The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48
Open accessAbstract
A histone-binding protein that declines with age in the human dentate gyrus can reverse age-related memory deficits in mice.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“BDNF plays roles in plasticity and cognitive improvement.”
From 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience (2023) · cites this paper as [27]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172
An anatomically comprehensive atlas of the adult human brain transcriptome
Hawrylycz, M. J., Lein, E. S., Guillozet-Bongaarts, A. L., Shen, E. H., Ng, L., Miller, J. A., van de Lagemaat, L. N., Smith, K. A., Ebbert, A., Riley, Z. L., et al. (2012) · Nature · doi:10.1038/nature11405 · Cited by 3,083
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796 · cited 1×
“Postmortem studies have suggested that the entorhinal cortex (EC) as well as the CA1 subregion and the subiculum are the hippocampal subregions that are most affected by AD (2, 3), whereas the dentate gyrus (DG) and CA3 are relatively preserved (2, 4, 5).”
BackgroundIncreasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · Science · doi:10.1126/science.1186088 · Cited by 951
Object recognition memory and the rodent hippocampus
Broadbent, N. J., Gaskin, S., Squire, L. R., & Clark, R. E. (2010) · Learning & Memory · doi:10.1101/lm.1650110 · Cited by 568
Imaging hippocampal function across the human life span: Is memory decline normal or not?
Small, S. A., Tsai, W. Y., DeLaPaz, R., Mayeux, R., & Stern, Y. (2002) · Annals of Neurology · doi:10.1002/ana.10105 · Cited by 205
Self-citationChen, Y.-J. J., Johnson, M. A., Lieberman, M. D., Goodchild, R. E., Schobel, S., Lewandowski, N., Rosoklija, G., Liu, R.-C., Gingrich, J. A., Small, S., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1815-08.2008 · Cited by 188
Self-citationAltered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice
Verbitsky, M., Yonan, A. L., Malleret, G., Kandel, E. R., Gilliam, T. C., & Pavlidis, P. (2004) · Learning & Memory · doi:10.1101/lm.68204 · Cited by 158
Research works printed but not linked: 41
- 10.1038/nrn3085 · DOI
- 10.1212/WNL.58.12.1791 · DOI · Paper page
- 10.1016/0197-4580(93)90113-P · DOI
- 10.1002/1531-8249(199904)45:4<466::AID-ANA8>3.0.CO;2-Q · DOI
- 10.1002/nbm.1022 · DOI
- 10.1001/archneur.64.10.1467 · DOI
- 10.1073/pnas.0400285101 · DOI
- 10.1101/lm.1315109 · DOI
- Yassa M. A., Lacy J. W., Stark S. M., Albert M. S., Gallagher M., Stark C. E., Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus 21, 968–979 (2011). · DOI · Paper page
- 10.1101/lm.1768110 · DOI
- Brickman A. M., Stern Y., Small S. A., Hippocampal subregions differentially associate with standardized memory tests. Hippocampus 21, 923–928 (2011). · DOI
- 10.1523/JNEUROSCI.4006-05.2005 · DOI
- 10.1002/ana.20667 · DOI · Paper page
- 10.1128/MCB.20.14.4970-4978.2000 · DOI
- 10.1016/j.neuron.2004.05.021 · DOI · Paper page
- 10.1016/j.neuron.2004.06.002 · DOI · Paper page
- 10.1523/JNEUROSCI.0296-07.2007 · DOI
- 10.1016/S0006-8993(02)03562-X · DOI
- 10.1016/j.neurobiolaging.2009.12.019 · DOI
- 10.1128/MCB.19.9.5847 · DOI
- 10.1126/science.274.5293.1678 · DOI · Paper page
- 10.1093/geronb/50B.3.P171 · DOI
- 10.1037/0882-7974.7.2.299 · DOI
- 10.1126/science.7618082 · DOI
- 10.1016/S0197-4580(88)80103-9 · DOI
- 10.1523/JNEUROSCI.09-10-03568.1989 · DOI
- 10.1016/S0531-5565(02)00160-2 · DOI
