Cited by 109Memory and Neural MechanismsNeurogenesis and neuroplasticity mechanismsGenomics and Chromatin Dynamics

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Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48

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Pavlopoulos, Elias, Jones, Sidonie, Kosmidis, Stylianos, Close, Maggie, Kim, Carla, Kovalerchik, Olga, Small, Scott A., Kandel, Eric R.·2013·Science Translational Medicine

DOI 10.1126/scitranslmed.3006373PMC PMC4940031

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Abstract

A histone-binding protein that declines with age in the human dentate gyrus can reverse age-related memory deficits in mice.

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Background

Authors: Pavlopoulos, E., Jones, S., Kosmidis, S., Close, M., Kim, C., Kovalerchik, O., Small, S. A., & Kandel, E. R.
Affiliations: Howard Hughes Medical Institute (US)
Columbia University (US)
Corresponding author: Jones, Sidonie
Kosmidis, Stylianos
Small, Scott A.
Kandel, Eric R.
ORCID: Kosmidis, Stylianos
Kim, Carla
Small, Scott A.
Kandel, Eric R.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2013-08-28
Volume: 5
Issue: 200
Pages: 200ra115-200ra115
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3006373
PMC: PMC4940031
OpenAlex: W2104064321
Cited by: 109
References: 50
Citations by year: 2026: 3 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 12 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 10 · 2015: 12 · 2014: 22 · 2013: 5
FWCI: 8.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG034618, R01AG025161, P50AG008702)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: age-related memory decline, RbAp48, histone-binding proteins, histone acetylation, dentate gyrus, hippocampus, cognitive aging, Alzheimer's disease, gene expression profiling, hippocampal-dependent memory, entorhinal cortex, novel object recognition, Morris water maze
MeSH terms: Acetylation, Adult, Aged, Aged, 80 and over, Aging, Animals, Female, Genes, Dominant, Histones, Humans, Male, Membrane Proteins, Memory Disorders, Middle Aged, Organ Specificity, Phosphoproteins, Protein Binding, RNA, Messenger, Gene Expression Regulation, Developmental, Dentate Gyrus, Oligonucleotide Array Sequence Analysis, Mice, Histone Acetyltransferases, Retinoblastoma-Binding Protein 4

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Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48

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