The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2 -deficient mice
Open accessAbstract
Using optogenetics to modulate the excitation/inhibition balance in the prefrontal cortex of an autism-like mouse model rescued social behavior deficits.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“while in CNTNAP2 deficient mice a decreased ratio of GABA to glutamate is seen in the medial prefrontal cortex (Selimbeyoglu et al. 2017), a finding paralleling results in autism patients (Harada et al. 2011).”
From Dysfunctional Autism Risk Genes Cause Circuit-Specific Connectivity Deficits With Distinct Developmental Trajectories (2018) · cites this paper as Selimbeyoglu et al. 2017
In the citing paper
“Although our experiment cannot prove a direct cause–effect relationship, we have shown a time-dependent relationship between the altered connectivity in prefrontal and ventral striatal networks that may be related to the imbalanced excitation/inhibition in mPFC of CNTNAP2−/− mice (Selimbeyoglu et al. 2017).”
From Dysfunctional Autism Risk Genes Cause Circuit-Specific Connectivity Deficits With Distinct Developmental Trajectories (2018) · cites this paper as Selimbeyoglu et al. 2017
In the citing paper
“social deficits present in mice lacking the Cntnap2 gene were rescued by correcting E/I imbalance via optogenetic activation of inhibitory PV neurons or inhibition of excitatory pyramidal neurons in the mPFC [126].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [126]
In the citing paper
“earlier findings that decreasing mPFC excitatory activity can rescue social deficits in an ASD mouse model24”
From Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits (2020) · cites this paper as [24]
In the citing paper
“Neural circuit manipulation in combination with neural recordings provide direct evidence that elevated mPFC activity results in ASD-related phenotypes, whereas decreasing mPFC activity is sufficient to rescue abnormal behaviors in ASD models22,23,24.”
From Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits (2020) · cites this paper as [24]
In the citing paper
“Consistent with these results, social deficits in the CNTNP2-deficient mouse model of autism could be rescued by modulating the excitability of pyramidal neurons (Selimbeyoglu et al., 2017).”
From Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019) · cites this paper as Selimbeyoglu et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606
Self-citationDriving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603
Self-citationNeocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454
Self-citationImaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
Tian, L., Hires, S. A., Mao, T., Huber, D., Chiappe, M. E., Chalasani, S. H., Petreanu, L., Akerboom, J., McKinney, S. A., Schreiter, E. R., et al. (2009) · Nature Methods · doi:10.1038/nmeth.1398 · Cited by 1,967
Anxiety Disorders in Children and Adolescents with Autistic Spectrum Disorders: A Meta-Analysis
van Steensel, F. J. A., Bögels, S. M., & Perrin, S. (2011) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-011-0097-0 · Cited by 1,463
Natural neural projection dynamics underlying social behavior
Gunaydin, L. A., Grosenick, L., Finkelstein, J. C., Kauvar, I. V., Fenno, L. E., Adhikari, A., Lammel, S., Mirzabekov, J. J., Airan, R. D., Zalocusky, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.017 · Cited by 1,389
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Robertson, C. E., & Baron-Cohen, S. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.112 · Cited by 1,157
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182
Sohal, V. S., & Rubenstein, J. L. R. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0426-0 · Cited by 988
Ferguson, B. R., & Gao, W.-J. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00037 · Cited by 594
Antoine, M. W., Langberg, T., Schnepel, P., & Feldman, D. E. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.026 · Cited by 413
Medial prefrontal cortex in neurological diseases
