The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence
Open accessAbstract
Inhibiting acute injury–induced senescence mediated by TGFβ signaling in regenerative epithelium improves liver regeneration.
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“Similarly, transforming growth factor-β improves liver regeneration on injury by blocking paracrine senescence in neighbouring uninjured hepatocytes188.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [188]
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“While the role of paracrine senescence in cancer is yet undefined, it has been found to contribute to liver dysfunction upon acetaminophen overdose (Bird et al. 2018).”
From Senescence and the SASP: many therapeutic avenues (2020) · cites this paper as Bird et al. 2018
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“Other times, individual SASP components, such as TGF-β, might be pinpointed as disease drivers and targeting them specifically might be appropriate (Bird et al. 2018).”
From Senescence and the SASP: many therapeutic avenues (2020) · cites this paper as Bird et al. 2018
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Cites
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“These findings contrast with previous reports in which senescence after injury in other organs may facilitate regeneration (37) and limit fibrosis after liver injury (11).”
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Exacerbation of gefitinib-induced liver injury by glutathione reduction in mice
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Hepatocyte-Specific MET Deletion Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice
Jain, S., Mukherjee, R., Williams, G., Liu, J.-J., Faccioli, L. A. P., Hu, Z., Florentino, R. M., Michalopoulos, G. K., Soto–Gutiérrez, A., Liu, S., et al. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.09.010 · Cited by 2
“5,32,34 Apart from these pathways, XBP1 and UPR were consistently found to be among the top significant pathway/upstream regulators inhibited in MET KO mice in all the transcriptomic analyses.”
ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation
Sahu, S. K., Memczak, S., Thakurela, S., Lu, J., Gupta, P., Mutukula, N., Hirano, A., Zhang, Y., Hishida, T., Kurita, M., et al. (2026) · Cell stem cell · doi:10.1016/j.stem.2026.05.009 · Cited by 2
Cellular senescence during aging and chronic liver diseases
Jurk, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00005-5 · Cited by 2
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Hematopoietic Stem Cells of Bone Marrow and Their Total RNA in Rat Liver Regeneration
Онищенко, Н. А., Shagidulin, M. Y., Гоникова, З. З., Nikolskaya, A. O., Кирсанова, Л. А., Venediktov, A. A., Pokidova, K., Александрович, К. Е., Kuznetsova, N. V., Kozlov, I., et al. (2025) · Applied Sciences · doi:10.3390/app15073782 · Cited by 2
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Acute liver injury progression is associated with dynamic enteric eubiosis alteration in mice
Mei, F., Chen, T., Zhang, X., & Chen, P. (2022) · Medicine in Microecology · doi:10.1016/j.medmic.2022.100063 · Cited by 1
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Cao, L., & Zhao, Y. W. (2026) · Cytotechnology · doi:10.1007/s10616-026-01020-9 · Cited by 1
“Notably, inhibition of the TGF-β signaling pathway effectively reduces the hepatic senescence burden and promotes tissue regeneration (Bird et al. 2018), suggesting that targeting this pathway may be an effective approach to alleviate MASLD-associated hepatocyte senescence.”
Tsouri, E., Athanasopoulou, N., Akkari, L., & Vegna, S. (2026) · Seminars in Immunology · doi:10.1016/j.smim.2026.102053 · Cited by 1
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Liver diseases fibrosis and cirrhosis
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Self-citationStem cell signaling molecules and pathways in liver regeneration
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Senolytic treatment targets aberrant p21-expression to restore liver regeneration in adult micePreprint
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“6 treatment (Bird et al., 2018), Mdm2-deletion (Lu et al.”
BackgroundKiourtis, C., Wilczynska, A., Nixon, C., Clark, W. A., May, S., & Bird, T. G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.19.431990 · Cited by 1
Self-citationSRC activation skews cell fate from apoptosis to senescencePreprint
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“…is known to be inhibitory of hepatocyte proliferation after a partial hepatectomy and to inhibit liver regeneration after APAP toxicity, is increased in untreated APAP-ALF mice while significantly decreased in treated APAP-ALF mice to a similar level to that of healthy mice (Bird et al., 2018).”
BackgroundSmith, A. R., Rizvi, F., Everton, E., Adeagbo, A., Wu, S. Y., Tam, Y. K., Muramatsu, H., Pardi, N., Weissman, D., & Gouon–Evans, V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.11.575286 · Cited by 1
“Given that p21 expression is naturally occurring in hepatocytes, especially those adjacent to the necrotic areas in the liver of APAP overdosed patients 42 , we recapitulated this context by injecting NSG mice with one dose of AAV8-TBG-p21 virus 2 weeks prior to APAP overdose.”
