Cited by 778Phagocytosis and Immune RegulationCell death mechanisms and regulationAutophagy in Disease and Therapy

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Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

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Chao, Mark P., Jaiswal, Siddhartha, Weissman-Tsukamoto, Rachel, Alizadeh, Ash A., Gentles, Andrew J., Volkmer, Jens, Weiskopf, Kipp, Willingham, Stephen B., Raveh, Tal, Park, Christopher Y., Majeti, Ravindra, Weissman, Irving L.·2010·Science Translational Medicine

DOI 10.1126/scitranslmed.3001375PMC PMC4126904

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Calreticulin-induced phagocytosis of cancer cells can be counterbalanced by CD47 expression.

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The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
Self-citation
Identification of human brain tumour initiating cells
Singh, S. K., Hawkins, C. E., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M. D., & Dirks, P. B. (2004) · Nature · doi:10.1038/nature03128 · Cited by 7,564
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., Minden, M., Paterson, B., Caligiuri, M. A., & Dick, J. E. (1994) · Nature · doi:10.1038/367645a0 · Cited by 4,783
Calreticulin exposure dictates the immunogenicity of cancer cell death
Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
Dai, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni179 · Cited by 1,807
CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells
Majeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.045 · Cited by 1,752
Self-citation
CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
Jaiswal, S., Jamieson, C. H. M., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., Traver, D. J., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.046 · Cited by 1,578
Self-citation
A blast from the past: clearance of apoptotic cells regulates immune responses
Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574
Immune surveillance of tumors
Swann, J. B., & Smyth, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31405 · Cited by 1,518

Show all 55 references

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Simon, L., Constanzo, J., Terraza‐Aguirre, C., Elfekih, Z. I., Berthelot, J., Benkhaled, B. T., Haute, T., Pednekar, K. P., Clark, K., Emerson, S., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122748 · Cited by 40
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Tan, M., Zhu, L., Zhuang, H., Hao, Y., Gao, S., Liu, S., Liu, Q., Liu, D., Liu, J., & Lin, B. (2015) · Europe PMC (PubMed Central) · Cited by 36
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Self-citation
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Authors: Chao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., Majeti, R., & Weissman, I. L.
Affiliations: Institute for Stem Cell Biology and Regenerative Medicine (US)
Massachusetts General Hospital (US)
Stanford Medicine (US)
Stanford University (US)
Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Chao, Mark P.
Majeti, Ravindra
Weissman, Irving L.
ORCID: Chao, Mark P.
Jaiswal, Siddhartha
Alizadeh, Ash A.
Gentles, Andrew J.
Weiskopf, Kipp
Raveh, Tal
Park, Christopher Y.
Majeti, Ravindra
Weissman, Irving L.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-12-22
Volume: 2
Issue: 63
Pages: 63ra94-63ra94
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3001375
PMC: PMC4126904
OpenAlex: W2142541925
Cited by: 776
References: 55
Citations by year: 2026: 35 · 2025: 51 · 2024: 62 · 2023: 81 · 2022: 76 · 2021: 72 · 2020: 62 · 2019: 54 · 2018: 40 · 2017: 48 · 2016: 36 · 2015: 49 · 2014: 31 · 2013: 28 · 2012: 36
FWCI: 10.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Cancer Institute (U54CA149145, CA09302, P01CA139490, R01CA086017, T32CA009302)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: calreticulin, CD47, anti-CD47 antibody, low density lipoprotein receptor-related protein, tumor immune evasion, prognostic factors, acute myeloid leukemia, non-Hodgkin lymphoma, bladder cancer, neuroblastoma, innate immunity
MeSH terms: Animals, Urinary Bladder Neoplasms, Cell Line, Flow Cytometry, Humans, Lymphoma, Non-Hodgkin, Phagocytosis, Leukemia, Myeloid, Acute, Calreticulin, Cell Line, Tumor, Mice, CD47 Antigen, In Vitro Techniques

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Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

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