Xu, P., Chen, A., Li, Y., Xing, X., & Lü, H. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00006.2019 · Cited by 360
Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits
Kelly, E., Meng, F., Fujita, H., Morgado, F., Kazemi, Y., Rice, L. C., Ren, C., Escamilla, C. O., Gibson, J. M., Sajadi, S., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0665-z · Cited by 280
Inoue, M., Takeuchi, A., Manita, S., Horigane, S., Sakamoto, M., Kawakami, R., Yamaguchi, K., Otomo, K., Yokoyama, H., Kim, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.007 · Cited by 245
Self-citationPrefrontal–amygdala circuits in social decision-making
Gangopadhyay, P., Chawla, M., Monte, O. D., & Chang, S. W. C. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00738-9 · Cited by 266
Parvalbumin interneuron vulnerability and brain disorders
Ruden, J. B., Dugan, L. L., & Konradi, C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-0778-9 · Cited by 194
Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour
Jennings, J. H., Kim, C. K., Marshel, J. H., Raffiee, M., Li, Y., Quirin, S., Pak, S., Ramakrishnan, C., & Deisseroth, K. A. (2019) · Nature · doi:10.1038/s41586-018-0866-8 · Cited by 219
Self-citationVentral hippocampal projections to the medial prefrontal cortex regulate social memory
Phillips, M. L., Robinson, H. A., & Pozzo-Miller, L. (2019) · eLife · doi:10.7554/elife.44182 · Cited by 205
Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice
Scheggia, D., Managò, F., Maltese, F., Bruni, S., Nigro, M., Dautan, D., Latuske, P., Contarini, G., Gomez-Gonzalo, M., Requie, L. M., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0551-8 · Cited by 192
Ferguson, B. R., & Gao, W.-J. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.033 · Cited by 186
Cortical interneurons in autism
Contractor, A., Ethell, I. M., & Portera‐Cailliau, C. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00967-6 · Cited by 186
Trakoshis, S., Martínez‐Cañada, P., Rocchi, F., Canella, C., You, W., Chakrabarti, B., Ruigrok, A. N. V., Bullmore, E. T., Suckling, J., Markicevic, M., et al. (2020) · eLife · doi:10.7554/elife.55684 · Cited by 176
Social Behavior Is Modulated by Valence-Encoding mPFC-Amygdala Sub-circuitry
Huang, W., Zucca, A., Levy, J., & Page, D. T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107899 · Cited by 171
Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice
Jung, H., Park, H., Choi, Y., Kang, H., Lee, E., Kweon, H., Roh, J. D., Ellegood, J., Choi, W., Kang, J., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0208-z · Cited by 157
Gong, X., Mendoza-Halliday, D., Ting, J. T., Kaiser, T., Sun, X., Bastos, A. M., Wimmer, R. D., Guo, B., Chen, Q., Zhou, Y., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.032 · Cited by 152
Self-citationBicks, L. K., Yamamuro, K., Flanigan, M. E., Kim, J. M., Kato, D., Lucas, E. K., Koike, H., Peng, M. S., Brady, D. M., Chandrasekaran, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14740-z · Cited by 150
Sacai, H., Sakoori, K., Konno, K., Nagahama, K., Suzuki, H., Watanabe, T., Watanabe, M., Uesaka, N., & Kano, M. (2020) · Nature Communications · doi:10.1038/s41467-020-18861-3 · Cited by 148
Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration
Henstridge, C. M., Tzioras, M., & Paolicelli, R. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00063 · Cited by 155
Lazaro, M. T., Taxidis, J., Shuman, T., Bachmutsky, I., Ikrar, T., Santos, R., Marcello, G. M., Mylavarapu, A., Chandra, S., Foreman, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.006 · Cited by 125
Dynamics of social representation in the mouse prefrontal cortex
Levy, D. R., Tamir, T., Kaufman, M., Parabucki, A., Weissbrod, A., Schneidman, E., & Yizhar, O. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0531-z · Cited by 135
Differential Encoding in Prefrontal Cortex Projection Neuron Classes Across Cognitive Tasks
Lui, J. H., Nguyen, N. D., Grutzner, S. M., Darmanis, S., Peixoto, D., Wagner, M. J., Allen, W. E., Kebschull, J. M., Richman, E. B., Ren, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.046 · Cited by 124