- 10.1016/j.cell.2011.09.056 · DOI
- 10.1210/jc.2006-2199 · DOI
- 10.1074/jbc.M702195200 · DOI
- 10.1038/297681a0 · DOI · Paper page
- 10.1097/FBP.0b013e3282d28f83 · DOI · Paper page
- 10.1007/s11357-006-9015-7 · DOI
- 10.1002/(SICI)1522-2586(199901)9:1<44::AID-JMRI6>3.0.CO;2-7 · DOI
- 10.1038/npp.2009.58 · DOI · Paper page
- 10.2174/156720506779025161 · DOI
- 10.1523/JNEUROSCI.4737-10.2011 · DOI
- 10.1016/j.preteyeres.2007.07.002 · DOI
- 10.1073/pnas.0806883105 · DOI · Paper page
- 10.1073/pnas.96.9.5280 · DOI
- 10.1016/S0896-6273(00)80958-7 · DOI · Paper page
Cited by
Sorted by citations
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081
TDP-43 is a key player in the clinical features associated with Alzheimer’s disease
Josephs, K. A., Whitwell, J. L., Weigand, S. D., Murray, M. E., Tosakulwong, N., Liesinger, A. M., Petrucelli, L., Senjem, M. L., Knopman, D. S., Boeve, B. F., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1269-z · Cited by 481
“The dentate fascia was selected for the burden analysis since the dentate fascia has been demonstrated to be most strongly associated with memory loss [36].”
Taurine deficiency as a driver of aging
Singh, P. P., Gollapalli, K., Mangiola, S., Schranner, D., Yusuf, M. A., Chamoli, M., Shi, S. L., Lopes-Bastos, B., Nair, T., Riermeier, A., et al. (2023) · Science · doi:10.1126/science.abn9257 · Cited by 475
Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
Brickman, A. M., Khan, U., Provenzano, F. A., Yeung, L., SUZUKI, W. A., Schroeter, H., Wall, M. M., Sloan, R. P., & Small, S. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3850 · Cited by 354
Self-citationHippocampal neurogenesis: Learning to remember
Lazarov, O., & Hollands, C. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.006 · Cited by 297
“Thus it is thought that age-related memory loss begins in the DG (Pavlopoulos et al., 2013).”
Background
Metadata
- Authors
- Pavlopoulos, E., Jones, S., Kosmidis, S., Close, M., Kim, C., Kovalerchik, O., Small, S. A., & Kandel, E. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Columbia University (US)
- Corresponding author
- Jones, Sidonie
- Kosmidis, Stylianos
- Small, Scott A.
- Kandel, Eric R.
- Venue
- Science Translational Medicine
- Published
- 2013-08-28
- Volume
- 5
- Issue
- 200
- Pages
- 200ra115-200ra115
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4940031
- OpenAlex
- W2104064321
- Cited by
- 109
- References
- 50
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 12 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 10 · 2015: 12 · 2014: 22 · 2013: 5
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG034618, R01AG025161, P50AG008702)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- age-related memory decline, RbAp48, histone-binding proteins, histone acetylation, dentate gyrus, hippocampus, cognitive aging, Alzheimer's disease, gene expression profiling, hippocampal-dependent memory, entorhinal cortex, novel object recognition, Morris water maze
- MeSH terms
- Acetylation, Adult, Aged, Aged, 80 and over, Aging, Animals, Female, Genes, Dominant, Histones, Humans, Male, Membrane Proteins, Memory Disorders, Middle Aged, Organ Specificity, Phosphoproteins, Protein Binding, RNA, Messenger, Gene Expression Regulation, Developmental, Dentate Gyrus, Oligonucleotide Array Sequence Analysis, Mice, Histone Acetyltransferases, Retinoblastoma-Binding Protein 4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