BackgroundMethodSingle-Cell Resolution of Cellular Damage Illuminates Disease ProgressionPreprint
Padvitski, T., Avila, P. U., Chen, H., Özel, C., Braun, F., Kroll, M.-K., Vossen, C., Wienand, P., Butt, L., Unnersjö‐Jess, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.20.639269 · Cited by 1
Notch signalling mediates secondary senescencePreprint
Teo, Y. V., Rattanavirotkul, N., Salzano, A., Quintanilla, A., Tarrats, N., Kiourtis, C., Mueller, M., Green, A. R., Adams, P. D., Acosta, J. C., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/554741
Self-citationHepatocytes and Bile Formation
Gupta, S. K., & Wang, D. Q. ‐. (2019) · Encyclopedia of Gastroenterology · doi:10.1016/b978-0-12-801238-3.65715-x
Stavropoulos, A., Divolis, G., Manioudaki, M., Gavriil, A., Kloukina, I., Perrea, D. N., Sountoulidis, A., Ford, E., Doulou, A., Apostolidou, A. C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.23.453185
“Recent studies have highlighted a negative role of TGFβ-signaling in liver regeneration after APAP-induced liver injury (24, 25).”
BackgroundResultInfluentialRazali, N., Moriyama, Y., Chiu, Y., Suda, K., & Kono, K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.27.497690 · Cited by 1
“This was shown by the significant increase of p21-, p16-, and SA-β-gal-positive cells in response to wounding (27-30).”
BackgroundEffects of Growth Factors and Cytokines on the Liver Regeneration Phase of DILI
魏, 亚. (2022) · Advances in Clinical Medicine · doi:10.12677/acm.2022.1281130
Massoud, G. P., Eid, A. E., Booz, G. W., Rached, L., Yabluchanskiy, A., & Zouein, F. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823679-6.00009-6 · Cited by 1
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“The correspondence between the estimated values and the actual values measured by flow cytometry for neutrophils, monocytes, NK cells, and eosinophils at each time point of GSE111828 was evaluated (Fig.”
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Molecular Targets of microRNAs during Liver Regeneration after Acute Injury: Recent Advances
Loi, R., Simbula, G., & Pibiri, M. (2024) · Gene Expression · doi:10.14218/ge.23.00175
“29 Despite these findings, the processes involved in LR during APAP hepatotoxicity are still poorly understood; further studies are crucial for developing regenerative therapies for the treatment of drug-induced ALF.”
Liver regeneration after acetaminophen overdose
Bhushan, B., & Apte, U. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15877-3.00016-8
Self-citationShrestha, S. (2024) · University of North Texas Digital Library (University of North Texas) · doi:10.12794/metadc2415948
Hepatic Defenses Against Toxicity: Liver Regeneration and Tissue Repair
Apte, U. M., Bhushan, B., & Dadhania, V. P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00285-0
Self-citationXu, T., & Li, D. (2025) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2025.2524249
Sánchez-Guerrero, G., Chavez, D. K., Jaeschke, H., & Ramachandran, A. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70448
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“Multiple studies have shown that an up-regulation of TGF β 1 occurred during acute liver injury and is a driving factor for necrosis and senescence (Bird et al., 2018; McMillin et al., 2014, 2019).”
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692543
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Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692561
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692555
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692546
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Kofler, A., Poelsler, L. H., Oberhuber, R., & Primavesi, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-10997-2_1
Zhu, D., Lu, Y., Jamil, S., Ashfaq, H., Al-Emam, A., & Hassan, H. M. (2026) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2026.127836
Effet du TGFβ produit par le microenvironnement sur les tumeurs du pancréas exocrine
Cardot‐Ruffino, V. (2019) · theses.fr (ABES) · doi:10.70675/5a044019zf697z4071z9643zee4c85ba364f
Distinct fibroblast and perivascular senotypes define spatial niches that regulate fibrosisPreprint
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Zhou, Y., Zeng, M., Fu, G., & Gao, Y. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11172-y
Senescent Human Liver Endothelial Cells Mediate CD4 + T Cell Recruitment via ICOSL
Patten, D. A., Lumley, A., Wilkinson, A. L., O'Keeffe, A., Yin, K., Shirgaonkar, N., Gao, R., DasGupta, R., Hoare, M., & Shetty, S. (2026) · Immunology · doi:10.1111/imm.70159
“Several key studies have implicated senescence in disease pathogenesis, with hepatocyte senescence strongly induced in both acute [6, 7] and chronic liver injury [8–10].”
