“A recent study provided a biological basis of this phenomenon with the demonstration that fetal mast cells are sensitized by allergen‐specific maternal IgE that passes the placenta, resulting in hypersensitivity upon postnatal encounter with the allergen. 63”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [63]
Citations
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IgE and mast cells in allergic disease
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Cited by
Sorted by citations
Mast cell ontogeny: From fetal development to life‐long health and disease
Chia, S. L., Kapoor, S., Carvalho, C., Bajénoff, M., & Gentek, R. (2023) · Immunological Reviews · doi:10.1111/imr.13191 · Cited by 60
Metadata
- Authors
- Msallam, R., Balla, J., Rathore, A. P. S., Kared, H., Malleret, B., Saron, W. A. A., Liu, Z., Hang, J. W., Dutertre, C. A., Larbi, A., Chan, J. K. Y., St. John, A. L., & Ginhoux, F.
- Affiliations
- Singapore Immunology Network (SIgN), A*STAR, Singapore 138648, Singapore.
- Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
- Department of Pathology, Duke University Medical Center, Durham, NC 27705, USA.
- Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.
- Department of Reproductive Medicine, KK Women’s and Children’s Hospital, Singapore 229899, Singapore.
- ORCID
- Venue
- Science
- Published
- 2020-11-20
- Volume
- 370
- Issue
- 6519
- Pages
- 941-950
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 105
- References
- 4
- Language
- en
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