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Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47
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Calreticulin-induced phagocytosis of cancer cells can be counterbalanced by CD47 expression.
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“increased CD47 levels on the surface of malignant cells correlate with dismal prognosis in subjects with AML, esophageal carcinoma, and ovarian cancer [888–891].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [890]
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Metadata
- Authors
- Chao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., Majeti, R., & Weissman, I. L.
- Affiliations
- Institute for Stem Cell Biology and Regenerative Medicine (US)
- Massachusetts General Hospital (US)
- Stanford Medicine (US)
- Stanford University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Chao, Mark P.
- Majeti, Ravindra
- Weissman, Irving L.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2010-12-22
- Volume
- 2
- Issue
- 63
- Pages
- 63ra94-63ra94
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4126904
- OpenAlex
- W2142541925
- Cited by
- 776
- References
- 55
- Citations by year
- 2026: 35 · 2025: 51 · 2024: 62 · 2023: 81 · 2022: 76 · 2021: 72 · 2020: 62 · 2019: 54 · 2018: 40 · 2017: 48 · 2016: 36 · 2015: 49 · 2014: 31 · 2013: 28 · 2012: 36
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (U54CA149145, CA09302, P01CA139490, R01CA086017, T32CA009302)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- calreticulin, CD47, anti-CD47 antibody, low density lipoprotein receptor-related protein, tumor immune evasion, prognostic factors, acute myeloid leukemia, non-Hodgkin lymphoma, bladder cancer, neuroblastoma, innate immunity
- MeSH terms
- Animals, Urinary Bladder Neoplasms, Cell Line, Flow Cytometry, Humans, Lymphoma, Non-Hodgkin, Phagocytosis, Leukemia, Myeloid, Acute, Calreticulin, Cell Line, Tumor, Mice, CD47 Antigen, In Vitro Techniques
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