Cell migration promotes dynamic cellular interactions to control cerebral cortex morphogenesis
Silva, C. G., Peyre, E., & Nguyen, L. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0148-y · Cited by 125
Sun, Q., Li, X., Li, A., Zhang, J., Ding, Z., Gong, H., & Luo, Q. (2020) · iScience · doi:10.1016/j.isci.2020.100894 · Cited by 105
Human cerebral organoids establish subcortical projections in the mouse brain after transplantation
Dong, X., Xu, S., Chen, X., Tao, M., Tang, X.-Y., Fang, K.-H., Xu, M., Pan, Y., Chen, Y., He, S., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00910-4 · Cited by 121
Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits
Kanellopoulos, A. K., Mariano, V., Spinazzi, M., Woo, Y. J., Mclean, C., Pech, U., Li, K. W., Armstrong, J. D., Giangrande, A., Callaerts, P., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.044 · Cited by 119
Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors
Tsai, P. T., Rudolph, S., Guo, C., Ellegood, J., Gibson, J. M., Schaeffer, S. M., Mogavero, J. N., Lerch, J. P., Regehr, W. G., & Şahin, M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.039 · Cited by 111
Jabarin, R., Netser, S., & Wagner, S. (2022) · Molecular Autism · doi:10.1186/s13229-022-00521-6 · Cited by 119
Pharmacological modulation of AMPA receptor rescues social impairments in animal models of autism
Kim, J., Park, K., Kang, R. J., Gonzales, E. L., Kim, D. G., Oh, H. A., Seung, H., Ko, M. J., Kwon, K. J., Kim, K. C., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0098-5 · Cited by 111
Self-citationAutism Spectrum Disorder: Focus on Glutamatergic Neurotransmission
Montanari, M., Martella, G., Bonsi, P., & Meringolo, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073861 · Cited by 114
Red‐Blood‐Cell Waveguide as a Living Biosensor and Micromotor
Li, Y., Liu, X., Xu, X., Xin, H., Zhang, Y., & Li, B. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201905568 · Cited by 99
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes
Matsumura, K., Seiriki, K., Okada, S., Nagase, M., Ayabe, S., Yamada, I., Furuse, T., Shibuya, H., Yasuda, Y., Yamamori, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14697-z · Cited by 107
Structural mechanisms of selectivity and gating in anion channelrhodopsins
KATO, H. E., Kim, Y. S., Paggi, J. M., Evans, K. E., Allen, W. E., Richardson, C. E., Inoue, K., Ito, S., Ramakrishnan, C., Fenno, L. E., et al. (2018) · Nature · doi:10.1038/s41586-018-0504-5 · Cited by 93
Self-citationNeural circuit dysfunction in mouse models of neurodevelopmental disorders
del Pino, I., Rico, B., & Marín, Ó. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.12.013 · Cited by 100
Zerbi, V., Ielacqua, G. D., Markicevic, M., Haberl, M. G., Ellisman, M. H., A-Bhaskaran, A., Frick, A., Rudin, M., & Wenderoth, N. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy046 · Cited by 81
Single-Molecule Analysis and Engineering of DNA Motors
Mohapatra, S., Lin, C.-T., Feng, X. A., Basu, A., & Ha, T. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00361 · Cited by 89
Dysregulation of Parvalbumin Expression in the Cntnap2−/− Mouse Model of Autism Spectrum Disorder
Lauber, E., Filice, F., & Schwaller, B. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00262 · Cited by 94
Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda
Grzadzinski, R., Amso, D., Landa, R. J., Watson, L. R., Guralnick, M. J., Zwaigenbaum, L., Deák, G. O., Estes, A. M., Brian, J. A., Bath, K. G., et al. (2021) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-021-09393-y · Cited by 98
The Three-Dimensional Signal Collection Field for Fiber Photometry in Brain Tissue
Pisanello, M., Pisano, F., Hyun, M., Maglie, E., Balena, A., Vittorio, M. D., Sabatini, B. L., & Pisanello, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00082 · Cited by 85
Li, L., Lu, L., Ren, Y., Tang, G. Y., Zhao, Y., Cai, X., Shi, Z. H., Ding, H., Liu, C., Cheng, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28539-7 · Cited by 89
Meningeal lymphatics-microglia axis regulates synaptic physiology