The Zinc–Senescence Axis in Skin Aging and Wound Healing: A Narrative Review
Mutig, K., Singh, P. B., Azhibek, D., & Lebedeva, S. A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177713
Desulfinylation of the deubiquitinase USP7 by SRXN1 attenuates oxidative acute liver injury
Ke, M., Kim, J.-W., 徐, 美., Wang, J., Liu, L., Syamprasad, N. P., Yang, B., Wang, X., Li, H., Ren, S., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2620180123
Cellular senescence: six decades of discovery and reinvention
Klaver, M., Steeneken, L. S., Veeningen, N., Altulea, A., & Demaria, M. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00922-w
Zhu, H., Hou, Y., Li, X., Tang, Y., Jiang, Z., Zhang, Y., Zhang, X., Du, J., Zhu, Y., Dong, H., et al. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71195
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Metadata
- Authors
- Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., Ferreira-Gonzalez, S., Cole, A. M., Hay, T., Simpson, K. J., Clark, W., Hedley, A., Clarke, M., Gentaz, P., Nixon, C., Bryce, S., Kiourtis, C., Sprangers, J., Nibbs, R. J. B., Van Rooijen, N., Bartholin, L., McGreal, S. R., Apte, U., Barry, S. T., Iredale, J. P., Clarke, A. R., Serrano, M., Roskams, T. A., Sansom, O. J., & Forbes, S. J.
- Affiliations
- MRC Centre for Regenerative Medicine (GB)
- Cancer Research UK Scotland Institute (GB)
- Spanish National Cancer Research Centre (ES)
- Universitair Ziekenhuis Leuven (BE)
- Medical Research Council (MRC) Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
- Cardiff University (GB)
- University of Glasgow (GB)
- Vrije Universiteit Medical Center, Department of Molecular Cell Biology, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands.
- Lyon 1 Université (FR)
- University of Kansas Medical Center (US)
- AstraZeneca (United Kingdom) (GB)
- University of Bristol (GB)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Bird, Thomas G.
- Clarke, Alan R.
- ORCID
- Bird, Thomas G.
- Müller, Miryam
- Boulter, Luke
- Vincent, David F.
- Ridgway, Rachel A.
- Lopez-Guadamillas, Elena
- Lu, Wei-Yu
- Jamieson, Thomas
- Govaere, Olivier
- Campbell, Andrew D.
- Ferreira-Gonzalez, Sofía
- Cole, Alicia M.
- Hay, Trevor
- Clark, William
- Hedley, Ann
- Clarke, Mairi
- Gentaz, Pauline
- Nixon, Colin
- Bryce, Steven
- Kiourtis, Christos
- Nibbs, Robert J. B.
- Van Rooijen, Nico
- Bartholin, Laurent
- McGreal, Steven R.
- Apte, Udayan
- Barry, Simon T.
- Iredale, John P.
- Clarke, Alan R.
- Serrano, Manuel
- Roskams, Tania A.
- Sansom, Owen J.
- Forbes, Stuart J.
- Venue
- Science Translational Medicine
- Published
- 2018-08-15
- Volume
- 10
- Issue
- 454
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6420144
- OpenAlex
- W2887276938
- Cited by
- 261
- References
- 61
- Citations by year
- 2026: 16 · 2025: 34 · 2024: 47 · 2023: 42 · 2022: 31 · 2021: 28 · 2020: 37 · 2019: 24 · 2018: 2
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Edinburgh Research Explorer (University of Edinburgh) (publishedVersion, other-oa)
- Bristol Research (University of Bristol) (publishedVersion, other-oa)
- Explore Bristol Research (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (R01 DK98414)
- Wellcome Trust (107492Z, 081604AIA)
- Medical Research Council (G1000868, G0900992)
- Cancer Research UK (2016-CRUK core running, A12481)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- acute liver injury, liver regeneration, hepatocyte senescence, paracrine senescence, TGF-β1, acetaminophen toxicity, p21, macrophages, hepatocyte proliferation, acute liver failure
- MeSH terms
- Animals, Disease Models, Animal, Humans, Liver, Liver Regeneration, Macrophages, Male, Mice, Inbred C57BL, Necrosis, Signal Transduction, Transforming Growth Factor beta, Cellular Senescence, Paracrine Communication, Hepatocytes, Cyclin-Dependent Kinase Inhibitor p21
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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