Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

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Neuroblastoma: an ongoing cold front for cancer immunotherapy

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Cell-Death-Associated Molecular Patterns As Determinants of Cancer Immunogenicity

Ladoire, S., Hannani, D., Vétizou, M., Locher, C., Aymeric, L., Apétoh, L., Kepp, O., Kroemer, G., Ghiringhelli, F., & Zitvogel, L. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5133 · Cited by 50

Loss-of-function alleles ofP2RX7andTLR4fail to affect the response to chemotherapy in non-small cell lung cancer

Vacchelli, E., Galluzzi, L., Rousseau, V., Rigoni, A., Tesnière, A., Delahaye, N., Schlemmer, F., Menger, L., Sukkurwala, A. Q., Adjemian, S., et al. (2012) · OncoImmunology · doi:10.4161/onci.18684 · Cited by 53

Anticancer effects of anti-CD47 immunotherapy in vivo

Iribarren, K., Buqué, A., Mondragón, L., Xie, W., Lévesque, S., Pol, J. G., Zitvogel, L., Kepp, O., & Kroemer, G. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1550619 · Cited by 46

Improving the efficacy of osteosarcoma therapy: combining drugs that turn cancer cell ‘don't eat me’ signals off and ‘eat me’ signals on

Mohanty, S., Aghighi, M., Yerneni, K., Theruvath, J. L., & Daldrup-Link, H. E. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12556 · Cited by 46

Combined targeting of glioblastoma stem cells of different cellular states disrupts malignant progression

Lu, C., Kang, T., Zhang, J., Yang, K., Liu, Y., Song, K., Lin, Q., Dixit, D., Gimple, R. C., Zhang, Q., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58366-5 · Cited by 51

Histone deacetylase inhibitors valproic acid and vorinostat enhance trastuzumab-mediated antibody-dependent cell-mediated phagocytosis

Laengle, J., Kabiljo, J., Hunter, L., Homola, J., Prodinger, S., Egger, G., & Bergmann, M. M. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000195 · Cited by 45

Prospects of antibodies targeting CD47 or CD24 in the treatment of glioblastoma

Wu, H., Liu, J., Wang, Z., Yuan, W., & Chen, L. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13714 · Cited by 45

Reprogramming NK Cells and Macrophages via Combined Antibody and Cytokine Therapy Primes Tumors for Elimination by Checkpoint Blockade

Wang, C., Cui, A., Bukenya, M., Aung, A., Pradhan, D., Whittaker, C. A., Agarwal, Y., Thomas, A., Liang, S., Amlashi, P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110021 · Cited by 43

Immunogenicity and cytotoxicity of a platinum( iv ) complex derived from capsaicin

Sun, Y., Yin, E., Tan, Y., Yang, T., Song, D., Jin, S., Guo, Z., & Wang, X. (2020) · Dalton Transactions · doi:10.1039/d0dt03470c · Cited by 42

Immune Cycle‐Based Strategies for Cancer Immunotherapy

Li, Y., Liu, X., Zhang, X., Pan, W., Li, N., & Tang, B. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107540 · Cited by 42

Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes

Wong, D. Y. Q., Ong, W. W. F., & Ang, W. H. (2015) · Angewandte Chemie · doi:10.1002/ange.201500934 · Cited by 42

Moonlighting Proteins Are Important Players in Cancer Immunology

Adamo, A., Frusteri, C., Pallotta, M. T., Pirali, T., Sartoris, S., & Ugel, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.613069 · Cited by 41

Combinatory Delivery of Etoposide and siCD47 in a Lipid Polymer Hybrid Delays Lung Tumor Growth in an Experimental Melanoma Lung Metastatic Model

Abdel‐Bar, H. M., Walters, A. A., Wang, J. T.-W., & Al‐Jamal, K. T. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001853 · Cited by 41

Microglia and Brain Macrophages as Drivers of Glioma Progression

Zheng, Y., & Graeber, M. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415612 · Cited by 40

Recent advances on nanostructured biomaterials in osteosarcoma treatment

Feng, C., Jiang, Y., Wang, T., Tian, D., Shen, C., Wang, Y., & Qian, H. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215315 · Cited by 40

CD47 Expression Defines Efficacy of Rituximab with CHOP in Non–Germinal Center B-cell (Non-GCB) Diffuse Large B-cell Lymphoma Patients (DLBCL), but Not in GCB DLBCL

Bouwstra, R., He, Y. Z., de Boer, J., Kooistra, H., Cendrowicz, E., Fehrmann, R. S. N., Ammatuna, E., zu Eulenburg, C., Nijland, M., Huls, G. A., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0781 · Cited by 48

PET/MRI Improves Management of Children with Cancer

Baratto, L., Hawk, K. E., States, L. J., Qi, J., Gatidis, S., Kiru, L., & Daldrup-Link, H. E. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.120.259747 · Cited by 42

Targeting the Innate Immune System as Immunotherapy for Acute Myeloid Leukemia

Curran, E. K., Corrales, L. P., & Kline, J. P. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00083 · Cited by 41

Building on the backbone of CD47-based therapy in cancer: Combination strategies, mechanisms, and future perspectives

Ye, Z.-H., Yu, W., Huang, M., Chen, J., & Lu, J. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.12.016 · Cited by 41

Stem-Cell Aging and Pathways to Precancer Evolution

Jamieson, C. H. M., & Weissman, I. L. (2023) · New England Journal of Medicine · doi:10.1056/nejmra2304431 · Cited by 39

Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators

Wu, J., Jordan, M., & Waxman, D. J. (2016) · BMC Cancer · doi:10.1186/s12885-016-2597-2 · Cited by 44

CD47‐SIRP α Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer

Catalán, R., Orozco‐Morales, M., Hernández‐Pedro, N., Güijosa, A., Colín-González, A. L., Ávila‐Moreno, F., & Arrieta, O. G. (2020) · Journal of Immunology Research · doi:10.1155/2020/9435030 · Cited by 40

Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk

Feng, M., Chen, J. Y., Weissman-Tsukamoto, R., Volkmer, J.-P., Ho, P. Y., McKenna, K. M., Cheshier, S. H., Zhang, M., Ring, N. G., Gip, P., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424907112 · Cited by 253

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P. D., Mitra, S. S., Wang, J., Contreras-Trujillo, H., Martin, R. K., Cohen, J. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121623109 · Cited by 1,706

A Calreticulin Tail: C-terminal Mutants of Calreticulin Allow Cancer Cells to Evade Phagocytosis

Kaur, A., & Raghavan, M. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.01.024 · Cited by 5

CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity

Tang, Z.-H., Zhong, M., Qian, J., Galindo, C. C., Davidson, D., Li, J., Zhao, Y., Hui, E., & Veillette, A. (2023) · Nature Immunology · doi:10.1038/s41590-023-01671-2 · Cited by 66

The Macrophage ‘Do not eat me’ signal, CD47, is a clinically validated cancer immunotherapy target

Takimoto, C. H. M., Chao, M. P., Gibbs, C., Mccamish, M. A., Liu, J., Chen, J. Y., Majeti, R., & Weissman, I. L. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz006 · Cited by 128