Kim, K., Abramishvili, D., Du, S., Papadopoulos, Z., Cao, J., Herz, J., Smirnov, I., Thomas, J., Colonna, M., & Kipnis, J. (2025) · Cell · doi:10.1016/j.cell.2025.02.022 · Cited by 86
Hartl, C., Ramaswami, G., Pembroke, W. G., Muller, S., Pintacuda, G., Saha, A., Parsana, P., Battle, A. J., Lage, K., & Geschwind, D. H. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00887-5 · Cited by 86
Xie, Y., Xu, Z., Xia, M., Liu, J., Shou, X., Cui, Z., Liao, X., & Yong He, A. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.12.004 · Cited by 81
Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse
Choe, K. Y., Bethlehem, R. A. I., Safrin, M., Dong, H., Salman, E., Li, Y., Grinevich, V., Golshani, P., DeNardo, L. A., Peñagarikano, O., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.031 · Cited by 81
Saint‐Martin, M., Joubert, B., Pellier‐Monnin, V., Pascual, O., Noraz, N., & Honnorat, J. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14081 · Cited by 91
Liu, L., Xu, H., Wang, J., Li, J., Tian, Y., Zheng, J., He, M., Xu, T., Wu, Z., Li, W., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay4073 · Cited by 85
Masuda, F., Nakajima, S., Miyazaki, T., Yoshida, K., Tsugawa, S., Wada, M., Ogyu, K., Croarkin, P. E., Blumberger, D. M., Daskalakis, Z. J., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0444-3 · Cited by 83
Wu, Y., Wu, M., Vázquez‐Guardado, A., Kim, J., Zhang, X., Avila, R. O., Kim, J., Deng, Y., Yu, Y., Melzer, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32947-0 · Cited by 79
New insights on synaptic dysfunction in neuropsychiatric disorders
Caldeira, G. L., Peça, J., & Carvalho, A. L. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.01.004 · Cited by 76
Ajram, L. A., Pereira, A. C., Durieux, A. M. S., Velthuis, H., Petrinovic, M. M., & McAlonan, G. M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.09.010 · Cited by 81
Kiss, B., Laszlovszky, I., Krámos, B., Visegrády, A., Bobok, A. Á., Lévay, G. I., Lendvai, B., & Román, V. (2021) · Biomolecules · doi:10.3390/biom11010104 · Cited by 74
The social dilemma: prefrontal control of mammalian sociability
Yizhar, O., & Levy, D. R. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.01.007 · Cited by 76
Neural circuits regulating prosocial behaviors
Walsh, J. J., Christoffel, D. J., & Malenka, R. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01348-8 · Cited by 72
Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice
Xing, X., Zhang, J., Wu, K., Cao, B., Li, X., Jiang, F., Hu, Z., Xia, K., & Li, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-39434-5 · Cited by 77
Mohapatra, A. N., & Wagner, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1205199 · Cited by 71
Reichelt, A. C., Gibson, G. D., Abbott, K. N., & Hare, D. J. (2019) · Food & Function · doi:10.1039/c8fo02118j · Cited by 65
Paternò, R., Marafiga, J. R., Ramsay, H. J., Li, T., Salvati, K. A., & Baraban, S. C. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109970 · Cited by 74
Alteration of Gut Microbiota: New Strategy for Treating Autism Spectrum Disorder
Liu, J., Gao, Z., Chuanqi, L., Liu, T., Gao, J., Cai, Y., & Fan, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.792490 · Cited by 71
Li, J., Wu, X., Zhao, L.-J., Sun, H.-X., Hong, J., Wu, F.-L., Chen, S., Chen, T., Li, H., Dong, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38264-4 · Cited by 63
What we can learn from a genetic rodent model about autism
Möhrle, D., Fernández, M. C., Peñagarikano, O., Frick, A., Allman, B. L., & Schmid, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.015 · Cited by 60
CNTNAP2 stabilizes interneuron dendritic arbors through CASK
Gao, R., Piguel, N. H., Melendez-Zaidi, A. E., Martin‐de‐Saavedra, M. D., Yoon, S., Forrest, M. P., Myczek, K., Zhang, F. G., Russell, T. A., Csernansky, J. G., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0027-3 · Cited by 57
Cortical interneuron function in autism spectrum condition
Lunden, J. W., Durens, M., Phillips, A. W., & Nestor, M. W. (2018) · Pediatric Research · doi:10.1038/s41390-018-0214-6 · Cited by 56
