Cited by 778Phagocytosis and Immune RegulationCell death mechanisms and regulationAutophagy in Disease and Therapy

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Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

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Chao, Mark P., Jaiswal, Siddhartha, Weissman-Tsukamoto, Rachel, Alizadeh, Ash A., Gentles, Andrew J., Volkmer, Jens, Weiskopf, Kipp, Willingham, Stephen B., Raveh, Tal, Park, Christopher Y., Majeti, Ravindra, Weissman, Irving L.·2010·Science Translational Medicine

DOI 10.1126/scitranslmed.3001375PMC PMC4126904

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Calreticulin-induced phagocytosis of cancer cells can be counterbalanced by CD47 expression.

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Authors: Chao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., Majeti, R., & Weissman, I. L.
Affiliations: Institute for Stem Cell Biology and Regenerative Medicine (US)
Massachusetts General Hospital (US)
Stanford Medicine (US)
Stanford University (US)
Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Chao, Mark P.
Majeti, Ravindra
Weissman, Irving L.
ORCID: Chao, Mark P.
Jaiswal, Siddhartha
Alizadeh, Ash A.
Gentles, Andrew J.
Weiskopf, Kipp
Raveh, Tal
Park, Christopher Y.
Majeti, Ravindra
Weissman, Irving L.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-12-22
Volume: 2
Issue: 63
Pages: 63ra94-63ra94
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3001375
PMC: PMC4126904
OpenAlex: W2142541925
Cited by: 776
References: 55
Citations by year: 2026: 35 · 2025: 51 · 2024: 62 · 2023: 81 · 2022: 76 · 2021: 72 · 2020: 62 · 2019: 54 · 2018: 40 · 2017: 48 · 2016: 36 · 2015: 49 · 2014: 31 · 2013: 28 · 2012: 36
FWCI: 10.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Cancer Institute (U54CA149145, CA09302, P01CA139490, R01CA086017, T32CA009302)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: calreticulin, CD47, anti-CD47 antibody, low density lipoprotein receptor-related protein, tumor immune evasion, prognostic factors, acute myeloid leukemia, non-Hodgkin lymphoma, bladder cancer, neuroblastoma, innate immunity
MeSH terms: Animals, Urinary Bladder Neoplasms, Cell Line, Flow Cytometry, Humans, Lymphoma, Non-Hodgkin, Phagocytosis, Leukemia, Myeloid, Acute, Calreticulin, Cell Line, Tumor, Mice, CD47 Antigen, In Vitro Techniques

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Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

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