Lee, S., Lee, E., Kim, R., Kim, J., Lee, S., Park, H., Yang, E., Kim, H., & Kim, E. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00209 · Cited by 54
Self-citationTransient Cognitive Impairment in Epilepsy
Landi, S., Petrucco, L., Sicca, F., & Ratto, G. M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00458 · Cited by 57
Smith, J. R., DiSalvo, M., Green, A., Ceranoglu, T. A., Anteraper, S. A., Croarkin, P. E., & Joshi, G. (2022) · Neuropsychology Review · doi:10.1007/s11065-022-09564-1 · Cited by 57
Mechanisms Underlying Circuit Dysfunction in Neurodevelopmental Disorders
Exposito-Alonso, D., & Rico, B. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-072820-023642 · Cited by 49
Oxytocin and excitation/inhibition balance in social recognition
Lopatina, O. L., Komleva, Y. K., Gorina, Y. V., Olovyannikova, R. Y., Труфанова, Л. В., Hashimoto, T., Takahashi, T., Kikuchi, M., Minabe, Y., Higashida, H., et al. (2018) · Neuropeptides · doi:10.1016/j.npep.2018.09.003 · Cited by 53
Miyoshi, G., Ueta, Y., Natsubori, A., Hiraga, K., Osaki, H., Yagasaki, Y., Kishi, Y., Yanagawa, Y., Fishell, G., Machold, R. P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23987-z · Cited by 56
Amegandjin, C. A., Choudhury, M., Jadhav, V., Carriço, J. N., Quintal, A., Berryer, M. H., Snapyan, M., Chattopadhyaya, B., Saghatelyan, A., & Cristo, G. D. (2021) · Nature Communications · doi:10.1038/s41467-021-23939-7 · Cited by 53
Step by step: cells with multiple functions in cortical circuit assembly
Cossart, R., & Garel, S. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00585-6 · Cited by 54
Reichelt, A. C., Loughman, A., Bernard, A., Raipuria, M., Abbott, K. N., Dachtler, J., Van, T. T. H., & Moore, R. J. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1537169 · Cited by 49
Cognitive impairment in psychiatric diseases: Biomarkers of diagnosis, treatment, and prevention
Wang, Y., Meng, W., Liu, Z., An, Q., & Hu, X. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1046692 · Cited by 51
Casanova, M. F., Shaban, M., Ghazal, M. A., El-Baz, A. S., Casanova, M., Opriș, I. C., & Sokhadze, E. M. (2020) · Brain Sciences · doi:10.3390/brainsci10070423 · Cited by 53
Keeping Excitation–Inhibition Ratio in Balance
Kirischuk, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105746 · Cited by 48
Dopamine, vocalization, and astrocytes
Turk, A. Z., Marchoubeh, M. L., Fritsch, I., Maguire, G. A., & SheikhBahaei, S. (2021) · Brain and Language · doi:10.1016/j.bandl.2021.104970 · Cited by 44
Dissecting the neurobiology of linguistic disorganisation and impoverishment in schizophrenia
Palaniyappan, L. K. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.08.015 · Cited by 53
Prefrontal-amygdalar oscillations related to social behavior in mice
Kuga, N., Abe, R., Takano, K., Ikegaya, Y., & Sasaki, T. (2022) · eLife · doi:10.7554/elife.78428 · Cited by 47
Xu, P., Yue, Y., Su, J., Sun, X., Du, H., Liu, Z., Simha, R., Zhou, J., Zeng, C., & Lü, H. (2022) · Nature Communications · doi:10.1038/s41467-022-31578-9 · Cited by 49
Kelly, E., Escamilla, C. O., & Tsai, P. T. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.012 · Cited by 46
Home-cage hypoactivity in mouse genetic models of autism spectrum disorder
Angelakos, C. C., Tudor, J. C., Ferri, S. L., Jongens, T. A., & Abel, T. G. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.02.010 · Cited by 44
Role of BDNF in the development of an OFC-amygdala circuit regulating sociability in mouse and human
Li, A., Jing, D., Dellarco, D. V., Hall, B. S., Yang, R., Heilberg, R. T., Huang, C., Liston, C. M., Casey, B. J., & Lee, F. S. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0422-4 · Cited by 43
Yoo, T., Cho, H., Park, H., Lee, J., & Kim, E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00458 · Cited by 41
Smith, C. J. W., Kingsbury, M. A., Dziabis, J. E., Hanamsagar, R., Malacon, K. E., Tran, J. N., Norris, H. A., Gulino, M., Bordt, E. A., & Bilbo, S. D. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.08.013 · Cited by 47
Shankopathies in the Developing Brain in Autism Spectrum Disorders
Vyas, Y., Cheyne, J. E., Lee, K., Jung, Y., Cheung, P. Y., & Montgomery, J. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.775431 · Cited by 46
Casanova, M. F., Sokhadze, E. M., Casanova, M., & Li, X. (2020) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2020.100832 · Cited by 45
Frost, N. A., Haggart, A., & Sohal, V. S. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001235 · Cited by 40
Kalinowska, M., van der Lei, M. B., Kitiashvili, M., Mamcarz, M., Oliveira, M. M., Longo, F., & Klann, E. (2021) · Molecular Autism · doi:10.1186/s13229-022-00509-2 · Cited by 39
Lee, E., Lee, S., Shin, J. J., Choi, W., Chung, C., Lee, S., Kim, J., Ha, S., Kim, R., Yoo, T., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25356-2 · Cited by 41
Self-citationSpinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone
Zhang, Z., Su, J., Tang, J., Chung, L., Page, J. C., Winter, C. C., Liu, Y., Kegeles, E., Conti, S., Zhang, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.04.022 · Cited by 41
Large-scale metagenomic analysis of oral microbiomes reveals markers for autism spectrum disorders
Manghi, P., Filosi, M., Zolfo, M., Casten, L. G., García-Valiente, A., Mattevi, S., Heidrich, V., Golzato, D., Perini, S., Thomas, A. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53934-7 · Cited by 42
Park, G., Jeon, S. J., Ko, I. O., Park, J. H., Lee, K. C., Kim, M., Shin, C. Y., Kim, H., & Lee, Y. (2022) · Molecular Brain · doi:10.1186/s13041-022-00904-z · Cited by 37
Shepard, R. M., Heslin, K. A., Hagerdorn, P. L., & Coutellier, L. D. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0436-3 · Cited by 39
Dopamine D2 receptors in pyramidal neurons in the medial prefrontal cortex regulate social behavior
Chen, H. H., Xiong, X.-X., Jin, S.-Y., He, X., He, X., Yang, J.-M., Gao, T., & Chen, Y. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.107042 · Cited by 36
Somatosensory cortex hyperconnectivity and impaired whisker-dependent responses in Cntnap2−/− mice
Balasco, L., Pagani, M., Pangrazzi, L., Chelini, G., Viscido, F., Chama, A. G. C., Galbusera, A., Provenzano, G., Gozzi, A., & Bozzi, Y. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105742 · Cited by 41
USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-Dependent Protein Levels
Campbell, M. K., & Sheng, M. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3305-17.2018 · Cited by 35
PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex
McEachern, E., Coley, A. A., Yang, S.-S., & Gao, W. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108277 · Cited by 33
A systematic review of cannabidiol trials in neurodevelopmental disorders
Parrella, N.-F., Hill, A. T., Enticott, P. G., Barhoun, P., Bower, I. S., & Ford, T. C. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173607 · Cited by 34
Metadata
- Authors
- Selimbeyoglu, A., Kim, C. K., Inoue, M., Lee, S. Y., Hong, A. S. O., Kauvar, I., Ramakrishnan, C., Fenno, L. E., Davidson, T. J., Wright, M., & Deisseroth, K.
- Affiliations
- Stanford University (US)
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Deisseroth, Karl
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2017-08-02
- Volume
- 9
- Issue
- 401
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5723386
- OpenAlex
- W2740920123
- Cited by
- 326
- References
- 47
- Citations by year
- 2026: 30 · 2025: 40 · 2024: 34 · 2023: 35 · 2022: 37 · 2021: 45 · 2020: 41 · 2019: 38 · 2018: 24 · 2017: 2
- FWCI
- 19.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute (award299942, None)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- CNTNAP2, prefrontal cortex, excitation-inhibition balance, social behavior, autism spectrum disorder, knockout mice, neural circuit modulation, social dysfunction
- MeSH terms
- Animals, Autistic Disorder, Behavior, Animal, Genetic Engineering, Membrane Proteins, Mice, Inbred C57BL, Movement, Nerve Tissue Proteins, Neurons, Parvalbumins, Social Behavior, Prefrontal Cortex, Mice, Knockout, Opsins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
